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Protein

Solute carrier family 22 member 2

Gene

Slc22a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei451Involved in recognition of organic cations and participates in structural changes that occur during translocation of organic cationsBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-112311 Neurotransmitter clearance
R-MMU-181430 Norepinephrine Neurotransmitter Release Cycle
R-MMU-2161517 Abacavir transmembrane transport
R-MMU-442660 Na+/Cl- dependent neurotransmitter transporters
R-MMU-549127 Organic cation transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 2
Alternative name(s):
Organic cation transporter 2
Gene namesi
Name:Slc22a2
Synonyms:Oct2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1335072 Slc22a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 150ExtracellularSequence analysisAdd BLAST108
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 177CytoplasmicSequence analysis6
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 210ExtracellularSequence analysisAdd BLAST12
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 238CytoplasmicSequence analysis7
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 263ExtracellularSequence analysis4
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 348CytoplasmicSequence analysisAdd BLAST64
Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
Topological domaini370 – 375ExtracellularSequence analysis6
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Topological domaini397 – 404CytoplasmicSequence analysis8
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Topological domaini426 – 432ExtracellularSequence analysis7
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
Topological domaini454 – 464CytoplasmicSequence analysisAdd BLAST11
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Topological domaini486 – 494ExtracellularSequence analysis9
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
Topological domaini516 – 553CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073662

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003209581 – 553Solute carrier family 22 member 2Add BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO70577
PaxDbiO70577
PRIDEiO70577

PTM databases

iPTMnetiO70577
PhosphoSitePlusiO70577

Expressioni

Tissue specificityi

Expressed in kidney and ureter. To a lower extent, also expressed in brain and embryo.1 Publication

Gene expression databases

BgeeiENSMUSG00000040966 Expressed in 55 organ(s), highest expression level in adult mammalian kidney
GenevisibleiO70577 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041186

Chemistry databases

BindingDBiO70577

Structurei

3D structure databases

ProteinModelPortaliO70577
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234568
HOVERGENiHBG061545
InParanoidiO70577
KOiK08199
OMAiNMQRPRK
OrthoDBiEOG091G05AC
PhylomeDBiO70577
TreeFamiTF315847

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00898 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O70577-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPTVDDILEH IGEFHLFQKQ TFFLLALLSG AFTPIYVGIV FLGFTPNHHC
60 70 80 90 100
RSPGVAELSQ RCGWSPAEEL NYTVPGLGSA GEVSFLSQCM RYEVDWNQST
110 120 130 140 150
LDCVDPLSSL AANRSHLPLS PCEHGWVYDT PGSSIVTEFN LVCAHSWMLD
160 170 180 190 200
LFQSLVNVGF FIGAVGIGYL ADRFGRKFCL LVTILINAIS GVLMAISPNY
210 220 230 240 250
AWMLVFRFLQ GLVSKAGWLI GYILITEFVG LGYRRTVGIC YQIAFTVGLL
260 270 280 290 300
ILAGVAYALP NWRWLQFAVT LPNFCFLLYF WCIPESPRWL ISQNKNAKAM
310 320 330 340 350
KIIKHIAKKN GKSVPVSLQS LTADEDTGMK LNPSFLDLVR TPQIRKHTLI
360 370 380 390 400
LMYNWFTSSV LYQGLIMHMG LAGDNIYLDF FYSALVEFPA AFIIILTIDR
410 420 430 440 450
IGRRYPWAVS NMVAGAACLA SVFIPDDLQW LKITVACLGR MGITIAYEMV
460 470 480 490 500
CLVNAELYPT YIRNLAVLVC SSMCDIGGIV TPFLVYRLTD IWLEFPLVVF
510 520 530 540 550
AVVGLVAGGL VLLLPETKGK ALPETIEDAE KMQRPRKKKE KRIYLQVKKA

ELS
Length:553
Mass (Da):61,831
Last modified:August 1, 1998 - v1
Checksum:i1E9744F0D5415483
GO
Isoform 2 (identifier: O70577-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-544: RPRKKKEKRIY → SLGRLVQTVCH
     545-553: Missing.

Note: No experimental confirmation available.
Show »
Length:544
Mass (Da):60,544
Checksum:i3A50BB93491211AE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031775534 – 544RPRKKKEKRIY → SLGRLVQTVCH in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_031776545 – 553Missing in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006036 mRNA Translation: CAA06827.1
AK052658 mRNA Translation: BAC35086.1
BC015250 mRNA Translation: AAH15250.1
BC069911 mRNA Translation: AAH69911.1
AF481054 Genomic DNA Translation: AAM22158.1
CCDSiCCDS28392.1 [O70577-1]
RefSeqiNP_038695.1, NM_013667.2 [O70577-1]
XP_011244498.1, XM_011246196.1
UniGeneiMm.17322

Genome annotation databases

EnsembliENSMUST00000046959; ENSMUSP00000041186; ENSMUSG00000040966 [O70577-1]
GeneIDi20518
KEGGimmu:20518
UCSCiuc008akw.1 mouse [O70577-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006036 mRNA Translation: CAA06827.1
AK052658 mRNA Translation: BAC35086.1
BC015250 mRNA Translation: AAH15250.1
BC069911 mRNA Translation: AAH69911.1
AF481054 Genomic DNA Translation: AAM22158.1
CCDSiCCDS28392.1 [O70577-1]
RefSeqiNP_038695.1, NM_013667.2 [O70577-1]
XP_011244498.1, XM_011246196.1
UniGeneiMm.17322

3D structure databases

ProteinModelPortaliO70577
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041186

Chemistry databases

BindingDBiO70577
ChEMBLiCHEMBL2073662

PTM databases

iPTMnetiO70577
PhosphoSitePlusiO70577

Proteomic databases

MaxQBiO70577
PaxDbiO70577
PRIDEiO70577

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046959; ENSMUSP00000041186; ENSMUSG00000040966 [O70577-1]
GeneIDi20518
KEGGimmu:20518
UCSCiuc008akw.1 mouse [O70577-1]

Organism-specific databases

CTDi6582
MGIiMGI:1335072 Slc22a2

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234568
HOVERGENiHBG061545
InParanoidiO70577
KOiK08199
OMAiNMQRPRK
OrthoDBiEOG091G05AC
PhylomeDBiO70577
TreeFamiTF315847

Enzyme and pathway databases

ReactomeiR-MMU-112311 Neurotransmitter clearance
R-MMU-181430 Norepinephrine Neurotransmitter Release Cycle
R-MMU-2161517 Abacavir transmembrane transport
R-MMU-442660 Na+/Cl- dependent neurotransmitter transporters
R-MMU-549127 Organic cation transport

Miscellaneous databases

PROiPR:O70577
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040966 Expressed in 55 organ(s), highest expression level in adult mammalian kidney
GenevisibleiO70577 MM

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00898 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiS22A2_MOUSE
AccessioniPrimary (citable) accession number: O70577
Secondary accession number(s): Q8BWF6, Q8K4X8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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