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Protein

Ficolin-2

Gene

Fcn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi250CalciumBy similarity1
Metal bindingi252CalciumBy similarity1
Metal bindingi254Calcium; via carbonyl oxygenBy similarity1
Metal bindingi256Calcium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processComplement activation lectin pathway, Immunity, Innate immunity
LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-166662 Lectin pathway of complement activation
R-MMU-166663 Initial triggering of complement
R-MMU-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Ficolin-2
Alternative name(s):
Collagen/fibrinogen domain-containing protein 2
Ficolin-B
Ficolin-beta
L-ficolin
Gene namesi
Name:Fcn2
Synonyms:Fcnb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1341158 Fcnb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000000914018 – 314Ficolin-2Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi99 ↔ 127By similarity
Disulfide bondi106 ↔ 134By similarity
Disulfide bondi258 ↔ 271By similarity
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO70497
PaxDbiO70497
PRIDEiO70497

Expressioni

Gene expression databases

BgeeiENSMUSG00000026835 Expressed in 24 organ(s), highest expression level in bone marrow
CleanExiMM_FCNB
ExpressionAtlasiO70497 baseline and differential
GenevisibleiO70497 MM

Interactioni

Subunit structurei

Homotrimer. Interacts with elastin. Interacts with MASP1 and MASP2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028179

Structurei

3D structure databases

ProteinModelPortaliO70497
SMRiO70497
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 96Collagen-likeAdd BLAST57
Domaini97 – 314Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST218

Domaini

The fibrinogen-like domain (FBG) contains calcium-binding sites that may be involved in carbohydrate binding.By similarity

Sequence similaritiesi

Belongs to the ficolin lectin family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150813
HOGENOMiHOG000037127
HOVERGENiHBG001644
InParanoidiO70497
KOiK10104
OMAiWYADCHA
OrthoDBiEOG091G03M1
PhylomeDBiO70497
TreeFamiTF329953

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 1 hit
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O70497-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGSAALFV LTLTVHAAGT CPELKVLDLE GYKQLTILQG CPGLPGAAGP
60 70 80 90 100
KGEAGAKGDR GESGLPGIPG KEGPTGPKGN QGEKGIRGEK GDSGPSQSCA
110 120 130 140 150
TGPRTCKELL TQGHFLTGWY TIYLPDCRPL TVLCDMDTDG GGWTVFQRRL
160 170 180 190 200
DGSVDFFRDW TSYKRGFGSQ LGEFWLGNDN IHALTTQGTS ELRVDLSDFE
210 220 230 240 250
GKHDFAKYSS FQIQGEAEKY KLILGNFLGG GAGDSLTPHN NRLFSTKDQD
260 270 280 290 300
NDGSTSSCAM GYHGAWWYSQ CHTSNLNGLY LRGPHKSYAN GVNWKSWRGY
310
NYSCKVSEMK VRLI
Length:314
Mass (Da):33,984
Last modified:December 12, 2006 - v2
Checksum:i6C1467BF0BE96E67
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U9R5Q3U9R5_MOUSE
Ficolin B
Fcnb
253Annotation score:
B2FDG6B2FDG6_MOUSE
Ficolin B
Fcnb
112Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130L → M in AAC98781 (PubMed:9851834).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107220 mRNA Translation: AAI07221.1
BC107221 mRNA Translation: AAI07222.1
AF063217 mRNA Translation: AAC98781.1
CCDSiCCDS15832.1
RefSeqiNP_034320.1, NM_010190.1
UniGeneiMm.182935

Genome annotation databases

EnsembliENSMUST00000028179; ENSMUSP00000028179; ENSMUSG00000026835
GeneIDi14134
KEGGimmu:14134
UCSCiuc008ixv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC107220 mRNA Translation: AAI07221.1
BC107221 mRNA Translation: AAI07222.1
AF063217 mRNA Translation: AAC98781.1
CCDSiCCDS15832.1
RefSeqiNP_034320.1, NM_010190.1
UniGeneiMm.182935

3D structure databases

ProteinModelPortaliO70497
SMRiO70497
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028179

Proteomic databases

MaxQBiO70497
PaxDbiO70497
PRIDEiO70497

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028179; ENSMUSP00000028179; ENSMUSG00000026835
GeneIDi14134
KEGGimmu:14134
UCSCiuc008ixv.1 mouse

Organism-specific databases

CTDi14134
MGIiMGI:1341158 Fcnb

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150813
HOGENOMiHOG000037127
HOVERGENiHBG001644
InParanoidiO70497
KOiK10104
OMAiWYADCHA
OrthoDBiEOG091G03M1
PhylomeDBiO70497
TreeFamiTF329953

Enzyme and pathway databases

ReactomeiR-MMU-166662 Lectin pathway of complement activation
R-MMU-166663 Initial triggering of complement
R-MMU-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

PROiPR:O70497
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026835 Expressed in 24 organ(s), highest expression level in bone marrow
CleanExiMM_FCNB
ExpressionAtlasiO70497 baseline and differential
GenevisibleiO70497 MM

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 1 hit
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFCN2_MOUSE
AccessioniPrimary (citable) accession number: O70497
Secondary accession number(s): Q3KNL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: December 12, 2006
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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