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Protein

Regulator of G-protein signaling 19

Gene

Rgs19

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, predominantly to G(i)-alpha-3. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein (By similarity).By similarity

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: RGD
  • GTPase activator activity Source: RGD

GO - Biological processi

  • negative regulation of signal transduction Source: UniProtKB-KW
  • regulation of G-protein coupled receptor protein signaling pathway Source: RGD
  • response to ethanol Source: RGD

Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 19
Short name:
RGS19
Alternative name(s):
G-alpha-interacting protein
Short name:
GAIP
Gene namesi
Name:Rgs19
Synonyms:Gaip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi629471 Rgs19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi24S → A: 50% reduction of phosphorylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042311 – 216Regulator of G-protein signaling 19Add BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Phosphoserine; by CK21 Publication1
Modified residuei97PhosphoserineBy similarity1
Modified residuei151Phosphoserine; by MAPK1 and MAPK3By similarity1

Post-translational modificationi

Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).By similarity
Phosphorylated, mainly on serine residues.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiO70521
PRIDEiO70521

PTM databases

iPTMnetiO70521
PhosphoSitePlusiO70521

Expressioni

Gene expression databases

BgeeiENSRNOG00000016547
GenevisibleiO70521 RN

Interactioni

Subunit structurei

Interacts with GIPC PDZ domain.

Binary interactionsi

WithEntry#Exp.IntActNotes
Gipc1Q9Z2542EBI-8685536,EBI-991162

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: RGD

Protein-protein interaction databases

BioGridi248744, 1 interactor
IntActiO70521, 1 interactor
MINTiO70521
STRINGi10116.ENSRNOP00000022451

Structurei

3D structure databases

ProteinModelPortaliO70521
SMRiO70521
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 206RGSPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni207 – 216Interaction with GIPC10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 49Poly-CysAdd BLAST11

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233513
HOVERGENiHBG013233
InParanoidiO70521
KOiK16449
OMAiQEPSAHT
OrthoDBiEOG091G0BDG
PhylomeDBiO70521

Family and domain databases

InterProiView protein in InterPro
IPR016137 RGS
IPR036305 RGS_sf
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

O70521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTPHEAEKQ HTGPEEADRP PSMSSHDAAP SGPPSRNPCC LCWCCCCSCS
60 70 80 90 100
WNQERQRAWQ VSRESKLQPL PSCEVCTPPS PEEVQSWAQS FDKLMHSPTG
110 120 130 140 150
RSVFRAFLRT EYSEENMLFW LACEELKTEA DRHVVDEKAR LIYEDYVSIL
160 170 180 190 200
SPKEVSLDSR VREGINRKMQ EPSPHTFDDA QLQIYTLMHR DSYPRFLTSP
210
TYRSLLLQGA PQSSEA
Length:216
Mass (Da):24,738
Last modified:August 1, 1998 - v1
Checksum:i554C479D4DD89238
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068136 mRNA Translation: AAC19130.1
BC088141 mRNA Translation: AAH88141.1
RefSeqiNP_067693.1, NM_021661.2
XP_006235863.2, XM_006235801.3
UniGeneiRn.88166

Genome annotation databases

EnsembliENSRNOT00000022451; ENSRNOP00000022451; ENSRNOG00000016547
GeneIDi59293
KEGGirno:59293
UCSCiRGD:629471 rat

Similar proteinsi

Entry informationi

Entry nameiRGS19_RAT
AccessioniPrimary (citable) accession number: O70521
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: July 18, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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