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Protein

Prefoldin subunit 2

Gene

Pfdn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

GO - Molecular functioni

GO - Biological processi

  • positive regulation of cytoskeleton organization Source: MGI
  • protein folding Source: MGI

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 2
Gene namesi
Name:Pfdn2
Synonyms:Pfd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1276111 Pfdn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001248361 – 154Prefoldin subunit 2Add BLAST154

Proteomic databases

EPDiO70591
MaxQBiO70591
PaxDbiO70591
PeptideAtlasiO70591
PRIDEiO70591

2D gel databases

REPRODUCTION-2DPAGEiIPI00119545
O70591

PTM databases

iPTMnetiO70591
PhosphoSitePlusiO70591

Expressioni

Gene expression databases

BgeeiENSMUSG00000006412 Expressed in 285 organ(s), highest expression level in lateral hypothalamic area
CleanExiMM_PFDN2
ExpressionAtlasiO70591 baseline and differential
GenevisibleiO70591 MM

Interactioni

Subunit structurei

Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner (By similarity). Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to c-Myc; interacts with its N-terminal domain.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202121, 27 interactors
IntActiO70591, 28 interactors
MINTiO70591
STRINGi10090.ENSMUSP00000120106

Structurei

3D structure databases

ProteinModelPortaliO70591
SMRiO70591
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiKOG4098 Eukaryota
ENOG4111S6I LUCA
GeneTreeiENSGT00390000009272
HOVERGENiHBG008172
InParanoidiO70591
KOiK09549
OMAiDPERKCF
OrthoDBiEOG091G11OU
PhylomeDBiO70591
TreeFamiTF313252

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR027235 PFD2
IPR002777 PFD_beta-like
IPR009053 Prefoldin
PANTHERiPTHR13303 PTHR13303, 1 hit
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O70591-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADSSGRVGK SGGSGAGKGA VSAEQVIAGF NRLRQEQRGL ASKAAELEME
60 70 80 90 100
LNEHSLVIDT LKEVDETRKC YRMVGGVLVE RTVKEVLPAL EGNKEQIQKI
110 120 130 140 150
IETLSQQLQA KGKELNEFRE KHNIRLMGED EKPAAKENSE GAGAKASSAG

VLVS
Length:154
Mass (Da):16,534
Last modified:August 13, 2002 - v2
Checksum:iA34F229309AC6715
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WJ30F8WJ30_MOUSE
Prefoldin subunit 2
Pfdn2
129Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14 – 17SGAG → TARW in CAA76760 (PubMed:9630229).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17393 mRNA Translation: CAA76760.1
BC026839 mRNA Translation: AAH26839.1
BC049606 mRNA Translation: AAH49606.1
CCDSiCCDS15491.1
RefSeqiNP_035200.2, NM_011070.3
UniGeneiMm.10756

Genome annotation databases

EnsembliENSMUST00000135941; ENSMUSP00000120106; ENSMUSG00000006412
GeneIDi18637
KEGGimmu:18637
UCSCiuc007doc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17393 mRNA Translation: CAA76760.1
BC026839 mRNA Translation: AAH26839.1
BC049606 mRNA Translation: AAH49606.1
CCDSiCCDS15491.1
RefSeqiNP_035200.2, NM_011070.3
UniGeneiMm.10756

3D structure databases

ProteinModelPortaliO70591
SMRiO70591
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202121, 27 interactors
IntActiO70591, 28 interactors
MINTiO70591
STRINGi10090.ENSMUSP00000120106

PTM databases

iPTMnetiO70591
PhosphoSitePlusiO70591

2D gel databases

REPRODUCTION-2DPAGEiIPI00119545
O70591

Proteomic databases

EPDiO70591
MaxQBiO70591
PaxDbiO70591
PeptideAtlasiO70591
PRIDEiO70591

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000135941; ENSMUSP00000120106; ENSMUSG00000006412
GeneIDi18637
KEGGimmu:18637
UCSCiuc007doc.1 mouse

Organism-specific databases

CTDi5202
MGIiMGI:1276111 Pfdn2

Phylogenomic databases

eggNOGiKOG4098 Eukaryota
ENOG4111S6I LUCA
GeneTreeiENSGT00390000009272
HOVERGENiHBG008172
InParanoidiO70591
KOiK09549
OMAiDPERKCF
OrthoDBiEOG091G11OU
PhylomeDBiO70591
TreeFamiTF313252

Miscellaneous databases

ChiTaRSiPfdn2 mouse
PROiPR:O70591
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006412 Expressed in 285 organ(s), highest expression level in lateral hypothalamic area
CleanExiMM_PFDN2
ExpressionAtlasiO70591 baseline and differential
GenevisibleiO70591 MM

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR027235 PFD2
IPR002777 PFD_beta-like
IPR009053 Prefoldin
PANTHERiPTHR13303 PTHR13303, 1 hit
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPFD2_MOUSE
AccessioniPrimary (citable) accession number: O70591
Secondary accession number(s): Q8R0H2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: August 13, 2002
Last modified: September 12, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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