Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Polymeric immunoglobulin receptor

Gene

Pigr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Polymeric immunoglobulin receptor
Short name:
PIgR
Short name:
Poly-Ig receptor
Cleaved into the following chain:
Gene namesi
Name:Pigr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:103080 Pigr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 645ExtracellularSequence analysisAdd BLAST627
Transmembranei646 – 668HelicalSequence analysisAdd BLAST23
Topological domaini669 – 771CytoplasmicSequence analysisAdd BLAST103

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001490219 – 771Polymeric immunoglobulin receptorAdd BLAST753
ChainiPRO_000001490319 – 611Secretory componentAdd BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 110PROSITE-ProRule annotation
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi152 ↔ 220PROSITE-ProRule annotation
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi257 ↔ 324PROSITE-ProRule annotation
Disulfide bondi370 ↔ 440PROSITE-ProRule annotation
Glycosylationi420N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi471N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi484 ↔ 546PROSITE-ProRule annotation
Modified residuei680PhosphoserineBy similarity1
Modified residuei689PhosphoserineCombined sources1
Modified residuei696PhosphoserineBy similarity1
Modified residuei742PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO70570
PaxDbiO70570
PeptideAtlasiO70570
PRIDEiO70570

PTM databases

iPTMnetiO70570
PhosphoSitePlusiO70570

Expressioni

Gene expression databases

BgeeiENSMUSG00000026417 Expressed in 106 organ(s), highest expression level in left colon
CleanExiMM_PIGR
ExpressionAtlasiO70570 baseline and differential
GenevisibleiO70570 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202157, 2 interactors
STRINGi10090.ENSMUSP00000027675

Structurei

Secondary structure

1771
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO70570
SMRiO70570
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 120Ig-like V-type 1Add BLAST100
Domaini135 – 237Ig-like V-type 2Add BLAST103
Domaini245 – 351Ig-like V-type 3Add BLAST107
Domaini352 – 457Ig-like V-type 4Add BLAST106
Domaini463 – 563Ig-like V-type 5Add BLAST101

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHXB Eukaryota
ENOG41128ZA LUCA
GeneTreeiENSGT00530000063436
HOGENOMiHOG000115545
HOVERGENiHBG008199
InParanoidiO70570
KOiK13073
OMAiYWCGVKQ
OrthoDBiEOG091G03V3
PhylomeDBiO70570
TreeFamiTF334441

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 4 hits
SMARTiView protein in SMART
SM00409 IG, 5 hits
SM00406 IGv, 4 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O70570-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLYLFTLLV TVFSGVSTKS PIFGPQEVSS IEGDSVSITC YYPDTSVNRH
60 70 80 90 100
TRKYWCRQGA SGMCTTLISS NGYLSKEYSG RANLINFPEN NTFVINIEQL
110 120 130 140 150
TQDDTGSYKC GLGTSNRGLS FDVSLEVSQV PELPSDTHVY TKDIGRNVTI
160 170 180 190 200
ECPFKRENAP SKKSLCKKTN QSCELVIDST EKVNPSYIGR AKLFMKGTDL
210 220 230 240 250
TVFYVNISHL THNDAGLYIC QAGEGPSADK KNVDLQVLAP EPELLYKDLR
260 270 280 290 300
SSVTFECDLG REVANEAKYL CRMNKETCDV IINTLGKRDP DFEGRILITP
310 320 330 340 350
KDDNGRFSVL ITGLRKEDAG HYQCGAHSSG LPQEGWPIQT WQLFVNEEST
360 370 380 390 400
IPNRRSVVKG VTGGSVAIAC PYNPKESSSL KYWCRWEGDG NGHCPVLVGT
410 420 430 440 450
QAQVQEEYEG RLALFDQPGN GTYTVILNQL TTEDAGFYWC LTNGDSRWRT
460 470 480 490 500
TIELQVAEAT REPNLEVTPQ NATAVLGETF TVSCHYPCKF YSQEKYWCKW
510 520 530 540 550
SNKGCHILPS HDEGARQSSV SCDQSSQLVS MTLNPVSKED EGWYWCGVKQ
560 570 580 590 600
GQTYGETTAI YIAVEERTRG SSHVNPTDAN ARAKVALEEE VVDSSISEKE
610 620 630 640 650
NKAIPNPGPF ANEREIQNVG DQAQENRASG DAGSADGQSR SSSSKVLFST
660 670 680 690 700
LVPLGLVLAV GAIAVWVARV RHRKNVDRMS ISSYRTDISM ADFKNSRDLG
710 720 730 740 750
GNDNMGASPD TQQTVIEGKD EIVTTTECTA EPEESKKAKR SSKEEADMAY
760 770
SAFLLQSSTI AAQVHDGPQE A
Length:771
Mass (Da):84,999
Last modified:August 1, 1998 - v1
Checksum:i78C81302EC710730
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z2D3D3Z2D3_MOUSE
Polymeric immunoglobulin receptor
Pigr
211Annotation score:
D3YVM4D3YVM4_MOUSE
Polymeric immunoglobulin receptor
Pigr
200Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159A → V in AAA67440 (PubMed:7836758).Curated1
Sequence conflicti396V → A in AAA67440 (PubMed:7836758).Curated1
Sequence conflicti620G → R in AAA67440 (PubMed:7836758).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06431 mRNA Translation: AAA67440.1
U83434
, U83427, U83428, U83429, U83430, U83431, U83432, U83433 Genomic DNA Translation: AAC53585.1
Y16524
, Y16525, Y16526, Y16527, Y16528, Y16529, Y16530, Y16531, Y16532 Genomic DNA Translation: CAA76272.1
CCDSiCCDS15260.1
RefSeqiNP_035212.2, NM_011082.3
UniGeneiMm.276414

Genome annotation databases

EnsembliENSMUST00000027675; ENSMUSP00000027675; ENSMUSG00000026417
GeneIDi18703
KEGGimmu:18703
UCSCiuc011wrk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06431 mRNA Translation: AAA67440.1
U83434
, U83427, U83428, U83429, U83430, U83431, U83432, U83433 Genomic DNA Translation: AAC53585.1
Y16524
, Y16525, Y16526, Y16527, Y16528, Y16529, Y16530, Y16531, Y16532 Genomic DNA Translation: CAA76272.1
CCDSiCCDS15260.1
RefSeqiNP_035212.2, NM_011082.3
UniGeneiMm.276414

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NOBX-ray1.51A20-133[»]
4NOFX-ray1.65A/B133-245[»]
ProteinModelPortaliO70570
SMRiO70570
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202157, 2 interactors
STRINGi10090.ENSMUSP00000027675

PTM databases

iPTMnetiO70570
PhosphoSitePlusiO70570

Proteomic databases

MaxQBiO70570
PaxDbiO70570
PeptideAtlasiO70570
PRIDEiO70570

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027675; ENSMUSP00000027675; ENSMUSG00000026417
GeneIDi18703
KEGGimmu:18703
UCSCiuc011wrk.1 mouse

Organism-specific databases

CTDi5284
MGIiMGI:103080 Pigr

Phylogenomic databases

eggNOGiENOG410IHXB Eukaryota
ENOG41128ZA LUCA
GeneTreeiENSGT00530000063436
HOGENOMiHOG000115545
HOVERGENiHBG008199
InParanoidiO70570
KOiK13073
OMAiYWCGVKQ
OrthoDBiEOG091G03V3
PhylomeDBiO70570
TreeFamiTF334441

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiPigr mouse
PROiPR:O70570
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026417 Expressed in 106 organ(s), highest expression level in left colon
CleanExiMM_PIGR
ExpressionAtlasiO70570 baseline and differential
GenevisibleiO70570 MM

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 4 hits
SMARTiView protein in SMART
SM00409 IG, 5 hits
SM00406 IGv, 4 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPIGR_MOUSE
AccessioniPrimary (citable) accession number: O70570
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 12, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again