UniProtKB - O73736 (O73736_DANRE)
Protein
Receptor protein serine/threonine kinase
Gene
acvr1l
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Catalytic activityi
- EC:2.7.11.30ARBA annotation
- ATP + L-threonyl-[receptor-protein] = ADP + H+ + O-phospho-L-threonyl-[receptor-protein]ARBA annotationEC:2.7.11.30ARBA annotation
Cofactori
Mg2+ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 232 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: ZFIN
- protein serine/threonine kinase activity Source: GO_Central
- SMAD binding Source: GO_Central
- transforming growth factor beta receptor activity, type I Source: GO_Central
GO - Biological processi
- angiogenesis Source: GO_Central
- anterior/posterior pattern specification Source: ZFIN
- BMP signaling pathway Source: ZFIN
- brain development Source: ZFIN
- cardiac atrium development Source: ZFIN
- cartilage development Source: ZFIN
- cellular response to growth factor stimulus Source: GO_Central
- central nervous system formation Source: ZFIN
- determination of heart left/right asymmetry Source: ZFIN
- determination of left/right asymmetry in diencephalon Source: ZFIN
- determination of left/right asymmetry in lateral mesoderm Source: ZFIN
- determination of left/right symmetry Source: ZFIN
- determination of ventral identity Source: ZFIN
- dorsal/ventral pattern formation Source: ZFIN
- dorsal convergence Source: ZFIN
- embryonic caudal fin morphogenesis Source: ZFIN
- embryonic heart tube development Source: ZFIN
- embryonic heart tube morphogenesis Source: ZFIN
- embryonic hemopoiesis Source: ZFIN
- heart development Source: GO_Central
- heart jogging Source: ZFIN
- heart looping Source: ZFIN
- lateral mesoderm development Source: ZFIN
- liver development Source: ZFIN
- mesoderm morphogenesis Source: ZFIN
- negative regulation of calcium-dependent cell-cell adhesion Source: ZFIN
- odontogenesis Source: ZFIN
- ossification Source: ZFIN
- proepicardium development Source: ZFIN
- protein phosphorylation Source: ZFIN
- regulation of BMP signaling pathway Source: ZFIN
- transforming growth factor beta receptor signaling pathway Source: GO_Central
- vasculature development Source: ZFIN
Keywordsi
Molecular function | Kinase, ReceptorImported, Serine/threonine-protein kinaseARBA annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor protein serine/threonine kinaseARBA annotation (EC:2.7.11.30ARBA annotation) |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-990415-9, acvr1l |
Subcellular locationi
Plasma Membrane
- BMP receptor complex Source: ZFIN
- integral component of plasma membrane Source: ZFIN
- plasma membrane Source: GO_Central
Other locations
- cell cortex Source: ZFIN
- cytoplasm Source: ZFIN
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 120 – 143 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5015096805 | 22 – 506 | Receptor protein serine/threonine kinaseSequence analysisAdd BLAST | 485 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000014986, Expressed in gastrula and 32 other tissues |
Interactioni
GO - Molecular functioni
- SMAD binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000111550 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 175 – 204 | GSInterPro annotationAdd BLAST | 30 | |
Domaini | 205 – 499 | Protein kinaseInterPro annotationAdd BLAST | 295 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.ARBA annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG2052, Eukaryota |
GeneTreei | ENSGT00940000166078 |
HOGENOMi | CLU_000288_8_5_1 |
OMAi | THSQADN |
OrthoDBi | 776697at2759 |
TreeFami | TF314724 |
Family and domain databases
InterProi | View protein in InterPro IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O73736-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGHCSTQIII LFLLQFLQTS AKDVSIDCMC VGSDCNEQQC TGDQCYTSVI
60 70 80 90 100
ISNDVTTFKR GCLIGPASKR MTCSATASAS HVVECCSQHM CNANVSKETL
110 120 130 140 150
LRLLLTSPEE KKTVHYRVEM LVLFVLGPFV VLGLLSFLAL LVCRRLHHGR
160 170 180 190 200
LERLHEFDTE QGAIDGLIAS NVGDSTLADL MDHSCTSGSG SGLPFLVQRT
210 220 230 240 250
VARQISLVEC VGKGRYGEVW RGQWQGENVA VKIFSSRDEK SWFRETEIYN
260 270 280 290 300
TVLLRHENIL GFMASDMTSR NSSTQLWLIT HYHENGSLYD YLQRVAVEMA
310 320 330 340 350
DGLHMAASIA SGLVHLHTEI FGTEGKPAIA HRDLKSKNIL VKKDLQCCIA
360 370 380 390 400
DLGLAVTHTQ SDNQLDVGNN PKVGTKRYMA PEVLDETIQT DCFDAYKRVD
410 420 430 440 450
IWAFGLVLWE IARRTISNGI VEEYKPPFYD LVPNDPSFDD MRKVVCVEQQ
460 470 480 490 500
RPFIPNRWFS DPTLSALVKL MKECWYQNPS ARLTALRIKK TLDKIHSSLE
KGKTDC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9QIU0 | E9QIU0_DANRE | Activin A receptor, type 1-like | acvr1l | 106 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CT476817 Genomic DNA No translation available. AF038425 mRNA Translation: AAC18033.1 BC162313 mRNA Translation: AAI62313.1 BC162317 mRNA Translation: AAI62317.1 |
RefSeqi | NP_571420.1, NM_131345.1 |
Genome annotation databases
Ensembli | ENSDART00000017977; ENSDARP00000003221; ENSDARG00000014986 ENSDART00000127520; ENSDARP00000111550; ENSDARG00000014986 |
GeneIDi | 30615 |
KEGGi | dre:30615 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CT476817 Genomic DNA No translation available. AF038425 mRNA Translation: AAC18033.1 BC162313 mRNA Translation: AAI62313.1 BC162317 mRNA Translation: AAI62317.1 |
RefSeqi | NP_571420.1, NM_131345.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000111550 |
Genome annotation databases
Ensembli | ENSDART00000017977; ENSDARP00000003221; ENSDARG00000014986 ENSDART00000127520; ENSDARP00000111550; ENSDARG00000014986 |
GeneIDi | 30615 |
KEGGi | dre:30615 |
Organism-specific databases
CTDi | 30615 |
ZFINi | ZDB-GENE-990415-9, acvr1l |
Phylogenomic databases
eggNOGi | KOG2052, Eukaryota |
GeneTreei | ENSGT00940000166078 |
HOGENOMi | CLU_000288_8_5_1 |
OMAi | THSQADN |
OrthoDBi | 776697at2759 |
TreeFami | TF314724 |
Gene expression databases
Bgeei | ENSDARG00000014986, Expressed in gastrula and 32 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | O73736_DANRE | |
Accessioni | O73736Primary (citable) accession number: O73736 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | August 1, 1998 |
Last sequence update: | August 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |