Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Telethonin

Gene

Tcap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Telethonin
Alternative name(s):
Titin cap protein
Gene namesi
Name:Tcap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1330233 Tcap

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724841 – 167TelethoninAdd BLAST167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO70548
PRIDEiO70548

PTM databases

iPTMnetiO70548
PhosphoSitePlusiO70548

Expressioni

Gene expression databases

BgeeiENSMUSG00000007877 Expressed in 108 organ(s), highest expression level in tarsal region
CleanExiMM_TCAP
ExpressionAtlasiO70548 baseline and differential
GenevisibleiO70548 MM

Interactioni

Subunit structurei

Interacts with MYOZ1, MYOZ2 and MYOZ3. Interacts with CSRP3. Interacts directly with the N-terminal Ig-like domains of 2 titin (TTN) molecules. Interacts with ANKRD2; the interaction is direct (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-127 Titin-Telethonin complex
STRINGi10090.ENSMUSP00000008021

Structurei

3D structure databases

ProteinModelPortaliO70548
SMRiO70548
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IIUD Eukaryota
ENOG4111SDJ LUCA
GeneTreeiENSGT00390000012014
HOGENOMiHOG000237275
HOVERGENiHBG004497
InParanoidiO70548
KOiK19879
OMAiGVREHQL
OrthoDBiEOG091G0MDX
PhylomeDBiO70548
TreeFamiTF333228

Family and domain databases

Gene3Di2.20.160.10, 1 hit
InterProiView protein in InterPro
IPR015667 Telethonin
IPR023111 Titin-like_dom_sf
PANTHERiPTHR15143 PTHR15143, 1 hit
PfamiView protein in Pfam
PF09470 Telethonin, 1 hit

Sequencei

Sequence statusi: Complete.

O70548-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSELSCQV SEENQERREA FWAEWKDLTL STRPEEGCSL HEEDTQRHET
60 70 80 90 100
YHRQGQCQAV VQRSPWLVMR LGILGRGLQE YQLPYQRVLP LPIFTPTKVG
110 120 130 140 150
ASKEEREETP IQLRELLALE TALGGQCVER QDVAEITKQL PPVVPVSKPG
160
PLRRTLSRSM SQEAQRG
Length:167
Mass (Da):19,078
Last modified:August 1, 1998 - v1
Checksum:i2CB1F6F5415B4DC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223854 mRNA Translation: CAA11585.1
Y15845 mRNA Translation: CAB38077.1
BC027631 mRNA Translation: AAH27631.1
CCDSiCCDS25346.1
RefSeqiNP_035670.2, NM_011540.2
UniGeneiMm.10762

Genome annotation databases

EnsembliENSMUST00000008021; ENSMUSP00000008021; ENSMUSG00000007877
GeneIDi21393
KEGGimmu:21393
UCSCiuc007lgf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223854 mRNA Translation: CAA11585.1
Y15845 mRNA Translation: CAB38077.1
BC027631 mRNA Translation: AAH27631.1
CCDSiCCDS25346.1
RefSeqiNP_035670.2, NM_011540.2
UniGeneiMm.10762

3D structure databases

ProteinModelPortaliO70548
SMRiO70548
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-127 Titin-Telethonin complex
STRINGi10090.ENSMUSP00000008021

PTM databases

iPTMnetiO70548
PhosphoSitePlusiO70548

Proteomic databases

PaxDbiO70548
PRIDEiO70548

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008021; ENSMUSP00000008021; ENSMUSG00000007877
GeneIDi21393
KEGGimmu:21393
UCSCiuc007lgf.1 mouse

Organism-specific databases

CTDi8557
MGIiMGI:1330233 Tcap

Phylogenomic databases

eggNOGiENOG410IIUD Eukaryota
ENOG4111SDJ LUCA
GeneTreeiENSGT00390000012014
HOGENOMiHOG000237275
HOVERGENiHBG004497
InParanoidiO70548
KOiK19879
OMAiGVREHQL
OrthoDBiEOG091G0MDX
PhylomeDBiO70548
TreeFamiTF333228

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Miscellaneous databases

ChiTaRSiTcap mouse
PROiPR:O70548
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007877 Expressed in 108 organ(s), highest expression level in tarsal region
CleanExiMM_TCAP
ExpressionAtlasiO70548 baseline and differential
GenevisibleiO70548 MM

Family and domain databases

Gene3Di2.20.160.10, 1 hit
InterProiView protein in InterPro
IPR015667 Telethonin
IPR023111 Titin-like_dom_sf
PANTHERiPTHR15143 PTHR15143, 1 hit
PfamiView protein in Pfam
PF09470 Telethonin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTELT_MOUSE
AccessioniPrimary (citable) accession number: O70548
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again