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Protein

Monocarboxylate transporter 2

Gene

Slc16a7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-433692 Proton-coupled monocarboxylate transport

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 2
Short name:
MCT 2
Alternative name(s):
Solute carrier family 16 member 7
Gene namesi
Name:Slc16a7
Synonyms:Mct2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1330284 Slc16a7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 60ExtracellularSequence analysisAdd BLAST23
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Topological domaini82 – 90CytoplasmicSequence analysis9
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 116ExtracellularSequence analysis5
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 149CytoplasmicSequence analysisAdd BLAST12
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 174ExtracellularSequence analysis4
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 245CytoplasmicSequence analysisAdd BLAST50
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 281ExtracellularSequence analysisAdd BLAST15
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Topological domaini303 – 311CytoplasmicSequence analysis9
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 337ExtracellularSequence analysis5
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Topological domaini359 – 372CytoplasmicSequence analysisAdd BLAST14
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 405ExtracellularSequence analysisAdd BLAST12
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 484CytoplasmicSequence analysisAdd BLAST58

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002113881 – 484Monocarboxylate transporter 2Add BLAST484

Proteomic databases

PaxDbiO70451
PRIDEiO70451

PTM databases

iPTMnetiO70451
PhosphoSitePlusiO70451

Expressioni

Tissue specificityi

Detected in testis and in spermatozoa (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000020102 Expressed in 219 organ(s), highest expression level in testis
ExpressionAtlasiO70451 baseline and differential
GenevisibleiO70451 MM

Interactioni

Subunit structurei

Interacts with GRID2IP. Interacts with BSG.2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065433

Structurei

3D structure databases

ProteinModelPortaliO70451
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMVS Eukaryota
ENOG4111F0K LUCA
GeneTreeiENSGT00760000118926
HOGENOMiHOG000280688
HOVERGENiHBG006384
InParanoidiO70451
KOiK08184
OMAiGMYTPFV
OrthoDBiEOG091G05SW
PhylomeDBiO70451
TreeFamiTF313792

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004743 MCT
IPR027178 MCT2
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF25 PTHR11360:SF25, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00892 2A0113, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O70451-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSEPSAPLP QPLPPDGGWG WVVVCASFIS IGFSYAFPKA VTVFFKDIQE
60 70 80 90 100
IFNTTSSQIA WISSIMLAVM YAGGPISSVL VNNYGSRPVV IVGGLLCCIG
110 120 130 140 150
MILASYSNSV IELYLTVGFI GGLGLAFNLQ PALTIIGKYF YRRRPLANGC
160 170 180 190 200
AMAGSPVFLS TLAPFNQYLF NNYGWKGSFL ILGGIFLHSC VAGCLMRPVG
210 220 230 240 250
PSPNTKKSKS KVGSRHDSTL KKASKVSTAQ KVNRFLDFSL FMHRGFLIYL
260 270 280 290 300
SGNVILFLGI FAPIIFLAQY AKHIGVDDYN SAFLLSVMAF IDMFARPSVG
310 320 330 340 350
LIANTSLIRP RIQYLFSSAI IFTGICHLLC PLATTYSALV VYVVFFGLGF
360 370 380 390 400
GSISSLLFEC LMDIVGATRF SSAVGLTTIV ECCPVLFGPP LAGKLLDITG
410 420 430 440 450
EYKYLYIASG TVVLVSGTYL LIGNAINYRL LDKERKREKA KKKKSASHAS
460 470 480
REMEALNRSK QDEVTVKASN AHNPPSDRDK ESNI
Length:484
Mass (Da):52,604
Last modified:August 1, 1998 - v1
Checksum:iA23B62BCA4C5DF5E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GSA7A0A1B0GSA7_MOUSE
Monocarboxylate transporter 2
Slc16a7
55Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058054 mRNA Translation: AAC13719.1
AK076612 mRNA Translation: BAC36415.1
CCDSiCCDS24218.1
RefSeqiNP_035521.1, NM_011391.1
XP_006513469.1, XM_006513406.3
XP_006513471.1, XM_006513408.3
XP_006513472.1, XM_006513409.3
XP_006513473.1, XM_006513410.3
XP_006513474.1, XM_006513411.1
XP_006513475.1, XM_006513412.3
XP_006513476.1, XM_006513413.3
XP_017169350.1, XM_017313861.1
UniGeneiMm.29161
Mm.455126
Mm.458462

Genome annotation databases

EnsembliENSMUST00000063318; ENSMUSP00000065433; ENSMUSG00000020102
ENSMUST00000105257; ENSMUSP00000100892; ENSMUSG00000020102
ENSMUST00000210780; ENSMUSP00000147560; ENSMUSG00000020102
ENSMUST00000211781; ENSMUSP00000147968; ENSMUSG00000020102
GeneIDi20503
KEGGimmu:20503
UCSCiuc007hgx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058054 mRNA Translation: AAC13719.1
AK076612 mRNA Translation: BAC36415.1
CCDSiCCDS24218.1
RefSeqiNP_035521.1, NM_011391.1
XP_006513469.1, XM_006513406.3
XP_006513471.1, XM_006513408.3
XP_006513472.1, XM_006513409.3
XP_006513473.1, XM_006513410.3
XP_006513474.1, XM_006513411.1
XP_006513475.1, XM_006513412.3
XP_006513476.1, XM_006513413.3
XP_017169350.1, XM_017313861.1
UniGeneiMm.29161
Mm.455126
Mm.458462

3D structure databases

ProteinModelPortaliO70451
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065433

PTM databases

iPTMnetiO70451
PhosphoSitePlusiO70451

Proteomic databases

PaxDbiO70451
PRIDEiO70451

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063318; ENSMUSP00000065433; ENSMUSG00000020102
ENSMUST00000105257; ENSMUSP00000100892; ENSMUSG00000020102
ENSMUST00000210780; ENSMUSP00000147560; ENSMUSG00000020102
ENSMUST00000211781; ENSMUSP00000147968; ENSMUSG00000020102
GeneIDi20503
KEGGimmu:20503
UCSCiuc007hgx.1 mouse

Organism-specific databases

CTDi9194
MGIiMGI:1330284 Slc16a7

Phylogenomic databases

eggNOGiENOG410IMVS Eukaryota
ENOG4111F0K LUCA
GeneTreeiENSGT00760000118926
HOGENOMiHOG000280688
HOVERGENiHBG006384
InParanoidiO70451
KOiK08184
OMAiGMYTPFV
OrthoDBiEOG091G05SW
PhylomeDBiO70451
TreeFamiTF313792

Enzyme and pathway databases

ReactomeiR-MMU-433692 Proton-coupled monocarboxylate transport

Miscellaneous databases

PROiPR:O70451
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020102 Expressed in 219 organ(s), highest expression level in testis
ExpressionAtlasiO70451 baseline and differential
GenevisibleiO70451 MM

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004743 MCT
IPR027178 MCT2
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF25 PTHR11360:SF25, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00892 2A0113, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOT2_MOUSE
AccessioniPrimary (citable) accession number: O70451
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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