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Protein

Gremlin-1

Gene

GREM1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that may play a role in the development of the medial pallium and during optic nerve and pecten development by modulating BMP signaling.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Gremlin-1
Gene namesi
Name:GREM1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000671825 – 184Gremlin-1Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi94 ↔ 144By similarity
Disulfide bondi108 ↔ 158By similarity
Disulfide bondi118 ↔ 176By similarity
Disulfide bondi122 ↔ 178By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO73755

Expressioni

Developmental stagei

In brain first detected at E6 and persisted until E14. On E10 brain, expressed in the dorsal region of the telencephalic hemispheres and cells located in the ventral diencephalon. On E14 head, expressed in the meninges of the spinal cord. Expressed in the developing optic nerve and at the optic nerve/pecten junction.1 Publication

Gene expression databases

BgeeiENSGALG00000009724 Expressed in 6 organ(s), highest expression level in colon

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037126

Structurei

3D structure databases

ProteinModelPortaliO73755
SMRiO73755
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 184CTCKAdd BLAST91

Sequence similaritiesi

Belongs to the DAN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IG3Z Eukaryota
ENOG4111HEF LUCA
GeneTreeiENSGT00510000046909
HOGENOMiHOG000237358
HOVERGENiHBG051837
InParanoidiO73755
OMAiRVKECRC
OrthoDBiEOG091G0GL9
PhylomeDBiO73755
TreeFamiTF106445

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR004133 DAN
IPR017159 Gremlin-1/2
PfamiView protein in Pfam
PF03045 DAN, 1 hit
PIRSFiPIRSF037254 Gremlin_precursor, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O73755-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRTLYAIGA VFLLTGFLLP TAEGRKRNRG SQGAIPPPDK DQPNDSEQMQ
60 70 80 90 100
TQQQSGSRHR ERGKGTSMPA EEVLESSQEA LHITERKYLK RDWCKTQPLK
110 120 130 140 150
QTIHEEGCNS RTIINRFCYG QCNSFYIPRH VRKEEGSFQS CSFCKPKKFT
160 170 180
TMTVTLNCPE LQPPRKKKRI TRVKECRCIS IDLD
Length:184
Mass (Da):21,166
Last modified:August 1, 1998 - v1
Checksum:i3510B44E8F6DD5EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045799 mRNA Translation: AAC41280.1
RefSeqiNP_990309.1, NM_204978.2
UniGeneiGga.19740
Gga.2961

Genome annotation databases

EnsembliENSGALT00000015827; ENSGALP00000037126; ENSGALG00000009724
GeneIDi395826
KEGGigga:395826

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045799 mRNA Translation: AAC41280.1
RefSeqiNP_990309.1, NM_204978.2
UniGeneiGga.19740
Gga.2961

3D structure databases

ProteinModelPortaliO73755
SMRiO73755
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037126

Proteomic databases

PaxDbiO73755

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000015827; ENSGALP00000037126; ENSGALG00000009724
GeneIDi395826
KEGGigga:395826

Organism-specific databases

CTDi26585

Phylogenomic databases

eggNOGiENOG410IG3Z Eukaryota
ENOG4111HEF LUCA
GeneTreeiENSGT00510000046909
HOGENOMiHOG000237358
HOVERGENiHBG051837
InParanoidiO73755
OMAiRVKECRC
OrthoDBiEOG091G0GL9
PhylomeDBiO73755
TreeFamiTF106445

Miscellaneous databases

PROiPR:O73755

Gene expression databases

BgeeiENSGALG00000009724 Expressed in 6 organ(s), highest expression level in colon

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR004133 DAN
IPR017159 Gremlin-1/2
PfamiView protein in Pfam
PF03045 DAN, 1 hit
PIRSFiPIRSF037254 Gremlin_precursor, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGREM1_CHICK
AccessioniPrimary (citable) accession number: O73755
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: August 1, 1998
Last modified: October 10, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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