Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Voltage-dependent calcium channel gamma-1 subunit

Gene

Cacng1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.2 Publications

GO - Molecular functioni

  • calcium channel regulator activity Source: UniProtKB
  • voltage-gated calcium channel activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-5576892 Phase 0 - rapid depolarisation
R-MMU-5576893 Phase 2 - plateau phase

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-1 subunit
Alternative name(s):
Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma
Gene namesi
Name:Cacng1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1206582 Cacng1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicCurated10
Transmembranei11 – 29HelicalBy similarityAdd BLAST19
Topological domaini30 – 109ExtracellularCuratedAdd BLAST80
Transmembranei110 – 130HelicalBy similarityAdd BLAST21
Topological domaini131 – 135CytoplasmicCurated5
Transmembranei136 – 156HelicalBy similarityAdd BLAST21
Topological domaini157 – 180ExtracellularCuratedAdd BLAST24
Transmembranei181 – 205HelicalBy similarityAdd BLAST25
Topological domaini206 – 223CytoplasmicCuratedAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646701 – 223Voltage-dependent calcium channel gamma-1 subunitAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi57 ↔ 81By similarity
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO70578
PRIDEiO70578

PTM databases

PhosphoSitePlusiO70578

Expressioni

Tissue specificityi

Detected in skeletal muscle (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000020722 Expressed in 78 organ(s), highest expression level in triceps surae
ExpressionAtlasiO70578 baseline and differential
GenevisibleiO70578 MM

Interactioni

Subunit structurei

Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1 (PubMed:10799530, PubMed:12409298). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2 (By similarity).By similarity2 Publications

Protein-protein interaction databases

ComplexPortaliCPX-3191 Skeletal muscle VGCC complex
STRINGi10090.ENSMUSP00000021065

Structurei

3D structure databases

ProteinModelPortaliO70578
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH0I Eukaryota
ENOG4111J5G LUCA
GeneTreeiENSGT00390000007786
HOGENOMiHOG000293219
HOVERGENiHBG003868
InParanoidiO70578
KOiK04866
OMAiEKNCSYF
OrthoDBiEOG091G0IU0
PhylomeDBiO70578
TreeFamiTF331651

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR005421 VDCC_g1su
IPR008368 VDCC_gsu
PfamiView protein in Pfam
PF13903 Claudin_2, 1 hit
PRINTSiPR01792 VDCCGAMMA
PR01601 VDCCGAMMA1

Sequencei

Sequence statusi: Complete.

O70578-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQTKTAKVR VTLFFILVGG VLAMVAVVTD HWAVLSPHLE HHNETCEAAH
60 70 80 90 100
FGLWRICTAR VAVHNKDKSC EHVTPSGEKN CSYFRHFNPG ESSEIFEFTT
110 120 130 140 150
QKEYSISAAA IAIFSLGFII VGSICAFLSF GNKRDYLLRP ASMFYAFAGL
160 170 180 190 200
CLIVSVEVMR QSVKRMIDSE DTVWIEHYYS WSFACACAAF ILLFLGGLFL
210 220
LLFSLPRMPQ NPWESCMDAE PEH
Length:223
Mass (Da):25,120
Last modified:August 1, 1998 - v1
Checksum:i3712F856CAFAE5F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006306 mRNA Translation: CAA06966.1
CCDSiCCDS25570.1
RefSeqiNP_031608.1, NM_007582.2
UniGeneiMm.57093

Genome annotation databases

EnsembliENSMUST00000021065; ENSMUSP00000021065; ENSMUSG00000020722
GeneIDi12299
KEGGimmu:12299
UCSCiuc007may.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006306 mRNA Translation: CAA06966.1
CCDSiCCDS25570.1
RefSeqiNP_031608.1, NM_007582.2
UniGeneiMm.57093

3D structure databases

ProteinModelPortaliO70578
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3191 Skeletal muscle VGCC complex
STRINGi10090.ENSMUSP00000021065

PTM databases

PhosphoSitePlusiO70578

Proteomic databases

PaxDbiO70578
PRIDEiO70578

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021065; ENSMUSP00000021065; ENSMUSG00000020722
GeneIDi12299
KEGGimmu:12299
UCSCiuc007may.1 mouse

Organism-specific databases

CTDi786
MGIiMGI:1206582 Cacng1

Phylogenomic databases

eggNOGiENOG410IH0I Eukaryota
ENOG4111J5G LUCA
GeneTreeiENSGT00390000007786
HOGENOMiHOG000293219
HOVERGENiHBG003868
InParanoidiO70578
KOiK04866
OMAiEKNCSYF
OrthoDBiEOG091G0IU0
PhylomeDBiO70578
TreeFamiTF331651

Enzyme and pathway databases

ReactomeiR-MMU-5576892 Phase 0 - rapid depolarisation
R-MMU-5576893 Phase 2 - plateau phase

Miscellaneous databases

PROiPR:O70578
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020722 Expressed in 78 organ(s), highest expression level in triceps surae
ExpressionAtlasiO70578 baseline and differential
GenevisibleiO70578 MM

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR005421 VDCC_g1su
IPR008368 VDCC_gsu
PfamiView protein in Pfam
PF13903 Claudin_2, 1 hit
PRINTSiPR01792 VDCCGAMMA
PR01601 VDCCGAMMA1
ProtoNetiSearch...

Entry informationi

Entry nameiCCG1_MOUSE
AccessioniPrimary (citable) accession number: O70578
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: August 1, 1998
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again