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Protein

Transmembrane protein 131

Gene

Tmem131

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in the immune response to viral infection.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 131
Alternative name(s):
Protein RW1
Gene namesi
Name:Tmem131
Synonyms:D1Bwg0491e, Kiaa0257, Rw1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1927110 Tmem131

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1089 – 1109HelicalSequence analysisAdd BLAST21
Transmembranei1116 – 1136HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000975391 – 1877Transmembrane protein 131Add BLAST1877

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1318PhosphoserineBy similarity1
Modified residuei1338PhosphoserineBy similarity1
Modified residuei1371PhosphoserineBy similarity1
Modified residuei1857PhosphoserineBy similarity1
Modified residuei1865PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO70472
MaxQBiO70472
PaxDbiO70472
PeptideAtlasiO70472
PRIDEiO70472

PTM databases

iPTMnetiO70472
PhosphoSitePlusiO70472

Expressioni

Gene expression databases

BgeeiENSMUSG00000026116 Expressed in 271 organ(s), highest expression level in pancreas
CleanExiMM_TMEM131
ExpressionAtlasiO70472 baseline and differential
GenevisibleiO70472 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027290

Structurei

3D structure databases

SMRiO70472
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 61Ala-richAdd BLAST57
Compositional biasi1302 – 1328Pro-richAdd BLAST27
Compositional biasi1613 – 1824Ser-richAdd BLAST212

Sequence similaritiesi

Belongs to the TMEM131 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3620 Eukaryota
ENOG410Z7NH LUCA
GeneTreeiENSGT00530000063614
HOGENOMiHOG000168804
HOVERGENiHBG017768
InParanoidiO70472
OMAiLEFQVFR
OrthoDBiEOG091G0HKE
PhylomeDBiO70472
TreeFamiTF321435

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR039877 TMEM131-like
IPR022113 TMEM131-like_dom
PANTHERiPTHR22050 PTHR22050, 1 hit
PfamiView protein in Pfam
PF12371 TMEM131_like, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O70472-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKRAGGAAA AAAAASTSSA AGLEPAAGRG GGPRSAAAGL LGALHLVMTL
60 70 80 90 100
VVAAARAEKE AFIQSESIIE VLRFDDGGLL QTETTLGLGS YQQKSISLYR
110 120 130 140 150
GNCRPIRFEP PMLDFHEQPV GMPKMEKVYL HNPSSEETIT LVSISATTSH
160 170 180 190 200
FHASFFQNRK ILPGGNTSFD VVFLARVVGN VENTLFINTS NHGVFTYQVF
210 220 230 240 250
GVGVPNPYRL RPFLGARVPV NSSFSPIINI HNPHSEPLQV VEMYSSGGDL
260 270 280 290 300
HLELPTGQQG GTRKLWEIPP YETKGVMRAS FSSREADNHT AFIRIKTNAS
310 320 330 340 350
DSTEFIILPV EVEVTTAPGI YSSTEMLDFG TLRTQDLPKV LNLHLLNSGT
360 370 380 390 400
KDVPITSVRP TPQNDAITVH FKPVTLKASE SKYTKVASIS FDASRAKKPS
410 420 430 440 450
QFSGKITVKA KEKSYSKLEI PYQAEVLDGY LGFDHAATLF HIQDSPADPV
460 470 480 490 500
ERPIYLTNTF SFAILIHDVL LPEEARIMFQ VHNFSQPVLI LPNESGYIFT
510 520 530 540 550
LFFMPSTSSM HIDNNILLVT NASKFHLPVR VYTGFLDYFV LPPKIEERFI
560 570 580 590 600
DFGVLSATEA SSILFAIINS NPIELAIKSW HIIGDGLSIE LVATERGNRS
610 620 630 640 650
TVIASLPELE RSSLPDQSPV TLASGHFAVF RVKLTAKKLE GVHDGAIQIT
660 670 680 690 700
TDYEILTIPV KAVIAVGSLT CFPKHMVLPP SFPGKIVHQS LNIMNSFSQK
710 720 730 740 750
VKIQQIRSLS EDVRFYYKRL RGNREDLEPG KKSKIANIYF DPGLQCGDHC
760 770 780 790 800
YIGLPFLSKS EPKVQPGVAM QEDLWDADWD AHQSLFKAWM GIKENAGHRL
810 820 830 840 850
NAMFEVNTDL QKNIVSKVSA ELSWPSVLSS PRLLKFPLTN TNCSSEEEIS
860 870 880 890 900
LENPADVPVY VQFIPLALYS NPSVFADKLV SRFNLSKVAK LDLRTLEFQV
910 920 930 940 950
YRNSAHPLQS PTGFTEGLSR HFILNLILKP GEKKSVKVKF TPLHNRTVSS
960 970 980 990 1000
LIIVRNNLTV MDAVMVQGQG TTENLRVAGK LPGPGSSLRF KITEALLKDC
1010 1020 1030 1040 1050
IDRLKLREPN FTLKRTFKVE NTGQLEIRVE TIEISGYACE GYGFKVVNCQ
1060 1070 1080 1090 1100
EFALSANASR DIVILFTPDF TASRVIRELK FVTSSGSEFV FVLNASLPYH
1110 1120 1130 1140 1150
MLAACAEALP RPNWELALYI IISGVMSALF LLVIGTAYLE AQGIWEPFRR
1160 1170 1180 1190 1200
RLSFEASNPP FDVGRPFDLR RIVGISSEGN LNTLGCEHSH GRGFYSNASS
1210 1220 1230 1240 1250
RPGTGSHRQC GTSVHPHSSH GSKNSADVDN VRTRNSSSMS SRTSPQAAAS
1260 1270 1280 1290 1300
QSTSKTSPLV SETAAATQGH TASRKSRGAK QGQHSSQHHS HSHSPLEQHS
1310 1320 1330 1340 1350
QPPPPVPQHQ EPPPERLSPA PLTHPSHPER ASTTRHSSED SDITSLIEAM
1360 1370 1380 1390 1400
DKDFDHHDSS PLDVFTEQPP SPMSKSKGKG KSLQQRKAKP PKKQEEKEKR
1410 1420 1430 1440 1450
GKGKPQEDEL KDALADDDSS STTTETSNPD TEPLLREDTE KHKGRPAVPE
1460 1470 1480 1490 1500
KQESELSQGK PKSKKLLNAK KEIPTDVKGS SFELPYTPSL ENKQRRNLPT
1510 1520 1530 1540 1550
KIPLPTTLAS GSKSRNPPKT KGTNKLVENR PVALSKFLPS SQELGNTSSS
1560 1570 1580 1590 1600
EGEKDSPPPE WDAVPVHKPS SSTDSLYKLS LQTLNADIFL KQRQTSPTPA
1610 1620 1630 1640 1650
SPSLPTAPCP FTSRGSYSSV VNSSGSDTKA KQTSSSKSKL TKAASLPGKN
1660 1670 1680 1690 1700
GNPTFAAVAA GYDKSPGGNG FAKISSNKSD FSSSLGISHI PVDSDGSDSS
1710 1720 1730 1740 1750
GLWSPVSNPN SPDFTPLNSF SAFGNSFNLT GAVFSKLSRS CSQSSQRSWN
1760 1770 1780 1790 1800
EFNSGPSYLW DSPATDPSPS WPASSSSPTH TATSILGNSS GLWSTTPFSS
1810 1820 1830 1840 1850
SIWSSNINSN LPFSTPTNAL SSISLMGTEN SAAAHTPSAS GPADDLGQTY
1860 1870
NPWRIWSPTV GRRSSDPWSN SHFPHEN
Length:1,877
Mass (Da):204,651
Last modified:April 5, 2011 - v2
Checksum:iDADE201489DEF45B
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YW65A0A0A6YW65_MOUSE
Transmembrane protein 131
Tmem131
61Annotation score:
A0A087WQG5A0A087WQG5_MOUSE
Transmembrane protein 131
Tmem131
171Annotation score:
A0A087WRG7A0A087WRG7_MOUSE
Transmembrane protein 131
Tmem131
146Annotation score:
A0A0A6YXP8A0A0A6YXP8_MOUSE
Transmembrane protein 131
Tmem131
56Annotation score:

Sequence cautioni

The sequence AAC15232 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti488V → A in AAC15232 (PubMed:10996388).Curated1
Sequence conflicti750C → R in AAC15232 (PubMed:10996388).Curated1
Sequence conflicti776D → N in AAC15232 (PubMed:10996388).Curated1
Sequence conflicti935S → F in BAC41405 (Ref. 3) Curated1
Sequence conflicti1790S → R in BAC41405 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084389 Genomic DNA No translation available.
AC123854 Genomic DNA No translation available.
AF060565 mRNA Translation: AAC15232.1 Sequence problems.
AB093221 mRNA Translation: BAC41405.1
CCDSiCCDS35538.1
PIRiT14280
RefSeqiNP_061360.2, NM_018872.2
UniGeneiMm.186943

Genome annotation databases

EnsembliENSMUST00000027290; ENSMUSP00000027290; ENSMUSG00000026116
ENSMUST00000194563; ENSMUSP00000142307; ENSMUSG00000026116
GeneIDi56030
KEGGimmu:56030
UCSCiuc007ard.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084389 Genomic DNA No translation available.
AC123854 Genomic DNA No translation available.
AF060565 mRNA Translation: AAC15232.1 Sequence problems.
AB093221 mRNA Translation: BAC41405.1
CCDSiCCDS35538.1
PIRiT14280
RefSeqiNP_061360.2, NM_018872.2
UniGeneiMm.186943

3D structure databases

SMRiO70472
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027290

PTM databases

iPTMnetiO70472
PhosphoSitePlusiO70472

Proteomic databases

EPDiO70472
MaxQBiO70472
PaxDbiO70472
PeptideAtlasiO70472
PRIDEiO70472

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027290; ENSMUSP00000027290; ENSMUSG00000026116
ENSMUST00000194563; ENSMUSP00000142307; ENSMUSG00000026116
GeneIDi56030
KEGGimmu:56030
UCSCiuc007ard.1 mouse

Organism-specific databases

CTDi23505
MGIiMGI:1927110 Tmem131
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3620 Eukaryota
ENOG410Z7NH LUCA
GeneTreeiENSGT00530000063614
HOGENOMiHOG000168804
HOVERGENiHBG017768
InParanoidiO70472
OMAiLEFQVFR
OrthoDBiEOG091G0HKE
PhylomeDBiO70472
TreeFamiTF321435

Miscellaneous databases

ChiTaRSiTmem131 mouse
PROiPR:O70472
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026116 Expressed in 271 organ(s), highest expression level in pancreas
CleanExiMM_TMEM131
ExpressionAtlasiO70472 baseline and differential
GenevisibleiO70472 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR039877 TMEM131-like
IPR022113 TMEM131-like_dom
PANTHERiPTHR22050 PTHR22050, 1 hit
PfamiView protein in Pfam
PF12371 TMEM131_like, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM131_MOUSE
AccessioniPrimary (citable) accession number: O70472
Secondary accession number(s): Q8CHH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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