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Protein

Tetraspanin-6

Gene

Tspan6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-6
Short name:
Tspan-6
Alternative name(s):
Transmembrane 4 superfamily member 6
Gene namesi
Name:Tspan6
Synonyms:Tm4sf6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1926264 Tspan6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 59ExtracellularSequence analysisAdd BLAST19
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 93CytoplasmicSequence analysisAdd BLAST13
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 208ExtracellularSequence analysisAdd BLAST94
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 245CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192471 – 245Tetraspanin-6Add BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO70401
PaxDbiO70401
PeptideAtlasiO70401
PRIDEiO70401

PTM databases

iPTMnetiO70401
SwissPalmiO70401

Expressioni

Gene expression databases

CleanExiMM_TSPAN6

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084838

Structurei

3D structure databases

ProteinModelPortaliO70401
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
HOGENOMiHOG000230656
HOVERGENiHBG107306
InParanoidiO70401

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O70401-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPSRRLQT KPVITCLKSV LLIYTFIFWI TGVILLAVGI WGKVSLENYF
60 70 80 90 100
SLLNEKATNV PFVLIGTGTV IILLGTFGCF ATCRTSAWML KLYAMFLTLI
110 120 130 140 150
FLVELVAAIV GFVFRHEIKN SFKSNYENAL KEYNSTGDYR SEAVDKIQST
160 170 180 190 200
LHCCGVTNYG DWKGTNYYSE TGFPKSCCKL EGCYPQRDAD KVNEEGCFIK
210 220 230 240
VMTTIESEMG VVAGISFGVA CFQLIGIFLA YCLSRAITNN QYEIV
Length:245
Mass (Da):27,333
Last modified:August 1, 1998 - v1
Checksum:i25F68411E3602A12
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q99L96Q99L96_MOUSE
Tetraspanin
Tspan6 Tm4sf6, mCG_9501
245Annotation score:
H3BJJ0H3BJJ0_MOUSE
Tetraspanin-6
Tspan6
199Annotation score:
H3BL26H3BL26_MOUSE
Tetraspanin-6
Tspan6
166Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053454 mRNA Translation: AAC69711.1
CCDSiCCDS30387.1
PIRiA59260
UniGeneiMm.46701

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053454 mRNA Translation: AAC69711.1
CCDSiCCDS30387.1
PIRiA59260
UniGeneiMm.46701

3D structure databases

ProteinModelPortaliO70401
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084838

PTM databases

iPTMnetiO70401
SwissPalmiO70401

Proteomic databases

MaxQBiO70401
PaxDbiO70401
PeptideAtlasiO70401
PRIDEiO70401

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1926264 Tspan6

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
HOGENOMiHOG000230656
HOVERGENiHBG107306
InParanoidiO70401

Miscellaneous databases

PROiPR:O70401
SOURCEiSearch...

Gene expression databases

CleanExiMM_TSPAN6

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSN6_MOUSE
AccessioniPrimary (citable) accession number: O70401
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: February 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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