UniProtKB - O70595 (ABCB6_RAT)
Protein
ATP-binding cassette sub-family B member 6, mitochondrial
Gene
Abcb6
Organism
Rattus norvegicus (Rat)
Status
Functioni
Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis (By similarity).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 599 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 623 – 634 | ATPPROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled heme transmembrane transporter activity Source: RGD
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATP binding Source: RGD
- efflux transmembrane transporter activity Source: RGD
- heme binding Source: RGD
GO - Biological processi
- brain development Source: RGD
- heme transport Source: RGD
- porphyrin-containing compound biosynthetic process Source: RGD
- skin development Source: RGD
- transmembrane transport Source: GO_Central
Keywordsi
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-RNO-1369007, Mitochondrial ABC transporters |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-binding cassette sub-family B member 6, mitochondrialAlternative name(s): Ubiquitously-expressed mammalian ABC half transporter |
Gene namesi | Name:Abcb6 Synonyms:Umat |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 71077, Abcb6 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Plasma membrane
- Cell membrane By similarity
Golgi apparatus
- Golgi apparatus By similarity
Mitochondrion
- Mitochondrion outer membrane By similarity; Multi-pass membrane protein PROSITE-ProRule annotation
Cytosol
- cytosol Source: Ensembl
Endoplasmic reticulum
- endoplasmic reticulum Source: RGD
Endosome
- endosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: RGD
Mitochondrion
- integral component of mitochondrial outer membrane Source: RGD
- mitochondrial envelope Source: RGD
- mitochondrial outer membrane Source: RGD
- mitochondrion Source: RGD
Nucleus
- nucleoplasm Source: Ensembl
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- vacuolar membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 27 – 47 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 73 – 93 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 107 – 127 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 148 – 168 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 186 – 206 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 376 – 396 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 409 – 431 | HelicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Transmembranei | 500 – 520 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 530 – 550 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion outer membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000268679 | 1 – 836 | ATP-binding cassette sub-family B member 6, mitochondrialAdd BLAST | 836 |
Proteomic databases
jPOSTi | O70595 |
PaxDbi | O70595 |
PRIDEi | O70595 |
PTM databases
PhosphoSitePlusi | O70595 |
Expressioni
Tissue specificityi
Ubiquitously expressed. Highly expressed in testis by meiotic pachytene spermatocytes and post-meiotic early spermatids.2 Publications
Gene expression databases
Bgeei | ENSRNOG00000018697, Expressed in pancreas and 20 other tissues |
ExpressionAtlasi | O70595, baseline and differential |
Genevisiblei | O70595, RN |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000025627 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 265 – 556 | ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST | 292 | |
Domaini | 590 – 824 | ABC transporterPROSITE-ProRule annotationAdd BLAST | 235 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0056, Eukaryota |
GeneTreei | ENSGT00940000156160 |
HOGENOMi | CLU_000604_32_0_1 |
InParanoidi | O70595 |
OMAi | YVLFASY |
OrthoDBi | 248727at2759 |
PhylomeDBi | O70595 |
TreeFami | TF105194 |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR032410, MTABC_N IPR027417, P-loop_NTPase IPR039421, Type_I_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 1 hit PF00005, ABC_tran, 1 hit PF16185, MTABC_N, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O70595-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVTVGNYCEA EGPAGPAWTQ NGLSPCFFYT LVPSTLMTLG VLALVLVLPC
60 70 80 90 100
RRREVPAGTE ELSWAAGPRV APYALQLSLA ILQMALPLAS LAGRVGTARG
110 120 130 140 150
VRLPGYLLLA SVLESLASAC GLWLLVVERS QARQSLAMGV WMKFRHSLGL
160 170 180 190 200
LLLWTVTFAA ENLVLVSWNS PQWWWSRADL GQQVQFGLWV LRYMTSGGLF
210 220 230 240 250
ILGLWAPGLR PQSYTLHVNE EDQDGGRNQG RSTDPRSTWR DLGRKLRLLS
260 270 280 290 300
GYLWPRGSPS LQLTVLLCMG LMGLDRALNV LVPIFYRDIV NLLTSKAPWS
310 320 330 340 350
SLAWTVTTYV FLKFLQGGGT GSTGFVSNLR TFLWIRVQQF TSRGVELRLF
360 370 380 390 400
SHLHELSLRW HLGRRTGEVL RIVDRGTSSV TGLLSYLVFN IIPTLADIII
410 420 430 440 450
GIIYFSMFFN AWFGLIVFLC MSLYLILTIM VTEWRAKFRR DMNTQENATR
460 470 480 490 500
ARAVDSLLNF ETVKYYNAEG YELERYREAI LKFQGLEWKS TASLVLLNQT
510 520 530 540 550
QNMVIGFGLL AGSLLCAYFV SERRLQVGDF VLFGTYITQL YMPLNWFGTY
560 570 580 590 600
YRMIQTNFID MENMFDLLKE ETEVKDVPGA GPLRFHKGRV EFENVHFSYA
610 620 630 640 650
DGRETLQDVS FTVMPGQTVA LVGPSGAGKS TILRLLFRFY DISSGCIRID
660 670 680 690 700
GQDISQVTQI SLRSHIGVVP QDTVLFNDTI ANNIRYGRVT AGDSEIQAAA
710 720 730 740 750
QAAGIHDAIL SFPEGYETQV GERGLKLSGG EKQRVAIART ILKAPDIILL
760 770 780 790 800
DEATSALDTS NERAIQASLA KVCTNRTTIV VAHRLSTVVN ADQILVIKDG
810 820 830
CIIERGRHEA LLSRGGVYAE MWQLQQQGQE TVPEDS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K4U1 | A0A0G2K4U1_RAT | ATP-binding cassette sub-family B m... | Abcb6 | 293 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ003004 mRNA Translation: CAA05793.1 BC085712 mRNA Translation: AAH85712.1 |
PIRi | JE0248 |
RefSeqi | NP_542149.1, NM_080582.1 |
Genome annotation databases
Ensembli | ENSRNOT00000025627; ENSRNOP00000025627; ENSRNOG00000018697 |
GeneIDi | 140669 |
KEGGi | rno:140669 |
UCSCi | RGD:71077, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ003004 mRNA Translation: CAA05793.1 BC085712 mRNA Translation: AAH85712.1 |
PIRi | JE0248 |
RefSeqi | NP_542149.1, NM_080582.1 |
3D structure databases
SMRi | O70595 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000025627 |
PTM databases
PhosphoSitePlusi | O70595 |
Proteomic databases
jPOSTi | O70595 |
PaxDbi | O70595 |
PRIDEi | O70595 |
Genome annotation databases
Ensembli | ENSRNOT00000025627; ENSRNOP00000025627; ENSRNOG00000018697 |
GeneIDi | 140669 |
KEGGi | rno:140669 |
UCSCi | RGD:71077, rat |
Organism-specific databases
CTDi | 10058 |
RGDi | 71077, Abcb6 |
Phylogenomic databases
eggNOGi | KOG0056, Eukaryota |
GeneTreei | ENSGT00940000156160 |
HOGENOMi | CLU_000604_32_0_1 |
InParanoidi | O70595 |
OMAi | YVLFASY |
OrthoDBi | 248727at2759 |
PhylomeDBi | O70595 |
TreeFami | TF105194 |
Enzyme and pathway databases
Reactomei | R-RNO-1369007, Mitochondrial ABC transporters |
Miscellaneous databases
PROi | PR:O70595 |
Gene expression databases
Bgeei | ENSRNOG00000018697, Expressed in pancreas and 20 other tissues |
ExpressionAtlasi | O70595, baseline and differential |
Genevisiblei | O70595, RN |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR032410, MTABC_N IPR027417, P-loop_NTPase IPR039421, Type_I_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 1 hit PF00005, ABC_tran, 1 hit PF16185, MTABC_N, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ABCB6_RAT | |
Accessioni | O70595Primary (citable) accession number: O70595 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | August 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families