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UniProtKB - O70589 (CSKP_MOUSE)

Entry version 195 (07 Oct 2020)
Sequence version 2 (17 Apr 2007)
Previous versions | rss
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Protein

Peripheral plasma membrane protein CASK

Gene

Cask

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (PubMed:10846156).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Note: Unlike other protein kinases, does not require a divalent cation such as magnesium for catalytic activity.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Differs from archetypal CaMK members in that the kinase domain exhibits a constitutively active conformation and the autoinhibitory region does not engage in direct contact with the ATP-binding cleft, although it still binds Ca2+/CAM.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei41ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei141By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi18 – 26ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.11.1, 3474

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-212676, Dopamine Neurotransmitter Release Cycle
R-MMU-6794361, Neurexins and neuroligins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peripheral plasma membrane protein CASK (EC:2.7.11.1)
Alternative name(s):
Calcium/calmodulin-dependent serine protein kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CaskImported
Synonyms:Lin-21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1309489, Cask

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000945691 – 926Peripheral plasma membrane protein CASKAdd BLAST926

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei51PhosphoserineBy similarity1
Modified residuei151Phosphoserine; by autocatalysisBy similarity1
Modified residuei155Phosphoserine; by autocatalysisBy similarity1
Modified residuei182PhosphothreonineCombined sources1
Modified residuei313PhosphoserineBy similarity1
Isoform 3 (identifier: O70589-3)
Modified residuei570PhosphoserineCombined sources1
Modified residuei571PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O70589

MaxQB - The MaxQuant DataBase

More...MaxQBi		O70589

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O70589

PeptideAtlas

More...PeptideAtlasi		O70589

PRoteomics IDEntifications database

More...PRIDEi		O70589

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O70589

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O70589

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O70589

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000031012, Expressed in cortical plate and 312 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O70589, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O70589, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

CASK and LIN7 form a tripartite complex with CASKIN1 (By similarity).

Component of the brain-specific heterotrimeric complex (LIN-10-LIN-2-LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which associates with the motor protein KIF17 to transport vesicles along microtubules (PubMed:10846156).

Forms a heterotrimeric complex with DLG1 and LIN7B via their L27 domains (PubMed:22337881, PubMed:15863617).

Identified in a complex with ACTN4, IQGAP1, MAGI2, NPHS1, SPTAN1 and SPTBN1 (By similarity).

Part of a complex containing CASK, TBR1 and TSPYL2 (PubMed:10749215, PubMed:15066269).

Interacts with WHRN (By similarity).

Interacts (via the PDZ, SH3 and guanylate kinase-like domains) with NRXN1 (via C-terminus) (PubMed:25385611).

Interacts with CASKIN1, APBA1, LIN7(A/B/C), and L27 domain of DLG1 and isoform 2 of DLG4 (By similarity).

Interacts with FCHSD2 (By similarity).

Interacts with KIRREL3 (By similarity).

Interacts with TBR1 (By similarity).

Interacts with TSPYL2 (PubMed:15066269).

By similarity6 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		198491, 27 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O70589

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		O70589

Protein interaction database and analysis system

More...IntActi		O70589, 20 interactors

Molecular INTeraction database

More...MINTi		O70589

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000033321

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O70589, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1926
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O70589

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O70589

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 276Protein kinasePROSITE-ProRule annotationAdd BLAST265
Domaini343 – 398L27 1PROSITE-ProRule annotationAdd BLAST56
Domaini402 – 455L27 2PROSITE-ProRule annotationAdd BLAST54
Domaini490 – 571PDZPROSITE-ProRule annotationAdd BLAST82
Domaini612 – 682SH3PROSITE-ProRule annotationAdd BLAST71
Domaini739 – 911Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST173

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni305 – 315Calmodulin-bindingAdd BLAST11
Regioni482 – 909Required for interaction with NRXN1 (via C-terminal tail)By similarityAdd BLAST428

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The first L27 domain binds DLG1 and the second L27 domain probably binds LIN7.By similarity
The protein kinase domain mediates the interaction with FCHSD2.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Curated
Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0033, Eukaryota
KOG0609, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155600

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O70589

KEGG Orthology (KO)

More...KOi		K06103

Database of Orthologous Groups

More...OrthoDBi		95102at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O70589

TreeFam database of animal gene trees

More...TreeFami		TF314263

Family and domain databases

Conserved Domains Database

More...CDDi		cd12081, SH3_CASK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035473, CASK_SH3
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR020590, Guanylate_kinase_CS
IPR011009, Kinase-like_dom_sf
IPR014775, L27_C
IPR004172, L27_dom
IPR036892, L27_dom_sf
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000719, Prot_kinase_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00625, Guanylate_kin, 1 hit
PF02828, L27, 2 hits
PF00595, PDZ, 1 hit
PF00069, Pkinase, 1 hit
PF00018, SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00072, GuKc, 1 hit
SM00569, L27, 2 hits
SM00228, PDZ, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101288, SSF101288, 2 hits
SSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 1 hit
SSF52540, SSF52540, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00856, GUANYLATE_KINASE_1, 1 hit
PS50052, GUANYLATE_KINASE_2, 1 hit
PS51022, L27, 2 hits
PS50106, PDZ, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O70589-1) [UniParc]FASTAAdd to basket
Also known as: CASK-B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADDDVLFED VYELCEVIGK GPFSVVRRCI NRETGQQFAV KIVDVAKFTS 
        60         70         80         90        100
SPGLSTEDLK REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC 
       110        120        130        140        150
FEIVKRADAG FVYSEAVASH YMRQILEALR YCHDNNIIHR DVKPHCVLLA 
       160        170        180        190        200
SKENSAPVKL GGFGVAIQLG ESGLVAGGRV GTPHFMAPEV VKREPYGKPV 
       210        220        230        240        250
DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR QWSHISESAK 
       260        270        280        290        300
DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA 
       310        320        330        340        350
RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGL LAAERAVSQV 
       360        370        380        390        400
LDSLEEIHAL TDCSEKDLDF LHSVFQDQHL HTLLDLYDKI NTKSSPQIRN 
       410        420        430        440        450
PPSDAVQRAK EVLEEISCYP ENNDAKELKR ILTQPHFMAL LQTHDVVAHE 
       460        470        480        490        500
VYSDEALRVT PPPTSPYLNG DSPESANGDM DMENVTRVRL VQFQKNTDEP 
       510        520        530        540        550
MGITLKMNEL NHCIVARIMH GGMIHRQGTL HVGDEIREIN GISVANQTVE 
       560        570        580        590        600
QLQKMLREMR GSITFKIVPS YRTQSSSCER DSPSTSRQSP ANGHSSTNNS 
       610        620        630        640        650
VSDLPSTTQP KGRQIYVRAQ FEYDPAKDDL IPCKEAGIRF RVGDIIQIIS 
       660        670        680        690        700
KDDHNWWQGK LENSKNGTAG LIPSPELQEW RVACIAMEKT KQEQQASCTW 
       710        720        730        740        750
FGKKKKQYKD KYLAKHNAVF DQLDLVTYEE VVKLPAFKRK TLVLLGAHGV 
       760        770        780        790        800
GRRHIKNTLI TKHPDRFAYP IPHTTRPPKK DEENGKNYYF VSHDQMMQDI 
       810        820        830        840        850
SNNEYLEYGS HEDAMYGTKL ETIRKIHEQG LIAILDVEPQ ALKVLRTAEF 
       860        870        880        890        900
APFVVFIAAP TITPGLNEDE SLQRLQKESD VLQRTYAHYF DLTIINNEID 
       910        920 
ETIRHLEEAV ELVCTAPQWV PVSWVY
Length:926
Mass (Da):105,109
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADD2008CE53E0018
GO
Isoform 2 (identifier: O70589-2) [UniParc]FASTAAdd to basket
Also known as: CASK-A

The sequence of this isoform differs from the canonical sequence as follows:
     580-664: RDSPSTSRQS...NWWQGKLENS → VISLTSLSYP...KIKAKYRKLQ
     665-926: Missing.

Show »
Length:664
Mass (Da):74,907
Checksum:iB60B1EB9E3091CB6
GO
Isoform 3 (identifier: O70589-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-345: Missing.
     580-602: Missing.

Show »
Length:897
Mass (Da):102,100
Checksum:i4AEBC03D2EEE3F68
GO
Isoform 4 (identifier: O70589-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-345: Missing.
     603-614: Missing.

Show »
Length:908
Mass (Da):103,145
Checksum:i0413DFBEA74F4E37
GO
Isoform 5 (identifier: O70589-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-345: Missing.

Show »
Length:920
Mass (Da):104,455
Checksum:iDD0E0B86503865A6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A067XG53A0A067XG53_MOUSE
Peripheral plasma membrane protein ...
Cask
871Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AUH5B1AUH5_MOUSE
Peripheral plasma membrane protein ...
Cask
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6ZQR2F6ZQR2_MOUSE
Peripheral plasma membrane protein ...
Cask
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Y9I5F6Y9I5_MOUSE
Peripheral plasma membrane protein ...
Cask
282Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CD87F7CD87_MOUSE
Peripheral plasma membrane protein ...
Cask
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AUH6B1AUH6_MOUSE
Peripheral plasma membrane protein ...
Cask
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti298F → L in CAA76646 (PubMed:9787075).Curated1
Sequence conflicti298F → L in CAA76647 (PubMed:9787075).Curated1
Sequence conflicti666N → K in CAA76646 (PubMed:9787075).Curated1
Sequence conflicti666N → K in CAA76647 (PubMed:9787075).Curated1
Sequence conflicti677 – 679LQE → IQG in CAA76646 (PubMed:9787075).Curated3
Sequence conflicti677 – 679LQE → IQG in CAA76647 (PubMed:9787075).Curated3
Sequence conflicti720 – 723FDQL → LII in CAA76646 (PubMed:9787075).Curated4
Sequence conflicti720 – 723FDQL → LII in CAA76647 (PubMed:9787075).Curated4
Sequence conflicti742L → S in CAA76646 (PubMed:9787075).Curated1
Sequence conflicti742L → S in CAA76647 (PubMed:9787075).Curated1
Sequence conflicti769Y → C in CAA76646 (PubMed:9787075).Curated1
Sequence conflicti769Y → C in CAA76647 (PubMed:9787075).Curated1
Sequence conflicti798Q → R in CAA76646 (PubMed:9787075).Curated1
Sequence conflicti798Q → R in CAA76647 (PubMed:9787075).Curated1
Sequence conflicti816Y → F in CAA76646 (PubMed:9787075).Curated1
Sequence conflicti816Y → F in CAA76647 (PubMed:9787075).Curated1
Sequence conflicti821 – 823ETI → DH in CAA76646 (PubMed:9787075).Curated3
Sequence conflicti821 – 823ETI → DH in CAA76647 (PubMed:9787075).Curated3
Sequence conflicti851A → P in CAA76646 (PubMed:9787075).Curated1
Sequence conflicti851A → P in CAA76647 (PubMed:9787075).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024614340 – 345Missing in isoform 3, isoform 4 and isoform 5. 1 Publication6
Alternative sequenceiVSP_003152580 – 664RDSPS…KLENS → VISLTSLSYPNLPISSEFLT NFLLMAECFCFLGNCFCCAV TTLHTNFTTKITEQKEVPPT SSALLACRYLQPFCSKIKAK YRKLQ in isoform 2. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_024615580 – 602Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_024616603 – 614Missing in isoform 4. CuratedAdd BLAST12
Alternative sequenceiVSP_003153665 – 926Missing in isoform 2. 1 PublicationAdd BLAST262

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y17138 mRNA Translation: CAA76647.1
Y17137 mRNA Translation: CAA76646.1
AL671117 Genomic DNA No translation available.
AL672204 Genomic DNA No translation available.
BX005215 Genomic DNA No translation available.
AK136523 mRNA Translation: BAE23024.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS40878.1 [O70589-3]
CCDS72343.1 [O70589-5]

NCBI Reference Sequences

More...RefSeqi		NP_001271432.1, NM_001284503.1 [O70589-1]
NP_001271433.1, NM_001284504.1
NP_001271434.1, NM_001284505.1 [O70589-5]
NP_033936.2, NM_009806.3 [O70589-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000033321; ENSMUSP00000033321; ENSMUSG00000031012 [O70589-4]
ENSMUST00000115436; ENSMUSP00000111096; ENSMUSG00000031012 [O70589-3]
ENSMUST00000115438; ENSMUSP00000111098; ENSMUSG00000031012 [O70589-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		12361

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:12361

UCSC genome browser

More...UCSCi		uc009srp.2, mouse [O70589-3]
uc009srq.2, mouse [O70589-1]
uc012hez.2, mouse [O70589-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17138 mRNA Translation: CAA76647.1
Y17137 mRNA Translation: CAA76646.1
AL671117 Genomic DNA No translation available.
AL672204 Genomic DNA No translation available.
BX005215 Genomic DNA No translation available.
AK136523 mRNA Translation: BAE23024.1
CCDSiCCDS40878.1 [O70589-3]
CCDS72343.1 [O70589-5]
RefSeqiNP_001271432.1, NM_001284503.1 [O70589-1]
NP_001271433.1, NM_001284504.1
NP_001271434.1, NM_001284505.1 [O70589-5]
NP_033936.2, NM_009806.3 [O70589-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y74NMR-B/D405-454[»]
SMRiO70589
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi198491, 27 interactors
CORUMiO70589
ELMiO70589
IntActiO70589, 20 interactors
MINTiO70589
STRINGi10090.ENSMUSP00000033321

PTM databases

iPTMnetiO70589
PhosphoSitePlusiO70589
SwissPalmiO70589

Proteomic databases

jPOSTiO70589
MaxQBiO70589
PaxDbiO70589
PeptideAtlasiO70589
PRIDEiO70589

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4529, 294 antibodies

The DNASU plasmid repository

More...DNASUi		12361

Genome annotation databases

EnsembliENSMUST00000033321; ENSMUSP00000033321; ENSMUSG00000031012 [O70589-4]
ENSMUST00000115436; ENSMUSP00000111096; ENSMUSG00000031012 [O70589-3]
ENSMUST00000115438; ENSMUSP00000111098; ENSMUSG00000031012 [O70589-5]
GeneIDi12361
KEGGimmu:12361
UCSCiuc009srp.2, mouse [O70589-3]
uc009srq.2, mouse [O70589-1]
uc012hez.2, mouse [O70589-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8573
MGIiMGI:1309489, Cask

Phylogenomic databases

eggNOGiKOG0033, Eukaryota
KOG0609, Eukaryota
GeneTreeiENSGT00940000155600
InParanoidiO70589
KOiK06103
OrthoDBi95102at2759
PhylomeDBiO70589
TreeFamiTF314263

Enzyme and pathway databases

BRENDAi2.7.11.1, 3474
ReactomeiR-MMU-212676, Dopamine Neurotransmitter Release Cycle
R-MMU-6794361, Neurexins and neuroligins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		12361, 2 hits in 19 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Cask, mouse
EvolutionaryTraceiO70589

Protein Ontology

More...PROi		PR:O70589
RNActiO70589, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000031012, Expressed in cortical plate and 312 other tissues
ExpressionAtlasiO70589, baseline and differential
GenevisibleiO70589, MM

Family and domain databases

CDDicd12081, SH3_CASK, 1 hit
Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR035473, CASK_SH3
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR020590, Guanylate_kinase_CS
IPR011009, Kinase-like_dom_sf
IPR014775, L27_C
IPR004172, L27_dom
IPR036892, L27_dom_sf
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000719, Prot_kinase_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF00625, Guanylate_kin, 1 hit
PF02828, L27, 2 hits
PF00595, PDZ, 1 hit
PF00069, Pkinase, 1 hit
PF00018, SH3_1, 1 hit
SMARTiView protein in SMART
SM00072, GuKc, 1 hit
SM00569, L27, 2 hits
SM00228, PDZ, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF101288, SSF101288, 2 hits
SSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 1 hit
SSF52540, SSF52540, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00856, GUANYLATE_KINASE_1, 1 hit
PS50052, GUANYLATE_KINASE_2, 1 hit
PS51022, L27, 2 hits
PS50106, PDZ, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSKP_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O70589
Secondary accession number(s): A2ADP8
, A2ADP9, A2ADQ4, O70588, Q3UW92
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 17, 2007
Last modified: October 7, 2020
This is version 195 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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