UniProtKB - O70511 (ANK3_RAT)
Ankyrin-3
Ank3
Functioni
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- cytoskeletal protein binding Source: BHF-UCL
- ion channel binding Source: BHF-UCL
- phosphorylation-dependent protein binding Source: UniProtKB
- protein-macromolecule adaptor activity Source: BHF-UCL
- spectrin binding Source: BHF-UCL
- structural constituent of cytoskeleton Source: RGD
GO - Biological processi
- axon guidance Source: RGD
- axonogenesis Source: RGD
- cellular response to magnesium ion Source: UniProtKB
- clustering of voltage-gated sodium channels Source: RGD
- establishment of protein localization Source: RGD
- Golgi to plasma membrane protein transport Source: RGD
- magnesium ion homeostasis Source: UniProtKB
- maintenance of protein location in plasma membrane Source: RGD
- membrane assembly Source: BHF-UCL
- mitotic cytokinesis Source: RGD
- negative regulation of delayed rectifier potassium channel activity Source: UniProtKB
- neuromuscular junction development Source: RGD
- neuronal action potential Source: RGD
- plasma membrane organization Source: RGD
- positive regulation of cation channel activity Source: BHF-UCL
- positive regulation of cell communication by electrical coupling Source: RGD
- positive regulation of gene expression Source: BHF-UCL
- positive regulation of homotypic cell-cell adhesion Source: RGD
- positive regulation of membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
- positive regulation of membrane potential Source: BHF-UCL
- positive regulation of protein targeting to membrane Source: RGD
- positive regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
- positive regulation of sodium ion transport Source: BHF-UCL
- protein localization to axon Source: UniProtKB
- protein localization to plasma membrane Source: BHF-UCL
- regulation of potassium ion transport Source: BHF-UCL
- signal transduction Source: InterPro
- synapse organization Source: RGD
Names & Taxonomyi
Protein namesi | Recommended name: Ankyrin-3Short name: ANK-3 Alternative name(s): Ankyrin-G |
Gene namesi | Name:Ank3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620157, Ank3 |
Subcellular locationi
Lysosome
- Lysosome By similarity
Plasma membrane
- Cell membrane 1 Publication
- sarcolemma 2 Publications
- postsynaptic cell membrane 1 Publication
- T-tubule 1 Publication
Cytoskeleton
- cytoskeleton By similarity
Other locations
- axon 1 Publication
Note: When transfected in root dorsal ganglia, predominantly located in the axolemma of the axon proximal segments (PubMed:9744885). Also associated with the plasma membrane in neuron cell bodies, although at a lower level than in the axon proximal segment (PubMed:9744885). Isoform 1 is restricted to the axolemma of the axon proximal segment. Isoforms containing the muscle-specific 76 amino-acid insertion localize to the sarcolemma and on the postsynaptic membrane of neuromuscular junctions (PubMed:11796721).
Cytoskeleton
- cytoskeleton Source: GO_Central
- spectrin-associated cytoskeleton Source: BHF-UCL
Endoplasmic reticulum
- sarcoplasmic reticulum Source: RGD
Lysosome
- lysosome Source: UniProtKB-SubCell
Plasma Membrane
- basal plasma membrane Source: RGD
- basolateral plasma membrane Source: RGD
- lateral plasma membrane Source: RGD
- plasma membrane Source: BHF-UCL
- postsynaptic membrane Source: RGD
- sarcolemma Source: BHF-UCL
- T-tubule Source: BHF-UCL
Other locations
- axon Source: RGD
- axon initial segment Source: BHF-UCL
- cell surface Source: BHF-UCL
- costamere Source: BHF-UCL
- dendrite Source: RGD
- intercalated disc Source: BHF-UCL
- membrane Source: RGD
- neuromuscular junction Source: RGD
- neuron projection Source: RGD
- node of Ranvier Source: ARUK-UCL
- paranode region of axon Source: RGD
- synapse Source: RGD
- Z disc Source: RGD
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Lysosome, Membrane, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000429632 | 1 – 2622 | Ankyrin-3Add BLAST | 2622 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 39 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 631 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 855 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 869 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 875 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 921 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 924 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 930 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 965 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 967 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1121 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1458 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1469 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1621 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1624 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1984 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 2102 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 2114 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 2117 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 2457 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 2475 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 2544 | PhosphoserineCombined sources | 1 | ||
Isoform 4 (identifier: O70511-4) | |||||
Modified residuei | 851 | PhosphoserineCombined sources | 1 | ||
Isoform 5 (identifier: O70511-5) | |||||
Modified residuei | 851 | PhosphoserineCombined sources | 1 | ||
Isoform 2 (identifier: O70511-2) | |||||
Modified residuei | 1679 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | O70511 |
PaxDbi | O70511 |
PRIDEi | O70511 |
PTM databases
iPTMneti | O70511 |
PhosphoSitePlusi | O70511 |
SwissPalmi | O70511 |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
May be a constituent of a NFASC/NRCAM/ankyrin G complex.
Interacts with RHBG. Directly interacts with DMD and betaDAG1; this interaction does not interfere with DMD-binding and is required for DMD and betaDAG1 retention at costameres.
Interacts (via N-terminal ANK repeats) with SCHIP1 isoform 7 (via C-terminus); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs) (By similarity).
Interacts with PLEC and FLNC (PubMed:21223964).
Isoform 7 interacts with PLEC and FLNC through its muscle-specific C-terminal sequence.
Interacts with KCNA1; this inhibits channel activity (By similarity).
Interacts (via ANK repeats) with IQCJ-SCHIP1; required for IQCJ-SCHIP1 localization at axon initial segments (AIS) and nodes of Ranvier (By similarity).
Interacts with SCHIP1 (By similarity).
Interacts with SCN5A (By similarity).
By similarity1 PublicationBinary interactionsi
Isoform 7 [O70511-7]
With | #Exp. | IntAct |
---|---|---|
FLNC [Q14315] from Homo sapiens. | 2 | EBI-9663485,EBI-489954 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- cytoskeletal protein binding Source: BHF-UCL
- ion channel binding Source: BHF-UCL
- phosphorylation-dependent protein binding Source: UniProtKB
- spectrin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 262995, 4 interactors |
CORUMi | O70511 |
DIPi | DIP-60342N |
IntActi | O70511, 9 interactors |
STRINGi | 10116.ENSRNOP00000043687 |
Structurei
Secondary structure
3D structure databases
SMRi | O70511 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 73 – 102 | ANK 1Add BLAST | 30 | |
Repeati | 106 – 135 | ANK 2Add BLAST | 30 | |
Repeati | 139 – 168 | ANK 3Add BLAST | 30 | |
Repeati | 172 – 201 | ANK 4Add BLAST | 30 | |
Repeati | 203 – 230 | ANK 5Add BLAST | 28 | |
Repeati | 242 – 271 | ANK 6Add BLAST | 30 | |
Repeati | 275 – 304 | ANK 7Add BLAST | 30 | |
Repeati | 308 – 337 | ANK 8Add BLAST | 30 | |
Repeati | 341 – 370 | ANK 9Add BLAST | 30 | |
Repeati | 374 – 403 | ANK 10Add BLAST | 30 | |
Repeati | 407 – 436 | ANK 11Add BLAST | 30 | |
Repeati | 440 – 469 | ANK 12Add BLAST | 30 | |
Repeati | 473 – 502 | ANK 13Add BLAST | 30 | |
Repeati | 506 – 535 | ANK 14Add BLAST | 30 | |
Repeati | 539 – 568 | ANK 15Add BLAST | 30 | |
Repeati | 572 – 601 | ANK 16Add BLAST | 30 | |
Repeati | 605 – 634 | ANK 17Add BLAST | 30 | |
Repeati | 638 – 667 | ANK 18Add BLAST | 30 | |
Repeati | 671 – 700 | ANK 19Add BLAST | 30 | |
Repeati | 704 – 733 | ANK 20Add BLAST | 30 | |
Repeati | 737 – 766 | ANK 21Add BLAST | 30 | |
Repeati | 770 – 799 | ANK 22Add BLAST | 30 | |
Repeati | 803 – 832 | ANK 23Add BLAST | 30 | |
Domaini | 992 – 1147 | ZU5 1PROSITE-ProRule annotationAdd BLAST | 156 | |
Domaini | 1149 – 1296 | ZU5 2PROSITE-ProRule annotationAdd BLAST | 148 | |
Domaini | 2336 – 2420 | DeathPROSITE-ProRule annotationAdd BLAST | 85 |
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG4177, Eukaryota |
OrthoDBi | 1011028at2759 |
Family and domain databases
CDDi | cd08803, Death_ank3, 1 hit |
Gene3Di | 1.25.40.20, 3 hits |
InterProi | View protein in InterPro IPR037971, Ank3_Death IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR040745, Ankyrin_UPA IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 7 hits PF13606, Ank_3, 1 hit PF00531, Death, 1 hit PF17809, UPA_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 22 hits SM00005, DEATH, 1 hit SM00218, ZU5, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48403, SSF48403, 3 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 21 hits PS50017, DEATH_DOMAIN, 1 hit PS51145, ZU5, 2 hits |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAHAASQLKK NRDLEINAEE ETEKKKKHRK RSRDRKKKSD ANASYLRAAR
60 70 80 90 100
AGHLEKALDY IKNGVDVNIC NQNGLNALHL ASKEGHVEVV SELLQREANV
110 120 130 140 150
DAATKKGNTA LHIASLAGQA EVVKVLVTNG ANVNAQSQNG FTPLYMAAQE
160 170 180 190 200
NHLEVVRFLL DNGASQSLAT EDGFTPLAVA LQQGHDQVVS LLLENDTKGK
210 220 230 240 250
VRLPALHIAA RKDDTKAAAL LLQNDTNADI ESKMVVNRAT ESGFTPLHIA
260 270 280 290 300
AHYGNINVAT LLLNRAAAVD FTARNDITPL HVASKRGNAN MVKLLLDRGA
310 320 330 340 350
KIDAKTRDGL TPLHCGARSG HEQVVEMLLD RAAPILSKTK NGLSPLHMAT
360 370 380 390 400
QGDHLNCVQL LLQHNVPVDD VTNDYLTALH VAAHCGHYKV AKVLLDKKAN
410 420 430 440 450
PNAKALNGFT PLHIACKKNR IRVMELLLKH GASIQAVTES GLTPIHVAAF
460 470 480 490 500
MGHVNIVSQL MHHGASPNTT NVRGETALHM AARSGQAEVV RYLVQDGAQV
510 520 530 540 550
EAKAKDDQTP LHISARLGKA DIVQQLLQQG ASPNAATTSG YTPLHLSARE
560 570 580 590 600
GHEDVAAFLL DHGASLSITT KKGFTPLHVA AKYGKLEVAS LLLQKSASPD
610 620 630 640 650
AAGKSGLTPL HVAAHYDNQK VALLLLDQGA SPHAAAKNGY TPLHIAAKKN
660 670 680 690 700
QMDIATSLLE YGADANAVTR QGIASVHLAA QEGHVDMVSL LLSRNANVNL
710 720 730 740 750
SNKSGLTPLH LAAQEDRVNV AEVLVNQGAH VDAQTKMGYT PLHVGCHYGN
760 770 780 790 800
IKIVNFLLQH SAKVNAKTKN GYTPLHQAAQ QGHTHIINVL LQNNASPNEL
810 820 830 840 850
TVNGNTALAI ARRLGYISVV DTLKVVTEEI MTTTTITEKH KMNVPETMNE
860 870 880 890 900
VLDMSDDEVG KASAPEKLSD GEYISDGEEG EDAITGDTDK YLGPQDLKEL
910 920 930 940 950
GDDSLPAEGY VGFSLGARSA SLRSFSSDRS YTLNRSSYAR DSMMIEELLV
960 970 980 990 1000
PSKEQHLPFT REFDSDSLRH YSWAADTLDN VNLVSSPVHS GFLVSFMVDA
1010 1020 1030 1040 1050
RGGSMRGSRH HGMRIIIPPR KCTAPTRITC RLVKRHKLAN PPPMVEGEGL
1060 1070 1080 1090 1100
ASRLVEMGPA GAQFLGPVIV EIPHFGSMRG KERELIVLRS ENGETWKEHQ
1110 1120 1130 1140 1150
FDSKNEDLSE LLNGMDEELD SPEELGTKRI CRIITKDFPQ YFAVVSRIKQ
1160 1170 1180 1190 1200
ESNQIGPEGG ILSSTTVPLV QASFPEGALT KRIRVGLQAQ PVPEETVKKI
1210 1220 1230 1240 1250
LGNKATFSPI VTVEPRRRKF HKPITMTIPV PPPSGEGVSN GYKGDTTPSL
1260 1270 1280 1290 1300
RLLCSITGGT SPAQWEDITG TTPLTFIKDC VSFTTNVSAR FWLADCHQVL
1310 1320 1330 1340 1350
ETVGLASQLY RELICVPYMA KFVVFAKTND PVESSLRCFC MTDDRVDKTL
1360 1370 1380 1390 1400
EQQENFEEVA RSKDIEVLEG KPIYVDCYGN LAPLTKGGQQ LVFNFYSFKE
1410 1420 1430 1440 1450
NRLPFSIKVR DTSQEPCGRL SFLKEPKTTK GLPQTAVCNL NITLPAHKKA
1460 1470 1480 1490 1500
EKADRRQSFT SLALRKRYSY LTEPSMKTVE RSSGTARSLP TTYSHKPFFS
1510 1520 1530 1540 1550
TRPYQSWTTT PITVPGPAKS GSLSSSPSNT PSASPLKSIW SVSTPSPIKS
1560 1570 1580 1590 1600
TLGASTTSSV KSISDVASPI RSFRTISSPI RTVASPSPYN TQVASGTLGR
1610 1620 1630 1640 1650
VPTITEATPI KGVAPNSTLS SRTSPVTTAG SLLEKSSITM TPPASPKANI
1660 1670 1680 1690 1700
TMYSSSLPFK SIITSAAPLI SSPLKSVVSP TKSAADVIST AKAAMASTLS
1710 1720 1730 1740 1750
SPLKQMSGHA EVALVNGSVS PLKYPSSSAL INGCKATATL QDKISTATNA
1760 1770 1780 1790 1800
VSSVVSAAPD TVEKALSTTT AMPFSPLRSY VSAAAPSAFQ SLRAPSASAL
1810 1820 1830 1840 1850
YNSLGPSVGV TTSSVTSSII TVPVYSVGNV LAEPALKKLP DSNSLTKSAA
1860 1870 1880 1890 1900
ALLSPIKTLT TETRPQPHFN RTSSPVKSSL FLASSALKPS VPSSLSSSQE
1910 1920 1930 1940 1950
ILKDVAEMKE DLMRMTAILQ TDVPEEKPFQ TDLPREGRID DEEPFKIVEK
1960 1970 1980 1990 2000
VKEDLVKVSE ILKKDVCVES KGPPKSPKSD KGHSPEDDWT EFSSEEIREA
2010 2020 2030 2040 2050
RQAAASHAPS LPERVHGKAN LTRVIDYLTN DIGSSSLTNL KYKFEEAKKE
2060 2070 2080 2090 2100
GEERQKRILK PAMALQEHKL KMPPASMRPS TSEKELCKMA DSFFGTDAIL
2110 2120 2130 2140 2150
ESPDDFSQHD QDKSPLSDSG FETRSEKTPS APQSAESTGP KPLFHEVPIP
2160 2170 2180 2190 2200
PVITETRTEV VHVIRSYEPS TGEIPQSQPE DPVSPKPPPT FMELEPKPTA
2210 2220 2230 2240 2250
LSIKEKVKAF QMKASSEEED HSRVLSKGMR VKEETHITTT TRMVYHSPPG
2260 2270 2280 2290 2300
SECASERIEE TMSVHDIMKA FQSGRDPSKE LAGLFEHKSA MSPDVAKSAA
2310 2320 2330 2340 2350
ETSAQHAEKD NQMKPKLERI IEVHIEKGPQ SPCERTDIRM AIVADHLGLS
2360 2370 2380 2390 2400
WTELARELNF SVDEINQIRV ENPNSLISQS FMLLKKWVTR DGKNATTDAL
2410 2420 2430 2440 2450
TSVLTKINRI DIVTLLEGPI FDYGNISGTR SFADENNVFH DPVDGWQNET
2460 2470 2480 2490 2500
PSGSLESPAQ ARRITGGLLD RLDDSSDQVR DPITSYLTGE AGKFEANGNH
2510 2520 2530 2540 2550
AEVIPEAKAK AYFPESQNDI GKQSIKENLK PKTHGCGRAE EPVSPLTAYQ
2560 2570 2580 2590 2600
KSLEETSKLV IEDAPKPCVP VGMKKMTRTP ADGKARLNLQ EEEGSARSEP
2610 2620
KQGEGYKVKT KKEIRNVEKK AH
The sequence of this isoform differs from the canonical sequence as follows:
1-36: MAHAASQLKKNRDLEINAEEETEKKKKHRKRSRDRK → MSEEAKEKTAKPAHRKRKG
234-241: Missing.
858-878: Missing.
922-927: LRSFSS → PKISS
1466-2444: KRYSYLTEPS...ENNVFHDPVD → PQSPCERTDI...RAELAMSSLA
2601-2601: K → KDLRHSESDS...GPQERKQDDV
The sequence of this isoform differs from the canonical sequence as follows:
1-36: MAHAASQLKKNRDLEINAEEETEKKKKHRKRSRDRK → MSEEAKEKTAKPAHRKRKG
234-241: Missing.
858-878: Missing.
922-927: LRSFSS → PKISS
1466-2328: Missing.
2601-2601: K → KQVKSPGEAF...GPQERKQDDV
The sequence of this isoform differs from the canonical sequence as follows:
1-880: MAHAASQLKK...GEYISDGEEG → MALPHS
922-927: LRSFSS → PKISS
1466-2444: KRYSYLTEPS...ENNVFHDPVD → PQSPCERTDI...RAELAMSSLA
2601-2601: K → KVKSPGEAFT...GPQERKQDDV
The sequence of this isoform differs from the canonical sequence as follows:
1-880: MAHAASQLKK...GEYISDGEEG → MALPHS
922-927: LRSFSS → PKISS
1466-2444: KRYSYLTEPS...ENNVFHDPVD → PQSPCERTDI...RAELAMSSLA
2601-2601: K → KDLRHSESDS...GPQERKQDDV
The sequence of this isoform differs from the canonical sequence as follows:
1-880: MAHAASQLKK...GEYISDGEEG → MALPHS
922-927: LRSFSS → PKISS
1466-2328: Missing.
2601-2601: K → KVKSPGEAFT...GPQERKQDDV
The sequence of this isoform differs from the canonical sequence as follows:
1-880: MAHAASQLKK...GEYISDGEEG → MALPHS
922-927: LRSFSS → PKISS
1466-2328: Missing.
2601-2601: K → KDLRHSESDS...GPQERKQDDV
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K0J3 | A0A0G2K0J3_RAT | Ankyrin-3 | Ank3 | 2,615 | Annotation score: | ||
A0A0G2K1Q7 | A0A0G2K1Q7_RAT | Ankyrin-3 | Ank3 | 1,963 | Annotation score: | ||
A0A0G2K1R9 | A0A0G2K1R9_RAT | Ankyrin-3 | Ank3 | 2,557 | Annotation score: | ||
A0A0G2K4D0 | A0A0G2K4D0_RAT | Ankyrin-3 | Ank3 | 1,725 | Annotation score: | ||
A0A0G2K2B9 | A0A0G2K2B9_RAT | Ankyrin-3 | Ank3 | 1,848 | Annotation score: | ||
A0A0G2JUJ5 | A0A0G2JUJ5_RAT | Ankyrin-3 | Ank3 | 977 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 246 | P → S in AAC78143 (PubMed:9744885).Curated | 1 | |
Sequence conflicti | 635 | A → S in CAH19223 (PubMed:15953600).Curated | 1 | |
Sequence conflicti | 635 | A → S in CAH19224 (PubMed:15953600).Curated | 1 | |
Sequence conflicti | 667 | A → P in AAC78143 (PubMed:9744885).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055004 | 1 – 880 | MAHAA…DGEEG → MALPHS in isoform 4, isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST | 880 | |
Alternative sequenceiVSP_055005 | 1 – 36 | MAHAA…SRDRK → MSEEAKEKTAKPAHRKRKG in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_055006 | 234 – 241 | Missing in isoform 2 and isoform 3. 1 Publication | 8 | |
Alternative sequenceiVSP_055007 | 858 – 878 | Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_055008 | 922 – 927 | LRSFSS → PKISS in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. 2 Publications | 6 | |
Alternative sequenceiVSP_055009 | 1466 – 2444 | KRYSY…HDPVD → PQSPCERTDIRMAIVADHLG LSWTELARELNFSVDEINQI RVENPNSLISQSFMLLKKWV TRDGKNATTDALTSVLTKIN RIDIVTLLEGPIFDYGNISG TRSFADENNVFHDPVDGHPS FQVELETPMGLYCTPPTPFQ QDDHFSDNSSIESPFRTPSR LSDGLMPSQGSIEHPAGGPP VVTAEDTSLEDSKMDDSVTV TETADPLDVDESQLKDLCQS ECAHCWASVPGVPSGGPQAE PLRAQTRKVGVSSEQQEKGD SGPEEEMADDKVRSLFEDIQ LEEVEAEEMTEDEGQAILNR VPRAELAMSSLA in isoform 2, isoform 4 and isoform 5. 1 PublicationAdd BLAST | 979 | |
Alternative sequenceiVSP_055010 | 1466 – 2328 | Missing in isoform 3, isoform 6 and isoform 7. 2 PublicationsAdd BLAST | 863 | |
Alternative sequenceiVSP_055011 | 2601 | K → KDLRHSESDSSSEEERRVTT RVIRRRVIIKGEEAKTIPGE SVTEEQFTDEEGNLITRKIT RKVIRRIGPQERKQDDV in isoform 2, isoform 5 and isoform 7. 2 Publications | 1 | |
Alternative sequenceiVSP_055012 | 2601 | K → KQVKSPGEAFTRMTACCYKD LRHSESDSSSEEERRVTTRV IRRRVIIKGEEAKTIPGESV TEEQFTDEEGNLITRKITRK VIRRIGPQERKQDDV in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_055013 | 2601 | K → KVKSPGEAFTRMTACCYKDL RHSESDSSSEEERRVTTRVI RRRVIIKGEEAKTIPGESVT EEQFTDEEGNLITRKITRKV IRRIGPQERKQDDV in isoform 4 and isoform 6. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF102552 mRNA Translation: AAC78143.1 AJ428573 mRNA Translation: CAD21705.1 AJ812019 mRNA Translation: CAH19219.1 AJ812021 mRNA Translation: CAH19221.1 AJ812022 mRNA Translation: CAH19222.1 AJ812023 mRNA Translation: CAH19223.1 AJ812024 mRNA Translation: CAH19224.1 |
RefSeqi | NP_001029156.1, NM_001033984.1 [O70511-1] NP_113993.1, NM_031805.1 [O70511-2] |
Genome annotation databases
GeneIDi | 361833 |
KEGGi | rno:361833 |
UCSCi | RGD:620157, rat |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF102552 mRNA Translation: AAC78143.1 AJ428573 mRNA Translation: CAD21705.1 AJ812019 mRNA Translation: CAH19219.1 AJ812021 mRNA Translation: CAH19221.1 AJ812022 mRNA Translation: CAH19222.1 AJ812023 mRNA Translation: CAH19223.1 AJ812024 mRNA Translation: CAH19224.1 |
RefSeqi | NP_001029156.1, NM_001033984.1 [O70511-1] NP_113993.1, NM_031805.1 [O70511-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5YIP | X-ray | 1.85 | B | 1985-2010 | [»] | |
5YIQ | X-ray | 2.60 | D | 1985-2010 | [»] | |
6A9X | X-ray | 2.20 | A | 1987-2010 | [»] | |
6M3P | X-ray | 3.31 | C/E | 975-1465 | [»] | |
6M3R | X-ray | 4.31 | E | 975-1465 | [»] | |
SMRi | O70511 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 262995, 4 interactors |
CORUMi | O70511 |
DIPi | DIP-60342N |
IntActi | O70511, 9 interactors |
STRINGi | 10116.ENSRNOP00000043687 |
PTM databases
iPTMneti | O70511 |
PhosphoSitePlusi | O70511 |
SwissPalmi | O70511 |
Proteomic databases
jPOSTi | O70511 |
PaxDbi | O70511 |
PRIDEi | O70511 |
Protocols and materials databases
ABCDi | O70511, 6 sequenced antibodies |
Genome annotation databases
GeneIDi | 361833 |
KEGGi | rno:361833 |
UCSCi | RGD:620157, rat |
Organism-specific databases
CTDi | 288 |
RGDi | 620157, Ank3 |
Phylogenomic databases
eggNOGi | KOG4177, Eukaryota |
OrthoDBi | 1011028at2759 |
Miscellaneous databases
PROi | PR:O70511 |
Family and domain databases
CDDi | cd08803, Death_ank3, 1 hit |
Gene3Di | 1.25.40.20, 3 hits |
InterProi | View protein in InterPro IPR037971, Ank3_Death IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR040745, Ankyrin_UPA IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 7 hits PF13606, Ank_3, 1 hit PF00531, Death, 1 hit PF17809, UPA_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 22 hits SM00005, DEATH, 1 hit SM00218, ZU5, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48403, SSF48403, 3 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 21 hits PS50017, DEATH_DOMAIN, 1 hit PS51145, ZU5, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANK3_RAT | |
Accessioni | O70511Primary (citable) accession number: O70511 Secondary accession number(s): Q574D7 Q8VDA0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | April 7, 2021 | |
This is version 152 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references