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Protein

Peroxisomal membrane protein PMP34

Gene

Slc25a17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD+), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD+ from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-389599 Alpha-oxidation of phytanate

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PMP34
Alternative name(s):
34 kDa peroxisomal membrane protein
Solute carrier family 25 member 17
Gene namesi
Name:Slc25a17
Synonyms:Pmp34, Pmp35
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1342248 Slc25a17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicBy similarity9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 66LumenalSequence analysisAdd BLAST36
Transmembranei67 – 87Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini88 – 104CytoplasmicSequence analysisAdd BLAST17
Transmembranei105 – 125Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini126 – 160LumenalSequence analysisAdd BLAST35
Transmembranei161 – 181Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini182 – 202CytoplasmicSequence analysisAdd BLAST21
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 280LumenalSequence analysisAdd BLAST57
Transmembranei281 – 301Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini302 – 307CytoplasmicBy similarity6

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000907061 – 307Peroxisomal membrane protein PMP34Add BLAST307

Proteomic databases

EPDiO70579
MaxQBiO70579
PaxDbiO70579
PeptideAtlasiO70579
PRIDEiO70579

PTM databases

PhosphoSitePlusiO70579

Expressioni

Tissue specificityi

Expressed in liver.

Gene expression databases

BgeeiENSMUSG00000022404
GenevisibleiO70579 MM

Interactioni

Subunit structurei

Interacts (via N- and C-terminus peroxisomal targeting regions) with PEX19; the interaction occurs with the newly synthesized SLC25A17 in the cytosol.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023040

Structurei

3D structure databases

ProteinModelPortaliO70579
SMRiO70579
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 92Solcar 1Add BLAST86
Repeati99 – 192Solcar 2Add BLAST94
Repeati200 – 294Solcar 3Add BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 147Necessary for targeting to peroxisomes and interaction with PEX19By similarityAdd BLAST147
Regioni244 – 307Necessary for targeting to peroxisomes and interaction with PEX19By similarityAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi190 – 199Peroxisome localization signalBy similarity10

Domaini

The N- and C-terminal portions are exposed to the cytoplasm. A region between helical transmembrane domains (TM) 4 and 5 and TM1-TM3 or TM4-TM6 are necessary for the peroxisome-targeting activity (By similarity). Lacks a typical peroxisomal sorting signal.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0769 Eukaryota
ENOG410ZNC0 LUCA
GeneTreeiENSGT00920000149129
HOGENOMiHOG000159426
HOVERGENiHBG003235
InParanoidiO70579
KOiK13354
OMAiYITVKSQ
OrthoDBiEOG091G0DMQ
PhylomeDBiO70579
TreeFamiTF324772

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

O70579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVLSYESL VHAVAGAVGS VTAMTVFFPL DTARLRLQVD EKRKSKTTHA
60 70 80 90 100
VLLEIIKEEG LLAPYRGWFP VISSLCCSNF VYFYTFNSLK AVWVKGQRSS
110 120 130 140 150
TGKDLVVGFV AGVVNVLLTT PLWVVNTRLK LQGAKFRNED IIPTNYKGII
160 170 180 190 200
DAFHQIIRDE GILALWNGTF PSLLLVFNPA IQFMFYEGLK RQLLKKRMKL
210 220 230 240 250
SSLDVFIIGA IAKAIATTVT YPMQTVQSIL RFGRHRLNPE NRTLGSLRNV
260 270 280 290 300
LSLLHQRVKR FGIMGLYKGL EAKLLQTVLT AALMFLVYEK LTAATFTVMG

LKSTHKH
Length:307
Mass (Da):34,413
Last modified:August 1, 1998 - v1
Checksum:i8CE406CE66D0EB06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006341 mRNA Translation: CAA06984.1
AK002388 mRNA Translation: BAB22062.1
BC008571 mRNA Translation: AAH08571.1
BC011292 mRNA Translation: AAH11292.1
CCDSiCCDS27666.1
RefSeqiNP_035529.1, NM_011399.3
UniGeneiMm.222536

Genome annotation databases

EnsembliENSMUST00000023040; ENSMUSP00000023040; ENSMUSG00000022404
GeneIDi20524
KEGGimmu:20524
UCSCiuc007wwk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPM34_MOUSE
AccessioniPrimary (citable) accession number: O70579
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: August 1, 1998
Last modified: June 20, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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