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Protein

Reticulon-2

Gene

Rtn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • intracellular protein transmembrane transport Source: MGI
  • regulation of glucose import Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-2
Alternative name(s):
Neuroendocrine-specific protein-like 1
Short name:
NSP-like protein 1
Neuroendocrine-specific protein-like I
Short name:
NSP-like protein I
Short name:
NSPLI
Gene namesi
Name:Rtn2
Synonyms:Nspl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107612 Rtn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Transmembranei390 – 410HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001681621 – 471Reticulon-2Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1
Modified residuei228PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO70622
PeptideAtlasiO70622
PRIDEiO70622

PTM databases

iPTMnetiO70622
PhosphoSitePlusiO70622

Expressioni

Tissue specificityi

Expressed predominantly in neural and muscular tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000030401 Expressed in 267 organ(s), highest expression level in vastus lateralis
CleanExiMM_RTN2
ExpressionAtlasiO70622 baseline and differential
GenevisibleiO70622 MM

Interactioni

Subunit structurei

Interacts with SPAST. Interacts with TMEM33.By similarity

Protein-protein interaction databases

BioGridi203033, 1 interactor
IntActiO70622, 1 interactor
MINTiO70622
STRINGi10090.ENSMUSP00000032559

Structurei

3D structure databases

ProteinModelPortaliO70622
SMRiO70622
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini272 – 471ReticulonPROSITE-ProRule annotationAdd BLAST200

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1792 Eukaryota
ENOG410XPKH LUCA
GeneTreeiENSGT00390000009934
HOGENOMiHOG000015254
HOVERGENiHBG099866
InParanoidiO70622
KOiK20722
OMAiYWKDMER
OrthoDBiEOG091G0TIO
PhylomeDBiO70622
TreeFamiTF105431

Family and domain databases

InterProiView protein in InterPro
IPR003388 Reticulon
PfamiView protein in Pfam
PF02453 Reticulon, 1 hit
PROSITEiView protein in PROSITE
PS50845 RETICULON, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O70622-1) [UniParc]FASTAAdd to basket
Also known as: Brain

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGQVLPVFAH CKEAPSTASS TPDSTEGGND DSDFRELHTA REFSEDEEEE
60 70 80 90 100
TTSQDWGTPR ELTFSYIAFD GVVGSGGRRD SVVRRPRPQG RSVSEPRDPP
110 120 130 140 150
QQSGLGDSLE SIPSLSQSPE PGRRGDPDPV PPAERPLEEL RLRLDQLGWV
160 170 180 190 200
VRSAGSGEDS ATSSSTPLEN EEPDGLEASE AGEETNLELR LAQSLHLQLE
210 220 230 240 250
VLTPQLSPSS GTPQAHTPSP QRSQDSNSGP DDEPLLNVVE EHWRLLEQEP
260 270 280 290 300
ITAQCLDSTD QSEFMLEPLL LVADLLYWKD TRTSGAVFTG LMASLLCLLH
310 320 330 340 350
FSIVSVAAHL ALLGLCATIS LRVYRKVLQA VHRGDGTNPF QAYLDMDLTL
360 370 380 390 400
TREQTERLSQ QIASHVVSTA TQLRHFFLVE DLVDSLKLAL LFYILTFVGA
410 420 430 440 450
IFNGLTLVIL GVVALFTVPL LYRQHQAQID QYVGLVTNQL SHIKAKIRAK
460 470
IPGTGTLAPT ASVSGSKAKA E
Length:471
Mass (Da):51,347
Last modified:August 1, 1998 - v1
Checksum:i9BBD8F372CF63AD3
GO
Isoform 2 (identifier: O70622-2) [UniParc]FASTAAdd to basket
Also known as: Muscle

The sequence of this isoform differs from the canonical sequence as follows:
     1-267: Missing.
     268-271: PLLL → MGSK

Show »
Length:204
Mass (Da):22,239
Checksum:i07AFC32A9BAA6930
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0056501 – 267Missing in isoform 2. 1 PublicationAdd BLAST267
Alternative sequenceiVSP_005651268 – 271PLLL → MGSK in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038537 Genomic DNA Translation: AAC14906.1
AF038537 Genomic DNA Translation: AAC14907.1
AF038538 mRNA Translation: AAC14908.1
AF038539 mRNA Translation: AAC14909.1
AF093624 Genomic DNA Translation: AAD13195.1
BC031370 mRNA Translation: AAH31370.1
CCDSiCCDS20896.1 [O70622-1]
CCDS39797.1 [O70622-2]
RefSeqiNP_001020535.1, NM_001025364.3 [O70622-2]
NP_038676.1, NM_013648.6 [O70622-1]
UniGeneiMm.24142

Genome annotation databases

EnsembliENSMUST00000032559; ENSMUSP00000032559; ENSMUSG00000030401 [O70622-1]
ENSMUST00000108468; ENSMUSP00000104108; ENSMUSG00000030401 [O70622-2]
GeneIDi20167
KEGGimmu:20167
UCSCiuc009flh.2 mouse [O70622-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038537 Genomic DNA Translation: AAC14906.1
AF038537 Genomic DNA Translation: AAC14907.1
AF038538 mRNA Translation: AAC14908.1
AF038539 mRNA Translation: AAC14909.1
AF093624 Genomic DNA Translation: AAD13195.1
BC031370 mRNA Translation: AAH31370.1
CCDSiCCDS20896.1 [O70622-1]
CCDS39797.1 [O70622-2]
RefSeqiNP_001020535.1, NM_001025364.3 [O70622-2]
NP_038676.1, NM_013648.6 [O70622-1]
UniGeneiMm.24142

3D structure databases

ProteinModelPortaliO70622
SMRiO70622
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203033, 1 interactor
IntActiO70622, 1 interactor
MINTiO70622
STRINGi10090.ENSMUSP00000032559

PTM databases

iPTMnetiO70622
PhosphoSitePlusiO70622

Proteomic databases

PaxDbiO70622
PeptideAtlasiO70622
PRIDEiO70622

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032559; ENSMUSP00000032559; ENSMUSG00000030401 [O70622-1]
ENSMUST00000108468; ENSMUSP00000104108; ENSMUSG00000030401 [O70622-2]
GeneIDi20167
KEGGimmu:20167
UCSCiuc009flh.2 mouse [O70622-1]

Organism-specific databases

CTDi6253
MGIiMGI:107612 Rtn2

Phylogenomic databases

eggNOGiKOG1792 Eukaryota
ENOG410XPKH LUCA
GeneTreeiENSGT00390000009934
HOGENOMiHOG000015254
HOVERGENiHBG099866
InParanoidiO70622
KOiK20722
OMAiYWKDMER
OrthoDBiEOG091G0TIO
PhylomeDBiO70622
TreeFamiTF105431

Miscellaneous databases

ChiTaRSiRtn2 mouse
PROiPR:O70622
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030401 Expressed in 267 organ(s), highest expression level in vastus lateralis
CleanExiMM_RTN2
ExpressionAtlasiO70622 baseline and differential
GenevisibleiO70622 MM

Family and domain databases

InterProiView protein in InterPro
IPR003388 Reticulon
PfamiView protein in Pfam
PF02453 Reticulon, 1 hit
PROSITEiView protein in PROSITE
PS50845 RETICULON, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRTN2_MOUSE
AccessioniPrimary (citable) accession number: O70622
Secondary accession number(s): O70620
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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