UniProtKB - O70354 (CAH11_MOUSE)
Protein
Carbonic anhydrase-related protein 11
Gene
Ca11
Organism
Mus musculus (Mouse)
Status
Functioni
Does not have a catalytic activity.
GO - Molecular functioni
- hydro-lyase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- one-carbon metabolic process Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Carbonic anhydrase-related protein 11Alternative name(s): CA-RP XI Short name: CA-XI Short name: CARP XI Carbonic anhydrase-related protein 2 Short name: CA-RP II Short name: CARP-2 |
Gene namesi | Name:Ca11 Synonyms:Car11, Carp2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1336193, Car11 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- basolateral plasma membrane Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000004246 | 24 – 328 | Carbonic anhydrase-related protein 11Add BLAST | 305 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 118 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | O70354 |
PRIDEi | O70354 |
PTM databases
GlyConnecti | 2183, 4 N-Linked glycans (2 sites) |
GlyGeni | O70354, 2 sites |
iPTMneti | O70354 |
PhosphoSitePlusi | O70354 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000003273, Expressed in superior frontal gyrus and 219 other tissues |
Genevisiblei | O70354, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000003360 |
Miscellaneous databases
RNActi | O70354, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 303 | Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST | 271 |
Sequence similaritiesi
Belongs to the alpha-carbonic anhydrase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG0382, Eukaryota |
GeneTreei | ENSGT00940000162098 |
HOGENOMi | CLU_039326_7_0_1 |
InParanoidi | O70354 |
OMAi | TSPGCHE |
OrthoDBi | 1377476at2759 |
PhylomeDBi | O70354 |
TreeFami | TF352926 |
Family and domain databases
CDDi | cd03121, alpha_CARP_X_XI_like, 1 hit |
Gene3Di | 3.10.200.10, 1 hit |
InterProi | View protein in InterPro IPR041878, Alpha_CARP_X/XI IPR001148, CA_dom IPR036398, CA_dom_sf IPR023561, Carbonic_anhydrase_a-class |
PANTHERi | PTHR18952, PTHR18952, 1 hit |
Pfami | View protein in Pfam PF00194, Carb_anhydrase, 1 hit |
SMARTi | View protein in SMART SM01057, Carb_anhydrase, 1 hit |
SUPFAMi | SSF51069, SSF51069, 1 hit |
PROSITEi | View protein in PROSITE PS51144, ALPHA_CA_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
O70354-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGAARLSAP QALVLWAALG AAAHIGPAPD PEDWWSYKEN LQGNFVPGPP
60 70 80 90 100
FWGLVNAAWS LCAVGKRQSP VDVELKRVLY DPFLPPLRLS TGGEKLRGTL
110 120 130 140 150
YNTGRHVSFL PASRPVVNVS GGPLLYSHRL SELRLLFGAR DGAGSEHQIN
160 170 180 190 200
HEGFSAEVQL IHFNQELYGN LSAASRGPNG LAILSLFVNV AGSSNPFLSR
210 220 230 240 250
LLNRDTITRI SYKNDAYFLQ DLSLELLFPE SFGFITYQGS LSTPPCSETV
260 270 280 290 300
TWILIDRALN ITSLQMHSLR LLSQNPPSQI FQSLSGNGRP LQPLAHRALR
310 320
GNRDPRHPER RCRGPNYRLH VDGGPHGR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GRJ7 | A0A1B0GRJ7_MOUSE | Carbonic anhydrase 11 | Car11 | 82 | Annotation score: | ||
A0A1B0GT65 | A0A1B0GT65_MOUSE | Carbonic anhydrase 11 | Car11 | 26 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB079601 mRNA Translation: BAC07262.1 BC019393 mRNA Translation: AAH19393.1 AF050105 mRNA Translation: AAD08801.1 |
CCDSi | CCDS21259.1 |
RefSeqi | NP_033930.1, NM_009800.4 |
Genome annotation databases
Ensembli | ENSMUST00000003360; ENSMUSP00000003360; ENSMUSG00000003273 |
GeneIDi | 12348 |
KEGGi | mmu:12348 |
UCSCi | uc009gwr.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB079601 mRNA Translation: BAC07262.1 BC019393 mRNA Translation: AAH19393.1 AF050105 mRNA Translation: AAD08801.1 |
CCDSi | CCDS21259.1 |
RefSeqi | NP_033930.1, NM_009800.4 |
3D structure databases
SMRi | O70354 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000003360 |
PTM databases
GlyConnecti | 2183, 4 N-Linked glycans (2 sites) |
GlyGeni | O70354, 2 sites |
iPTMneti | O70354 |
PhosphoSitePlusi | O70354 |
Proteomic databases
PaxDbi | O70354 |
PRIDEi | O70354 |
Protocols and materials databases
Antibodypediai | 31755, 103 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000003360; ENSMUSP00000003360; ENSMUSG00000003273 |
GeneIDi | 12348 |
KEGGi | mmu:12348 |
UCSCi | uc009gwr.1, mouse |
Organism-specific databases
CTDi | 12348 |
MGIi | MGI:1336193, Car11 |
Phylogenomic databases
eggNOGi | KOG0382, Eukaryota |
GeneTreei | ENSGT00940000162098 |
HOGENOMi | CLU_039326_7_0_1 |
InParanoidi | O70354 |
OMAi | TSPGCHE |
OrthoDBi | 1377476at2759 |
PhylomeDBi | O70354 |
TreeFami | TF352926 |
Miscellaneous databases
BioGRID-ORCSi | 12348, 1 hit in 17 CRISPR screens |
PROi | PR:O70354 |
RNActi | O70354, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000003273, Expressed in superior frontal gyrus and 219 other tissues |
Genevisiblei | O70354, MM |
Family and domain databases
CDDi | cd03121, alpha_CARP_X_XI_like, 1 hit |
Gene3Di | 3.10.200.10, 1 hit |
InterProi | View protein in InterPro IPR041878, Alpha_CARP_X/XI IPR001148, CA_dom IPR036398, CA_dom_sf IPR023561, Carbonic_anhydrase_a-class |
PANTHERi | PTHR18952, PTHR18952, 1 hit |
Pfami | View protein in Pfam PF00194, Carb_anhydrase, 1 hit |
SMARTi | View protein in SMART SM01057, Carb_anhydrase, 1 hit |
SUPFAMi | SSF51069, SSF51069, 1 hit |
PROSITEi | View protein in PROSITE PS51144, ALPHA_CA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAH11_MOUSE | |
Accessioni | O70354Primary (citable) accession number: O70354 Secondary accession number(s): Q8VEA9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 9, 2003 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families