Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Small proline-rich protein 2K

Gene

Sprr2k

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).By similarity

GO - Biological processi

  • epidermis development Source: UniProtKB
  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: UniProtKB

Keywordsi

Biological processKeratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Small proline-rich protein 2K
Gene namesi
Name:Sprr2k
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1330344 Sprr2k

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001500231 – 68Small proline-rich protein 2KAdd BLAST68

Proteomic databases

MaxQBiO70562
PaxDbiO70562
PRIDEiO70562

Expressioni

Tissue specificityi

Not expressed in uterus.1 Publication

Gene expression databases

CleanExiMM_SPRR2K

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 261; truncated6
Repeati27 – 3529
Repeati36 – 4439
Repeati45 – 5349

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 653.5 X 9 AA approximate tandem repeatsAdd BLAST45

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Family and domain databases

InterProiView protein in InterPro
IPR026075 SPRR/LCE
IPR029142 SPRR2
PANTHERiPTHR23263 PTHR23263, 1 hit
PfamiView protein in Pfam
PF14820 SPRR2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O70562-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYQEQQCKQ LCQPLPVCPP PKPCSPPKCP EPCPPPKCPE TCPPQPCQRK
60
CPPVLEAPCQ QKCPSKSK
Length:68
Mass (Da):7,499
Last modified:August 1, 1998 - v1
Checksum:i2AF0A81A4F6DFBED
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E8D1G5E8D1_MOUSE
Small proline-rich protein 2K
Sprr2k mCG_119406
68Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005569 Genomic DNA Translation: CAA06598.1
AY158995 mRNA Translation: AAN86832.1
CCDSiCCDS38512.1
RefSeqiNP_035607.2, NM_011477.3
UniGeneiMm.57085

Genome annotation databases

GeneIDi20765
KEGGimmu:20765

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005569 Genomic DNA Translation: CAA06598.1
AY158995 mRNA Translation: AAN86832.1
CCDSiCCDS38512.1
RefSeqiNP_035607.2, NM_011477.3
UniGeneiMm.57085

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiO70562
PaxDbiO70562
PRIDEiO70562

Protocols and materials databases

DNASUi20765
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20765
KEGGimmu:20765

Organism-specific databases

CTDi20765
MGIiMGI:1330344 Sprr2k

Miscellaneous databases

PROiPR:O70562
SOURCEiSearch...

Gene expression databases

CleanExiMM_SPRR2K

Family and domain databases

InterProiView protein in InterPro
IPR026075 SPRR/LCE
IPR029142 SPRR2
PANTHERiPTHR23263 PTHR23263, 1 hit
PfamiView protein in Pfam
PF14820 SPRR2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPR2K_MOUSE
AccessioniPrimary (citable) accession number: O70562
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: August 1, 1998
Last modified: July 5, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again