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Protein

Transcription factor Sp3

Gene

Sp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri623 – 647C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri653 – 677C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri683 – 705C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3232118 SUMOylation of transcription factors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor Sp3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sp3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1277166 Sp3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000471421 – 783Transcription factor Sp3Add BLAST783

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei72PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei553N6-acetyllysine; alternate1 Publication1
Cross-linki553Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki553Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki553Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei565PhosphoserineCombined sources1
Modified residuei568PhosphoserineCombined sources1
Cross-linki595Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei648PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylated by histone acetyltransferase p300, deacetylated by HDACs. Acetylation/deacetylation states regulate transcriptional activity. Acetylation appears to activate transcription. Alternate sumoylation and acetylation at Lys-553 also control transcriptional activity (By similarity).By similarity
Sumoylated on all isoforms. Sumoylated on 2 sites in longer isoforms with Lys-553 being the major site. Sumoylation at this site promotes nuclear localization to the nuclear periphery, nuclear dots and PML nuclear bodies. Sumoylation on Lys-553 represses the transactivation activity, except for the largest isoform which has little effect on transactivation. Alternate sumoylation and acetylation at Lys-553 also control transcriptional activity (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O70494

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O70494

PeptideAtlas

More...
PeptideAtlasi
O70494

PRoteomics IDEntifications database

More...
PRIDEi
O70494

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O70494

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O70494

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027109 Expressed in 301 organ(s), highest expression level in indifferent gonad

CleanEx database of gene expression profiles

More...
CleanExi
MM_SP3

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O70494 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts with HDAC1; the interaction deacetylates SP3 and regulates its transcriptional activity. Interacts with HDAC2 (preferably the CK2-phosphorylated form); the interaction deacetylates SP3 and regulates its transcriptional activity. Ceramides can also regulate acetylation/deacetylation events through altering the interaction of HDAC with SP3. Interacts with MEIS2 isoform Meis2D and PBX1 isoform PBX1a (By similarity).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
203418, 7 interactors

Protein interaction database and analysis system

More...
IntActi
O70494, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099750

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O70494

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O70494

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni140 – 239Transactivation domain (Gln-rich)By similarityAdd BLAST100
Regioni352 – 501Transactivation domain (Gln-rich)By similarityAdd BLAST150
Regioni536 – 622Repressor domainBy similarityAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi20 – 28Poly-Gly9
Compositional biasi32 – 40Poly-Gln9
Compositional biasi45 – 102Ala-richAdd BLAST58
Compositional biasi336 – 339Poly-Ser4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri623 – 647C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri653 – 677C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri683 – 705C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155099

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234295

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG008933

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O70494

KEGG Orthology (KO)

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KOi
K09193

Identification of Orthologs from Complete Genome Data

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OMAi
IAQQTIH

Database of Orthologous Groups

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OrthoDBi
1085860at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O70494

TreeFam database of animal gene trees

More...
TreeFami
TF350150

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030452 SP3
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

The PANTHER Classification System

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PANTHERi
PTHR23235:SF3 PTHR23235:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00096 zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667 SSF57667, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O70494-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAPEKPVKQ EEMAALDVDG GGGGGGHGEY LQQQQQQQQQ HGNGAAAAAA
60 70 80 90 100
QDTQPSPLAL LAATCSKIGP PSPGDDDEEA AVAAAAGVPA AAAGATGDLA
110 120 130 140 150
SAQLGGAPNR WEVLSATPTT IKDEAGNLVQ IPGAATSSGQ YVLPLQNLQN
160 170 180 190 200
QQIFSVAPGS DSSNGTVSNV QYQVIPQIQS TDAQQVQIGF TGSSDNGGIN
210 220 230 240 250
QENSQIQIIP GSNQTLLASG TPPANIQNLI PQTGQVQVQG VAIGGSSFPG
260 270 280 290 300
QTQVVANVPL GLPGNITFVP INSVDLDSLG LSGSSQTMTA GINADGHLIN
310 320 330 340 350
TGQAMDSSDN SERTGERVSP DVNETNADTD LFVPTSSSSQ LPVTIDSTGI
360 370 380 390 400
LQQNTNSLTT TSGQVHSSDL QGNYIQSPVS EETQAQNIQV STAQPVVQHL
410 420 430 440 450
QLQDSQQPTS QAQIVQGITP QTIHGVQASG QNISQQALQN LQLQLNPGTF
460 470 480 490 500
LIQAQTVTPS GQITWQTFQV QGVQNLQNLQ IQNTAAQQIT LTPVQTLTLG
510 520 530 540 550
QVAAGGALTS TPVSLSTGQL PNLQTVTVNS IDSTGIQLHP GENADSPADI
560 570 580 590 600
RIKEEEPDPE EWQLSGDSTL NTNDLTHLRV QVVDEEGDQQ HQEGKRLRRV
610 620 630 640 650
ACTCPNCKEG GGRGTNLGKK KQHICHIPGC GKVYGKTSHL RAHLRWHSGE
660 670 680 690 700
RPFICNWMFC GKRFTRSDEL QRHRRTHTGE KKFVCPECSK RFMRSDHLAK
710 720 730 740 750
HIKTHQNKKV IHSSSTVLAS VEAGRDDALI TAGGTTLILA NIQQGSVSGI
760 770 780
GTVNTSATSN QDILTNTEIP LQLVTVSGNE TME
Length:783
Mass (Da):82,362
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE45A00D566454D61
GO
Isoform 2 (identifier: O70494-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-95: Missing.

Show »
Length:739
Mass (Da):78,364
Checksum:i22CEB08B93A699B0
GO
Isoform 3 (identifier: O70494-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.
     65-94: CSKIGPPSPGDDDEEAAVAAAAGVPAAAAG → MKEDRAAIAGRRRRGRRSCAHDEKTAADKR

Note: No experimental confirmation available.
Show »
Length:719
Mass (Da):76,729
Checksum:i8B16F3B85E282654
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH27797 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE21310 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti231 – 233PQT → TRP in AAH27797 (PubMed:15489334).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0167821 – 64Missing in isoform 3. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_01678352 – 95Missing in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_01678465 – 94CSKIG…AAAAG → MKEDRAAIAGRRRRGRRSCA HDEKTAADKR in isoform 3. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK004607 mRNA Translation: BAC25090.1
AK132702 mRNA Translation: BAE21310.1 Different initiation.
AL844840 Genomic DNA No translation available.
BC027797 mRNA Translation: AAH27797.2 Different initiation.
BC079874 mRNA Translation: AAH79874.1
AF062567 mRNA Translation: AAC16322.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS16122.1 [O70494-1]

NCBI Reference Sequences

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RefSeqi
NP_001018052.1, NM_001018042.3 [O70494-1]
NP_001091895.1, NM_001098425.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.124328
Mm.446209
Mm.465887

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000066003; ENSMUSP00000065807; ENSMUSG00000027109 [O70494-2]
ENSMUST00000102689; ENSMUSP00000099750; ENSMUSG00000027109 [O70494-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
20687

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:20687

UCSC genome browser

More...
UCSCi
uc008kca.2 mouse [O70494-1]
uc008kcb.2 mouse [O70494-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004607 mRNA Translation: BAC25090.1
AK132702 mRNA Translation: BAE21310.1 Different initiation.
AL844840 Genomic DNA No translation available.
BC027797 mRNA Translation: AAH27797.2 Different initiation.
BC079874 mRNA Translation: AAH79874.1
AF062567 mRNA Translation: AAC16322.1
CCDSiCCDS16122.1 [O70494-1]
RefSeqiNP_001018052.1, NM_001018042.3 [O70494-1]
NP_001091895.1, NM_001098425.1
UniGeneiMm.124328
Mm.446209
Mm.465887

3D structure databases

ProteinModelPortaliO70494
SMRiO70494
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203418, 7 interactors
IntActiO70494, 1 interactor
STRINGi10090.ENSMUSP00000099750

PTM databases

iPTMnetiO70494
PhosphoSitePlusiO70494

Proteomic databases

MaxQBiO70494
PaxDbiO70494
PeptideAtlasiO70494
PRIDEiO70494

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066003; ENSMUSP00000065807; ENSMUSG00000027109 [O70494-2]
ENSMUST00000102689; ENSMUSP00000099750; ENSMUSG00000027109 [O70494-1]
GeneIDi20687
KEGGimmu:20687
UCSCiuc008kca.2 mouse [O70494-1]
uc008kcb.2 mouse [O70494-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6670
MGIiMGI:1277166 Sp3

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000155099
HOGENOMiHOG000234295
HOVERGENiHBG008933
InParanoidiO70494
KOiK09193
OMAiIAQQTIH
OrthoDBi1085860at2759
PhylomeDBiO70494
TreeFamiTF350150

Enzyme and pathway databases

ReactomeiR-MMU-3232118 SUMOylation of transcription factors

Miscellaneous databases

Protein Ontology

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PROi
PR:O70494

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000027109 Expressed in 301 organ(s), highest expression level in indifferent gonad
CleanExiMM_SP3
GenevisibleiO70494 MM

Family and domain databases

InterProiView protein in InterPro
IPR030452 SP3
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR23235:SF3 PTHR23235:SF3, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSP3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O70494
Secondary accession number(s): A2AQK9
, Q68FF2, Q8CF64, Q8K378
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: January 10, 2006
Last modified: January 16, 2019
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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