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Protein

UDP-glucose 6-dehydrogenase

Gene

Ugdh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.1 Publication

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.1 Publication

Activity regulationi

UDP-alpha-D-xylose (UDX) acts as a feedback inhibitor by activating an allosteric switch.By similarity

Pathwayi: UDP-alpha-D-glucuronate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-glucose 6-dehydrogenase (Ugdh)
This subpathway is part of the pathway UDP-alpha-D-glucuronate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose, the pathway UDP-alpha-D-glucuronate biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADBy similarity1
Binding sitei41NADBy similarity1
Binding sitei165NADBy similarity1
Binding sitei260SubstrateBy similarity1
Active sitei276NucleophileBy similarity1
Binding sitei346NADBy similarity1
Binding sitei442SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADBy similarity6
Nucleotide bindingi89 – 93NADBy similarity5
Nucleotide bindingi130 – 131NADBy similarity2
Nucleotide bindingi276 – 279NADBy similarity4

GO - Molecular functioni

  • NAD binding Source: InterPro
  • UDP-glucose 6-dehydrogenase activity Source: CACAO

GO - Biological processi

  • gastrulation with mouth forming second Source: MGI
  • glycosaminoglycan biosynthetic process Source: GO_Central
  • UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway

Keywordsi

Molecular functionAllosteric enzyme, Oxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-MMU-173599 Formation of the active cofactor, UDP-glucuronate
UniPathwayi
UPA00038;UER00491

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Gene namesi
Name:Ugdh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1306785 Ugdh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740611 – 493UDP-glucose 6-dehydrogenaseAdd BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei107N6-acetyllysineCombined sources1
Modified residuei474PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO70475
PaxDbiO70475
PeptideAtlasiO70475
PRIDEiO70475

PTM databases

iPTMnetiO70475
PhosphoSitePlusiO70475
SwissPalmiO70475

Expressioni

Gene expression databases

BgeeiENSMUSG00000029201 Expressed in 301 organ(s), highest expression level in stomach
CleanExiMM_UGDH
ExpressionAtlasiO70475 baseline and differential
GenevisibleiO70475 MM

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

BioGridi204433, 3 interactors
IntActiO70475, 3 interactors
MINTiO70475
STRINGi10090.ENSMUSP00000031103

Structurei

3D structure databases

ProteinModelPortaliO70475
SMRiO70475
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni161 – 165Substrate bindingBy similarity5
Regioni220 – 224Substrate bindingBy similarity5
Regioni267 – 273Substrate bindingBy similarity7
Regioni338 – 339Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2666 Eukaryota
COG1004 LUCA
GeneTreeiENSGT00390000015355
HOGENOMiHOG000153773
HOVERGENiHBG003512
InParanoidiO70475
KOiK00012
OMAiRIITTNT
OrthoDBiEOG091G05RK
PhylomeDBiO70475
TreeFamiTF105671

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028356 UDPglc_DH_euk
PANTHERiPTHR11374 PTHR11374, 1 hit
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500133 UDPglc_DH_euk, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O70475-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVEIKKICCI GAGYVGGPTC SVIAHMCPEI RVTVVDVNEA RINAWNSPTL
60 70 80 90 100
PIYEPGLKEV VESCRGKNLF FSTNIDDAIR EADLVFISVN TPTKTYGMGK
110 120 130 140 150
GRAADLKYIE ACARRIVQNS NGYKIVTEKS TVPVRAAESI RRIFDANTKP
160 170 180 190 200
NLNLQVLSNP EFLAEGTAIK DLKNPDRVLI GGDETPEGQK AVRALCAVYE
210 220 230 240 250
HWVPKEKILT TNTWSSELSK LAANAFLAQR ISSINSISAL CEATGADVEE
260 270 280 290 300
VATAIGMDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW
310 320 330 340 350
QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS
360 370 380 390 400
IYISKYLMDE GAHLHIYDPK VPREQIVVDL SHPGVSADDQ VSRLVTISKD
410 420 430 440 450
PYEACDGAHA LVICTEWDMF KELDYERIHK KMLKPAFIFD GRRVLDGLHS
460 470 480 490
ELQTIGFQIE TIGKKVSSKR IPYTPGEIPK FSLQDPPNKK PKV
Length:493
Mass (Da):54,832
Last modified:August 1, 1998 - v1
Checksum:iC6234F3C1D7480C7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YXP9D3YXP9_MOUSE
UDP-glucose 6-dehydrogenase
Ugdh
156Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061017 mRNA Translation: AAC36096.1
BC006749 mRNA Translation: AAH06749.1
CCDSiCCDS19308.1
RefSeqiNP_033492.1, NM_009466.2
XP_006503925.1, XM_006503862.3
UniGeneiMm.344831

Genome annotation databases

EnsembliENSMUST00000031103; ENSMUSP00000031103; ENSMUSG00000029201
GeneIDi22235
KEGGimmu:22235
UCSCiuc008xns.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061017 mRNA Translation: AAC36096.1
BC006749 mRNA Translation: AAH06749.1
CCDSiCCDS19308.1
RefSeqiNP_033492.1, NM_009466.2
XP_006503925.1, XM_006503862.3
UniGeneiMm.344831

3D structure databases

ProteinModelPortaliO70475
SMRiO70475
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204433, 3 interactors
IntActiO70475, 3 interactors
MINTiO70475
STRINGi10090.ENSMUSP00000031103

PTM databases

iPTMnetiO70475
PhosphoSitePlusiO70475
SwissPalmiO70475

Proteomic databases

EPDiO70475
PaxDbiO70475
PeptideAtlasiO70475
PRIDEiO70475

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031103; ENSMUSP00000031103; ENSMUSG00000029201
GeneIDi22235
KEGGimmu:22235
UCSCiuc008xns.1 mouse

Organism-specific databases

CTDi7358
MGIiMGI:1306785 Ugdh

Phylogenomic databases

eggNOGiKOG2666 Eukaryota
COG1004 LUCA
GeneTreeiENSGT00390000015355
HOGENOMiHOG000153773
HOVERGENiHBG003512
InParanoidiO70475
KOiK00012
OMAiRIITTNT
OrthoDBiEOG091G05RK
PhylomeDBiO70475
TreeFamiTF105671

Enzyme and pathway databases

UniPathwayi
UPA00038;UER00491

ReactomeiR-MMU-173599 Formation of the active cofactor, UDP-glucuronate

Miscellaneous databases

ChiTaRSiUgdh mouse
PROiPR:O70475
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029201 Expressed in 301 organ(s), highest expression level in stomach
CleanExiMM_UGDH
ExpressionAtlasiO70475 baseline and differential
GenevisibleiO70475 MM

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028356 UDPglc_DH_euk
PANTHERiPTHR11374 PTHR11374, 1 hit
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500133 UDPglc_DH_euk, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUGDH_MOUSE
AccessioniPrimary (citable) accession number: O70475
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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