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UniProtKB - O70481 (UBR1_MOUSE)

Entry version 152 (02 Dec 2020)
Sequence version 2 (27 Jul 2011)
Previous versions | rss
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Protein

E3 ubiquitin-protein ligase UBR1

Gene

Ubr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity).By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri97 – 168UBR-typePROSITE-ProRule annotationAdd BLAST72
Zinc fingeri1101 – 1204RING-type; atypicalAdd BLAST104

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase UBR1 (EC:2.3.2.27)
Alternative name(s):
N-recognin-1
RING-type E3 ubiquitin transferase UBR1
Ubiquitin-protein ligase E3-alpha-1
Ubiquitin-protein ligase E3-alpha-I
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ubr1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1277977, Ubr1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable and fertile, but show a decreased mass of skeletal muscle and adipose tissue. They have exocrine pancreatic insufficiency with impaired stimulus-secretion coupling and increased susceptibiliy to pancreatic injury. UBR1 and UBR2 double knockout embryos die at midgestation, with defects in neurogenesis and cardiovascular development. These defects included reduced proliferation as well as precocious migration and differentiation of neural progenitor cells.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000561372 – 1757E3 ubiquitin-protein ligase UBR1Add BLAST1756

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei1182PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O70481

MaxQB - The MaxQuant DataBase

More...MaxQBi		O70481

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O70481

PeptideAtlas

More...PeptideAtlasi		O70481

PRoteomics IDEntifications database

More...PRIDEi		O70481

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O70481

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O70481

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in skeletal muscle and liver (at protein level). Broadly expressed, with highest levels in skeletal muscle and heart. Expressed in acinar cells of the pancreas. In testes, expressed primarily in spermatogonia.5 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in limb buds at 9.5-11.5 dpc.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In models of cancer cachexia, induced in muscle during the progression of wasting.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000027272, Expressed in cumulus cell and 288 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O70481, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RECQL4.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		204422, 8 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		O70481

Protein interaction database and analysis system

More...IntActi		O70481, 2 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000028728

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O70481, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O70481

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi864 – 869Poly-Pro6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.
The UBR-type zinc finger forms a pocket that mediates recognition of type 1 N-degrons. It exhibits preference for Arginine in first position, has poor affinity for histidine, and doesn't bind acetylated peptides (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UBR1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri97 – 168UBR-typePROSITE-ProRule annotationAdd BLAST72
Zinc fingeri1101 – 1204RING-type; atypicalAdd BLAST104

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1140, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183075

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001801_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O70481

Identification of Orthologs from Complete Genome Data

More...OMAi		AEMLVVC

Database of Orthologous Groups

More...OrthoDBi		81415at2759

TreeFam database of animal gene trees

More...TreeFami		TF323875

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003769, ClpS_core
IPR044046, E3_ligase_UBR-like_C
IPR014719, Ribosomal_L7/12_C/ClpS-like
IPR039164, UBR1-like
IPR036390, WH_DNA-bd_sf
IPR003126, Znf_UBR

The PANTHER Classification System

More...PANTHERi		PTHR21497, PTHR21497, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02617, ClpS, 1 hit
PF18995, PRT6_C, 1 hit
PF02207, zf-UBR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00396, ZnF_UBR1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785, SSF46785, 1 hit
SSF54736, SSF54736, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51157, ZF_UBR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O70481-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADEEMDGAE RMDVSPEPPL APQRPASWWD QQVDFYTAFL HHLAQLVPEI 
        60         70         80         90        100
YFAEMDPDLE KQEESVQMSI LTPLEWYLFG EDPDICLEKL KHSGAFQLCG 
       110        120        130        140        150
KVFKSGETTY SCRDCAIDPT CVLCMDCFQS SVHKNHRYKM HTSTGGGFCD 
       160        170        180        190        200
CGDTEAWKTG PFCVDHEPGR AGTTKESLHC PLNEEVIAQA RRIFPSVIKY 
       210        220        230        240        250
IVEMTIWEEE KELPPELQIR EKNERYYCVL FNDEHHSYDH VIYSLQRALD 
       260        270        280        290        300
CELAEAQLHT TAIDKEGRRA VKAGVYATCQ EAKEDIKSHS ENVSQHPLHV 
       310        320        330        340        350
EVLHSVVMAH QKFALRLGSW MNKIMSYSSD FRQIFCQACL VEEPGSENPC 
       360        370        380        390        400
LISRLMLWDA KLYKGARKIL HELIFSSFFM EMEYKKLFAM EFVKYYKQLQ 
       410        420        430        440        450
KEYISDDHER SISITALSVQ MLTVPTLARH LIEEQNVISV ITETLLEVLP 
       460        470        480        490        500
EYLDRNNKFN FQGYSQDKLG RVYAVICDLK YILISKPVIW TERLRAQFLE 
       510        520        530        540        550
GFRSFLKILT CMQGMEEIRR QVGQHIEVDP DWEAAIAIQM QLKNILLMFQ 
       560        570        580        590        600
EWCACDEDLL LVAYKECHKA VMRCSTNFMS STKTVVQLCG HSLETKSYKV 
       610        620        630        640        650
SEDLVSIHLP LSRTLAGLHV RLSRLGAISR LHEFVPFDGF QVEVLVEYPL 
       660        670        680        690        700
RCLVLVAQVV AEMWRRNGLS LISQVFYYQD VKCREEMYDK DIIMLQIGAS 
       710        720        730        740        750
IMDPNKFLLL VLQRYELTDA FNKTISTKDQ DLIKQYNTLI EEMLQVLIYI 
       760        770        780        790        800
VGERYVPGVG NVTREEVIMR EITHLLCIEP MPHSAIARNL PENENNETGL 
       810        820        830        840        850
ENVINKVATF KKPGVSGHGV YELKDESLKD FNMYFYHYSK TQHSKAEHMQ 
       860        870        880        890        900
KKRRKQENKD EALPPPPPPE FCPAFSKVVN LLSCDVMMYI LRTIFERAVD 
       910        920        930        940        950
MESNLWTEGM LQMAFHILAL GLLEEKQQLQ KAPEEEVAFD FYHKASRLGS 
       960        970        980        990       1000
SAMNAQNIQM LLEKLKGIPQ LESQKDMITW ILQMFDTVKR LREKSCLVVA 
      1010       1020       1030       1040       1050
TTSGLECVKS EEITHDKEKA ERKRKAEAAR LHRQKIMAQM SALQKNFIET 
      1060       1070       1080       1090       1100
HKLMYDNTSE VTGKEDSIME EESTSAVSEA SRIALGPKRG PAVTEKEVLT 
      1110       1120       1130       1140       1150
CILCQEEQEV KLENNAMVLS ACVQKSTALT QHRGKPVDHL GETLDPLFMD 
      1160       1170       1180       1190       1200
PDLAHGTYTG SCGHVMHAVC WQKYFEAVQL SSQQRIHVDL FDLESGEYLC 
      1210       1220       1230       1240       1250
PLCKSLCNTV IPIIPLQPQK INSENAEALA QLLTLARWIQ TVLARISGYN 
      1260       1270       1280       1290       1300
IKHAKGEAPA VPVLFNQGMG DSTFEFHSIL SFGVQSSVKY SNSIKEMVIL 
      1310       1320       1330       1340       1350
FATTIYRIGL KVPPDELDPR VPMMTWSTCA FTIQAIENLL GDEGKPLFGA 
      1360       1370       1380       1390       1400
LQNRQHNGLK ALMQFAVAQR TTCPQVLIHK HLARLLSVIL PNLQSENTPG 
      1410       1420       1430       1440       1450
LLSVDLFHVL VGAVLAFPSL YWDDTVDLQP SPLSSSYNHL YLFHLITMAH 
      1460       1470       1480       1490       1500
MLQILLTTDT DLSSGPPLAE GEEDSEEARC ASAFFVEVSQ HTDGLAGCGA 
      1510       1520       1530       1540       1550
PGWYLWLSLR NGITPYLRCA ALLFHYLLGV APPEELFANS AEGEFSALCS 
      1560       1570       1580       1590       1600
YLSLPTNLFL LFQEYWDTIR PLLQRWCGDP ALLKSLKQKS AVVRYPRKRN 
      1610       1620       1630       1640       1650
SLIELPEDYS CLLNQASHFR CPRSADDERK HPVLCLFCGA ILCSQNICCQ 
      1660       1670       1680       1690       1700
EIVNGEEVGA CVFHALHCGA GVCIFLKIRE CRVVLVEGKA RGCAYPAPYL 
      1710       1720       1730       1740       1750
DEYGETDPGL KRGNPLHLSR ERYRKLHLVW QQHCIIEEIA RSQETNQMLF 

GFNWQLL
Length:1,757
Mass (Da):200,240
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i935C0531A5F25A66
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH90969 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti639G → S in AAC40165 (PubMed:9653112).Curated1
Sequence conflicti639G → S in BAC40933 (PubMed:16141072).Curated1
Sequence conflicti888M → I in AAC40165 (PubMed:9653112).Curated1
Sequence conflicti901M → T in AAC40165 (PubMed:9653112).Curated1
Sequence conflicti964K → R in AAC40165 (PubMed:9653112).Curated1
Sequence conflicti973S → G in AAC40165 (PubMed:9653112).Curated1
Sequence conflicti1008V → I in AAC40165 (PubMed:9653112).Curated1
Sequence conflicti1357N → S in AAC40165 (PubMed:9653112).Curated1
Sequence conflicti1371T → A in AAC40165 (PubMed:9653112).Curated1
Sequence conflicti1464S → P in AAC40165 (PubMed:9653112).Curated1
Sequence conflicti1496A → T in AAC40165 (PubMed:9653112).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF061555 mRNA Translation: AAC40165.1
AH006182 Genomic DNA Translation: AAC23678.1
AL844548 Genomic DNA No translation available.
AL935168 Genomic DNA No translation available.
AK078173 mRNA Translation: BAC37160.1
AK089616 mRNA Translation: BAC40933.1
BC090969 mRNA Translation: AAH90969.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS16628.1

Protein sequence database of the Protein Information Resource

More...PIRi		T14318

NCBI Reference Sequences

More...RefSeqi		NP_033487.2, NM_009461.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000028728; ENSMUSP00000028728; ENSMUSG00000027272

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22222

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:22222

UCSC genome browser

More...UCSCi		uc008lxb.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061555 mRNA Translation: AAC40165.1
AH006182 Genomic DNA Translation: AAC23678.1
AL844548 Genomic DNA No translation available.
AL935168 Genomic DNA No translation available.
AK078173 mRNA Translation: BAC37160.1
AK089616 mRNA Translation: BAC40933.1
BC090969 mRNA Translation: AAH90969.1 Sequence problems.
CCDSiCCDS16628.1
PIRiT14318
RefSeqiNP_033487.2, NM_009461.2

3D structure databases

SMRiO70481
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi204422, 8 interactors
ELMiO70481
IntActiO70481, 2 interactors
STRINGi10090.ENSMUSP00000028728

PTM databases

iPTMnetiO70481
PhosphoSitePlusiO70481

Proteomic databases

EPDiO70481
MaxQBiO70481
PaxDbiO70481
PeptideAtlasiO70481
PRIDEiO70481

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23750, 182 antibodies

Genome annotation databases

EnsembliENSMUST00000028728; ENSMUSP00000028728; ENSMUSG00000027272
GeneIDi22222
KEGGimmu:22222
UCSCiuc008lxb.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		197131
MGIiMGI:1277977, Ubr1

Phylogenomic databases

eggNOGiKOG1140, Eukaryota
GeneTreeiENSGT00950000183075
HOGENOMiCLU_001801_2_0_1
InParanoidiO70481
OMAiAEMLVVC
OrthoDBi81415at2759
TreeFamiTF323875

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		22222, 0 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ubr1, mouse

Protein Ontology

More...PROi		PR:O70481
RNActiO70481, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000027272, Expressed in cumulus cell and 288 other tissues
GenevisibleiO70481, MM

Family and domain databases

Gene3Di3.30.1390.10, 1 hit
InterProiView protein in InterPro
IPR003769, ClpS_core
IPR044046, E3_ligase_UBR-like_C
IPR014719, Ribosomal_L7/12_C/ClpS-like
IPR039164, UBR1-like
IPR036390, WH_DNA-bd_sf
IPR003126, Znf_UBR
PANTHERiPTHR21497, PTHR21497, 1 hit
PfamiView protein in Pfam
PF02617, ClpS, 1 hit
PF18995, PRT6_C, 1 hit
PF02207, zf-UBR, 1 hit
SMARTiView protein in SMART
SM00396, ZnF_UBR1, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
SSF54736, SSF54736, 1 hit
PROSITEiView protein in PROSITE
PS51157, ZF_UBR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBR1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O70481
Secondary accession number(s): A2AQ54
, Q5BKR8, Q792M3, Q8BN40, Q8C5K3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 27, 2011
Last modified: December 2, 2020
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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