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Protein

Dystrobrevin beta

Gene

Dtnb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 284ZZ-typePROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Dystrobrevin beta
Short name:
DTN-B
Short name:
mDTN-B
Alternative name(s):
Beta-dystrobrevin
Gene namesi
Name:Dtnb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1203728 Dtnb

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000868791 – 659Dystrobrevin betaAdd BLAST659

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei394PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO70585
PaxDbiO70585
PRIDEiO70585

PTM databases

iPTMnetiO70585
PhosphoSitePlusiO70585
SwissPalmiO70585

Expressioni

Tissue specificityi

Expressed mainly in brain, kidney, liver and lung. In brain expressed in neurons of the cortex and hippocampus.

Gene expression databases

BgeeiENSMUSG00000071454 Expressed in 238 organ(s), highest expression level in testis
CleanExiMM_DTNB
ExpressionAtlasiO70585 baseline and differential
GenevisibleiO70585 MM

Interactioni

Subunit structurei

Interacts with dystrophin short form DP71 and syntrophins SNTG1 and SNTG2 (By similarity). Binds dystrobrevin binding protein 1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Kif5aP331754EBI-349714,EBI-349710

Protein-protein interaction databases

BioGridi199335, 1 interactor
CORUMiO70585
IntActiO70585, 7 interactors
MINTiO70585
STRINGi10090.ENSMUSP00000126194

Structurei

3D structure databases

ProteinModelPortaliO70585
SMRiO70585
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni369 – 418Syntrophin-binding regionAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili429 – 519Sequence analysisAdd BLAST91

Domaini

The coiled coil domain may mediate the interaction with dystrophin.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 284ZZ-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG4301 Eukaryota
ENOG410XP3C LUCA
GeneTreeiENSGT00760000119237
HOGENOMiHOG000230684
HOVERGENiHBG005539
InParanoidiO70585
OrthoDBiEOG091G02RL
TreeFamiTF343849

Family and domain databases

InterProiView protein in InterPro
IPR017432 Distrobrevin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR000433 Znf_ZZ
PfamiView protein in Pfam
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00569 ZZ, 1 hit
PIRSFiPIRSF038204 Distrobrevin, 1 hit
SMARTiView protein in SMART
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O70585-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIEEGGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL
60 70 80 90 100
HLVDIWNMIE AFRDNGLNTL DHSTEISVSR LETVISSIYY QLNKRLPSTH
110 120 130 140 150
QISVEQSISL LLNFMVAAYD SEGRGKLTVF SVKAMLATMC GGKMLDKLRY
160 170 180 190 200
IFSQMSDSNG LMMFGKLDQF LKEALKLPTA VFEGPSFGYT EHAVRTCFPQ
210 220 230 240 250
QKKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP VECSYCHCES
260 270 280 290 300
MMGFRYRCQQ CHNYQLCQNC FWRGHASGAH SNQHQMKEHS SWKSPAKKLS
310 320 330 340 350
HAISKSLGCV PSREPPHPVF PEQPEKPLDL AHLVPPRPLT NMNDTVVSHM
360 370 380 390 400
SSGVPTPTKR LQYSQDMPNL LADEHALIAS YVARLQHCTR VLDSPSRLDE
410 420 430 440 450
EHRLIARYAA RLAAEAGNMT RPPTDASFNF DANKQQRQLI AELENKNREI
460 470 480 490 500
LQEIQRLRLE HEQASQPTPE KAQQNPMLLA ELRLLRQRKD ELEQRMSALQ
510 520 530 540 550
ESRRELMVQL EGLMKLLKAQ ATGSPHTSPT HGGGRPMPMP VRSTSAGSTP
560 570 580 590 600
THGPQDSLSG VGGDVQEAFA QGTRRNLRND LLVAADSITN TMSSLVKELH
610 620 630 640 650
SGAEAEEQAG TEKTREGLPP RGTFLSVFLL HTWTKLAGCQ THSTSRERSQ

AYGKWGGTA
Length:659
Mass (Da):74,399
Last modified:June 28, 2011 - v3
Checksum:i27AB3141A65797A8
GO
Isoform 2 (identifier: O70585-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     518-518: K → KEEEQKQA
     603-608: AEAEEQ → EVTPVS
     609-659: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:615
Mass (Da):69,637
Checksum:i58AA5C4DA74227EA
GO

Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UZ87G3UZ87_MOUSE
Dystrobrevin
Dtnb
609Annotation score:
G3UY34G3UY34_MOUSE
Dystrobrevin
Dtnb
596Annotation score:
G3UXK0G3UXK0_MOUSE
Dystrobrevin
Dtnb
566Annotation score:
G3UYM7G3UYM7_MOUSE
Dystrobrevin
Dtnb
626Annotation score:
Q8K0N0Q8K0N0_MOUSE
Dystrobrevin
Dtnb
602Annotation score:
Q8C8Z9Q8C8Z9_MOUSE
Dystrobrevin
Dtnb
608Annotation score:
G3UZJ3G3UZJ3_MOUSE
Dystrobrevin beta
Dtnb
559Annotation score:
G3UYK9G3UYK9_MOUSE
Dystrobrevin beta
Dtnb
490Annotation score:
G3UYD1G3UYD1_MOUSE
Dystrobrevin beta
Dtnb
107Annotation score:
G3UXH9G3UXH9_MOUSE
Dystrobrevin beta
Dtnb
149Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence CAA75752 differs from that shown. Reason: Frameshift at position 621.Curated
The sequence CAA75752 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti412L → P in CAA75752 (PubMed:9540997).Curated1
Sequence conflicti465S → F in CAA05796 (PubMed:9419360).Curated1
Sequence conflicti465S → F in CAA09038 (PubMed:9799833).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004227518K → KEEEQKQA in isoform 2. 2 Publications1
Alternative sequenceiVSP_004228603 – 608AEAEEQ → EVTPVS in isoform 2. 2 Publications6
Alternative sequenceiVSP_004229609 – 659Missing in isoform 2. 2 PublicationsAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15742 mRNA Translation: CAA75752.1 Sequence problems.
AJ003007 mRNA Translation: CAA05796.1
AJ010204
, AJ010205, AJ010206, AJ010207, AJ010208, AJ010209, AJ010210, AJ010211, AJ010212, AJ010213, AJ010214, AJ010215, AJ010216, AJ010217, AJ010218, AJ010219, AJ010220, AJ010221 Genomic DNA Translation: CAA09038.1
AC155273 Genomic DNA No translation available.
CR974568 Genomic DNA No translation available.
AK019068 mRNA No translation available.
CCDSiCCDS49015.1 [O70585-1]
RefSeqiNP_001155937.1, NM_001162465.1 [O70585-1]
UniGeneiMm.286202

Genome annotation databases

EnsembliENSMUST00000101637; ENSMUSP00000099161; ENSMUSG00000071454 [O70585-2]
ENSMUST00000164578; ENSMUSP00000126194; ENSMUSG00000071454 [O70585-1]
GeneIDi13528
KEGGimmu:13528
UCSCiuc007mww.2 mouse [O70585-2]
uc007mwy.2 mouse [O70585-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15742 mRNA Translation: CAA75752.1 Sequence problems.
AJ003007 mRNA Translation: CAA05796.1
AJ010204
, AJ010205, AJ010206, AJ010207, AJ010208, AJ010209, AJ010210, AJ010211, AJ010212, AJ010213, AJ010214, AJ010215, AJ010216, AJ010217, AJ010218, AJ010219, AJ010220, AJ010221 Genomic DNA Translation: CAA09038.1
AC155273 Genomic DNA No translation available.
CR974568 Genomic DNA No translation available.
AK019068 mRNA No translation available.
CCDSiCCDS49015.1 [O70585-1]
RefSeqiNP_001155937.1, NM_001162465.1 [O70585-1]
UniGeneiMm.286202

3D structure databases

ProteinModelPortaliO70585
SMRiO70585
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199335, 1 interactor
CORUMiO70585
IntActiO70585, 7 interactors
MINTiO70585
STRINGi10090.ENSMUSP00000126194

PTM databases

iPTMnetiO70585
PhosphoSitePlusiO70585
SwissPalmiO70585

Proteomic databases

MaxQBiO70585
PaxDbiO70585
PRIDEiO70585

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101637; ENSMUSP00000099161; ENSMUSG00000071454 [O70585-2]
ENSMUST00000164578; ENSMUSP00000126194; ENSMUSG00000071454 [O70585-1]
GeneIDi13528
KEGGimmu:13528
UCSCiuc007mww.2 mouse [O70585-2]
uc007mwy.2 mouse [O70585-1]

Organism-specific databases

CTDi1838
MGIiMGI:1203728 Dtnb

Phylogenomic databases

eggNOGiKOG4301 Eukaryota
ENOG410XP3C LUCA
GeneTreeiENSGT00760000119237
HOGENOMiHOG000230684
HOVERGENiHBG005539
InParanoidiO70585
OrthoDBiEOG091G02RL
TreeFamiTF343849

Miscellaneous databases

PROiPR:O70585
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071454 Expressed in 238 organ(s), highest expression level in testis
CleanExiMM_DTNB
ExpressionAtlasiO70585 baseline and differential
GenevisibleiO70585 MM

Family and domain databases

InterProiView protein in InterPro
IPR017432 Distrobrevin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR000433 Znf_ZZ
PfamiView protein in Pfam
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00569 ZZ, 1 hit
PIRSFiPIRSF038204 Distrobrevin, 1 hit
SMARTiView protein in SMART
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDTNB_MOUSE
AccessioniPrimary (citable) accession number: O70585
Secondary accession number(s): E9Q0F2, O70563, Q9CTZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: June 28, 2011
Last modified: November 7, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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