Sp3

Functionⁱ

Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping (By similarity).By similarity1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	623 – 647	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	653 – 677	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	683 – 705	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

chromatin binding
Source: MGI
Inferred from direct assayⁱ
- 15522233
DNA binding
Source: MGI
Inferred from direct assayⁱ
- 14630713
- 15094381
DNA-binding transcription factor activity
Source: MGI
Traceable author statementⁱ
- 15282343
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
double-stranded DNA binding
Source: MGI
Inferred from direct assayⁱ
- 15282343
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: UniProtKB
Inferred from direct assayⁱ
- 17130167
proximal promoter sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 15511642
- 19943855
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 17670746
RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

B cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 12676787
definitive hemopoiesis
Source: MGI
Inferred from genetic interactionⁱ
- 17584888
embryonic camera-type eye morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 17584888
embryonic placenta development
Source: MGI
Inferred from genetic interactionⁱ
- 17584888
embryonic process involved in female pregnancy
Source: MGI
Inferred from genetic interactionⁱ
- 17584888
embryonic skeletal system development
Source: MGI
Inferred from genetic interactionⁱ
- 17584888
enucleate erythrocyte differentiation
Source: MGI
Inferred from genetic interactionⁱ
- 17584888
erythrocyte differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 12676787
granulocyte differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 12676787
in utero embryonic development
Source: MGI
Inferred from genetic interactionⁱ
- 17584888
liver development
Source: MGI
Inferred from genetic interactionⁱ
- 17584888
lung development
Source: MGI
Inferred from genetic interactionⁱ
- 17584888
megakaryocyte differentiation
Source: MGI
Inferred from genetic interactionⁱ
- 17584888
monocyte differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 12676787
natural killer cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 12676787
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 17130167
ossification
Source: MGI
Inferred from genetic interactionⁱ
- 17584888
positive regulation of transcription, DNA-templated Source: MGI
positive regulation of transcription by RNA polymerase II Source: MGI
regulation of transcription, DNA-templated Source: MGI
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
T cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 12676787
trophectodermal cell differentiation
Source: MGI
Inferred from genetic interactionⁱ
- 17584888

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3232118 SUMOylation of transcription factors

Reactomeⁱ

R-MMU-3232118 SUMOylation of transcription factors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor Sp3
Gene namesⁱ	Name:Sp3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:1277166 Sp3

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047142	1 – 783	Transcription factor Sp3Add BLAST		783

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	72	PhosphoserineCombined sources	1
Cross-linkⁱ	122	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residueⁱ	553	N6-acetyllysine; alternate1 Publication	1
Cross-linkⁱ	553	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linkⁱ	553	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linkⁱ	553	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	565	PhosphoserineCombined sources	1
Modified residueⁱ	568	PhosphoserineCombined sources	1
Cross-linkⁱ	595	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	648	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Acetylated by histone acetyltransferase p300, deacetylated by HDACs. Acetylation/deacetylation states regulate transcriptional activity. Acetylation appears to activate transcription. Alternate sumoylation and acetylation at Lys-553 also control transcriptional activity (By similarity).By similarity

Sumoylated on all isoforms. Sumoylated on 2 sites in longer isoforms with Lys-553 being the major site. Sumoylation at this site promotes nuclear localization to the nuclear periphery, nuclear dots and PML nuclear bodies. Sumoylation on Lys-553 represses the transactivation activity, except for the largest isoform which has little effect on transactivation. Alternate sumoylation and acetylation at Lys-553 also control transcriptional activity (By similarity).By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O70494
PaxDbⁱ	O70494
PeptideAtlas More...PeptideAtlasⁱ	O70494
PRIDEⁱ	O70494

PTM databases

iPTMnetⁱ	O70494
PhosphoSitePlusⁱ	O70494

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000027109 Expressed in 301 organ(s), highest expression level in indifferent gonad
CleanExⁱ	MM_SP3
Genevisibleⁱ	O70494 MM

Interactionⁱ

Subunit structureⁱ

Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts with HDAC1; the interaction deacetylates SP3 and regulates its transcriptional activity. Interacts with HDAC2 (preferably the CK2-phosphorylated form); the interaction deacetylates SP3 and regulates its transcriptional activity. Ceramides can also regulate acetylation/deacetylation events through altering the interaction of HDAC with SP3. Interacts with MEIS2 isoform Meis2D and PBX1 isoform PBX1a (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	203418, 7 interactors
IntActⁱ	O70494, 1 interactor
STRINGⁱ	10090.ENSMUSP00000099750

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O70494
SMRⁱ	O70494
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	140 – 239	Transactivation domain (Gln-rich)By similarityAdd BLAST	100
Regionⁱ	352 – 501	Transactivation domain (Gln-rich)By similarityAdd BLAST	150
Regionⁱ	536 – 622	Repressor domainBy similarityAdd BLAST	87

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	20 – 28	Poly-Gly	9
Compositional biasⁱ	32 – 40	Poly-Gln	9
Compositional biasⁱ	45 – 102	Ala-richAdd BLAST	58
Compositional biasⁱ	336 – 339	Poly-Ser	4

Sequence similaritiesⁱ

Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	623 – 647	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	653 – 677	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	683 – 705	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118984
HOGENOMⁱ	HOG000234295
HOVERGENⁱ	HBG008933
InParanoidⁱ	O70494
KEGG Orthology (KO) More...KOⁱ	K09193
OMAⁱ	IAQQTIH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HX6
PhylomeDBⁱ	O70494
TreeFamⁱ	TF350150

Family and domain databases

InterProⁱ	View protein in InterPro IPR030452 SP3 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR23235:SF3 PTHR23235:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: O70494-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAPEKPVKQ EEMAALDVDG GGGGGGHGEY LQQQQQQQQQ HGNGAAAAAA 
        60         70         80         90        100
QDTQPSPLAL LAATCSKIGP PSPGDDDEEA AVAAAAGVPA AAAGATGDLA 
       110        120        130        140        150
SAQLGGAPNR WEVLSATPTT IKDEAGNLVQ IPGAATSSGQ YVLPLQNLQN 
       160        170        180        190        200
QQIFSVAPGS DSSNGTVSNV QYQVIPQIQS TDAQQVQIGF TGSSDNGGIN 
       210        220        230        240        250
QENSQIQIIP GSNQTLLASG TPPANIQNLI PQTGQVQVQG VAIGGSSFPG 
       260        270        280        290        300
QTQVVANVPL GLPGNITFVP INSVDLDSLG LSGSSQTMTA GINADGHLIN 
       310        320        330        340        350
TGQAMDSSDN SERTGERVSP DVNETNADTD LFVPTSSSSQ LPVTIDSTGI 
       360        370        380        390        400
LQQNTNSLTT TSGQVHSSDL QGNYIQSPVS EETQAQNIQV STAQPVVQHL 
       410        420        430        440        450
QLQDSQQPTS QAQIVQGITP QTIHGVQASG QNISQQALQN LQLQLNPGTF 
       460        470        480        490        500
LIQAQTVTPS GQITWQTFQV QGVQNLQNLQ IQNTAAQQIT LTPVQTLTLG 
       510        520        530        540        550
QVAAGGALTS TPVSLSTGQL PNLQTVTVNS IDSTGIQLHP GENADSPADI 
       560        570        580        590        600
RIKEEEPDPE EWQLSGDSTL NTNDLTHLRV QVVDEEGDQQ HQEGKRLRRV 
       610        620        630        640        650
ACTCPNCKEG GGRGTNLGKK KQHICHIPGC GKVYGKTSHL RAHLRWHSGE 
       660        670        680        690        700
RPFICNWMFC GKRFTRSDEL QRHRRTHTGE KKFVCPECSK RFMRSDHLAK 
       710        720        730        740        750
HIKTHQNKKV IHSSSTVLAS VEAGRDDALI TAGGTTLILA NIQQGSVSGI 
       760        770        780 
GTVNTSATSN QDILTNTEIP LQLVTVSGNE TME

Length:783

Mass (Da):82,362

Last modified:January 10, 2006 - v2

Checksum:ⁱE45A00D566454D61

GO

Isoform 2 (identifier: O70494-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
52-95: Missing.

« Hide

        10         20         30         40         50
MTAPEKPVKQ EEMAALDVDG GGGGGGHGEY LQQQQQQQQQ HGNGAAAAAA 
        60         70         80         90        100
QTGDLASAQL GGAPNRWEVL SATPTTIKDE AGNLVQIPGA ATSSGQYVLP 
       110        120        130        140        150
LQNLQNQQIF SVAPGSDSSN GTVSNVQYQV IPQIQSTDAQ QVQIGFTGSS 
       160        170        180        190        200
DNGGINQENS QIQIIPGSNQ TLLASGTPPA NIQNLIPQTG QVQVQGVAIG 
       210        220        230        240        250
GSSFPGQTQV VANVPLGLPG NITFVPINSV DLDSLGLSGS SQTMTAGINA 
       260        270        280        290        300
DGHLINTGQA MDSSDNSERT GERVSPDVNE TNADTDLFVP TSSSSQLPVT 
       310        320        330        340        350
IDSTGILQQN TNSLTTTSGQ VHSSDLQGNY IQSPVSEETQ AQNIQVSTAQ 
       360        370        380        390        400
PVVQHLQLQD SQQPTSQAQI VQGITPQTIH GVQASGQNIS QQALQNLQLQ 
       410        420        430        440        450
LNPGTFLIQA QTVTPSGQIT WQTFQVQGVQ NLQNLQIQNT AAQQITLTPV 
       460        470        480        490        500
QTLTLGQVAA GGALTSTPVS LSTGQLPNLQ TVTVNSIDST GIQLHPGENA 
       510        520        530        540        550
DSPADIRIKE EEPDPEEWQL SGDSTLNTND LTHLRVQVVD EEGDQQHQEG 
       560        570        580        590        600
KRLRRVACTC PNCKEGGGRG TNLGKKKQHI CHIPGCGKVY GKTSHLRAHL 
       610        620        630        640        650
RWHSGERPFI CNWMFCGKRF TRSDELQRHR RTHTGEKKFV CPECSKRFMR 
       660        670        680        690        700
SDHLAKHIKT HQNKKVIHSS STVLASVEAG RDDALITAGG TTLILANIQQ 
       710        720        730 
GSVSGIGTVN TSATSNQDIL TNTEIPLQLV TVSGNETME

Show »

Length:739

Mass (Da):78,364

Checksum:ⁱ22CEB08B93A699B0

GO

Isoform 3 (identifier: O70494-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-64: Missing.
65-94: CSKIGPPSPGDDDEEAAVAAAAGVPAAAAG → MKEDRAAIAGRRRRGRRSCAHDEKTAADKR

« Hide

        10         20         30         40         50
MKEDRAAIAG RRRRGRRSCA HDEKTAADKR ATGDLASAQL GGAPNRWEVL 
        60         70         80         90        100
SATPTTIKDE AGNLVQIPGA ATSSGQYVLP LQNLQNQQIF SVAPGSDSSN 
       110        120        130        140        150
GTVSNVQYQV IPQIQSTDAQ QVQIGFTGSS DNGGINQENS QIQIIPGSNQ 
       160        170        180        190        200
TLLASGTPPA NIQNLIPQTG QVQVQGVAIG GSSFPGQTQV VANVPLGLPG 
       210        220        230        240        250
NITFVPINSV DLDSLGLSGS SQTMTAGINA DGHLINTGQA MDSSDNSERT 
       260        270        280        290        300
GERVSPDVNE TNADTDLFVP TSSSSQLPVT IDSTGILQQN TNSLTTTSGQ 
       310        320        330        340        350
VHSSDLQGNY IQSPVSEETQ AQNIQVSTAQ PVVQHLQLQD SQQPTSQAQI 
       360        370        380        390        400
VQGITPQTIH GVQASGQNIS QQALQNLQLQ LNPGTFLIQA QTVTPSGQIT 
       410        420        430        440        450
WQTFQVQGVQ NLQNLQIQNT AAQQITLTPV QTLTLGQVAA GGALTSTPVS 
       460        470        480        490        500
LSTGQLPNLQ TVTVNSIDST GIQLHPGENA DSPADIRIKE EEPDPEEWQL 
       510        520        530        540        550
SGDSTLNTND LTHLRVQVVD EEGDQQHQEG KRLRRVACTC PNCKEGGGRG 
       560        570        580        590        600
TNLGKKKQHI CHIPGCGKVY GKTSHLRAHL RWHSGERPFI CNWMFCGKRF 
       610        620        630        640        650
TRSDELQRHR RTHTGEKKFV CPECSKRFMR SDHLAKHIKT HQNKKVIHSS 
       660        670        680        690        700
STVLASVEAG RDDALITAGG TTLILANIQQ GSVSGIGTVN TSATSNQDIL 
       710 
TNTEIPLQLV TVSGNETME

Note: No experimental confirmation available.

Show »

Length:719

Mass (Da):76,729

Checksum:ⁱ8B16F3B85E282654

GO

Sequence cautionⁱ

The sequence AAH27797 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAE21310 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	231 – 233	PQT → TRP in AAH27797 (PubMed:15489334).Curated		3

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_016782	1 – 64	Missing in isoform 3. 1 PublicationAdd BLAST	64
Alternative sequenceⁱVSP_016783	52 – 95	Missing in isoform 2. 1 PublicationAdd BLAST	44
Alternative sequenceⁱVSP_016784	65 – 94	CSKIG…AAAAG → MKEDRAAIAGRRRRGRRSCA HDEKTAADKR in isoform 3. 1 PublicationAdd BLAST	30

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK004607 mRNA Translation: BAC25090.1 AK132702 mRNA Translation: BAE21310.1 Different initiation. AL844840 Genomic DNA No translation available. BC027797 mRNA Translation: AAH27797.2 Different initiation. BC079874 mRNA Translation: AAH79874.1 AF062567 mRNA Translation: AAC16322.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16122.1 [O70494-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001018052.1, NM_001018042.3 [O70494-1] NP_001091895.1, NM_001098425.1
UniGeneⁱ	Mm.124328 Mm.446209 Mm.465887

Genome annotation databases

Ensemblⁱ	ENSMUST00000066003; ENSMUSP00000065807; ENSMUSG00000027109 [O70494-2] ENSMUST00000102689; ENSMUSP00000099750; ENSMUSG00000027109 [O70494-1]
GeneIDⁱ	20687
KEGGⁱ	mmu:20687
UCSC genome browser More...UCSCⁱ	uc008kca.2 mouse [O70494-1] uc008kcb.2 mouse [O70494-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O70494	Sp3 (Fragment)		MOUSE		688	UniRef100_O70494

Protein	Similar proteins		Species	Score	Length	Source
O70494	Transcription factor Sp3		HUMAN		781	UniRef90_O70494
Sp3 (Fragment)		MOUSE		688
Uncharacterized protein		PIG		789
transcription factor Sp3		NEOSC		785
transcription factor Sp3 isoform X1		ODORO		783
+59
O70494-2	transcription factor Sp3		PHYCD		918	UniRef90_O70494-2
Sp3 transcription factor		ORNAN		772
Uncharacterized protein (Fragment)		MACFA		738
Uncharacterized protein (Fragment)		MACMU		738
SP3 isoform 2 (Fragment)		PANTR		737
+7
O70494-3	transcription factor Sp3		TURTR		887	UniRef90_O70494-3
Sp3 transcription factor		GORGO		722
Sp3 transcription factor		PANTR		721
Uncharacterized protein		PANPA		721
Sp3 transcription factor		SAIBB		720
+22

Protein	Similar proteins		Species	Score	Length	Source
O70494	Transcription factor Sp3		HUMAN		781	UniRef50_O70494
Transcription factor Sp3		CHICK		771
Sp3 (Fragment)		MOUSE		688
Uncharacterized protein		PIG		789
transcription factor Sp3		NEOSC		785
+299

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK004607 mRNA Translation: BAC25090.1 AK132702 mRNA Translation: BAE21310.1 Different initiation. AL844840 Genomic DNA No translation available. BC027797 mRNA Translation: AAH27797.2 Different initiation. BC079874 mRNA Translation: AAH79874.1 AF062567 mRNA Translation: AAC16322.1
CCDSⁱ	CCDS16122.1 [O70494-1]
RefSeqⁱ	NP_001018052.1, NM_001018042.3 [O70494-1] NP_001091895.1, NM_001098425.1
UniGeneⁱ	Mm.124328 Mm.446209 Mm.465887

3D structure databases

ProteinModelPortalⁱ	O70494
SMRⁱ	O70494
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	203418, 7 interactors
IntActⁱ	O70494, 1 interactor
STRINGⁱ	10090.ENSMUSP00000099750

PTM databases

iPTMnetⁱ	O70494
PhosphoSitePlusⁱ	O70494

Proteomic databases

MaxQBⁱ	O70494
PaxDbⁱ	O70494
PeptideAtlasⁱ	O70494
PRIDEⁱ	O70494

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000066003; ENSMUSP00000065807; ENSMUSG00000027109 [O70494-2] ENSMUST00000102689; ENSMUSP00000099750; ENSMUSG00000027109 [O70494-1]
GeneIDⁱ	20687
KEGGⁱ	mmu:20687
UCSCⁱ	uc008kca.2 mouse [O70494-1] uc008kcb.2 mouse [O70494-2]

Organism-specific databases

CTDⁱ	6670
MGIⁱ	MGI:1277166 Sp3

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000118984
HOGENOMⁱ	HOG000234295
HOVERGENⁱ	HBG008933
InParanoidⁱ	O70494
KOⁱ	K09193
OMAⁱ	IAQQTIH
OrthoDBⁱ	EOG091G0HX6
PhylomeDBⁱ	O70494
TreeFamⁱ	TF350150

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3232118 SUMOylation of transcription factors

Reactomeⁱ

R-MMU-3232118 SUMOylation of transcription factors

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O70494
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000027109 Expressed in 301 organ(s), highest expression level in indifferent gonad
CleanExⁱ	MM_SP3
Genevisibleⁱ	O70494 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR030452 SP3 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR23235:SF3 PTHR23235:SF3, 1 hit
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SP3_MOUSE
Accessionⁱ	O70494Primary (citable) accession number: O70494 Secondary accession number(s): A2AQK9 , Q68FF2, Q8CF64, Q8K378
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 9, 2003
	Last sequence update:	January 10, 2006
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O70494 (SP3_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Transcription factor Sp3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ