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Protein

Small glutamine-rich tetratricopeptide repeat-containing protein alpha

Gene

Sgta

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (By similarity). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:12878599).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Alternative name(s):
Alpha-SGT
Small glutamine-rich protein with tetratricopeptide repeats 1
Gene namesi
Name:Sgta
Synonyms:Sgt, Sgt1, Stg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi620815 Sgta

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063671 – 314Small glutamine-rich tetratricopeptide repeat-containing protein alphaAdd BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81PhosphothreonineCombined sources1
Modified residuei84PhosphoserineCombined sources1
Modified residuei137N6-acetyllysineBy similarity1
Modified residuei302PhosphoserineBy similarity1
Modified residuei304PhosphothreonineBy similarity1
Modified residuei306PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO70593
PeptideAtlasiO70593
PRIDEiO70593

PTM databases

iPTMnetiO70593
PhosphoSitePlusiO70593

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSRNOG00000019891 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiO70593 RN

Interactioni

Subunit structurei

Homodimer (By similarity). Homooligomer (PubMed:12878599). Interacts with DNAJC5 and DNAJC5B (By similarity). Interacts (via TPR repeats) with HSP90AA1 (PubMed:15708368). Interacts (via Gln-rich region) with SLC2A1 (By similarity). Interacts with HSP90AB1 (By similarity). Interacts (via TPR repeats) with HSPA8/Hsc70; the interaction is direct (PubMed:15708368). Interacts with BAG6 (via ubiquitin-like domain); interaction prevents interaction between BAG6 and RNF126 (By similarity). Forms a multiprotein complex, at least composed of DNAJB12, DNAJB14, HSPA8/Hsc70 and SGTA; interaction with DNAJB14 and HSPA8/Hsc70 is direct (By similarity).By similarity2 Publications
(Microbial infection) Interacts with NS1 from parvovirus H-1 (PubMed:9557704).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249184, 2 interactors
STRINGi10116.ENSRNOP00000026960

Structurei

3D structure databases

ProteinModelPortaliO70593
SMRiO70593
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati91 – 124TPR 1Add BLAST34
Repeati125 – 158TPR 2Add BLAST34
Repeati159 – 192TPR 3Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi276 – 287Gln-richAdd BLAST12

Sequence similaritiesi

Belongs to the SGT family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0553 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00730000110724
HOGENOMiHOG000208193
HOVERGENiHBG000885
InParanoidiO70593
KOiK16365
OMAiNPGFMNM
OrthoDBiEOG091G0C0Q
PhylomeDBiO70593

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR032374 SGTA_dimer
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF16546 SGTA_dimer, 1 hit
PF00515 TPR_1, 2 hits
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O70593-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNRKRLAYA IIQFLHGQLR HGGLSSDAQE SLEVAIQCLE TAFGVTLEDS
60 70 80 90 100
DLALPQTLPE IFEAATASKE MPQDPRGPDR TPPSEEDSAE AERLKTEGNE
110 120 130 140 150
QMKLENFEAA VHLYGKAIEL NPANAVYFCN RAAAYSKLGN YVGAVQDCER
160 170 180 190 200
AIGIDPGYSK AYGRMGLALS SLNKHAEAVA YYKKALELDP DNDTYKSNLK
210 220 230 240 250
IAELKLREAP SPTGGVGSLD IAGLLNNPHF ITMASSLMNS PQLQQLMSGM
260 270 280 290 300
ISGGHNPLGT PGSSPQHSDL ASLIQAGQQF AQQMQQQNPE FVEQIRSQVV
310
RSRTPSASHE EQQE
Length:314
Mass (Da):34,157
Last modified:August 1, 1998 - v1
Checksum:i65EBBE9A773A7F28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ222724 mRNA Translation: CAA10960.1
AF368278 mRNA Translation: AAP29456.1
BC087642 mRNA Translation: AAH87642.1
RefSeqiNP_073194.1, NM_022703.3
UniGeneiRn.9655

Genome annotation databases

EnsembliENSRNOT00000026960; ENSRNOP00000026960; ENSRNOG00000019891
GeneIDi64667
KEGGirno:64667
UCSCiRGD:620815 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ222724 mRNA Translation: CAA10960.1
AF368278 mRNA Translation: AAP29456.1
BC087642 mRNA Translation: AAH87642.1
RefSeqiNP_073194.1, NM_022703.3
UniGeneiRn.9655

3D structure databases

ProteinModelPortaliO70593
SMRiO70593
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249184, 2 interactors
STRINGi10116.ENSRNOP00000026960

PTM databases

iPTMnetiO70593
PhosphoSitePlusiO70593

Proteomic databases

PaxDbiO70593
PeptideAtlasiO70593
PRIDEiO70593

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026960; ENSRNOP00000026960; ENSRNOG00000019891
GeneIDi64667
KEGGirno:64667
UCSCiRGD:620815 rat

Organism-specific databases

CTDi6449
RGDi620815 Sgta

Phylogenomic databases

eggNOGiKOG0553 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00730000110724
HOGENOMiHOG000208193
HOVERGENiHBG000885
InParanoidiO70593
KOiK16365
OMAiNPGFMNM
OrthoDBiEOG091G0C0Q
PhylomeDBiO70593

Miscellaneous databases

PROiPR:O70593

Gene expression databases

BgeeiENSRNOG00000019891 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiO70593 RN

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR032374 SGTA_dimer
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF16546 SGTA_dimer, 1 hit
PF00515 TPR_1, 2 hits
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSGTA_RAT
AccessioniPrimary (citable) accession number: O70593
Secondary accession number(s): Q548F5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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