UniProtKB - O70451 (MOT2_MOUSE)
Protein
Monocarboxylate transporter 2
Gene
Slc16a7
Organism
Mus musculus (Mouse)
Status
Functioni
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.1 Publication
GO - Molecular functioni
- lactate transmembrane transporter activity Source: UniProtKB
- monocarboxylic acid transmembrane transporter activity Source: GO_Central
- pyruvate transmembrane transporter activity Source: UniProtKB
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- lactate transmembrane transport Source: UniProtKB
- monocarboxylic acid transport Source: GO_Central
- plasma membrane lactate transport Source: MGI
- pyruvate transmembrane transport Source: UniProtKB
Keywordsi
Biological process | Symport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-433692 Proton-coupled monocarboxylate transport |
Names & Taxonomyi
Protein namesi | Recommended name: Monocarboxylate transporter 2Short name: MCT 2 Alternative name(s): Solute carrier family 16 member 7 |
Gene namesi | Name:Slc16a7 Synonyms:Mct2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1330284 Slc16a7 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- integral component of postsynaptic density membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: MGI
- glutamatergic synapse Source: MGI
- hippocampal mossy fiber to CA3 synapse Source: MGI
- parallel fiber to Purkinje cell synapse Source: MGI
- Schaffer collateral - CA1 synapse Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 16 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 17 – 37 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 38 – 60 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 61 – 81 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 82 – 90 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 91 – 111 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 112 – 116 | ExtracellularSequence analysis | 5 | |
Transmembranei | 117 – 137 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 138 – 149 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 150 – 170 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 171 – 174 | ExtracellularSequence analysis | 4 | |
Transmembranei | 175 – 195 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 196 – 245 | CytoplasmicSequence analysisAdd BLAST | 50 | |
Transmembranei | 246 – 266 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 267 – 281 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 282 – 302 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 303 – 311 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 312 – 332 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 333 – 337 | ExtracellularSequence analysis | 5 | |
Transmembranei | 338 – 358 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 359 – 372 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 373 – 393 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 394 – 405 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 406 – 426 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 427 – 484 | CytoplasmicSequence analysisAdd BLAST | 58 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211388 | 1 – 484 | Monocarboxylate transporter 2Add BLAST | 484 |
Proteomic databases
jPOSTi | O70451 |
PaxDbi | O70451 |
PRIDEi | O70451 |
PTM databases
iPTMneti | O70451 |
PhosphoSitePlusi | O70451 |
Expressioni
Tissue specificityi
Detected in testis and in spermatozoa (at protein level).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000020102 Expressed in 219 organ(s), highest expression level in testis |
ExpressionAtlasi | O70451 baseline and differential |
Genevisiblei | O70451 MM |
Interactioni
Subunit structurei
Interacts with GRID2IP. Interacts with BSG.2 Publications
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000065433 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IMVS Eukaryota ENOG4111F0K LUCA |
GeneTreei | ENSGT00940000157309 |
HOGENOMi | HOG000280688 |
HOVERGENi | HBG006384 |
InParanoidi | O70451 |
KOi | K08184 |
OMAi | GMYTPFV |
OrthoDBi | 916876at2759 |
PhylomeDBi | O70451 |
TreeFami | TF313792 |
Family and domain databases
CDDi | cd06174 MFS, 1 hit |
InterProi | View protein in InterPro IPR004743 MCT IPR027178 MCT2 IPR011701 MFS IPR020846 MFS_dom IPR036259 MFS_trans_sf |
PANTHERi | PTHR11360:SF25 PTHR11360:SF25, 1 hit |
Pfami | View protein in Pfam PF07690 MFS_1, 1 hit |
SUPFAMi | SSF103473 SSF103473, 1 hit |
TIGRFAMsi | TIGR00892 2A0113, 1 hit |
PROSITEi | View protein in PROSITE PS50850 MFS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O70451-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSEPSAPLP QPLPPDGGWG WVVVCASFIS IGFSYAFPKA VTVFFKDIQE
60 70 80 90 100
IFNTTSSQIA WISSIMLAVM YAGGPISSVL VNNYGSRPVV IVGGLLCCIG
110 120 130 140 150
MILASYSNSV IELYLTVGFI GGLGLAFNLQ PALTIIGKYF YRRRPLANGC
160 170 180 190 200
AMAGSPVFLS TLAPFNQYLF NNYGWKGSFL ILGGIFLHSC VAGCLMRPVG
210 220 230 240 250
PSPNTKKSKS KVGSRHDSTL KKASKVSTAQ KVNRFLDFSL FMHRGFLIYL
260 270 280 290 300
SGNVILFLGI FAPIIFLAQY AKHIGVDDYN SAFLLSVMAF IDMFARPSVG
310 320 330 340 350
LIANTSLIRP RIQYLFSSAI IFTGICHLLC PLATTYSALV VYVVFFGLGF
360 370 380 390 400
GSISSLLFEC LMDIVGATRF SSAVGLTTIV ECCPVLFGPP LAGKLLDITG
410 420 430 440 450
EYKYLYIASG TVVLVSGTYL LIGNAINYRL LDKERKREKA KKKKSASHAS
460 470 480
REMEALNRSK QDEVTVKASN AHNPPSDRDK ESNI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GSA7 | A0A1B0GSA7_MOUSE | Monocarboxylate transporter 2 | Slc16a7 | 55 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF058054 mRNA Translation: AAC13719.1 AK076612 mRNA Translation: BAC36415.1 |
CCDSi | CCDS24218.1 |
RefSeqi | NP_035521.1, NM_011391.1 XP_006513469.1, XM_006513406.3 XP_006513471.1, XM_006513408.3 XP_006513472.1, XM_006513409.3 XP_006513473.1, XM_006513410.3 XP_006513474.1, XM_006513411.1 XP_006513475.1, XM_006513412.3 XP_006513476.1, XM_006513413.3 XP_017169350.1, XM_017313861.1 |
UniGenei | Mm.29161 Mm.455126 Mm.458462 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF058054 mRNA Translation: AAC13719.1 AK076612 mRNA Translation: BAC36415.1 |
CCDSi | CCDS24218.1 |
RefSeqi | NP_035521.1, NM_011391.1 XP_006513469.1, XM_006513406.3 XP_006513471.1, XM_006513408.3 XP_006513472.1, XM_006513409.3 XP_006513473.1, XM_006513410.3 XP_006513474.1, XM_006513411.1 XP_006513475.1, XM_006513412.3 XP_006513476.1, XM_006513413.3 XP_017169350.1, XM_017313861.1 |
UniGenei | Mm.29161 Mm.455126 Mm.458462 |
3D structure databases
ProteinModelPortali | O70451 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000065433 |
PTM databases
iPTMneti | O70451 |
PhosphoSitePlusi | O70451 |
Proteomic databases
jPOSTi | O70451 |
PaxDbi | O70451 |
PRIDEi | O70451 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Organism-specific databases
CTDi | 9194 |
MGIi | MGI:1330284 Slc16a7 |
Phylogenomic databases
eggNOGi | ENOG410IMVS Eukaryota ENOG4111F0K LUCA |
GeneTreei | ENSGT00940000157309 |
HOGENOMi | HOG000280688 |
HOVERGENi | HBG006384 |
InParanoidi | O70451 |
KOi | K08184 |
OMAi | GMYTPFV |
OrthoDBi | 916876at2759 |
PhylomeDBi | O70451 |
TreeFami | TF313792 |
Enzyme and pathway databases
Reactomei | R-MMU-433692 Proton-coupled monocarboxylate transport |
Miscellaneous databases
PROi | PR:O70451 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020102 Expressed in 219 organ(s), highest expression level in testis |
ExpressionAtlasi | O70451 baseline and differential |
Genevisiblei | O70451 MM |
Family and domain databases
CDDi | cd06174 MFS, 1 hit |
InterProi | View protein in InterPro IPR004743 MCT IPR027178 MCT2 IPR011701 MFS IPR020846 MFS_dom IPR036259 MFS_trans_sf |
PANTHERi | PTHR11360:SF25 PTHR11360:SF25, 1 hit |
Pfami | View protein in Pfam PF07690 MFS_1, 1 hit |
SUPFAMi | SSF103473 SSF103473, 1 hit |
TIGRFAMsi | TIGR00892 2A0113, 1 hit |
PROSITEi | View protein in PROSITE PS50850 MFS, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | MOT2_MOUSE | |
Accessioni | O70451Primary (citable) accession number: O70451 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | August 1, 1998 | |
Last modified: | January 16, 2019 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot