Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 102 (07 Oct 2020)
Sequence version 1 (01 Aug 1998)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Amyloid-beta A4 protein

Gene

app

Organism
Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functional neuronal receptor which couples to intracellular signaling pathway through the GTP-binding protein G(O).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi148CopperPROSITE-ProRule annotation1
Metal bindingi152CopperPROSITE-ProRule annotation1
Metal bindingi169CopperPROSITE-ProRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei171Required for Cu(2+) reductionPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
LigandCopper, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Amyloid-beta A4 protein
Alternative name(s):
ABPP
Short name:
APP
Alzheimer disease amyloid A4 protein homolog
Amyloid precursor proteinCurated
Amyloid-beta precursor proteinCurated
Cleaved into the following chain:
Alternative name(s):
A-beta
APP-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:app
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri47145 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 711ExtracellularSequence analysisAdd BLAST693
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei712 – 732HelicalSequence analysisAdd BLAST21
Topological domaini733 – 780CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Amyloid, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000019919 – 780Amyloid-beta A4 proteinAdd BLAST762
ChainiPRO_0000000200682 – 724Amyloid-beta proteinSequence analysisAdd BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi39 ↔ 63PROSITE-ProRule annotation
Disulfide bondi74 ↔ 118PROSITE-ProRule annotation
Disulfide bondi99 ↔ 106PROSITE-ProRule annotation
Disulfide bondi134 ↔ 188PROSITE-ProRule annotation
Disulfide bondi145 ↔ 175PROSITE-ProRule annotation
Disulfide bondi159 ↔ 187PROSITE-ProRule annotation
Disulfide bondi327 ↔ 378PROSITE-ProRule annotation
Disulfide bondi336 ↔ 361PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi560N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
O73683

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O73683

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 190E1PROSITE-ProRule annotationAdd BLAST162
Domaini323 – 382BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST60
Domaini392 – 583E2PROSITE-ProRule annotationAdd BLAST192

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni29 – 124GFLD subdomainPROSITE-ProRule annotationAdd BLAST96
Regioni132 – 190CuBD subdomainPROSITE-ProRule annotationAdd BLAST59
Regioni769 – 772Clathrin-bindingBy similarity4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi767 – 772YENPXY motifBy similarity6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the APP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00109, KU, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.770, 1 hit
2.30.29.30, 1 hit
3.30.1490.140, 1 hit
3.90.570.10, 1 hit
4.10.230.10, 1 hit
4.10.410.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036669, Amyloid_Cu-bd_sf
IPR008155, Amyloid_glyco
IPR013803, Amyloid_glyco_Abeta
IPR037071, Amyloid_glyco_Abeta_sf
IPR011178, Amyloid_glyco_Cu-bd
IPR024329, Amyloid_glyco_E2_domain
IPR008154, Amyloid_glyco_extra
IPR015849, Amyloid_glyco_heparin-bd
IPR036454, Amyloid_glyco_heparin-bd_sf
IPR019745, Amyloid_glyco_intracell_CS
IPR028866, APP
IPR019543, APP_amyloid_C
IPR019744, APP_CUBD_CS
IPR036176, E2_sf
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR011993, PH-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23103, PTHR23103, 1 hit
PTHR23103:SF7, PTHR23103:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10515, APP_amyloid, 1 hit
PF12924, APP_Cu_bd, 1 hit
PF12925, APP_E2, 1 hit
PF02177, APP_N, 1 hit
PF03494, Beta-APP, 1 hit
PF00014, Kunitz_BPTI, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00203, AMYLOIDA4
PR00759, BASICPTASE
PR00204, BETAAMYLOID

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00006, A4_EXTRA, 1 hit
SM00131, KU, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109843, SSF109843, 1 hit
SSF56491, SSF56491, 1 hit
SSF57362, SSF57362, 1 hit
SSF89811, SSF89811, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00319, APP_CUBD, 1 hit
PS51869, APP_E1, 1 hit
PS51870, APP_E2, 1 hit
PS00320, APP_INTRA, 1 hit
PS50279, BPTI_KUNITZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O73683-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGHSVAWLLL VAAASTLAAE VPTDVSMGLL AEPQVAMFCG KINMHINVQS
60 70 80 90 100
GKWEPDPSGT KSCIGTKEGI LQYCQEVYPE LQITNVVEAN QPVSIQNWCK
110 120 130 140 150
KGRKQCRSHM HIVVPYRCLV GEFVSDALLV PDKCKFLHQE RMNQCESHLH
160 170 180 190 200
WHTVAKESCG DRAMNLHDYG MLLPCGIDRF RGVEFVCCPA EAERDMDSTE
210 220 230 240 250
KDADDSDVWW GGADNDYSDN SMVREPEPAE QQEETRPSVV EEEEEGEVAQ
260 270 280 290 300
EDDEEEEEVL DTDQDGDGEE DHEAADDEEE EEDVDEIDAF GESDDVDADE
310 320 330 340 350
PTTNVAMTTT TTTTTTESVE EVVRMFCWAH ADTGPCTASM PSWYFDAVDG
360 370 380 390 400
RTMYELMYGG CGGNMNNFES EEYCLSVCSS VVPTDMPSSP DAVDHYLETP
410 420 430 440 450
ADENEHAHFQ KAKESLEAKH RERMSQVMRE WEEAERQAKN LPRADKKIVI
460 470 480 490 500
QRFQEKVEAL EQEAASERQQ LVETHMARVE ALLNDRRRLA LENYLTALQQ
510 520 530 540 550
DPPRPRHVFS LLKKYVRAEQ KDRQHTLKHF EHVRMVDPKK AAQIRPQVLT
560 570 580 590 600
HLRVIEERMN QSLGLLYKVP GVADDIQDQV ELLQREQAEM AQQLANLQTD
610 620 630 640 650
VRVSYGNDAL MPDQELGDGQ ADLLPQEDTL GGVGFVHPES FNQLNTENQV
660 670 680 690 700
EPVDSRPTFE RGVPTRPVTG KSMEAVPELR METEDRQSTE YEVHHQKLVF
710 720 730 740 750
FAEDVGSNKG AIIGLMVGGV VIATVIVITL VMLRKKQYTS IHHGIIEVDA
760 770 780
AVTPEERHLS KMQQNGYENP TYKFFEQMQN
Length:780
Mass (Da):88,238
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60071BE94520191D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF018165 mRNA Translation: AAC41275.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018165 mRNA Translation: AAC41275.1

3D structure databases

BMRBiO73683
SMRiO73683
ModBaseiSearch...

Family and domain databases

CDDicd00109, KU, 1 hit
Gene3Di1.20.120.770, 1 hit
2.30.29.30, 1 hit
3.30.1490.140, 1 hit
3.90.570.10, 1 hit
4.10.230.10, 1 hit
4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR036669, Amyloid_Cu-bd_sf
IPR008155, Amyloid_glyco
IPR013803, Amyloid_glyco_Abeta
IPR037071, Amyloid_glyco_Abeta_sf
IPR011178, Amyloid_glyco_Cu-bd
IPR024329, Amyloid_glyco_E2_domain
IPR008154, Amyloid_glyco_extra
IPR015849, Amyloid_glyco_heparin-bd
IPR036454, Amyloid_glyco_heparin-bd_sf
IPR019745, Amyloid_glyco_intracell_CS
IPR028866, APP
IPR019543, APP_amyloid_C
IPR019744, APP_CUBD_CS
IPR036176, E2_sf
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR011993, PH-like_dom_sf
PANTHERiPTHR23103, PTHR23103, 1 hit
PTHR23103:SF7, PTHR23103:SF7, 1 hit
PfamiView protein in Pfam
PF10515, APP_amyloid, 1 hit
PF12924, APP_Cu_bd, 1 hit
PF12925, APP_E2, 1 hit
PF02177, APP_N, 1 hit
PF03494, Beta-APP, 1 hit
PF00014, Kunitz_BPTI, 1 hit
PRINTSiPR00203, AMYLOIDA4
PR00759, BASICPTASE
PR00204, BETAAMYLOID
SMARTiView protein in SMART
SM00006, A4_EXTRA, 1 hit
SM00131, KU, 1 hit
SUPFAMiSSF109843, SSF109843, 1 hit
SSF56491, SSF56491, 1 hit
SSF57362, SSF57362, 1 hit
SSF89811, SSF89811, 1 hit
PROSITEiView protein in PROSITE
PS00319, APP_CUBD, 1 hit
PS51869, APP_E1, 1 hit
PS51870, APP_E2, 1 hit
PS00320, APP_INTRA, 1 hit
PS50279, BPTI_KUNITZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA4_TETFL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O73683
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: August 1, 1998
Last modified: October 7, 2020
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again