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Protein

Phosphatidylinositol-glycan-specific phospholipase D

Gene

Gpld1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.1 Publication

Catalytic activityi

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate.

GO - Molecular functioni

  • glycosylphosphatidylinositol phospholipase D activity Source: UniProtKB
  • phospholipase D activity Source: MGI
  • sodium channel regulator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDAi3.1.4.50 3474

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol-glycan-specific phospholipase D (EC:3.1.4.50)
Short name:
PI-G PLD
Alternative name(s):
Glycoprotein phospholipase D
Glycosyl-phosphatidylinositol-specific phospholipase D
Short name:
GPI-PLD
Short name:
GPI-specific phospholipase D
Gene namesi
Name:Gpld1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:106604 Gpld1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000002205424 – 837Phosphatidylinositol-glycan-specific phospholipase DAdd BLAST814

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi477N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi496N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi586N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi599N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi655N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO70362
PaxDbiO70362
PeptideAtlasiO70362
PRIDEiO70362

PTM databases

GlyConnecti755
iPTMnetiO70362
PhosphoSitePlusiO70362

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021773

Structurei

3D structure databases

ProteinModelPortaliO70362
SMRiO70362
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati364 – 425FG-GAP 1PROSITE-ProRule annotationAdd BLAST62
Repeati431 – 492FG-GAP 2PROSITE-ProRule annotationAdd BLAST62
Repeati494 – 554FG-GAP 3PROSITE-ProRule annotationAdd BLAST61
Repeati561 – 619FG-GAP 4PROSITE-ProRule annotationAdd BLAST59
Repeati629 – 689FG-GAP 5PROSITE-ProRule annotationAdd BLAST61
Repeati701 – 767FG-GAP 6PROSITE-ProRule annotationAdd BLAST67
Repeati785 – 837FG-GAP 7PROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Belongs to the GPLD1 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IPB3 Eukaryota
ENOG4111ZDA LUCA
HOVERGENiHBG008185
InParanoidiO70362

Family and domain databases

Gene3Di2.130.10.130, 3 hits
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR001028 Gprt_PLipase_D
IPR013519 Int_alpha_beta-p
IPR028994 Integrin_alpha_N
IPR029002 PLPC/GPLD1
PfamiView protein in Pfam
PF01839 FG-GAP, 3 hits
PF00882 Zn_dep_PLPC, 1 hit
PRINTSiPR00718 PHPHLIPASED
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O70362-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAGRLWSSL LLLLPLFCSK SSSCGLSTHV EIGHRALEFL RLQDGRINYK
60 70 80 90 100
ELILEHQDAY QAGTVFPDAF YPSICKRGKY HDVSERTHWT PFLNASIHYI
110 120 130 140 150
RENYPLPWEK DTEKLVAFLF GITSHMVADL SWHNLGFLRT MGAIDFYNSY
160 170 180 190 200
SDAHSAGDFG GDVLSQFEFN FNYLSRRWYV PVRDLLRIYD NLYGRKVITK
210 220 230 240 250
DVLVDCTYLQ FLEMHGEMFA VSKLYSTYST KSPFLVEQFQ DYFLGGLDDM
260 270 280 290 300
AFWSTNIYRL TSFMLENGTS DCNLPENPLF ISCDGRNHTL SGSKVQKNDF
310 320 330 340 350
HRNLTMFISR DIRKNLNYTE RGVFYSTGSW ARPESVTFMY QTLERNLRLM
360 370 380 390 400
LAGSSQKNLN HVSSPSASYT LSVPYARLGW VMTSADLNQD GHGDLVVGAP
410 420 430 440 450
GYSHPGRFQI GRVYIIYGND LGLPPIDLDL NKEGILEGFQ PSGRFGSALA
460 470 480 490 500
VLDFNQDGLP DLAVGAPSVG SGQLTYNGSV YVYYGSQQGR LSSSPNVTIS
510 520 530 540 550
CKDTYCNLGW TLLATDADGD GRHDLVISSP FAPGGRKQKG IVATFYSHPR
560 570 580 590 600
RNDKELLTLE EADWKVNGEE DFSWFGYSLH GVTVANRSLL LIGSPTWKNV
610 620 630 640 650
SRMARSSHKK NQEEKSLGKV YGYFLPNRQS TITISGDKAM GKLGTSLSSG
660 670 680 690 700
YVRVNGTLTQ VLLVGAPTHD DVSKMAFLTM TLHQGGATRM YELAPEKTQP
710 720 730 740 750
ALLSTFSGDR RFSRFGSVLH LTDLDDDGLD EIIMAAPLRI TDVTSGLLGG
760 770 780 790 800
EDGRVYIYNG MYTTLGDMTG KCKSWMTPCP EEKAQYVLTS PEASSRFGSS
810 820 830
LVSVRSKGRN QVVVAAGRSS WGARLSGALH VYSFSSD
Length:837
Mass (Da):93,255
Last modified:August 1, 1998 - v1
Checksum:i9D007F479556CCC1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8VCU2Q8VCU2_MOUSE
Glycosylphosphatidylinositol specif...
Gpld1 mCG_3149
842Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050666 mRNA Translation: AAC77799.1
UniGeneiMm.291831

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050666 mRNA Translation: AAC77799.1
UniGeneiMm.291831

3D structure databases

ProteinModelPortaliO70362
SMRiO70362
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021773

PTM databases

GlyConnecti755
iPTMnetiO70362
PhosphoSitePlusiO70362

Proteomic databases

MaxQBiO70362
PaxDbiO70362
PeptideAtlasiO70362
PRIDEiO70362

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:106604 Gpld1

Phylogenomic databases

eggNOGiENOG410IPB3 Eukaryota
ENOG4111ZDA LUCA
HOVERGENiHBG008185
InParanoidiO70362

Enzyme and pathway databases

BRENDAi3.1.4.50 3474

Miscellaneous databases

PROiPR:O70362
SOURCEiSearch...

Family and domain databases

Gene3Di2.130.10.130, 3 hits
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR001028 Gprt_PLipase_D
IPR013519 Int_alpha_beta-p
IPR028994 Integrin_alpha_N
IPR029002 PLPC/GPLD1
PfamiView protein in Pfam
PF01839 FG-GAP, 3 hits
PF00882 Zn_dep_PLPC, 1 hit
PRINTSiPR00718 PHPHLIPASED
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPHLD_MOUSE
AccessioniPrimary (citable) accession number: O70362
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: June 20, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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