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Protein

DNA polymerase

Gene

POL

Organism
Bovine adenovirus 2 (BAdV-2) (Mastadenovirus bos2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.UniRule annotationBy similarity

Miscellaneous

This DNA polymerase requires a protein as a primer.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication, Viral DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:POLUniRule annotation
OrganismiBovine adenovirus 2 (BAdV-2) (Mastadenovirus bos2)
Taxonomic identifieri114429 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeMastadenovirusOvine mastadenovirus A
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000154597 Componenti: Genome

Subcellular locationi

  • Host nucleus UniRule annotationBy similarity

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000464901 – 1017DNA polymeraseAdd BLAST1017

Proteomic databases

PRIDEiO72539

Interactioni

Subunit structurei

Heterodimer with the terminal protein; this heterodimer binds to bp 9 to 18 of the genome. Forms a complex with viral pTP, DBP and hosts NFIA and POU2F1/OCT1 for initiation of replication.UniRule annotationBy similarity

Structurei

3D structure databases

ProteinModelPortaliO72539
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotationCurated

Phylogenomic databases

KOiK21923

Family and domain databases

HAMAPiMF_04055 ADV_DPOL, 1 hit
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR014382 DNA-dir_DNA_pol_B_adenovir
IPR017964 DNA-dir_DNA_pol_B_CS
IPR004868 DNA-dir_DNA_pol_B_mt/vir
IPR012337 RNaseH-like_sf
PfamiView protein in Pfam
PF03175 DNA_pol_B_2, 1 hit
PIRSFiPIRSF000788 DPol_ADV, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 2 hits
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

Sequencei

Sequence statusi: Complete.

O72539-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEALKPAEG ATFTYIKGRL IKQQAAVENP ILPFPIFFLI KQNKVFLIKS
60 70 80 90 100
FQSSQKCEFC GDFFANSHTC SVRRRDFYFH HINFKSSEWW SQISFQPIGS
110 120 130 140 150
CDDTKRFFLT YDVETYTWHG KHGKQLVPFM LVFHLSGELE LVSLSANIAE
160 170 180 190 200
QQRWLAWDTP HTYYYVSPIK GEIGKAFKDL RYEIQKQVTR LLWDNFVGEN
210 220 230 240 250
PELAEIQERH HVNHIDDITA EMHKIKTKGS PQFIEIYVIG HNICGFDEIV
260 270 280 290 300
LAAQVIHNRT DVLPAFKINR NFMPRNGKIL FNDISFCLPN PKYEKRKDFA
310 320 330 340 350
DWECGKLTAA DHKYQFVKFM VRDTFALTHT SLRNAAGAYE LPVEKGSCPY
360 370 380 390 400
EAVNEFYRIG SYQQDEDGFP SLRYWKSSEE YQLNKALWRE KNVGAYDIIQ
410 420 430 440 450
QTLHYCVQDV LVTSALVNKL QESYKNFIAS QVNLPDASFN IFQRPTISSN
460 470 480 490 500
SHAIFKQILY REVRPNKANL DNVLLAPSHE MYDYVRQSIR GGRCYPTYIG
510 520 530 540 550
IMEQPIYVYD ICGMYASALT HPFPSGQPLN PYERALAATE WIRKLENLEQ
560 570 580 590 600
KIDYFDECLL PGIFTIDADP PDELFLDELP PFCSRKGGRL CWANEPLRGE
610 620 630 640 650
VATSIDLITL HNRGWAVRIL PDERTTIFPE WKCVAKEYVQ LNIGAKEKAD
660 670 680 690 700
KEKNQTMRSI AKLLSNALYG SFATKLDNKK IVFSDQLEAS ASKTIARGNF
710 720 730 740 750
SIKSSSFIET DNFSAEIMPE FVVTYPPAPS AELDESDENE EHTLFIPKDS
760 770 780 790 800
HVTYKYKPIT FLETEDDDIC LHTLENNSPL IENNRYASHI ASFVLAWTRV
810 820 830 840 850
FVSEWAEFLY AEDRGKPLHQ RTIKSVYGDT DSLFVTEEGH RLMEQRGKHR
860 870 880 890 900
IKKNGGKLVF DPKNPSITWL VECETQCEKC KSDAFSSESV FLAPKLYALK
910 920 930 940 950
NTVCTCCGHV GKGKLRAKGH ATTELCYDTL AKCYLSDAQQ GSQRFHTSRL
960 970 980 990 1000
SLKRTLATNQ SNAAPFTVTE TTLTRTVRPW KDKTLVDIDG HRLMPYSKSN
1010
PNPRNNDVCW MTLPWNM
Length:1,017
Mass (Da):117,003
Last modified:August 1, 1998 - v1
Checksum:i86BBC666A1C6E902
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252854 Genomic DNA Translation: AAC16239.1
RefSeqiNP_064286.1, NC_002513.1

Genome annotation databases

GeneIDi1732721
KEGGivg:1732721

Similar proteinsi

Entry informationi

Entry nameiDPOL_ADEB2
AccessioniPrimary (citable) accession number: O72539
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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