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Protein
Submitted name:

Calcium-sensing receptor

Gene

casr

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Calcium-sensing receptorImported
Submitted name:
Calcium2+ sensing receptorImported
Gene namesi
Name:casrImported
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)Imported
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei598 – 623HelicalSequence analysisAdd BLAST26
Transmembranei635 – 656HelicalSequence analysisAdd BLAST22
Transmembranei668 – 690HelicalSequence analysisAdd BLAST23
Transmembranei711 – 730HelicalSequence analysisAdd BLAST20
Transmembranei755 – 777HelicalSequence analysisAdd BLAST23
Transmembranei789 – 811HelicalSequence analysisAdd BLAST23
Transmembranei817 – 839HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_501410207216 – 940Sequence analysisAdd BLAST925

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000043231

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini598 – 861G_PROTEIN_RECEP_F3_4InterPro annotationAdd BLAST264

Sequence similaritiesi

Belongs to the G-protein coupled receptor 3 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1056 Eukaryota
ENOG410XR6W LUCA
GeneTreeiENSGT00760000118974
HOGENOMiHOG000232092
OMAiGYTCLLA
OrthoDBiEOG091G01NA
TreeFamiTF331269

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR000337 GPCR_3
IPR011500 GPCR_3_9-Cys_dom
IPR038550 GPCR_3_9-Cys_sf
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PF07562 NCD3G, 1 hit
PRINTSiPR00248 GPCRMGR
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00979 G_PROTEIN_RECEP_F3_1, 1 hit
PS00980 G_PROTEIN_RECEP_F3_2, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequencei

Sequence statusi: Complete.

O73635-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRLVLHYLI LLGSGYVIST YGPNQRAQMT GDILLGGLFP IHFGISSKDE
60 70 80 90 100
NLAARPESTK CVRFNFRGFR WLQAMVFAIE EINNSSSLLP NITLGYRIFD
110 120 130 140 150
TCNTVSKALE ATLSFVAQNK IDSLNLDEFC NCTDHIPATI AVVGAAGSAV
160 170 180 190 200
STAVANLLSL FYIPQISYAS SSRLLSNKNQ YKSFMRTIPT DEHQATAMAD
210 220 230 240 250
VIEYFQWNWV IAVASDDDYG RPGIEKFEKE MEERDICIHL NELISQYFED
260 270 280 290 300
CEIKALVDRI ENSTAKVIVV FASGPDIEPL IKEMVRRNIT DRIWLASEAW
310 320 330 340 350
ASSSLIAKPE YLDVVEGTIG FVLKAGNIPG FREFLQQVQP KRGSHNEFVR
360 370 380 390 400
EFWEETFNCY LEDSPRLQES ENGSDSFRPL CTSEEDITSV ETPYLDHTHL
410 420 430 440 450
RISYNVYVAV YSIAHALQDI LSCTPGHGLF ANNSCADIKK MEAWQVLKQL
460 470 480 490 500
RHLNYTNSMG EKVHFDENAD MEANYTIINW HRSAEDGSVA FREVGYYHMH
510 520 530 540 550
ARRGAKLLID NTKMMWNAYS SEVPFSNCSE DCEPGTRKGI IDSMPTCCFE
560 570 580 590 600
CTECSDGEYS DHKDASICTK CPNNSWSSGN HTFCFLKEIE FLAWSEPFGI
610 620 630 640 650
ALAICAVLGV LLTAFVMGVF VRFRNTPIVK ASNRELSYVL LLSLICCFSS
660 670 680 690 700
SLIFIGEPQD WTCRLRQPAF GISFVLCISC ILVKTNRVLL VFEAKIPTSI
710 720 730 740 750
HRKWWGLNLQ FLLVFLCTFV QVMICVVWLY NAPPSSYRNH DIDEIIFITC
760 770 780 790 800
NEGSVMALGF LIGYTCLLAA ICFFFAFKSR KLPENFTEAK FITFCMLIFF
810 820 830 840 850
IVWISFIPAY FSTYGKFVSA VEAIAILASS YGMLACIFFN KVYIILFKPC
860 870 880 890 900
RNTIEEVRCS TAAHAFRVAA KATLKHRTTV RKKSNSIGST ASTPSSSISL
910 920 930 940
KTNSNDCDSA SGRHRPRVSF GSGTVMLSLS FEESRRSSLM
Length:940
Mass (Da):105,815
Last modified:August 1, 1998 - v1
Checksum:i06DAB7803B6878B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008857 Genomic DNA Translation: BAA26122.1

Genome annotation databases

EnsembliENSTRUT00000043376; ENSTRUP00000043231; ENSTRUG00000016870

Similar proteinsi

Entry informationi

Entry nameiO73635_TAKRU
AccessioniPrimary (citable) accession number: O73635
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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