Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 149 (07 Oct 2020)
Sequence version 3 (09 Jul 2014)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Ankyrin-3

Gene

Ank3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg2+ levels, and thereby contributes to the regulation of renal Mg2+ reabsorption (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin-3
Short name:
ANK-3
Alternative name(s):
Ankyrin-G
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ank3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
620157, Ank3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Lysosome, Membrane, Postsynaptic cell membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004296321 – 2622Ankyrin-3Add BLAST2622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei39PhosphoserineBy similarity1
Modified residuei631PhosphoserineCombined sources1
Modified residuei855PhosphoserineCombined sources1
Modified residuei869PhosphoserineCombined sources1
Modified residuei875PhosphoserineCombined sources1
Modified residuei921PhosphoserineCombined sources1
Modified residuei924PhosphoserineCombined sources1
Modified residuei930PhosphoserineBy similarity1
Modified residuei965PhosphoserineCombined sources1
Modified residuei967PhosphoserineCombined sources1
Modified residuei1121PhosphoserineCombined sources1
Modified residuei1458PhosphoserineCombined sources1
Modified residuei1469PhosphoserineBy similarity1
Modified residuei1621PhosphoserineBy similarity1
Modified residuei1624PhosphoserineBy similarity1
Modified residuei1984PhosphoserineCombined sources1
Modified residuei2102PhosphoserineCombined sources1
Modified residuei2114PhosphoserineCombined sources1
Modified residuei2117PhosphoserineCombined sources1
Modified residuei2457PhosphoserineCombined sources1
Modified residuei2475PhosphoserineBy similarity1
Modified residuei2544PhosphoserineCombined sources1
Isoform 4 (identifier: O70511-4)
Modified residuei851PhosphoserineCombined sources1
Isoform 5 (identifier: O70511-5)
Modified residuei851PhosphoserineCombined sources1
Isoform 2 (identifier: O70511-2)
Modified residuei1679PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O70511

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O70511

PRoteomics IDEntifications database

More...
PRIDEi
O70511

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O70511

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O70511

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O70511

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at highest levels in brain and testis, followed by skin, kidney, liver and spleen. Isoforms 2, 3, 4, 5, 6 and 7 may be specifically expressed in muscle tissues, including heart and skeletal muscle (extensor digitorum longus) (at protein level) (PubMed:11796721).3 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May be a constituent of a NFASC/NRCAM/ankyrin G complex.

Interacts with RHBG. Directly interacts with DMD and betaDAG1; this interaction does not interfere with DMD-binding and is required for DMD and betaDAG1 retention at costameres.

Interacts (via N-terminal ANK repeats) with SCHIP1 isoform 7 (via C-terminus); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs) (By similarity).

Interacts with PLEC and FLNC (PubMed:21223964).

Isoform 7 interacts with PLEC and FLNC through its muscle-specific C-terminal sequence.

Interacts with KCNA1; this inhibits channel activity (By similarity).

Interacts (via ANK repeats) with IQCJ-SCHIP1; required for IQCJ-SCHIP1 localization at axon initial segments (AIS) and nodes of Ranvier (By similarity).

Interacts with SCHIP1 (By similarity).

Interacts with SCN5A (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
262995, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O70511

Database of interacting proteins

More...
DIPi
DIP-60342N

Protein interaction database and analysis system

More...
IntActi
O70511, 7 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000043687

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12622
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O70511

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati73 – 102ANK 1Add BLAST30
Repeati106 – 135ANK 2Add BLAST30
Repeati139 – 168ANK 3Add BLAST30
Repeati172 – 201ANK 4Add BLAST30
Repeati203 – 230ANK 5Add BLAST28
Repeati242 – 271ANK 6Add BLAST30
Repeati275 – 304ANK 7Add BLAST30
Repeati308 – 337ANK 8Add BLAST30
Repeati341 – 370ANK 9Add BLAST30
Repeati374 – 403ANK 10Add BLAST30
Repeati407 – 436ANK 11Add BLAST30
Repeati440 – 469ANK 12Add BLAST30
Repeati473 – 502ANK 13Add BLAST30
Repeati506 – 535ANK 14Add BLAST30
Repeati539 – 568ANK 15Add BLAST30
Repeati572 – 601ANK 16Add BLAST30
Repeati605 – 634ANK 17Add BLAST30
Repeati638 – 667ANK 18Add BLAST30
Repeati671 – 700ANK 19Add BLAST30
Repeati704 – 733ANK 20Add BLAST30
Repeati737 – 766ANK 21Add BLAST30
Repeati770 – 799ANK 22Add BLAST30
Repeati803 – 832ANK 23Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini992 – 1147ZU5 1PROSITE-ProRule annotationAdd BLAST156
Domaini1149 – 1296ZU5 2PROSITE-ProRule annotationAdd BLAST148
Domaini2336 – 2420DeathPROSITE-ProRule annotationAdd BLAST85

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4177, Eukaryota

KEGG Orthology (KO)

More...
KOi
K10380

Database of Orthologous Groups

More...
OrthoDBi
1011028at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08803, Death_ank3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037971, Ank3_Death
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF13606, Ank_3, 1 hit
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 22 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 21 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O70511-1) [UniParc]FASTAAdd to basket
Also known as: AnkG270

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHAASQLKK NRDLEINAEE ETEKKKKHRK RSRDRKKKSD ANASYLRAAR
60 70 80 90 100
AGHLEKALDY IKNGVDVNIC NQNGLNALHL ASKEGHVEVV SELLQREANV
110 120 130 140 150
DAATKKGNTA LHIASLAGQA EVVKVLVTNG ANVNAQSQNG FTPLYMAAQE
160 170 180 190 200
NHLEVVRFLL DNGASQSLAT EDGFTPLAVA LQQGHDQVVS LLLENDTKGK
210 220 230 240 250
VRLPALHIAA RKDDTKAAAL LLQNDTNADI ESKMVVNRAT ESGFTPLHIA
260 270 280 290 300
AHYGNINVAT LLLNRAAAVD FTARNDITPL HVASKRGNAN MVKLLLDRGA
310 320 330 340 350
KIDAKTRDGL TPLHCGARSG HEQVVEMLLD RAAPILSKTK NGLSPLHMAT
360 370 380 390 400
QGDHLNCVQL LLQHNVPVDD VTNDYLTALH VAAHCGHYKV AKVLLDKKAN
410 420 430 440 450
PNAKALNGFT PLHIACKKNR IRVMELLLKH GASIQAVTES GLTPIHVAAF
460 470 480 490 500
MGHVNIVSQL MHHGASPNTT NVRGETALHM AARSGQAEVV RYLVQDGAQV
510 520 530 540 550
EAKAKDDQTP LHISARLGKA DIVQQLLQQG ASPNAATTSG YTPLHLSARE
560 570 580 590 600
GHEDVAAFLL DHGASLSITT KKGFTPLHVA AKYGKLEVAS LLLQKSASPD
610 620 630 640 650
AAGKSGLTPL HVAAHYDNQK VALLLLDQGA SPHAAAKNGY TPLHIAAKKN
660 670 680 690 700
QMDIATSLLE YGADANAVTR QGIASVHLAA QEGHVDMVSL LLSRNANVNL
710 720 730 740 750
SNKSGLTPLH LAAQEDRVNV AEVLVNQGAH VDAQTKMGYT PLHVGCHYGN
760 770 780 790 800
IKIVNFLLQH SAKVNAKTKN GYTPLHQAAQ QGHTHIINVL LQNNASPNEL
810 820 830 840 850
TVNGNTALAI ARRLGYISVV DTLKVVTEEI MTTTTITEKH KMNVPETMNE
860 870 880 890 900
VLDMSDDEVG KASAPEKLSD GEYISDGEEG EDAITGDTDK YLGPQDLKEL
910 920 930 940 950
GDDSLPAEGY VGFSLGARSA SLRSFSSDRS YTLNRSSYAR DSMMIEELLV
960 970 980 990 1000
PSKEQHLPFT REFDSDSLRH YSWAADTLDN VNLVSSPVHS GFLVSFMVDA
1010 1020 1030 1040 1050
RGGSMRGSRH HGMRIIIPPR KCTAPTRITC RLVKRHKLAN PPPMVEGEGL
1060 1070 1080 1090 1100
ASRLVEMGPA GAQFLGPVIV EIPHFGSMRG KERELIVLRS ENGETWKEHQ
1110 1120 1130 1140 1150
FDSKNEDLSE LLNGMDEELD SPEELGTKRI CRIITKDFPQ YFAVVSRIKQ
1160 1170 1180 1190 1200
ESNQIGPEGG ILSSTTVPLV QASFPEGALT KRIRVGLQAQ PVPEETVKKI
1210 1220 1230 1240 1250
LGNKATFSPI VTVEPRRRKF HKPITMTIPV PPPSGEGVSN GYKGDTTPSL
1260 1270 1280 1290 1300
RLLCSITGGT SPAQWEDITG TTPLTFIKDC VSFTTNVSAR FWLADCHQVL
1310 1320 1330 1340 1350
ETVGLASQLY RELICVPYMA KFVVFAKTND PVESSLRCFC MTDDRVDKTL
1360 1370 1380 1390 1400
EQQENFEEVA RSKDIEVLEG KPIYVDCYGN LAPLTKGGQQ LVFNFYSFKE
1410 1420 1430 1440 1450
NRLPFSIKVR DTSQEPCGRL SFLKEPKTTK GLPQTAVCNL NITLPAHKKA
1460 1470 1480 1490 1500
EKADRRQSFT SLALRKRYSY LTEPSMKTVE RSSGTARSLP TTYSHKPFFS
1510 1520 1530 1540 1550
TRPYQSWTTT PITVPGPAKS GSLSSSPSNT PSASPLKSIW SVSTPSPIKS
1560 1570 1580 1590 1600
TLGASTTSSV KSISDVASPI RSFRTISSPI RTVASPSPYN TQVASGTLGR
1610 1620 1630 1640 1650
VPTITEATPI KGVAPNSTLS SRTSPVTTAG SLLEKSSITM TPPASPKANI
1660 1670 1680 1690 1700
TMYSSSLPFK SIITSAAPLI SSPLKSVVSP TKSAADVIST AKAAMASTLS
1710 1720 1730 1740 1750
SPLKQMSGHA EVALVNGSVS PLKYPSSSAL INGCKATATL QDKISTATNA
1760 1770 1780 1790 1800
VSSVVSAAPD TVEKALSTTT AMPFSPLRSY VSAAAPSAFQ SLRAPSASAL
1810 1820 1830 1840 1850
YNSLGPSVGV TTSSVTSSII TVPVYSVGNV LAEPALKKLP DSNSLTKSAA
1860 1870 1880 1890 1900
ALLSPIKTLT TETRPQPHFN RTSSPVKSSL FLASSALKPS VPSSLSSSQE
1910 1920 1930 1940 1950
ILKDVAEMKE DLMRMTAILQ TDVPEEKPFQ TDLPREGRID DEEPFKIVEK
1960 1970 1980 1990 2000
VKEDLVKVSE ILKKDVCVES KGPPKSPKSD KGHSPEDDWT EFSSEEIREA
2010 2020 2030 2040 2050
RQAAASHAPS LPERVHGKAN LTRVIDYLTN DIGSSSLTNL KYKFEEAKKE
2060 2070 2080 2090 2100
GEERQKRILK PAMALQEHKL KMPPASMRPS TSEKELCKMA DSFFGTDAIL
2110 2120 2130 2140 2150
ESPDDFSQHD QDKSPLSDSG FETRSEKTPS APQSAESTGP KPLFHEVPIP
2160 2170 2180 2190 2200
PVITETRTEV VHVIRSYEPS TGEIPQSQPE DPVSPKPPPT FMELEPKPTA
2210 2220 2230 2240 2250
LSIKEKVKAF QMKASSEEED HSRVLSKGMR VKEETHITTT TRMVYHSPPG
2260 2270 2280 2290 2300
SECASERIEE TMSVHDIMKA FQSGRDPSKE LAGLFEHKSA MSPDVAKSAA
2310 2320 2330 2340 2350
ETSAQHAEKD NQMKPKLERI IEVHIEKGPQ SPCERTDIRM AIVADHLGLS
2360 2370 2380 2390 2400
WTELARELNF SVDEINQIRV ENPNSLISQS FMLLKKWVTR DGKNATTDAL
2410 2420 2430 2440 2450
TSVLTKINRI DIVTLLEGPI FDYGNISGTR SFADENNVFH DPVDGWQNET
2460 2470 2480 2490 2500
PSGSLESPAQ ARRITGGLLD RLDDSSDQVR DPITSYLTGE AGKFEANGNH
2510 2520 2530 2540 2550
AEVIPEAKAK AYFPESQNDI GKQSIKENLK PKTHGCGRAE EPVSPLTAYQ
2560 2570 2580 2590 2600
KSLEETSKLV IEDAPKPCVP VGMKKMTRTP ADGKARLNLQ EEEGSARSEP
2610 2620
KQGEGYKVKT KKEIRNVEKK AH
Length:2,622
Mass (Da):284,443
Last modified:July 9, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA17F304D792333F5
GO
Isoform 2 (identifier: O70511-2) [UniParc]FASTAAdd to basket
Also known as: AnkG217

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MAHAASQLKKNRDLEINAEEETEKKKKHRKRSRDRK → MSEEAKEKTAKPAHRKRKG
     234-241: Missing.
     858-878: Missing.
     922-927: LRSFSS → PKISS
     1466-2444: KRYSYLTEPS...ENNVFHDPVD → PQSPCERTDI...RAELAMSSLA
     2601-2601: K → KDLRHSESDS...GPQERKQDDV

Note: The 76 amino-acid long sequence from Asp-1888 to Val-1963 is encoded by a muscle-specific exon.Curated
Show »
Length:1,984
Mass (Da):216,577
Checksum:i45C2EEA326E36AD5
GO
Isoform 3 (identifier: O70511-3) [UniParc]FASTAAdd to basket
Also known as: AnkG197

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MAHAASQLKKNRDLEINAEEETEKKKKHRKRSRDRK → MSEEAKEKTAKPAHRKRKG
     234-241: Missing.
     858-878: Missing.
     922-927: LRSFSS → PKISS
     1466-2328: Missing.
     2601-2601: K → KQVKSPGEAF...GPQERKQDDV

Note: The 76 amino-acid long sequence from Asp-1710 to Val-1785 is encoded by a muscle-specific exon.Curated
Show »
Length:1,806
Mass (Da):197,423
Checksum:i6197309048CD689A
GO
Isoform 4 (identifier: O70511-4) [UniParc]FASTAAdd to basket
Also known as: Ank130

The sequence of this isoform differs from the canonical sequence as follows:
     1-880: MAHAASQLKK...GEYISDGEEG → MALPHS
     922-927: LRSFSS → PKISS
     1466-2444: KRYSYLTEPS...ENNVFHDPVD → PQSPCERTDI...RAELAMSSLA
     2601-2601: K → KVKSPGEAFT...GPQERKQDDV

Note: The 76 amino-acid long sequence from Asp-1077 to Val-1152 is encoded by a muscle-specific exon.Curated
Show »
Length:1,173
Mass (Da):129,941
Checksum:i9E0602541FE4FE65
GO
Isoform 5 (identifier: O70511-5) [UniParc]FASTAAdd to basket
Also known as: AnkG128

The sequence of this isoform differs from the canonical sequence as follows:
     1-880: MAHAASQLKK...GEYISDGEEG → MALPHS
     922-927: LRSFSS → PKISS
     1466-2444: KRYSYLTEPS...ENNVFHDPVD → PQSPCERTDI...RAELAMSSLA
     2601-2601: K → KDLRHSESDS...GPQERKQDDV

Note: The 76 amino-acid long sequence from Asp-1060 to Val-1135 is encoded by a muscle-specific exon.Curated
Show »
Length:1,156
Mass (Da):128,067
Checksum:i043E3872865D1117
GO
Isoform 6 (identifier: O70511-6) [UniParc]FASTAAdd to basket
Also known as: AnkG109

The sequence of this isoform differs from the canonical sequence as follows:
     1-880: MAHAASQLKK...GEYISDGEEG → MALPHS
     922-927: LRSFSS → PKISS
     1466-2328: Missing.
     2601-2601: K → KVKSPGEAFT...GPQERKQDDV

Note: The 76 amino-acid long sequence from Asp-881 to Val-956 is encoded by a muscle-specific exon.Curated
Show »
Length:977
Mass (Da):108,785
Checksum:i02844AE344A6561D
GO
Isoform 7 (identifier: O70511-7) [UniParc]FASTAAdd to basket
Also known as: AnkG107

The sequence of this isoform differs from the canonical sequence as follows:
     1-880: MAHAASQLKK...GEYISDGEEG → MALPHS
     922-927: LRSFSS → PKISS
     1466-2328: Missing.
     2601-2601: K → KDLRHSESDS...GPQERKQDDV

Note: The 76 amino-acid long sequence from Asp-864 to Val-939 is encoded by a muscle-specific exon.Curated
Show »
Length:960
Mass (Da):106,911
Checksum:iF850EF67D120878A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K0J3A0A0G2K0J3_RAT
Ankyrin-3
Ank3
2,615Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K1Q7A0A0G2K1Q7_RAT
Ankyrin-3
Ank3
1,963Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K1R9A0A0G2K1R9_RAT
Ankyrin-3
Ank3
2,557Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K4D0A0A0G2K4D0_RAT
Ankyrin-3
Ank3
1,725Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K2B9A0A0G2K2B9_RAT
Ankyrin-3
Ank3
1,848Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JUJ5A0A0G2JUJ5_RAT
Ankyrin-3
Ank3
977Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti246P → S in AAC78143 (PubMed:9744885).Curated1
Sequence conflicti635A → S in CAH19223 (PubMed:15953600).Curated1
Sequence conflicti635A → S in CAH19224 (PubMed:15953600).Curated1
Sequence conflicti667A → P in AAC78143 (PubMed:9744885).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0550041 – 880MAHAA…DGEEG → MALPHS in isoform 4, isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST880
Alternative sequenceiVSP_0550051 – 36MAHAA…SRDRK → MSEEAKEKTAKPAHRKRKG in isoform 2 and isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_055006234 – 241Missing in isoform 2 and isoform 3. 1 Publication8
Alternative sequenceiVSP_055007858 – 878Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_055008922 – 927LRSFSS → PKISS in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. 2 Publications6
Alternative sequenceiVSP_0550091466 – 2444KRYSY…HDPVD → PQSPCERTDIRMAIVADHLG LSWTELARELNFSVDEINQI RVENPNSLISQSFMLLKKWV TRDGKNATTDALTSVLTKIN RIDIVTLLEGPIFDYGNISG TRSFADENNVFHDPVDGHPS FQVELETPMGLYCTPPTPFQ QDDHFSDNSSIESPFRTPSR LSDGLMPSQGSIEHPAGGPP VVTAEDTSLEDSKMDDSVTV TETADPLDVDESQLKDLCQS ECAHCWASVPGVPSGGPQAE PLRAQTRKVGVSSEQQEKGD SGPEEEMADDKVRSLFEDIQ LEEVEAEEMTEDEGQAILNR VPRAELAMSSLA in isoform 2, isoform 4 and isoform 5. 1 PublicationAdd BLAST979
Alternative sequenceiVSP_0550101466 – 2328Missing in isoform 3, isoform 6 and isoform 7. 2 PublicationsAdd BLAST863
Alternative sequenceiVSP_0550112601K → KDLRHSESDSSSEEERRVTT RVIRRRVIIKGEEAKTIPGE SVTEEQFTDEEGNLITRKIT RKVIRRIGPQERKQDDV in isoform 2, isoform 5 and isoform 7. 2 Publications1
Alternative sequenceiVSP_0550122601K → KQVKSPGEAFTRMTACCYKD LRHSESDSSSEEERRVTTRV IRRRVIIKGEEAKTIPGESV TEEQFTDEEGNLITRKITRK VIRRIGPQERKQDDV in isoform 3. 1 Publication1
Alternative sequenceiVSP_0550132601K → KVKSPGEAFTRMTACCYKDL RHSESDSSSEEERRVTTRVI RRRVIIKGEEAKTIPGESVT EEQFTDEEGNLITRKITRKV IRRIGPQERKQDDV in isoform 4 and isoform 6. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF102552 mRNA Translation: AAC78143.1
AJ428573 mRNA Translation: CAD21705.1
AJ812019 mRNA Translation: CAH19219.1
AJ812021 mRNA Translation: CAH19221.1
AJ812022 mRNA Translation: CAH19222.1
AJ812023 mRNA Translation: CAH19223.1
AJ812024 mRNA Translation: CAH19224.1

NCBI Reference Sequences

More...
RefSeqi
NP_001029156.1, NM_001033984.1 [O70511-1]
NP_113993.1, NM_031805.1 [O70511-2]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
361833

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:361833

UCSC genome browser

More...
UCSCi
RGD:620157, rat

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102552 mRNA Translation: AAC78143.1
AJ428573 mRNA Translation: CAD21705.1
AJ812019 mRNA Translation: CAH19219.1
AJ812021 mRNA Translation: CAH19221.1
AJ812022 mRNA Translation: CAH19222.1
AJ812023 mRNA Translation: CAH19223.1
AJ812024 mRNA Translation: CAH19224.1
RefSeqiNP_001029156.1, NM_001033984.1 [O70511-1]
NP_113993.1, NM_031805.1 [O70511-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YIPX-ray1.85B1985-2010[»]
5YIQX-ray2.60D1985-2010[»]
6A9XX-ray2.20A1987-2010[»]
6M3PX-ray3.31C/E975-1465[»]
6M3RX-ray4.31E975-1465[»]
SMRiO70511
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi262995, 4 interactors
CORUMiO70511
DIPiDIP-60342N
IntActiO70511, 7 interactors
STRINGi10116.ENSRNOP00000043687

PTM databases

iPTMnetiO70511
PhosphoSitePlusiO70511
SwissPalmiO70511

Proteomic databases

jPOSTiO70511
PaxDbiO70511
PRIDEiO70511

Genome annotation databases

GeneIDi361833
KEGGirno:361833
UCSCiRGD:620157, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
288
RGDi620157, Ank3

Phylogenomic databases

eggNOGiKOG4177, Eukaryota
KOiK10380
OrthoDBi1011028at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O70511

Family and domain databases

CDDicd08803, Death_ank3, 1 hit
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR037971, Ank3_Death
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF13606, Ank_3, 1 hit
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 22 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 21 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANK3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O70511
Secondary accession number(s): Q574D7
, Q574D8, Q574D9, Q574E0, Q574E2, Q8VDA0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 7, 2020
This is version 149 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again