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UniProtKB - O73853 (CP17A_ICTPU)
Protein
Steroid 17-alpha-hydroxylase/17,20 lyase
Gene
cyp17a1
Organism
Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Status
Functioni
Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.
Catalytic activityi
- a C21-steroid + O2 + reduced [NADPH—hemoprotein reductase] = a 17α-hydroxy-C21-steroid + H+ + H2O + oxidized [NADPH—hemoprotein reductase]By similarityEC:1.14.14.19By similarity
- 17α-hydroxyprogesterone + O2 + reduced [NADPH—hemoprotein reductase] = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized [NADPH—hemoprotein reductase]By similarityEC:1.14.14.32By similarity
- 17α-hydroxypregnenolone + O2 + reduced [NADPH—hemoprotein reductase] = 3β-hydroxyandrost-5-en-17-one + acetate + 2 H+ + H2O + oxidized [NADPH—hemoprotein reductase]By similarityEC:1.14.14.32By similarity
Cofactori
hemeBy similarity
: steroid biosynthesis Pathwayi
This protein is involved in the pathway steroid biosynthesis, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway steroid biosynthesis and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 445 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- 17-alpha-hydroxyprogesterone aldolase activity Source: InterPro
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- steroid 17-alpha-monooxygenase activity Source: UniProtKB-EC
GO - Biological processi
- sex differentiation Source: InterPro
- steroid biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Lyase, Monooxygenase, Oxidoreductase |
Biological process | Lipid metabolism, Steroidogenesis |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00062 |
Names & Taxonomyi
Protein namesi | Recommended name: Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.14.19By similarity, EC:1.14.14.32By similarity)Alternative name(s): 17-alpha-hydroxyprogesterone aldolase CYPXVII Cytochrome P450 17A1 Cytochrome P450-C17 Short name: Cytochrome P450c17 |
Gene namesi | Name:cyp17a1 Synonyms:cyp17 |
Organismi | Ictalurus punctatus (Channel catfish) (Silurus punctatus) |
Taxonomic identifieri | 7998 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Siluriformes › Ictaluridae › Ictalurus |
Proteomesi |
|
Subcellular locationi
Other locations
- Membrane Curated
Other locations
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051945 | 1 – 514 | Steroid 17-alpha-hydroxylase/17,20 lyaseAdd BLAST | 514 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
OrthoDBi | 702827at2759 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR033282, CYP17A1 IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
PANTHERi | PTHR24289:SF7, PTHR24289:SF7, 1 hit |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
O73853-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGWLICFCVF AAIIIVALYL RKIHGFLVDD RAPPNLPSLP IIGSLLSINS
60 70 80 90 100
NSPPHIFFQQ LQKKYGDIYS LDMGSNRVII VNNHHHAKEV LLRKGKIFAG
110 120 130 140 150
RPRTVTTDIL TRDGKDIAFG DYSATWKFHR KIVHGALCMF GEGTASIEKI
160 170 180 190 200
ICREASSMCE ILTNLQSSAA DLAPELTRAV TNVVCTLCFS SSYKRGDPEF
210 220 230 240 250
EAMLKYSQGI VDTVAKDSLV DIFPWLQLFP NEDLRILRRC VSIRDKLLQK
260 270 280 290 300
KYEEHKADFS DNIQRDLFDA LLRAKNSSEN NNTSTQDVGL TDDHLLMTVG
310 320 330 340 350
DIFGAGVETT TTVLKWSILY LIHHPQVQRK IQEELDAKIG RDRHPQVNDR
360 370 380 390 400
GNLPYLEATI REVLRIRPVS PLLIPHVALS DANIGEYTVQ KGTRVIVNLW
410 420 430 440 450
SLHHDEKEWK NPELFNPERF LNEEGNSLCC PSLSYLPFGA GVRVCLGEAL
460 470 480 490 500
AKLELFLFLS WILQRFTLEV PGGQPLPELQ GKFRVVLQPQ KYKVIARLRT
510
GWEKSLQSQE SESG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF063837 mRNA Translation: AAC16551.1 |
RefSeqi | NP_001187242.1, NM_001200313.1 |
Genome annotation databases
GeneIDi | 100313515 |
KEGGi | ipu:100313515 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF063837 mRNA Translation: AAC16551.1 |
RefSeqi | NP_001187242.1, NM_001200313.1 |
3D structure databases
AlphaFoldDBi | O73853 |
SMRi | O73853 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7998.ENSIPUP00000036506 |
Genome annotation databases
GeneIDi | 100313515 |
KEGGi | ipu:100313515 |
Organism-specific databases
CTDi | 100313515 |
Phylogenomic databases
OrthoDBi | 702827at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00062 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR033282, CYP17A1 IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
PANTHERi | PTHR24289:SF7, PTHR24289:SF7, 1 hit |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP17A_ICTPU | |
Accessioni | O73853Primary (citable) accession number: O73853 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | August 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families