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Protein

Transcription factor COE3

Gene

coe3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri151 – 170C5-typeSequence analysisAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor COE3
Short name:
xCOE3
Alternative name(s):
Olf-1/EBF-like 2
Short name:
OE-2
Short name:
xEBF-3
Short name:
xOE-2
Gene namesi
Name:coe3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-962547 ebf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001078341 – 598Transcription factor COE3Add BLAST598

Proteomic databases

PRIDEiO73742

Interactioni

Subunit structurei

Forms either a homodimer or a heterodimer with a related family member.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei163Interaction with DNABy similarity1
Sitei172Interaction with DNABy similarity1

GO - Molecular functioni

Structurei

3D structure databases

SMRiO73742
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini264 – 347IPT/TIGAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni63 – 66Interaction with DNABy similarity4
Regioni197 – 204Interaction with DNABy similarity8
Regioni236 – 239Interaction with DNABy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi465 – 556Pro/Ser/Thr-richAdd BLAST92

Sequence similaritiesi

Belongs to the COE family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri151 – 170C5-typeSequence analysisAdd BLAST20

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG005108
KOiK09103

Family and domain databases

CDDicd11606 COE_DBD, 1 hit
cd01175 IPT_COE, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.3180, 1 hit
4.10.280.10, 2 hits
InterProiView protein in InterPro
IPR032200 COE_DBD
IPR038173 COE_DBD_sf
IPR032201 COE_HLH
IPR038006 COE_IPT
IPR036638 HLH_DNA-bd_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR003523 Transcription_factor_COE
IPR018350 Transcription_factor_COE_CS
PANTHERiPTHR10747 PTHR10747, 1 hit
PfamiView protein in Pfam
PF16422 COE1_DBD, 1 hit
PF16423 COE1_HLH, 1 hit
PF01833 TIG, 1 hit
SMARTiView protein in SMART
SM00429 IPT, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS01345 COE, 1 hit

Sequencei

Sequence statusi: Complete.

O73742-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFGIQENIPR GGTTMKEEPL GGGMNPVRSW MHTAGVVDAN TAAQSGVGLA
60 70 80 90 100
RAHFEKQPPS NLRKSNFFHF VLAMYDRQGQ PVEIERTTFV DFVEKDKEPN
110 120 130 140 150
SEKTNNGIHY KLQLLYSNGV RTEQDLYVRL IDSMTKQAII YEGQDKNPEM
160 170 180 190 200
CRVLLTHEIM CSRCCDKKSC GNRNETPSDP VIIDRFFLKF FLKCNQNCLK
210 220 230 240 250
NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH GRRARRLDPS
260 270 280 290 300
EGTAPSYLEN VATPCIKAIS PSEGWTTGGA TVIIIGDNFF DGLQVVFGTM
310 320 330 340 350
LVWSELITPH AIRVQTPPRH IPGVVEVTLS YKSKQFCKGA PGRFVYTALN
360 370 380 390 400
EPTIDYGFQR LQKVIPRHPG DPERLPKEVL LKRAADLVEA LYGMPHNNQE
410 420 430 440 450
IILKRAADIA EALYSVPRNH NQIPSLANTP SHSGMMGVNS FSSQLAVNVS
460 470 480 490 500
ETSQANDQVG YSRNTSSVSP RGYVPSSTPQ QSNYNTVSNS MNGYGNAGMP
510 520 530 540 550
NLGVPGSPGF LNGSSANSPY GIVPSSPTMA ASSVTLPSNC SSTHGIFSFS
560 570 580 590
PANVISAVKQ KSAFAPVVRP QASPPPSCTS ANGNGLQDMY FSPTFSKS
Length:598
Mass (Da):65,344
Last modified:May 4, 2001 - v2
Checksum:iAC61383E4CD58B0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040994 mRNA Translation: AAC15659.3
RefSeqiNP_001083801.1, NM_001090332.1
UniGeneiXl.632

Genome annotation databases

GeneIDi399125
KEGGixla:399125

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040994 mRNA Translation: AAC15659.3
RefSeqiNP_001083801.1, NM_001090332.1
UniGeneiXl.632

3D structure databases

SMRiO73742
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO73742

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399125
KEGGixla:399125

Organism-specific databases

CTDi399125
XenbaseiXB-GENE-962547 ebf3

Phylogenomic databases

HOVERGENiHBG005108
KOiK09103

Family and domain databases

CDDicd11606 COE_DBD, 1 hit
cd01175 IPT_COE, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.3180, 1 hit
4.10.280.10, 2 hits
InterProiView protein in InterPro
IPR032200 COE_DBD
IPR038173 COE_DBD_sf
IPR032201 COE_HLH
IPR038006 COE_IPT
IPR036638 HLH_DNA-bd_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR003523 Transcription_factor_COE
IPR018350 Transcription_factor_COE_CS
PANTHERiPTHR10747 PTHR10747, 1 hit
PfamiView protein in Pfam
PF16422 COE1_DBD, 1 hit
PF16423 COE1_HLH, 1 hit
PF01833 TIG, 1 hit
SMARTiView protein in SMART
SM00429 IPT, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS01345 COE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOE3_XENLA
AccessioniPrimary (citable) accession number: O73742
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 4, 2001
Last modified: September 12, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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