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Protein

Guanine nucleotide-binding protein G(z) subunit alpha

Gene

Gnaz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47MagnesiumBy similarity1
Metal bindingi182MagnesiumBy similarity1
Binding sitei327GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 47GTPBy similarity8
Nucleotide bindingi176 – 182GTPBy similarity7
Nucleotide bindingi201 – 205GTPBy similarity5
Nucleotide bindingi270 – 273GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-112043 PLC beta mediated events
R-MMU-202040 G-protein activation
R-MMU-418597 G alpha (z) signalling events
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(z) subunit alpha
Alternative name(s):
G(x) alpha chain
Gz-alpha
Gene namesi
Name:Gnaz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:95780 Gnaz

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCurated
ChainiPRO_00002036972 – 355Guanine nucleotide-binding protein G(z) subunit alphaAdd BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi3S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

EPDiO70443
PaxDbiO70443
PeptideAtlasiO70443
PRIDEiO70443

PTM databases

iPTMnetiO70443
PhosphoSitePlusiO70443
SwissPalmiO70443

Expressioni

Gene expression databases

BgeeiENSMUSG00000040009 Expressed in 198 organ(s), highest expression level in forebrain
ExpressionAtlasiO70443 baseline and differential
GenevisibleiO70443 MM

Interactioni

Subunit structurei

G-proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with ADGRB2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199975, 3 interactors
IntActiO70443, 3 interactors
STRINGi10090.ENSMUSP00000036087

Structurei

3D structure databases

ProteinModelPortaliO70443
SMRiO70443
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family. G(i/o/t/z) subfamily.Curated

Phylogenomic databases

eggNOGiKOG0082 Eukaryota
ENOG410XNVQ LUCA
GeneTreeiENSGT00760000118851
HOGENOMiHOG000038730
HOVERGENiHBG063184
InParanoidiO70443
KOiK04535
OMAiYRQLVFN
OrthoDBiEOG091G0VUT
PhylomeDBiO70443
TreeFamiTF300673

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR001408 Gprotein_alpha_I
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00441 GPROTEINAI
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70443-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCRQSSEEK EAARRSRRID RHLRSESQRQ RREIKLLLLG TSNSGKSTIV
60 70 80 90 100
KQMKIIHSGG FNLDACKEYK PLIIYNAIDS LTRIIRALAA LKIDFHNPDR
110 120 130 140 150
AYDAVQLFAL TGPAESKGEI TPELLGVMRR LWADPGAQAC FGRSSEYHLE
160 170 180 190 200
DNAAYYLNDL ERIAAPDYIP TVEDILRSRD MTTGIVENKF TFKELTFKMV
210 220 230 240 250
DVGGQRSERK KWIHCFEGVT AIIFCVELSG YDLKLYEDNQ TSRMAESLRL
260 270 280 290 300
FDSICNNNWF INTSLILFLN KKDLLAEKIR RIPLSVCFPE YKGQNTYEEA
310 320 330 340 350
AVYIQRQFED LNRNKETKEI YSHFTCATDT SNIQFVFDAV TDVIIQNNLK

YIGLC
Length:355
Mass (Da):40,850
Last modified:January 23, 2007 - v4
Checksum:i24590AE5B1FE5D50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210K → R in AAC37651 (PubMed:8013366).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014702 mRNA Translation: AAH14702.1
AF056973 Genomic DNA Translation: AAC13569.1
AF056972 mRNA Translation: AAC13568.1
L17074 mRNA Translation: AAC37651.1
CCDSiCCDS23922.1
RefSeqiNP_034441.1, NM_010311.3
XP_006513298.1, XM_006513235.3
XP_006513299.1, XM_006513236.1
XP_006513300.1, XM_006513237.2
UniGeneiMm.32595
Mm.393508

Genome annotation databases

EnsembliENSMUST00000037813; ENSMUSP00000036087; ENSMUSG00000040009
ENSMUST00000159991; ENSMUSP00000124639; ENSMUSG00000040009
GeneIDi14687
KEGGimmu:14687
UCSCiuc007fpt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014702 mRNA Translation: AAH14702.1
AF056973 Genomic DNA Translation: AAC13569.1
AF056972 mRNA Translation: AAC13568.1
L17074 mRNA Translation: AAC37651.1
CCDSiCCDS23922.1
RefSeqiNP_034441.1, NM_010311.3
XP_006513298.1, XM_006513235.3
XP_006513299.1, XM_006513236.1
XP_006513300.1, XM_006513237.2
UniGeneiMm.32595
Mm.393508

3D structure databases

ProteinModelPortaliO70443
SMRiO70443
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199975, 3 interactors
IntActiO70443, 3 interactors
STRINGi10090.ENSMUSP00000036087

PTM databases

iPTMnetiO70443
PhosphoSitePlusiO70443
SwissPalmiO70443

Proteomic databases

EPDiO70443
PaxDbiO70443
PeptideAtlasiO70443
PRIDEiO70443

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037813; ENSMUSP00000036087; ENSMUSG00000040009
ENSMUST00000159991; ENSMUSP00000124639; ENSMUSG00000040009
GeneIDi14687
KEGGimmu:14687
UCSCiuc007fpt.1 mouse

Organism-specific databases

CTDi2781
MGIiMGI:95780 Gnaz

Phylogenomic databases

eggNOGiKOG0082 Eukaryota
ENOG410XNVQ LUCA
GeneTreeiENSGT00760000118851
HOGENOMiHOG000038730
HOVERGENiHBG063184
InParanoidiO70443
KOiK04535
OMAiYRQLVFN
OrthoDBiEOG091G0VUT
PhylomeDBiO70443
TreeFamiTF300673

Enzyme and pathway databases

ReactomeiR-MMU-112043 PLC beta mediated events
R-MMU-202040 G-protein activation
R-MMU-418597 G alpha (z) signalling events
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

PROiPR:O70443
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040009 Expressed in 198 organ(s), highest expression level in forebrain
ExpressionAtlasiO70443 baseline and differential
GenevisibleiO70443 MM

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR001408 Gprotein_alpha_I
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00441 GPROTEINAI
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGNAZ_MOUSE
AccessioniPrimary (citable) accession number: O70443
Secondary accession number(s): O70442, Q61637, Q91WM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 166 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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