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Protein

Protein BTG4

Gene

Btg4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Shows marked antiproliferative activity, being able to induce G1 arrest.

GO - Biological processi

  • negative regulation of cell proliferation Source: GO_Central
  • negative regulation of mitotic cell cycle Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG4
Alternative name(s):
BTG family member 4
Protein PC3b
Gene namesi
Name:Btg4
Synonyms:Pc3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1860140 Btg4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438111 – 250Protein BTG4Add BLAST250

Proteomic databases

PaxDbiO70552
PRIDEiO70552

PTM databases

PhosphoSitePlusiO70552

Expressioni

Tissue specificityi

Highly expressed in testis and in olfactory epithelium.

Gene expression databases

BgeeiENSMUSG00000032056 Expressed in 65 organ(s), highest expression level in primary oocyte
CleanExiMM_BTG4
ExpressionAtlasiO70552 baseline and differential
GenevisibleiO70552 MM

Interactioni

Binary interactionsi

Protein-protein interaction databases

DIPiDIP-61987N
IntActiO70552, 4 interactors
STRINGi10090.ENSMUSP00000110074

Structurei

3D structure databases

ProteinModelPortaliO70552
SMRiO70552
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
GeneTreeiENSGT00550000074461
HOGENOMiHOG000234823
HOVERGENiHBG004332
InParanoidiO70552
KOiK14443
OrthoDBiEOG091G0U1P
TreeFamiTF105272

Family and domain databases

Gene3Di1.20.120.1120, 1 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR036054 BTG-like_sf
IPR033332 BTG4
PANTHERiPTHR22978:SF5 PTHR22978:SF5, 1 hit
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O70552-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRDEIATAVF FVTRLVKKHE KLSTQQIETF ALKLMTILFE KYRGHWHPDC
60 70 80 90 100
PSKGQAFRCI RINNNENKDP VLERACAESN VNFFHLGLPK EMTIWVDPYE
110 120 130 140 150
VCCRYGEKKH PFTIASFKGR WENWELAQHV SCAVNRATGD CSSGTSSDEE
160 170 180 190 200
SCSREAQIIP KVNNPKSVYQ VENFKQSLQP WFCLPRRKHL ADGRGFLPGA
210 220 230 240 250
ACHPVPKSSK WCRPASRRVD RYHWVNAQLF SGQTAPGEPG EEALSSLKQK
Length:250
Mass (Da):28,613
Last modified:September 18, 2013 - v2
Checksum:i9C175309C017F7BD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SVH3A0A1L1SVH3_MOUSE
Protein BTG4
Btg4
191Annotation score:
A0A1L1ST44A0A1L1ST44_MOUSE
Protein BTG4
Btg4
31Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37I → V in CAA06384 (PubMed:10995567).Curated1
Sequence conflicti158I → V in CAA06384 (PubMed:10995567).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005120 mRNA Translation: CAA06384.1
AB050983 mRNA Translation: BAB47554.2
AK136041 mRNA Translation: BAE22791.1
AK136149 mRNA Translation: BAE22846.1
AK161379 mRNA Translation: BAE36359.1
AC119831 Genomic DNA No translation available.
CCDSiCCDS40629.1
RefSeqiNP_062366.2, NM_019493.4
XP_006510562.1, XM_006510499.3
XP_006510563.1, XM_006510500.2
XP_006510564.1, XM_006510501.3
XP_006510565.1, XM_006510502.2
XP_017168979.1, XM_017313490.1
UniGeneiMm.431317

Genome annotation databases

EnsembliENSMUST00000114431; ENSMUSP00000110074; ENSMUSG00000032056
ENSMUST00000213680; ENSMUSP00000149181; ENSMUSG00000032056
GeneIDi56057
KEGGimmu:56057
UCSCiuc009pld.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005120 mRNA Translation: CAA06384.1
AB050983 mRNA Translation: BAB47554.2
AK136041 mRNA Translation: BAE22791.1
AK136149 mRNA Translation: BAE22846.1
AK161379 mRNA Translation: BAE36359.1
AC119831 Genomic DNA No translation available.
CCDSiCCDS40629.1
RefSeqiNP_062366.2, NM_019493.4
XP_006510562.1, XM_006510499.3
XP_006510563.1, XM_006510500.2
XP_006510564.1, XM_006510501.3
XP_006510565.1, XM_006510502.2
XP_017168979.1, XM_017313490.1
UniGeneiMm.431317

3D structure databases

ProteinModelPortaliO70552
SMRiO70552
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61987N
IntActiO70552, 4 interactors
STRINGi10090.ENSMUSP00000110074

PTM databases

PhosphoSitePlusiO70552

Proteomic databases

PaxDbiO70552
PRIDEiO70552

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114431; ENSMUSP00000110074; ENSMUSG00000032056
ENSMUST00000213680; ENSMUSP00000149181; ENSMUSG00000032056
GeneIDi56057
KEGGimmu:56057
UCSCiuc009pld.1 mouse

Organism-specific databases

CTDi54766
MGIiMGI:1860140 Btg4

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
GeneTreeiENSGT00550000074461
HOGENOMiHOG000234823
HOVERGENiHBG004332
InParanoidiO70552
KOiK14443
OrthoDBiEOG091G0U1P
TreeFamiTF105272

Miscellaneous databases

PROiPR:O70552
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032056 Expressed in 65 organ(s), highest expression level in primary oocyte
CleanExiMM_BTG4
ExpressionAtlasiO70552 baseline and differential
GenevisibleiO70552 MM

Family and domain databases

Gene3Di1.20.120.1120, 1 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR036054 BTG-like_sf
IPR033332 BTG4
PANTHERiPTHR22978:SF5 PTHR22978:SF5, 1 hit
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBTG4_MOUSE
AccessioniPrimary (citable) accession number: O70552
Secondary accession number(s): Q925T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: September 18, 2013
Last modified: November 7, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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