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Entry version 103 (13 Feb 2019)
Sequence version 1 (01 Aug 1998)
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Protein

Receptor for retinol uptake STRA6

Gene

Stra6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as retinol transporter (PubMed:23839944, PubMed:24852372). Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (By similarity). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:23839944). Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid and 11-cis-retinal (PubMed:22467576, PubMed:24852372). STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (PubMed:22467576, PubMed:23839944, PubMed:24852372). Does not transport retinoic acid (By similarity).By similarity4 Publications

Miscellaneous

The retinoic acid-induced activation is impaired in retinoic acid receptor gamma-null F9 cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processTransport
LigandRetinol-binding, Vitamin A

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.90.1.2 the vitamin a receptor/transporter (stra6) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor for retinol uptake STRA6
Alternative name(s):
Retinoic acid-responsive protein
Retinol-binding protein receptor STRA6
Stimulated by retinoic acid gene 6 protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Stra6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107742 Stra6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 50ExtracellularBy similarityAdd BLAST50
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei51 – 71HelicalBy similarityAdd BLAST21
Topological domaini72 – 97CytoplasmicBy similarityAdd BLAST26
Transmembranei98 – 118HelicalBy similarityAdd BLAST21
Topological domaini119 – 144ExtracellularBy similarityAdd BLAST26
Transmembranei145 – 165HelicalBy similarityAdd BLAST21
Topological domaini166 – 168CytoplasmicBy similarity3
Transmembranei169 – 189HelicalBy similarityAdd BLAST21
Topological domaini190 – 205ExtracellularBy similarityAdd BLAST16
Transmembranei206 – 226HelicalBy similarityAdd BLAST21
Topological domaini227 – 296CytoplasmicBy similarityAdd BLAST70
Transmembranei297 – 317HelicalBy similarityAdd BLAST21
Topological domaini318 – 368ExtracellularBy similarityAdd BLAST51
Transmembranei369 – 389HelicalBy similarityAdd BLAST21
Topological domaini390 – 423CytoplasmicBy similarityAdd BLAST34
Transmembranei424 – 444HelicalBy similarityAdd BLAST21
Topological domaini445 – 474ExtracellularBy similarityAdd BLAST30
Transmembranei475 – 495HelicalBy similarityAdd BLAST21
Topological domaini496 – 510CytoplasmicBy similarityAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei511 – 548HelicalBy similarityAdd BLAST38
Topological domaini549 – 670CytoplasmicBy similarityAdd BLAST122

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype at birth (PubMed:22467576, PubMed:23839944, PubMed:24852372). Measurement of the eye diameter indicates a tendency towards slightly smaller eye diameter 6 weeks after birth, and this difference persists in 5 and 10 month old animals (PubMed:22467576). The retina inner and outer segments are shorter in mutant mice (PubMed:22467576, PubMed:24852372). The number of cone cells in the retina is reduced, giving rise to a reduced cone response to light stimulation (PubMed:22467576). The retinal pigment epithelium displays discolored regions, where cells have large vacuoles and a reduced melanin content (PubMed:24852372). Retina and retinal pigment epithelium from dark-adapted mutant mice display strongly reduced levels of all-trans-retinol, all-trans-retinyl palmitate, 11-cis-retinal, 11-cis-retinyl palmitate and all-trans-retinal (PubMed:22467576, PubMed:24852372). Electroretinograms (ERG) of dark-adapted retinas from mutant mice display reduced a- and b-wave amplitude in response to light (PubMed:22467576). In another knockout model, the electroretinogram shows a complete lack of response to light (PubMed:24852372). Dietary vitamin A supplements can alleviate the ocular retinoid deficiency, and can prevent the altered retinal responses to light observed in mutant mice (PubMed:24852372). Other tissues and organs (brain, heart, kidney, liver, lungs, muscle, pancreas, spleen, testis and white adipose tissue) display grossly normal retinoid levels in 12 week old mice kept on normal chow (PubMed:23839944). Embryonic development appears grossly normal, also when females are fed a vitamin A-deficient diet (PubMed:23839944). Embryonic eye development is altered, leading to persistent hyperplastic primary vitreous that forms a conical mass of cells between the optic nerve exit point and the lens in the eyes of mutant mice (PubMed:22467576). In contrast, persistent hyperplastic primary vitreous was not observed in another knockout experiment (PubMed:24852372).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003112291 – 670Receptor for retinol uptake STRA6Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei644PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues in response to RBP4 binding (PubMed:21368206). Phosphorylation requires the presence of LRAT, suggesting it may be triggered by the uptake of retinol that is then metabolized within the cell to retinoids that function as signaling molecules (By similarity).By similarity1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
O70491

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O70491

PeptideAtlas

More...
PeptideAtlasi
O70491

PRoteomics IDEntifications database

More...
PRIDEi
O70491

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O70491

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O70491

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in the embryo (PubMed:9203140, PubMed:23839944). Detected in adult in the retinal pigment epithelium in the eye (PubMed:9203140, PubMed:22467576, PubMed:23839944, PubMed:24852372). In the adult, is highly expressed in cells that compose blood-organ barriers in the brain (choroid plexus and the brain microvascular), in testis (the basal layer of the seminiferous epithelium), in the yolk sac, and in the chorioallantoic placenta (PubMed:9203140, PubMed:23839944). Detected in white adipose tissue and skeletal muscle, but not in liver (at protein level) (PubMed:21368206). Widely expressed in adult, with high expression levels in the eye (PubMed:24852372). Detected in brain, cerebellum, testis, pituitary, pancreas, kidney, spleen, and female genital tract; and at very low levels in heart and lung (PubMed:9203140, PubMed:24852372). Not detected in liver (PubMed:9203140).5 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During embryogenesis, strongly expressed in the periocular mesenchyme, in the developing eyes, in respiratory mesenchymes, and in respiratory and bronchial epithelium, as well as in the developing central nervous system and in different embryonic gut derivatives (the epithelium of the pharyngeal pouches, mesenchyme of the esophagus, stomach, intestine, and rectum). In Sertoli cells expression depends on the stage of the spermatogenic cycle. During early placentation, is expressed in the yolk sac membrane and the chorionic plate. Expression was no longer detected in the yolk sac membrane during mid-late gestation, but was found in the labyrinthine zone of the chorioallantoic placenta. Expressed during early dorsoventral limb patterning and during endochondral ossification.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By retinoic acid. Synergistically up-regulated by Wnt1 and retinoids in mammary epithelial cells.4 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity). Interacts with JAK2 and STAT5. Interacts (via extracellular domains) with RBP4. Interacts (via cytoplasmic domains) with RBP1 (By similarity).By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000034880

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni235 – 294Interaction with RBP1By similarityAdd BLAST60

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contrary to predictions, contains nine transmembrane helices, with an extracellular N-terminus and a cytoplasmic C-terminus (By similarity). Besides, contains one long helix that dips into the membrane and then runs more or less parallel to the membrane surface (By similarity).By similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IDYH Eukaryota
ENOG410YGRH LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000154441

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG106311

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O70491

Database of Orthologous Groups

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OrthoDBi
325169at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O70491

TreeFam database of animal gene trees

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TreeFami
TF331851

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026612 STRA6

The PANTHER Classification System

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PANTHERi
PTHR21444:SF16 PTHR21444:SF16, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

O70491-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESQASENGS QTSSGVTDDY SSWYIEEPLG AEEVQPEGVI PLCQLTAPPA
60 70 80 90 100
LLHACLASLS FLVLLLLALL VRRRRLWPRC GHRGLGLPSP VDFLAGDLSW
110 120 130 140 150
TVPAAVFVVL FSNLCLLLPD ENPLPFLNLT AASSPDGEME TSRGPWKLLA
160 170 180 190 200
LLYYPALYYP LAACASAGHQ AAFLLGTVLS WAHFGVQVWQ KAECPQDPKI
210 220 230 240 250
YKHYSLLASL PLLLGLGFLS LWYPVQLVQS LRHRTGAGSQ GLQTSYSEKY
260 270 280 290 300
LRTLLCPKKL DSCSHPASKR SLLSRAWAFS HHSIYTPQPG FRLPLKLVIS
310 320 330 340 350
ATLTGTATYQ VALLLLVSVV PTVQKVRAGI NTDVSYLLAG FGIVLSEDRQ
360 370 380 390 400
EVVELVKHHL WTVEACYISA LVLSCASTFL LLIRSLRTHR ANLQALHRGA
410 420 430 440 450
ALDLDPPLQS IHPSRQAIVS WMSFCAYQTA FSCLGLLVQQ VIFFLGTTSL
460 470 480 490 500
AFLVFVPLLH GRNLLLLRSL ESTWPFWLTV ALAVILQNIA ANWIFLRTHH
510 520 530 540 550
GYPELTNRRM LCVATFLLFP INMLVGAIMA VWRVLISSLY NTVHLGQMDL
560 570 580 590 600
SLLPQRAASL DPGYHTYQNF LRIEASQSHP GVIAFCALLL HAPSPQPRPP
610 620 630 640 650
LAPQDSLRPA EEEEGMQLLQ TKDLMAKGAG HKGSQSRARW GLAYTLLHNP
660 670
SLQAFRKAAL TSAKANGTQP
Length:670
Mass (Da):73,775
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6ACE69F3EE16A4F7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J115A0A0R4J115_MOUSE
Receptor for retinol uptake STRA6
Stra6
670Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PZN4E9PZN4_MOUSE
Receptor for retinol uptake STRA6
Stra6
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q9S7E9Q9S7_MOUSE
Receptor for retinol uptake STRA6
Stra6
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YVZ1D3YVZ1_MOUSE
Receptor for retinol uptake STRA6
Stra6
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YUA2D3YUA2_MOUSE
Receptor for retinol uptake STRA6
Stra6
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q283E9Q283_MOUSE
Receptor for retinol uptake STRA6
Stra6
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q3G2E9Q3G2_MOUSE
Receptor for retinol uptake STRA6
Stra6
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QAQ2E9QAQ2_MOUSE
Receptor for retinol uptake STRA6
Stra6
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PZT7E9PZT7_MOUSE
Receptor for retinol uptake STRA6
Stra6
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YXW9D3YXW9_MOUSE
Receptor for retinol uptake STRA6
Stra6
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti234R → P in AAH75657 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF062476 mRNA Translation: AAC16016.1
BC075657 mRNA Translation: AAH75657.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS23236.1

NCBI Reference Sequences

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RefSeqi
NP_001155947.1, NM_001162475.1
NP_001155948.1, NM_001162476.1
NP_001155951.1, NM_001162479.1
NP_033317.2, NM_009291.2
XP_006511004.2, XM_006510941.3
XP_006511006.1, XM_006510943.3
XP_006511007.1, XM_006510944.3
XP_006511008.1, XM_006510945.3
XP_006511009.1, XM_006510946.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.10801

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
20897

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:20897

UCSC genome browser

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UCSCi
uc009pwi.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062476 mRNA Translation: AAC16016.1
BC075657 mRNA Translation: AAH75657.1
CCDSiCCDS23236.1
RefSeqiNP_001155947.1, NM_001162475.1
NP_001155948.1, NM_001162476.1
NP_001155951.1, NM_001162479.1
NP_033317.2, NM_009291.2
XP_006511004.2, XM_006510941.3
XP_006511006.1, XM_006510943.3
XP_006511007.1, XM_006510944.3
XP_006511008.1, XM_006510945.3
XP_006511009.1, XM_006510946.3
UniGeneiMm.10801

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034880

Protein family/group databases

TCDBi2.A.90.1.2 the vitamin a receptor/transporter (stra6) family

PTM databases

iPTMnetiO70491
PhosphoSitePlusiO70491

Proteomic databases

MaxQBiO70491
PaxDbiO70491
PeptideAtlasiO70491
PRIDEiO70491

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20897
KEGGimmu:20897
UCSCiuc009pwi.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64220
MGIiMGI:107742 Stra6

Phylogenomic databases

eggNOGiENOG410IDYH Eukaryota
ENOG410YGRH LUCA
HOGENOMiHOG000154441
HOVERGENiHBG106311
InParanoidiO70491
OrthoDBi325169at2759
PhylomeDBiO70491
TreeFamiTF331851

Miscellaneous databases

Protein Ontology

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PROi
PR:O70491

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR026612 STRA6
PANTHERiPTHR21444:SF16 PTHR21444:SF16, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTRA6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O70491
Secondary accession number(s): Q6DIA8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 1, 1998
Last modified: February 13, 2019
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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