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Protein

Syntaxin-7

Gene

Stx7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandIron

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-7
Gene namesi
Name:Stx7
Synonyms:Syn7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1858210 Stx7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 238CytoplasmicSequence analysisAdd BLAST237
Transmembranei239 – 259Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini260 – 261VesicularSequence analysis2

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002102142 – 261Syntaxin-7Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei4PhosphothreonineBy similarity1
Modified residuei45PhosphoserineCombined sources1
Modified residuei75PhosphoserineBy similarity1
Modified residuei79PhosphothreonineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei205PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO70439
MaxQBiO70439
PaxDbiO70439
PeptideAtlasiO70439
PRIDEiO70439
TopDownProteomicsiO70439

PTM databases

iPTMnetiO70439
PhosphoSitePlusiO70439
SwissPalmiO70439

Expressioni

Gene expression databases

CleanExiMM_STX7

Interactioni

Subunit structurei

Interacts with VPS11, VPS16 and VPS18. Interacts with VPS33A (By similarity). Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

CORUMiO70439
IntActiO70439, 6 interactors
MINTiO70439
STRINGi10090.ENSMUSP00000020174

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO70439
SMRiO70439
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO70439

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 227t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili47 – 68Sequence analysisAdd BLAST22

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0811 Eukaryota
COG5325 LUCA
HOGENOMiHOG000188453
HOVERGENiHBG053083
InParanoidiO70439
PhylomeDBiO70439

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF14523 Syntaxin_2, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O70439-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYTPGIGGD SAQLAQRISS NIQKITQCSV EIQRTLNQLG TPQDSPELRQ
60 70 80 90 100
LLQQKQQYTN QLAKETDKYI KEFGSLPTTP SEQRQRKIQK DRLVAEFTTS
110 120 130 140 150
LTNFQKAQRQ AAEREKEFVA RVRASSRVSG GFPEDSSKEK NLVSWESQTQ
160 170 180 190 200
PQVQVQDEEI TEDDLRLIHE RESSIRQLEA DIMDINEIFK DLGMMIHEQG
210 220 230 240 250
DMIDSIEANV ESAEVHVQQA NQQLSRAADY QRKSRKTLCI IIFILVVRIV
260
IICLIVWGLK G
Length:261
Mass (Da):29,821
Last modified:January 23, 2007 - v3
Checksum:i62F4E4B33F247ADB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BH40Q8BH40_MOUSE
Syntaxin-7
Stx7 Stx-7, mCG_6753
261Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056323 mRNA Translation: AAC15971.1
CCDSiCCDS23749.1
UniGeneiMm.248042

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056323 mRNA Translation: AAC15971.1
CCDSiCCDS23749.1
UniGeneiMm.248042

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GL2X-ray1.90B169-228[»]
ProteinModelPortaliO70439
SMRiO70439
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiO70439
IntActiO70439, 6 interactors
MINTiO70439
STRINGi10090.ENSMUSP00000020174

PTM databases

iPTMnetiO70439
PhosphoSitePlusiO70439
SwissPalmiO70439

Proteomic databases

EPDiO70439
MaxQBiO70439
PaxDbiO70439
PeptideAtlasiO70439
PRIDEiO70439
TopDownProteomicsiO70439

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1858210 Stx7

Phylogenomic databases

eggNOGiKOG0811 Eukaryota
COG5325 LUCA
HOGENOMiHOG000188453
HOVERGENiHBG053083
InParanoidiO70439
PhylomeDBiO70439

Miscellaneous databases

ChiTaRSiStx7 mouse
EvolutionaryTraceiO70439
PROiPR:O70439
SOURCEiSearch...

Gene expression databases

CleanExiMM_STX7

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF14523 Syntaxin_2, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTX7_MOUSE
AccessioniPrimary (citable) accession number: O70439
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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