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Protein

Interleukin-27 receptor subunit alpha

Gene

Il27ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.

GO - Molecular functioni

  • interleukin-27 receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-8984722 Interleukin-35 Signalling
R-MMU-9020956 Interleukin-27 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-27 receptor subunit alpha
Short name:
IL-27 receptor subunit alpha
Short name:
IL-27R subunit alpha
Short name:
IL-27R-alpha
Short name:
IL-27RA
Alternative name(s):
Type I T-cell cytokine receptor
Short name:
TCCR
WSX-1
Gene namesi
Name:Il27ra
Synonyms:Tccr, Wsx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1355318 Il27ra

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 510ExtracellularSequence analysisAdd BLAST486
Transmembranei511 – 531HelicalSequence analysisAdd BLAST21
Topological domaini532 – 623CytoplasmicSequence analysisAdd BLAST92

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001087725 – 623Interleukin-27 receptor subunit alphaAdd BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi360N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi461N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO70394
MaxQBiO70394
PaxDbiO70394
PRIDEiO70394

PTM databases

PhosphoSitePlusiO70394
SwissPalmiO70394

Expressioni

Tissue specificityi

Expressed in CD4+ and CD8+ T-cells, B-cells, natural killer cells and macrophages. Highest levels in CD4+ T-cells and natural killer cells. Expression highest in Th0 cells.1 Publication

Inductioni

Down-regulated on differentiation of CD4+ T-cells in both Th1 and TH2 cells.

Gene expression databases

BgeeiENSMUSG00000005465 Expressed in 71 organ(s), highest expression level in cardiac ventricle
CleanExiMM_IL27RA
GenevisibleiO70394 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005601

Structurei

3D structure databases

ProteinModelPortaliO70394
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 124Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST95
Domaini125 – 225Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST101
Domaini316 – 412Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST97
Domaini413 – 505Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST93

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi211 – 215WSXWS motif5
Motifi552 – 560Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK7Q Eukaryota
ENOG411182T LUCA
GeneTreeiENSGT00700000104610
HOGENOMiHOG000036880
HOVERGENiHBG052068
InParanoidiO70394
KOiK19598
OMAiPCELWVT
OrthoDBiEOG091G0BPO
TreeFamiTF338122

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O70394-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRLRVARLT PLELLLSLMS LLLGTRPHGS PGPLQCYSVG PLGILNCSWE
60 70 80 90 100
PLGDLETPPV LYHQSQKYHP NRVWEVKVPS KQSWVTIPRE QFTMADKLLI
110 120 130 140 150
WGTQKGRPLW SSVSVNLETQ MKPDTPQIFS QVDISEEATL EATVQWAPPV
160 170 180 190 200
WPPQKVLICQ FRYKECQAET WTRLEPQLKT DGLTPVEMQN LEPGTCYQVS
210 220 230 240 250
GRCQVENGYP WGEWSSPLSF QTPFLDPEDV WVSGTVCETS GKRAALLVWK
260 270 280 290 300
DPRPCVQVTY TVWFGAGDIT TTQEEVPCCK SPVPAWMEWA VVSPGNSTSW
310 320 330 340 350
VPPTNLSLVC LAPESAPCDV GVSSADGSPG IKVTWKQGTR KPLEYVVDWA
360 370 380 390 400
QDGDSLDKLN WTRLPPGNLS TLLPGEFKGG VPYRITVTAV YSGGLAAAPS
410 420 430 440 450
VWGFREELVP LAGPAVWRLP DDPPGTPVVA WGEVPRHQLR GQATHYTFCI
460 470 480 490 500
QSRGLSTVCR NVSSQTQTAT LPNLHLGSFK LWVTVSTVAG QGPPGPNLSL
510 520 530 540 550
HLPDNRIRWK ALPWFLSLWG LLLMGCGLSL ASTRCLQARC LHWRHKLLPQ
560 570 580 590 600
WIWERVPDPA NSNSGQPYIK EVSLPQPPKD GPILEVEEVE LQPVVESPKA
610 620
SAPIYSGYEK HFLPTPEELG LLV
Length:623
Mass (Da):69,093
Last modified:July 27, 2011 - v2
Checksum:iD683D282480242F0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156 – 158VLI → ALT in AAC40121 (PubMed:9600072).Curated3
Sequence conflicti156 – 158VLI → ALT in AAG27298 (PubMed:11057672).Curated3
Sequence conflicti156 – 158VLI → ALT in AAH32878 (PubMed:15489334).Curated3
Sequence conflicti170T → A in AAC40121 (PubMed:9600072).Curated1
Sequence conflicti170T → A in AAG27298 (PubMed:11057672).Curated1
Sequence conflicti170T → A in AAH32878 (PubMed:15489334).Curated1
Sequence conflicti476L → S in AAC40121 (PubMed:9600072).Curated1
Sequence conflicti476L → S in AAG27298 (PubMed:11057672).Curated1
Sequence conflicti476L → S in AAH32878 (PubMed:15489334).Curated1
Sequence conflicti497N → D in AAC40121 (PubMed:9600072).Curated1
Sequence conflicti497N → D in AAG27298 (PubMed:11057672).Curated1
Sequence conflicti497N → D in AAH32878 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053005 mRNA Translation: AAC40121.1
AF265243 mRNA Translation: AAG27298.1
AC156028 Genomic DNA No translation available.
BC032878 mRNA Translation: AAH32878.1
CCDSiCCDS22465.1
RefSeqiNP_057880.2, NM_016671.3
UniGeneiMm.38386

Genome annotation databases

EnsembliENSMUST00000005601; ENSMUSP00000005601; ENSMUSG00000005465
GeneIDi50931
KEGGimmu:50931
UCSCiuc009mlr.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053005 mRNA Translation: AAC40121.1
AF265243 mRNA Translation: AAG27298.1
AC156028 Genomic DNA No translation available.
BC032878 mRNA Translation: AAH32878.1
CCDSiCCDS22465.1
RefSeqiNP_057880.2, NM_016671.3
UniGeneiMm.38386

3D structure databases

ProteinModelPortaliO70394
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005601

PTM databases

PhosphoSitePlusiO70394
SwissPalmiO70394

Proteomic databases

EPDiO70394
MaxQBiO70394
PaxDbiO70394
PRIDEiO70394

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005601; ENSMUSP00000005601; ENSMUSG00000005465
GeneIDi50931
KEGGimmu:50931
UCSCiuc009mlr.2 mouse

Organism-specific databases

CTDi9466
MGIiMGI:1355318 Il27ra

Phylogenomic databases

eggNOGiENOG410IK7Q Eukaryota
ENOG411182T LUCA
GeneTreeiENSGT00700000104610
HOGENOMiHOG000036880
HOVERGENiHBG052068
InParanoidiO70394
KOiK19598
OMAiPCELWVT
OrthoDBiEOG091G0BPO
TreeFamiTF338122

Enzyme and pathway databases

ReactomeiR-MMU-8984722 Interleukin-35 Signalling
R-MMU-9020956 Interleukin-27 signaling

Miscellaneous databases

PROiPR:O70394
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005465 Expressed in 71 organ(s), highest expression level in cardiac ventricle
CleanExiMM_IL27RA
GenevisibleiO70394 MM

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiI27RA_MOUSE
AccessioniPrimary (citable) accession number: O70394
Secondary accession number(s): E9QNY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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