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Entry version 111 (07 Apr 2021)
Sequence version 1 (01 Aug 1998)
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Protein

Fructose-bisphosphate aldolase

Gene

ALDOB

Organism
Salmo salar (Atlantic salmon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotationARBA annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Hexokinase (LOC106589825), Hexokinase (LOC106564733), Hexokinase (LOC106589825), Hexokinase (LOC106612430), Phosphotransferase (LOC106585167), Hexokinase (LOC106585103), Hexokinase (LOC106587516), Phosphotransferase (LOC106580495), Hexokinase (LOC106580495), Phosphotransferase (LOC106580581), Phosphotransferase (LOC106585167), Phosphotransferase (LOC106568009), Phosphotransferase (LOC106585167), Hexokinase (LOC106585103), Phosphotransferase (LOC106580581), Phosphotransferase (LOC106585167), Hexokinase (LOC106612435)
  2. Glucose-6-phosphate isomerase (LOC106587569), Glucose-6-phosphate isomerase (G6PI)
  3. ATP-dependent 6-phosphofructokinase, liver type-like (LOC106593347), ATP-dependent 6-phosphofructokinase (LOC106568830), ATP-dependent 6-phosphofructokinase (k6pp), ATP-dependent 6-phosphofructokinase, muscle type-like (LOC106572730), ATP-dependent 6-phosphofructokinase (LOC106568830), ATP-dependent 6-phosphofructokinase (k6pp), ATP-dependent 6-phosphofructokinase (LOC106578535), ATP-dependent 6-phosphofructokinase (LOC106582566), ATP-dependent 6-phosphofructokinase (LOC106583067), ATP-dependent 6-phosphofructokinase (K6PP), ATP-dependent 6-phosphofructokinase (LOC106565515), ATP-dependent 6-phosphofructokinase (LOC106578535), ATP-dependent 6-phosphofructokinase (k6pp), ATP-dependent 6-phosphofructokinase (LOC106578535), ATP-dependent 6-phosphofructokinase (LOC106572792), ATP-dependent 6-phosphofructokinase (LOC106566997), ATP-dependent 6-phosphofructokinase (LOC106578535), ATP-dependent 6-phosphofructokinase (LOC106578535), ATP-dependent 6-phosphofructokinase (LOC106578535), ATP-dependent 6-phosphofructokinase (LOC106578535)
  4. Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (LOC106612788), Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase A, Fructose-bisphosphate aldolase (aldA), Fructose-bisphosphate aldolase (aldoc), Fructose-bisphosphate aldolase (LOC100194624), Fructose-bisphosphate aldolase (ALF1), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (LOC100194623), Fructose-bisphosphate aldolase (LOC106604855), Fructose-bisphosphate aldolase (ALDOA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyaseUniRule annotation
Biological processGlycolysisUniRule annotation
LigandSchiff baseARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00109;UER00183

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fructose-bisphosphate aldolaseUniRule annotationARBA annotation (EC:4.1.2.13UniRule annotationARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALDOBImported
Synonyms:aldobImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmo salar (Atlantic salmon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8030 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000087266 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
10151, Sal s 3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
O73866

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I fructose-bisphosphate aldolase family.UniRule annotationARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
799973at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029768, Aldolase_I_AS
IPR013785, Aldolase_TIM
IPR000741, FBA_I

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00274, Glycolytic, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00158, ALDOLASE_CLASS_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O73866-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTQFPSLSP EQKKELSDIA QRIVAPGKGI LAADESTGTM GKRLQKINVE
60 70 80 90 100
NNEENRRTFR DLLFSAVDPN CIGGIIFFHE TLYQMSDKGV LFPQVIKDKG
110 120 130 140 150
IVVGIKVDKG TAGLNGTDGE TTTQGLDGLS ERCAQYKKDG CDFAKWRCVL
160 170 180 190 200
KISDACPSDL AIAENANVLA RYASICQQNG LVPIVEPEIL PDGDHDLLRT
210 220 230 240 250
QYVTEKVLAA TYKALNDHHV YLEGTLLKPN MVTAGHSCPK KFTPQEVGMA
260 270 280 290 300
TVTALRRTVP AAVPGITFLS GGQSEEEATQ NLNAMNLTSL HRPWKLSFSY
310 320 330 340 350
GRALQASALA AWKGKAANKQ SAQDAFTSRA KSNGLASKGK YTAVSSDDQA
360
SMQSLHTANY VY
Length:362
Mass (Da):39,234
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC237A5E0B9C689DC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF067796 mRNA Translation: AAD11573.1
BT048247 mRNA Translation: ACI68048.1
BT050373 mRNA Translation: ACI70174.1

NCBI Reference Sequences

More...
RefSeqi
NP_001117099.1, NM_001123627.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSAT00000008512; ENSSSAP00000007976; ENSSSAG00000003802

Database of genes from NCBI RefSeq genomes

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GeneIDi
100136522

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sasa:100136522

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067796 mRNA Translation: AAD11573.1
BT048247 mRNA Translation: ACI68048.1
BT050373 mRNA Translation: ACI70174.1
RefSeqiNP_001117099.1, NM_001123627.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

Allergomei10151, Sal s 3

Proteomic databases

PRIDEiO73866

Genome annotation databases

EnsembliENSSSAT00000008512; ENSSSAP00000007976; ENSSSAG00000003802
GeneIDi100136522
KEGGisasa:100136522

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
229

Phylogenomic databases

OrthoDBi799973at2759

Enzyme and pathway databases

UniPathwayiUPA00109;UER00183

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768, Aldolase_I_AS
IPR013785, Aldolase_TIM
IPR000741, FBA_I
PfamiView protein in Pfam
PF00274, Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158, ALDOLASE_CLASS_I, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO73866_SALSA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O73866
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: April 7, 2021
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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