UniProtKB - O73742 (COE3_XENLA)
Protein
Transcription factor COE3
Gene
coe3
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Acts as a transcriptional activator.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 151 – 170 | C5-typeSequence analysisAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- protein dimerization activity Source: InterPro
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- positive regulation of transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor COE3Short name: xCOE3 Alternative name(s): Olf-1/EBF-like 2 Short name: OE-2 Short name: xEBF-3 Short name: xOE-2 |
Gene namesi | Name:coe3 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-962547, ebf3.L |
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000107834 | 1 – 598 | Transcription factor COE3Add BLAST | 598 |
Interactioni
Subunit structurei
Forms either a homodimer or a heterodimer with a related family member.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 163 | Interaction with DNABy similarity | 1 | |
Sitei | 172 | Interaction with DNABy similarity | 1 |
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 264 – 347 | IPT/TIGAdd BLAST | 84 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 63 – 66 | Interaction with DNABy similarity | 4 | |
Regioni | 197 – 204 | Interaction with DNABy similarity | 8 | |
Regioni | 236 – 239 | Interaction with DNABy similarity | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 465 – 556 | Pro/Ser/Thr-richAdd BLAST | 92 |
Sequence similaritiesi
Belongs to the COE family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 151 – 170 | C5-typeSequence analysisAdd BLAST | 20 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
OrthoDBi | 817293at2759 |
Family and domain databases
CDDi | cd11606, COE_DBD, 1 hit cd01175, IPT_COE, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.3180, 1 hit 4.10.280.10, 2 hits |
InterProi | View protein in InterPro IPR032200, COE_DBD IPR038173, COE_DBD_sf IPR032201, COE_HLH IPR038006, COE_IPT IPR036638, HLH_DNA-bd_sf IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR003523, Transcription_factor_COE IPR018350, Transcription_factor_COE_CS |
PANTHERi | PTHR10747, PTHR10747, 1 hit |
Pfami | View protein in Pfam PF16422, COE1_DBD, 1 hit PF16423, COE1_HLH, 1 hit PF01833, TIG, 1 hit |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS01345, COE, 1 hit |
i Sequence
Sequence statusi: Complete.
O73742-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFGIQENIPR GGTTMKEEPL GGGMNPVRSW MHTAGVVDAN TAAQSGVGLA
60 70 80 90 100
RAHFEKQPPS NLRKSNFFHF VLAMYDRQGQ PVEIERTTFV DFVEKDKEPN
110 120 130 140 150
SEKTNNGIHY KLQLLYSNGV RTEQDLYVRL IDSMTKQAII YEGQDKNPEM
160 170 180 190 200
CRVLLTHEIM CSRCCDKKSC GNRNETPSDP VIIDRFFLKF FLKCNQNCLK
210 220 230 240 250
NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH GRRARRLDPS
260 270 280 290 300
EGTAPSYLEN VATPCIKAIS PSEGWTTGGA TVIIIGDNFF DGLQVVFGTM
310 320 330 340 350
LVWSELITPH AIRVQTPPRH IPGVVEVTLS YKSKQFCKGA PGRFVYTALN
360 370 380 390 400
EPTIDYGFQR LQKVIPRHPG DPERLPKEVL LKRAADLVEA LYGMPHNNQE
410 420 430 440 450
IILKRAADIA EALYSVPRNH NQIPSLANTP SHSGMMGVNS FSSQLAVNVS
460 470 480 490 500
ETSQANDQVG YSRNTSSVSP RGYVPSSTPQ QSNYNTVSNS MNGYGNAGMP
510 520 530 540 550
NLGVPGSPGF LNGSSANSPY GIVPSSPTMA ASSVTLPSNC SSTHGIFSFS
560 570 580 590
PANVISAVKQ KSAFAPVVRP QASPPPSCTS ANGNGLQDMY FSPTFSKS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF040994 mRNA Translation: AAC15659.3 |
RefSeqi | NP_001083801.1, NM_001090332.1 |
Genome annotation databases
GeneIDi | 399125 |
KEGGi | xla:399125 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF040994 mRNA Translation: AAC15659.3 |
RefSeqi | NP_001083801.1, NM_001090332.1 |
3D structure databases
SMRi | O73742 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 399125 |
KEGGi | xla:399125 |
Organism-specific databases
CTDi | 399125 |
Xenbasei | XB-GENE-962547, ebf3.L |
Phylogenomic databases
OrthoDBi | 817293at2759 |
Family and domain databases
CDDi | cd11606, COE_DBD, 1 hit cd01175, IPT_COE, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.3180, 1 hit 4.10.280.10, 2 hits |
InterProi | View protein in InterPro IPR032200, COE_DBD IPR038173, COE_DBD_sf IPR032201, COE_HLH IPR038006, COE_IPT IPR036638, HLH_DNA-bd_sf IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR003523, Transcription_factor_COE IPR018350, Transcription_factor_COE_CS |
PANTHERi | PTHR10747, PTHR10747, 1 hit |
Pfami | View protein in Pfam PF16422, COE1_DBD, 1 hit PF16423, COE1_HLH, 1 hit PF01833, TIG, 1 hit |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS01345, COE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COE3_XENLA | |
Accessioni | O73742Primary (citable) accession number: O73742 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 4, 2001 | |
Last modified: | December 2, 2020 | |
This is version 105 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |