Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PDZ and LIM domain protein 1

Gene

Pdlim1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (By similarity). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi258Zinc 1By similarity1
Metal bindingi261Zinc 1By similarity1
Metal bindingi278Zinc 1By similarity1
Metal bindingi281Zinc 1By similarity1
Metal bindingi284Zinc 2By similarity1
Metal bindingi287Zinc 2By similarity1
Metal bindingi305Zinc 2By similarity1
Metal bindingi308Zinc 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • transcription coactivator activity Source: MGI

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ and LIM domain protein 1
Alternative name(s):
C-terminal LIM domain protein 1
Elfin
LIM domain protein CLP-36
Gene namesi
Name:Pdlim1
Synonyms:Clim1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1860611 Pdlim1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000758602 – 327PDZ and LIM domain protein 1Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei90PhosphoserineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei142PhosphotyrosineBy similarity1
Modified residuei314PhosphothreonineBy similarity1
Modified residuei319PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO70400
MaxQBiO70400
PaxDbiO70400
PeptideAtlasiO70400
PRIDEiO70400

PTM databases

iPTMnetiO70400
PhosphoSitePlusiO70400
SwissPalmiO70400

Expressioni

Tissue specificityi

Expressed in heart, lung, spleen, testis and skeletal muscle.1 Publication

Developmental stagei

Detected throughout the developing heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000055044 Expressed in 61 organ(s), highest expression level in placenta
CleanExiMM_PDLIM1
ExpressionAtlasiO70400 baseline and differential
GenevisibleiO70400 MM

Interactioni

Subunit structurei

Interacts with ACTN1, ACTN2 and ACTN4 (By similarity). Interacts with PDLIM4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi207571, 1 interactor
CORUMiO70400
IntActiO70400, 2 interactors
MINTiO70400
STRINGi10090.ENSMUSP00000064545

Structurei

3D structure databases

ProteinModelPortaliO70400
SMRiO70400
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 85PDZPROSITE-ProRule annotationAdd BLAST83
Domaini256 – 315LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiKOG1703 Eukaryota
ENOG410XRD4 LUCA
GeneTreeiENSGT00590000082980
HOGENOMiHOG000290704
HOVERGENiHBG061371
InParanoidiO70400
OMAiNTSSMTH
OrthoDBiEOG091G0A6C
PhylomeDBiO70400
TreeFamiTF106408

Family and domain databases

InterProiView protein in InterPro
IPR031847 DUF4749
IPR028537 PDLIM1
IPR001478 PDZ
IPR036034 PDZ_sf
IPR006643 Zasp-like_motif
IPR001781 Znf_LIM
PANTHERiPTHR24214:SF5 PTHR24214:SF5, 1 hit
PfamiView protein in Pfam
PF15936 DUF4749, 1 hit
PF00412 LIM, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
SM00228 PDZ, 1 hit
SM00735 ZM, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50106 PDZ, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O70400-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTQQIVLQG PGPWGFRLVG GKDFEQPLAI SRVTPGSKAA IANLCIGDLI
60 70 80 90 100
TAIDGEDTSS MTHLEAQNKI KGCADNMTLT VSRSEQKIWS PLVTEEGKRH
110 120 130 140 150
PYKMNLASEP QEVLHIGSAH NRSAMPFTAS PAPSTRVITN QYNSPTGLYS
160 170 180 190 200
SENISNFNNA VESKTSASGE EANSRPVVQP HPSGSLIIDK DSEVYKMLQE
210 220 230 240 250
KQELNEPPKQ STSFLVLQEI LESDGKGDPN KPSGFRSVKA PVTKVAASVG
260 270 280 290 300
NAQKLPICDK CGTGIVGVFV KLRDHHRHPE CYVCTDCGIN LKQKGHFFVE
310 320
DQIYCEKHAR ERVTPPEGYD VVTVFRE
Length:327
Mass (Da):35,774
Last modified:January 23, 2007 - v4
Checksum:i8A5EDA47F2E90C03
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R1V0S4R1V0_MOUSE
PDZ and LIM domain protein 1
Pdlim1
198Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21Missing in AAC08436 (PubMed:11596114).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053367 mRNA Translation: AAC08436.1
AK076285 mRNA Translation: BAC36288.1
AK088089 mRNA Translation: BAC40138.1
AK146225 mRNA Translation: BAE26993.1
BC004809 mRNA Translation: AAH04809.1
CCDSiCCDS37977.1
RefSeqiNP_058557.2, NM_016861.4
UniGeneiMm.5567

Genome annotation databases

EnsembliENSMUST00000068439; ENSMUSP00000064545; ENSMUSG00000055044
GeneIDi54132
KEGGimmu:54132
UCSCiuc008hkk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053367 mRNA Translation: AAC08436.1
AK076285 mRNA Translation: BAC36288.1
AK088089 mRNA Translation: BAC40138.1
AK146225 mRNA Translation: BAE26993.1
BC004809 mRNA Translation: AAH04809.1
CCDSiCCDS37977.1
RefSeqiNP_058557.2, NM_016861.4
UniGeneiMm.5567

3D structure databases

ProteinModelPortaliO70400
SMRiO70400
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207571, 1 interactor
CORUMiO70400
IntActiO70400, 2 interactors
MINTiO70400
STRINGi10090.ENSMUSP00000064545

PTM databases

iPTMnetiO70400
PhosphoSitePlusiO70400
SwissPalmiO70400

Proteomic databases

EPDiO70400
MaxQBiO70400
PaxDbiO70400
PeptideAtlasiO70400
PRIDEiO70400

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068439; ENSMUSP00000064545; ENSMUSG00000055044
GeneIDi54132
KEGGimmu:54132
UCSCiuc008hkk.2 mouse

Organism-specific databases

CTDi9124
MGIiMGI:1860611 Pdlim1

Phylogenomic databases

eggNOGiKOG1703 Eukaryota
ENOG410XRD4 LUCA
GeneTreeiENSGT00590000082980
HOGENOMiHOG000290704
HOVERGENiHBG061371
InParanoidiO70400
OMAiNTSSMTH
OrthoDBiEOG091G0A6C
PhylomeDBiO70400
TreeFamiTF106408

Miscellaneous databases

PROiPR:O70400
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055044 Expressed in 61 organ(s), highest expression level in placenta
CleanExiMM_PDLIM1
ExpressionAtlasiO70400 baseline and differential
GenevisibleiO70400 MM

Family and domain databases

InterProiView protein in InterPro
IPR031847 DUF4749
IPR028537 PDLIM1
IPR001478 PDZ
IPR036034 PDZ_sf
IPR006643 Zasp-like_motif
IPR001781 Znf_LIM
PANTHERiPTHR24214:SF5 PTHR24214:SF5, 1 hit
PfamiView protein in Pfam
PF15936 DUF4749, 1 hit
PF00412 LIM, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
SM00228 PDZ, 1 hit
SM00735 ZM, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDLI1_MOUSE
AccessioniPrimary (citable) accession number: O70400
Secondary accession number(s): Q99K93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 153 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again