coe3

Functionⁱ

Acts as a transcriptional activator.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	151 – 170	C5-typeSequence analysisAdd BLAST		20

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity Source: InterPro
metal ion binding Source: UniProtKB-KW
protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

multicellular organism development Source: UniProtKB-KW
positive regulation of transcription, DNA-templated Source: UniProtKB
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor COE3 Short name: xCOE3 Alternative name(s): Olf-1/EBF-like 2 Short name: OE-2 Short name: xEBF-3 Short name: xOE-2
Gene namesⁱ	Name:coe3
Organismⁱ	Xenopus laevis (African clawed frog)
Taxonomic identifierⁱ	8355 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Organism-specific databases

Xenbaseⁱ	XB-GENE-962547 ebf3

Xenbaseⁱ

XB-GENE-962547 ebf3

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000107834	1 – 598	Transcription factor COE3Add BLAST		598

Proteomic databases

PRIDEⁱ	O73742

PRIDEⁱ

O73742

Interactionⁱ

Subunit structureⁱ

Forms either a homodimer or a heterodimer with a related family member.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	163	Interaction with DNABy similarity		1
Siteⁱ	172	Interaction with DNABy similarity		1

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	O73742
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	264 – 347	IPT/TIGAdd BLAST		84

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	63 – 66	Interaction with DNABy similarity	4
Regionⁱ	197 – 204	Interaction with DNABy similarity	8
Regionⁱ	236 – 239	Interaction with DNABy similarity	4

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	465 – 556	Pro/Ser/Thr-richAdd BLAST		92

Sequence similaritiesⁱ

Belongs to the COE family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	151 – 170	C5-typeSequence analysisAdd BLAST		20

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

HOVERGENⁱ	HBG005108
KEGG Orthology (KO) More...KOⁱ	K09103

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11606 COE_DBD, 1 hit cd01175 IPT_COE, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit 2.60.40.3180, 1 hit 4.10.280.10, 2 hits
InterProⁱ	View protein in InterPro IPR032200 COE_DBD IPR038173 COE_DBD_sf IPR032201 COE_HLH IPR038006 COE_IPT IPR036638 HLH_DNA-bd_sf IPR013783 Ig-like_fold IPR014756 Ig_E-set IPR002909 IPT_dom IPR003523 Transcription_factor_COE IPR018350 Transcription_factor_COE_CS
PANTHERⁱ	PTHR10747 PTHR10747, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16422 COE1_DBD, 1 hit PF16423 COE1_HLH, 1 hit PF01833 TIG, 1 hit
SMARTⁱ	View protein in SMART SM00429 IPT, 1 hit
SUPFAMⁱ	SSF81296 SSF81296, 1 hit
PROSITEⁱ	View protein in PROSITE PS01345 COE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O73742-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFGIQENIPR GGTTMKEEPL GGGMNPVRSW MHTAGVVDAN TAAQSGVGLA 
        60         70         80         90        100
RAHFEKQPPS NLRKSNFFHF VLAMYDRQGQ PVEIERTTFV DFVEKDKEPN 
       110        120        130        140        150
SEKTNNGIHY KLQLLYSNGV RTEQDLYVRL IDSMTKQAII YEGQDKNPEM 
       160        170        180        190        200
CRVLLTHEIM CSRCCDKKSC GNRNETPSDP VIIDRFFLKF FLKCNQNCLK 
       210        220        230        240        250
NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH GRRARRLDPS 
       260        270        280        290        300
EGTAPSYLEN VATPCIKAIS PSEGWTTGGA TVIIIGDNFF DGLQVVFGTM 
       310        320        330        340        350
LVWSELITPH AIRVQTPPRH IPGVVEVTLS YKSKQFCKGA PGRFVYTALN 
       360        370        380        390        400
EPTIDYGFQR LQKVIPRHPG DPERLPKEVL LKRAADLVEA LYGMPHNNQE 
       410        420        430        440        450
IILKRAADIA EALYSVPRNH NQIPSLANTP SHSGMMGVNS FSSQLAVNVS 
       460        470        480        490        500
ETSQANDQVG YSRNTSSVSP RGYVPSSTPQ QSNYNTVSNS MNGYGNAGMP 
       510        520        530        540        550
NLGVPGSPGF LNGSSANSPY GIVPSSPTMA ASSVTLPSNC SSTHGIFSFS 
       560        570        580        590 
PANVISAVKQ KSAFAPVVRP QASPPPSCTS ANGNGLQDMY FSPTFSKS

Length:598

Mass (Da):65,344

Last modified:May 4, 2001 - v2

Checksum:ⁱAC61383E4CD58B0F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF040994 mRNA Translation: AAC15659.3
NCBI Reference Sequences More...RefSeqⁱ	NP_001083801.1, NM_001090332.1
UniGeneⁱ	Xl.632

Genome annotation databases

GeneIDⁱ	399125
KEGGⁱ	xla:399125

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O73742	Uncharacterized protein		XENLA		598	UniRef100_O73742

Protein	Similar proteins		Species	Score	Length	Source
O73742	Transcription factor COE3	)	HUMAN		596	UniRef90_Q9H4W6
Transcription factor COE3		MOUSE		596
EBF3 isoform 1		PANTR		596
transcription factor COE3 isoform X2		Enhydra lutris kenyoni		630
transcription factor COE3 isoform X1		Asian bonytongue		622
+500

Protein	Similar proteins		Species	Score	Length	Source
O73742	Transcription factor collier		DROME		575	UniRef50_P56721
Transcription factor COE1	)	HUMAN		591
Transcription factor COE1	)	MOUSE		591
Transcription factor COE1		RAT		584
Uncharacterized protein, isoform C		DROER		575
+1121

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF040994 mRNA Translation: AAC15659.3
RefSeqⁱ	NP_001083801.1, NM_001090332.1
UniGeneⁱ	Xl.632

3D structure databases

SMRⁱ	O73742
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	O73742

PRIDEⁱ

O73742

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	399125
KEGGⁱ	xla:399125

Organism-specific databases

CTDⁱ	399125
Xenbaseⁱ	XB-GENE-962547 ebf3

Phylogenomic databases

HOVERGENⁱ	HBG005108
KOⁱ	K09103

Family and domain databases

CDDⁱ	cd11606 COE_DBD, 1 hit cd01175 IPT_COE, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit 2.60.40.3180, 1 hit 4.10.280.10, 2 hits
InterProⁱ	View protein in InterPro IPR032200 COE_DBD IPR038173 COE_DBD_sf IPR032201 COE_HLH IPR038006 COE_IPT IPR036638 HLH_DNA-bd_sf IPR013783 Ig-like_fold IPR014756 Ig_E-set IPR002909 IPT_dom IPR003523 Transcription_factor_COE IPR018350 Transcription_factor_COE_CS
PANTHERⁱ	PTHR10747 PTHR10747, 1 hit
Pfamⁱ	View protein in Pfam PF16422 COE1_DBD, 1 hit PF16423 COE1_HLH, 1 hit PF01833 TIG, 1 hit
SMARTⁱ	View protein in SMART SM00429 IPT, 1 hit
SUPFAMⁱ	SSF81296 SSF81296, 1 hit
PROSITEⁱ	View protein in PROSITE PS01345 COE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	COE3_XENLA
Accessionⁱ	O73742Primary (citable) accession number: O73742
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	May 4, 2001
	Last modified:	September 12, 2018
	This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Documents

SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O73742 (COE3_XENLA)

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Transcription factor COE3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ