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Protein

Fibroblast growth factor-binding protein 1

Gene

Fgfbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a carrier protein that releases fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhances the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth (By similarity).By similarity

Miscellaneous

Expression is significantly up-regulated in skin papillomas and carcinomas.

GO - Molecular functioni

  • fibroblast growth factor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

ReactomeiR-MMU-190377 FGFR2b ligand binding and activation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor-binding protein 1
Short name:
FGF-BP
Short name:
FGF-BP1
Short name:
FGF-binding protein 1
Short name:
FGFBP-1
Gene namesi
Name:Fgfbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1096350 Fgfbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000024551321 – 251Fibroblast growth factor-binding protein 1Add BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi74 ↔ 91By similarity
Disulfide bondi100 ↔ 133By similarity
Disulfide bondi109 ↔ 145By similarity
Glycosylationi175O-linked (GalNAc...) serineBy similarity1
Disulfide bondi214 ↔ 251By similarity
Disulfide bondi231 ↔ 239By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO70514
PRIDEiO70514

PTM databases

PhosphoSitePlusiO70514

Expressioni

Tissue specificityi

Expressed in intestine, ovary, lung, placenta and normal and wounded skin.2 Publications

Developmental stagei

Expressed in digestive system, skin, hair follicles, the dental germ, respiratory tract, various glandular tissues, kidney, liver and certain areas of the central nervous system between 8 and 16 dpc (at protein level). Expressed. in embryo between 9 to 18 dpc. Expressed at 14 dpc in the epithelial cells and 18 dpc in basal epithelial cells of intestinal crypts. Expressed in mesenchymal and epidermal structures of the body wall at 9 dpc. Expressed in basal cells of the subepidermal layer of the skin at 12 dpc. Expressed in hair follicles at 14 dpc.2 Publications

Gene expression databases

BgeeiENSMUSG00000048373 Expressed in 170 organ(s), highest expression level in skin epidermis
CleanExiMM_FGFBP1
GenevisibleiO70514 MM

Interactioni

Subunit structurei

Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF7, FGF10, FGF22 and HSPG2 (By similarity). Interacts with FGF2.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199655, 4 interactors
STRINGi10090.ENSMUSP00000056900

Structurei

3D structure databases

ProteinModelPortaliO70514
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni210 – 251Sufficient for interaction with FGF2 and FGF2-induced effectsBy similarityAdd BLAST42

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZBN Eukaryota
ENOG4111SHY LUCA
GeneTreeiENSGT00730000111278
HOGENOMiHOG000013097
HOVERGENiHBG053095
InParanoidiO70514
OMAiLKVECTR
OrthoDBiEOG091G0Q03
PhylomeDBiO70514
TreeFamiTF335877

Family and domain databases

InterProiView protein in InterPro
IPR010510 FGF1-bd
PANTHERiPTHR15258 PTHR15258, 1 hit
PfamiView protein in Pfam
PF06473 FGF-BP1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70514-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLHSLILLS FLLLATQAFS EKVRKRAKNA PHSTAEEGVE GSAPSLGKAQ
60 70 80 90 100
NKQRSRTSKS LTHGKFVTKD QATCRWAVTE EEQGISLKVQ CTQADQEFSC
110 120 130 140 150
VFAGDPTDCL KHDKDQIYWK QVARTLRKQK NICRNAKSVL KTRVCRKRFP
160 170 180 190 200
ESNLKLVNPN ARGNTKPRKE KAEVSAREHN KVQEAVSTEP NRVKEDITLN
210 220 230 240 250
PAATQTMAIR DPECLEDPDV LNQRKTALEF CGESWSSICT FFLNMLQATS

C
Length:251
Mass (Da):28,294
Last modified:August 1, 1998 - v1
Checksum:i3449252921A9E98C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135N → D in AAB05227 (PubMed:9178765).Curated1
Sequence conflicti193V → I in AAB05227 (PubMed:9178765).Curated1
Sequence conflicti208A → T in AAB05227 (PubMed:9178765).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49641 mRNA Translation: AAB05227.1
AF065441 mRNA Translation: AAC17439.1
AK146625 mRNA Translation: BAE27314.1
BC065774 mRNA Translation: AAH65774.1
CCDSiCCDS19268.1
RefSeqiNP_001258545.1, NM_001271616.1
NP_032035.2, NM_008009.4
XP_006503774.1, XM_006503711.3
XP_006503775.1, XM_006503712.3
UniGeneiMm.46053

Genome annotation databases

EnsembliENSMUST00000061299; ENSMUSP00000056900; ENSMUSG00000048373
ENSMUST00000199481; ENSMUSP00000143011; ENSMUSG00000048373
ENSMUST00000199894; ENSMUSP00000142520; ENSMUSG00000048373
GeneIDi14181
KEGGimmu:14181
UCSCiuc008xid.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49641 mRNA Translation: AAB05227.1
AF065441 mRNA Translation: AAC17439.1
AK146625 mRNA Translation: BAE27314.1
BC065774 mRNA Translation: AAH65774.1
CCDSiCCDS19268.1
RefSeqiNP_001258545.1, NM_001271616.1
NP_032035.2, NM_008009.4
XP_006503774.1, XM_006503711.3
XP_006503775.1, XM_006503712.3
UniGeneiMm.46053

3D structure databases

ProteinModelPortaliO70514
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199655, 4 interactors
STRINGi10090.ENSMUSP00000056900

PTM databases

PhosphoSitePlusiO70514

Proteomic databases

PaxDbiO70514
PRIDEiO70514

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061299; ENSMUSP00000056900; ENSMUSG00000048373
ENSMUST00000199481; ENSMUSP00000143011; ENSMUSG00000048373
ENSMUST00000199894; ENSMUSP00000142520; ENSMUSG00000048373
GeneIDi14181
KEGGimmu:14181
UCSCiuc008xid.3 mouse

Organism-specific databases

CTDi9982
MGIiMGI:1096350 Fgfbp1

Phylogenomic databases

eggNOGiENOG410IZBN Eukaryota
ENOG4111SHY LUCA
GeneTreeiENSGT00730000111278
HOGENOMiHOG000013097
HOVERGENiHBG053095
InParanoidiO70514
OMAiLKVECTR
OrthoDBiEOG091G0Q03
PhylomeDBiO70514
TreeFamiTF335877

Enzyme and pathway databases

ReactomeiR-MMU-190377 FGFR2b ligand binding and activation

Miscellaneous databases

ChiTaRSiFgfbp1 mouse
PROiPR:O70514
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048373 Expressed in 170 organ(s), highest expression level in skin epidermis
CleanExiMM_FGFBP1
GenevisibleiO70514 MM

Family and domain databases

InterProiView protein in InterPro
IPR010510 FGF1-bd
PANTHERiPTHR15258 PTHR15258, 1 hit
PfamiView protein in Pfam
PF06473 FGF-BP1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGFP1_MOUSE
AccessioniPrimary (citable) accession number: O70514
Secondary accession number(s): Q62399
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: August 1, 1998
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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