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Protein

Gap junction delta-2 protein

Gene

Gjd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  • action potential Source: Ensembl
  • cell-cell signaling Source: RGD
  • chemical synaptic transmission Source: Ensembl
  • visual perception Source: Ensembl

Enzyme and pathway databases

ReactomeiR-RNO-112303 Electric Transmission Across Gap Junctions
R-RNO-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction delta-2 protein
Alternative name(s):
Connexin-36
Short name:
Cx36
Gap junction alpha-9 protein
Gene namesi
Name:Gjd2
Synonyms:Gja9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2694 Gjd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 42HelicalSequence analysisAdd BLAST23
Topological domaini43 – 75ExtracellularSequence analysisAdd BLAST33
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 197CytoplasmicSequence analysisAdd BLAST99
Transmembranei198 – 220HelicalSequence analysisAdd BLAST23
Topological domaini221 – 252ExtracellularSequence analysisAdd BLAST32
Transmembranei253 – 275HelicalSequence analysisAdd BLAST23
Topological domaini276 – 321CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578371 – 321Gap junction delta-2 proteinAdd BLAST321

Proteomic databases

PaxDbiO70610

Expressioni

Tissue specificityi

Highly expressed in neurons.

Gene expression databases

BgeeiENSRNOG00000008337
GenevisibleiO70610 RN

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

DIPiDIP-60789N
IntActiO70610, 1 interactor
STRINGi10116.ENSRNOP00000011078

Structurei

3D structure databases

SMRiO70610
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Delta-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ31 Eukaryota
ENOG410YRD5 LUCA
GeneTreeiENSGT00910000143998
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiO70610
KOiK07373
OMAiTNKETEP
OrthoDBiEOG091G0FB1
PhylomeDBiO70610
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 2 hits
InterProiView protein in InterPro
IPR000500 Connexin
IPR002260 Connexin36
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01131 CONNEXIN36
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

O70610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEWTILERL LEAAVQQHST MIGRILLTVV VIFRILIVAI VGETVYDDEQ
60 70 80 90 100
TMFVCNTLQP GCNQACYDRA FPISHIRYWV FQIIMVCTPS LCFITYSVHQ
110 120 130 140 150
SAKQRERRYS TVFLALDRDP AESIGGPGGT GGGGSGGSKR EDKKLQNAIV
160 170 180 190 200
NGVLQNTETT SKETEPDCLE VKELAPHPSG LRTAARSKLR RQEGISRFYI
210 220 230 240 250
IQVVFRNALE IGFLVGQYFL YGFSVPGLYE CNRYPCIKEV ECYVSRPTEK
260 270 280 290 300
TVFLVFMFAV SGICVVLNLA ELNHLGWRKI KLAVRGAQAK RKSVYEIRNK
310 320
DLPRVSVPNF GRTQSSDSAY V
Length:321
Mass (Da):36,052
Last modified:August 1, 1998 - v1
Checksum:i63D4C108214AEF5E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57T → A in CAC14913 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16898 mRNA Translation: CAA76528.1
AJ296282 mRNA Translation: CAC14913.1
RefSeqiNP_062154.1, NM_019281.2
UniGeneiRn.9904

Genome annotation databases

EnsembliENSRNOT00000011078; ENSRNOP00000011078; ENSRNOG00000008337
GeneIDi50564
KEGGirno:50564
UCSCiRGD:2694 rat

Similar proteinsi

Entry informationi

Entry nameiCXD2_RAT
AccessioniPrimary (citable) accession number: O70610
Secondary accession number(s): Q9ER25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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