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Protein

Homeobox protein PKNOX1

Gene

Pknox1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates transcription in the presence of PBX1A and HOXA1.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi259 – 321Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein PKNOX1
Alternative name(s):
PBX/knotted homeobox 1
Gene namesi
Name:Pknox1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1201409 Pknox1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492491 – 436Homeobox protein PKNOX1Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineCombined sources1
Modified residuei41PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO70477
MaxQBiO70477
PaxDbiO70477
PeptideAtlasiO70477
PRIDEiO70477

PTM databases

iPTMnetiO70477
PhosphoSitePlusiO70477

Expressioni

Gene expression databases

BgeeiENSMUSG00000006705 Expressed in 284 organ(s), highest expression level in rostral migratory stream
CleanExiMM_PKNOX1
GenevisibleiO70477 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202211, 11 interactors
STRINGi10090.ENSMUSP00000094966

Structurei

3D structure databases

ProteinModelPortaliO70477
SMRiO70477
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/MEIS homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00550000074260
HOGENOMiHOG000253922
HOVERGENiHBG055193
InParanoidiO70477
OMAiITAPVNM
OrthoDBiEOG091G09WJ
TreeFamiTF318093

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR032453 PKNOX/Meis_N
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
PF16493 Meis_PKNOX_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O70477-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMATQTLSID SYQDGQQMQV VTELKTEQDP NCSDPDAEGV SPPPIESQTP
60 70 80 90 100
MDADKQAIYR HPLFPLLALL FEKCEQSTQG SEGTTSASFD VDIENFVRKQ
110 120 130 140 150
EKDGKPFFCE DPETDNLMVK AIQVLRIHLL ELEKVNELCK DFCSRYIACL
160 170 180 190 200
KTKMNSETLL SGEPGSPYSP VQSQQIQSAI TGTLSPQGIV VPASALQQGN
210 220 230 240 250
VTMATVAGGT VYQPVTVVTP QGQVVTQALS PGTIRIQNSQ LQLQLNQDLS
260 270 280 290 300
ILHQEDGSSK NKRGVLPKHA TNVMRSWLFQ HIGHPYPTED EKKQIAAQTN
310 320 330 340 350
LTLLQVNNWF INARRRILQP MLDSSCSETP KTKKKPAQNR PVQRFWPDSL
360 370 380 390 400
ASGVAQATPS ELAMSEGAVV TITTPVNMNV DSLQSLSSDG ATLAVQQVMM
410 420 430
AGQSEDESVD STEDEGGALA PTHISGLVLE NSDSLQ
Length:436
Mass (Da):47,539
Last modified:July 27, 2011 - v3
Checksum:iAC549642781DFCA0
GO

Sequence cautioni

The sequence AAC15990 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251I → T in AAC15990 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061270 mRNA Translation: AAC15990.1 Different initiation.
AK131788 mRNA Translation: BAE20805.1
AK134000 mRNA Translation: BAE21975.1
BC052701 mRNA Translation: AAH52701.1
CCDSiCCDS28608.1
RefSeqiNP_057879.2, NM_016670.3
XP_006523917.1, XM_006523854.2
XP_006523918.1, XM_006523855.2
UniGeneiMm.259295

Genome annotation databases

EnsembliENSMUST00000097352; ENSMUSP00000094966; ENSMUSG00000006705
ENSMUST00000175806; ENSMUSP00000134852; ENSMUSG00000006705
ENSMUST00000176701; ENSMUSP00000135804; ENSMUSG00000006705
GeneIDi18771
KEGGimmu:18771
UCSCiuc008bvh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061270 mRNA Translation: AAC15990.1 Different initiation.
AK131788 mRNA Translation: BAE20805.1
AK134000 mRNA Translation: BAE21975.1
BC052701 mRNA Translation: AAH52701.1
CCDSiCCDS28608.1
RefSeqiNP_057879.2, NM_016670.3
XP_006523917.1, XM_006523854.2
XP_006523918.1, XM_006523855.2
UniGeneiMm.259295

3D structure databases

ProteinModelPortaliO70477
SMRiO70477
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202211, 11 interactors
STRINGi10090.ENSMUSP00000094966

PTM databases

iPTMnetiO70477
PhosphoSitePlusiO70477

Proteomic databases

EPDiO70477
MaxQBiO70477
PaxDbiO70477
PeptideAtlasiO70477
PRIDEiO70477

Protocols and materials databases

DNASUi18771
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097352; ENSMUSP00000094966; ENSMUSG00000006705
ENSMUST00000175806; ENSMUSP00000134852; ENSMUSG00000006705
ENSMUST00000176701; ENSMUSP00000135804; ENSMUSG00000006705
GeneIDi18771
KEGGimmu:18771
UCSCiuc008bvh.2 mouse

Organism-specific databases

CTDi5316
MGIiMGI:1201409 Pknox1

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00550000074260
HOGENOMiHOG000253922
HOVERGENiHBG055193
InParanoidiO70477
OMAiITAPVNM
OrthoDBiEOG091G09WJ
TreeFamiTF318093

Miscellaneous databases

ChiTaRSiPknox1 mouse
PROiPR:O70477
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006705 Expressed in 284 organ(s), highest expression level in rostral migratory stream
CleanExiMM_PKNOX1
GenevisibleiO70477 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR032453 PKNOX/Meis_N
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
PF16493 Meis_PKNOX_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPKNX1_MOUSE
AccessioniPrimary (citable) accession number: O70477
Secondary accession number(s): Q7TT01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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