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Protein

Oncostatin-M-specific receptor subunit beta

Gene

Osmr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with IL31RA to form the IL31 receptor (PubMed:9920829). Binds IL31 to activate STAT3 and possibly STAT1 and STAT5 (By similarity). Capable of transducing OSM-specific signaling events (By similarity).By similarity1 Publication

GO - Molecular functioni

  • cytokine binding Source: MGI
  • cytokine receptor activity Source: GO_Central
  • growth factor binding Source: MGI
  • oncostatin-M receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Oncostatin-M-specific receptor subunit beta
Alternative name(s):
Interleukin-31 receptor subunit beta
Short name:
IL-31 receptor subunit beta
Short name:
IL-31R subunit beta
Short name:
IL-31R-beta
Short name:
IL-31RB
Gene namesi
Name:Osmr
Synonyms:Osmrb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1330819 Osmr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 737ExtracellularSequence analysisAdd BLAST714
Transmembranei738 – 758HelicalSequence analysisAdd BLAST21
Topological domaini759 – 971CytoplasmicSequence analysisAdd BLAST213

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000025976024 – 971Oncostatin-M-specific receptor subunit betaAdd BLAST948

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi242 ↔ 252By similarity
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi541N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi577N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi689N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi722N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO70458
PaxDbiO70458
PeptideAtlasiO70458
PRIDEiO70458

PTM databases

iPTMnetiO70458
PhosphoSitePlusiO70458
SwissPalmiO70458

Expressioni

Tissue specificityi

Widely expressed (PubMed:9584176). Expressed at highest levels in the lung, heart, thymus and spleen (PubMed:9920829). Expressed in dorsal root ganglia (PubMed:25381841).3 Publications

Inductioni

Up-regulated by IL31 in dorsal root ganglia.1 Publication

Gene expression databases

CleanExiMM_OSMR

Interactioni

Subunit structurei

Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201984, 1 interactor
DIPiDIP-5787N
IntActiO70458, 1 interactor
MINTiO70458
STRINGi10090.ENSMUSP00000022746

Structurei

3D structure databases

ProteinModelPortaliO70458
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini332 – 425Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini427 – 523Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini524 – 620Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST97
Domaini622 – 733Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST112

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi412 – 416WSXWS motifBy similarity5
Motifi767 – 775Box 1 motifBy similarity9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.By similarity
The box 1 motif is required for JAK interaction and/or activation.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFCQ Eukaryota
ENOG410Y9XY LUCA
HOVERGENiHBG082088
InParanoidiO70458
KOiK05057
PhylomeDBiO70458

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003529 Hematopoietin_rcpt_Gp130_CS
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SUPFAMiSSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS01353 HEMATOPO_REC_L_F2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O70458-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFSVVLHPA FLLAVLSLRA SRSEVLEEPL PLTPEIHKVS FQLKLQEVNL
60 70 80 90 100
EWTVPALTHE ELNMIFQIEI SRLNISNTIW VENYSTTVKR EEAVRWNWTS
110 120 130 140 150
DIPLECVKHF IRIRALVDDT KSLPQSSWGN WSSWKEVNAK VSVEPDKSLI
160 170 180 190 200
FPKDKVLEEG SNVTICLMYG QNVYNVSCKL QDEPIHGEQL DSHVSLLKLN
210 220 230 240 250
NVVFLSDTGT NINCQATKGP KRIFGTVLFV SKVLEEPKNV SCETRDFKTL
260 270 280 290 300
DCSWEPGVDT TLTWRKQRFQ NYTLCESFSK RCEVSNYRNS YTWQITEGSQ
310 320 330 340 350
EMYNFTLTAE NQLRKRSVNI NFNLTHRVHP KAPQDVTLKI IGATKANMTW
360 370 380 390 400
KVHSHGNNYT LLCQVKLQYG EVIHEHNVSV HMSANYLFSD LDPDTKYKAF
410 420 430 440 450
VRCASANHFW KWSDWTQKEF STPETAPSQA LDVWRQVWSE NGRRIVTLFW
460 470 480 490 500
KPLLKSQANG KIISYNIVVE NEAKPTESEH YCVWAPALST NLSLDLQPYK
510 520 530 540 550
IRITTNNSMG ASPESLMVLS NDSGHEEVKE KTIKGIKDAF NISWEPVSGD
560 570 580 590 600
TMGYVVDWCA HSQDQRCDLQ WKNLGPNTTS TTITSDDFKP GVRYNFRIFE
610 620 630 640 650
RSVEHKARLV EKQRGYTQEL APLVNPKVEI PYSTPNSFVL RWPDYDSDFQ
660 670 680 690 700
AGFIKGYLVY VKSKEMQCNQ PWERTLLPDN SVLCKYDING SETKTLTVEN
710 720 730 740 750
LQPESLYEFF VTPYTSAGPG PNETFTKVTT PDARSHMLLQ IILPMTLCVL
760 770 780 790 800
LSIIVCYWKS QWVKEKCYPD IPNPYKSSIL SLIKSKKNPH LIMNVKDCIP
810 820 830 840 850
DVLEVINKAE GSKTQCVGSG KLHIEDVPTK PPIVPTEKDS SGPVPCIFFE
860 870 880 890 900
NFTYDQSAFD SGSHGLIPGP LKDTAHQLGL LAPPNKFQNV LKNDYMKPLV
910 920 930 940 950
ESPTEETSLI YVSQLASPMC GDKDTLATEP PVPVHGSEYK RQMVVPGSLA
960 970
SPSLKEDNSL TSTVLLGQGE Q
Length:971
Mass (Da):110,229
Last modified:August 1, 1998 - v1
Checksum:iBECAA85BBD47C1E7
GO
Isoform 2 (identifier: O70458-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     527-527: Missing.

Note: No experimental confirmation available.
Show »
Length:970
Mass (Da):110,100
Checksum:iCAD54A091AD24A82
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X8V6G3X8V6_MOUSE
Oncostatin M receptor, isoform CRA_...
Osmr mCG_5083
971Annotation score:
A0A0R4J268A0A0R4J268_MOUSE
Oncostatin-M-specific receptor subu...
Osmr
970Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti505T → A in BAA33725 (PubMed:9920829).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021530527Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058805 mRNA Translation: AAC40122.1
AB015978 mRNA Translation: BAA33725.1
CCDSiCCDS27368.1 [O70458-1]
CCDS79358.1 [O70458-2]
RefSeqiNP_001297398.1, NM_001310469.1
NP_035149.2, NM_011019.3
UniGeneiMm.10760

Genome annotation databases

GeneIDi18414
KEGGimmu:18414
UCSCiuc011zrc.1 mouse [O70458-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058805 mRNA Translation: AAC40122.1
AB015978 mRNA Translation: BAA33725.1
CCDSiCCDS27368.1 [O70458-1]
CCDS79358.1 [O70458-2]
RefSeqiNP_001297398.1, NM_001310469.1
NP_035149.2, NM_011019.3
UniGeneiMm.10760

3D structure databases

ProteinModelPortaliO70458
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201984, 1 interactor
DIPiDIP-5787N
IntActiO70458, 1 interactor
MINTiO70458
STRINGi10090.ENSMUSP00000022746

PTM databases

iPTMnetiO70458
PhosphoSitePlusiO70458
SwissPalmiO70458

Proteomic databases

MaxQBiO70458
PaxDbiO70458
PeptideAtlasiO70458
PRIDEiO70458

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi18414
KEGGimmu:18414
UCSCiuc011zrc.1 mouse [O70458-2]

Organism-specific databases

CTDi9180
MGIiMGI:1330819 Osmr

Phylogenomic databases

eggNOGiENOG410IFCQ Eukaryota
ENOG410Y9XY LUCA
HOVERGENiHBG082088
InParanoidiO70458
KOiK05057
PhylomeDBiO70458

Miscellaneous databases

ChiTaRSiOsmr mouse
PROiPR:O70458
SOURCEiSearch...

Gene expression databases

CleanExiMM_OSMR

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003529 Hematopoietin_rcpt_Gp130_CS
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SUPFAMiSSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS01353 HEMATOPO_REC_L_F2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOSMR_MOUSE
AccessioniPrimary (citable) accession number: O70458
Secondary accession number(s): O88821
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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