UniProtKB - O70343 (PRGC1_MOUSE)
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Ppargc1a
Functioni
Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:15744310, PubMed:12754525, PubMed:23217713, PubMed:9529258).
Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:15744310, PubMed:12754525, PubMed:23217713, PubMed:9529258).
Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed:15744310, PubMed:12754525, PubMed:23217713, PubMed:9529258).
Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed:15744310, PubMed:12754525, PubMed:23217713, PubMed:9529258).
Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed:12754525).
Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (By similarity).
Also involved in the integration of the circadian rhythms and energy metabolism (PubMed:17476214).
Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (PubMed:17476214).
By similarity5 PublicationsGO - Molecular functioni
- alpha-tubulin binding Source: MGI
- chromatin binding Source: MGI
- chromatin DNA binding Source: MGI
- DNA binding Source: MGI
- estrogen receptor binding Source: MGI
- nuclear receptor binding Source: MGI
- nuclear receptor coactivator activity Source: MGI
- peroxisome proliferator activated receptor binding Source: MGI
- promoter-specific chromatin binding Source: MGI
- RNA binding Source: UniProtKB-KW
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
- sequence-specific DNA binding Source: UniProtKB
- transcription coactivator activity Source: UniProtKB
- ubiquitin protein ligase binding Source: MGI
GO - Biological processi
- adipose tissue development Source: CACAO
- cellular response to follicle-stimulating hormone stimulus Source: MGI
- cellular response to oxidative stress Source: MGI
- cellular response to thyroid hormone stimulus Source: MGI
- cellular response to transforming growth factor beta stimulus Source: MGI
- circadian regulation of gene expression Source: UniProtKB
- energy homeostasis Source: UniProtKB
- mitochondrion organization Source: MGI
- negative regulation of glycolytic process Source: MGI
- negative regulation of mitochondrial fission Source: MGI
- negative regulation of neuron apoptotic process Source: MGI
- negative regulation of neuron death Source: UniProtKB
- negative regulation of protein phosphorylation Source: MGI
- negative regulation of signaling receptor activity Source: MGI
- negative regulation of smooth muscle cell migration Source: MGI
- negative regulation of smooth muscle cell proliferation Source: MGI
- positive regulation of ATP biosynthetic process Source: UniProtKB
- positive regulation of cellular respiration Source: UniProtKB
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
- positive regulation of fatty acid oxidation Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of glomerular visceral epithelial cell apoptotic process Source: MGI
- positive regulation of mitochondrial DNA metabolic process Source: UniProtKB
- positive regulation of mitochondrion organization Source: UniProtKB
- positive regulation of muscle tissue development Source: UniProtKB
- positive regulation of progesterone biosynthetic process Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of vascular associated smooth muscle cell proliferation Source: MGI
- regulation of circadian rhythm Source: UniProtKB
- regulation of NMDA receptor activity Source: MGI
- regulation of transcription, DNA-templated Source: UniProtKB
- respiratory electron transport chain Source: MGI
- response to activity Source: MGI
- response to dietary excess Source: MGI
- response to muscle activity Source: MGI
Keywordsi
Molecular function | Activator, RNA-binding |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxisome proliferator-activated receptor gamma coactivator 1-alphaShort name: PGC-1-alpha Short name: PPAR-gamma coactivator 1-alpha Short name: PPARGC-1-alpha |
Gene namesi | Name:Ppargc1a Synonyms:Pgc1, Pgc1a, Ppargc1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1342774, Ppargc1a |
VEuPathDBi | HostDB:ENSMUSG00000029167 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
- cytosolic ribosome Source: MGI
Mitochondrion
- mitochondrion Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
- PML body Source: UniProtKB-SubCell
Other locations
- apical dendrite Source: MGI
- chromatin Source: MGI
- cytoplasm Source: MGI
- euchromatin Source: MGI
- intracellular membrane-bounded organelle Source: MGI
- neuronal cell body Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 142 – 146 | LKKLL → AKKAA: Strongly reduces coactivation of RORA activity. 1 Publication | 5 | |
Mutagenesisi | 177 | T → A: Abolishes AMPK-mediated phosphorylation; when associated with A-538. 1 Publication | 1 | |
Mutagenesisi | 538 | S → A: Abolishes AMPK-mediated phosphorylation; when associated with A-177. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081733 | 1 – 797 | Peroxisome proliferator-activated receptor gamma coactivator 1-alphaAdd BLAST | 797 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 77 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 144 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 177 | Phosphothreonine; by AMPK1 Publication | 1 | |
Modified residuei | 183 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 253 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 270 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 277 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 320 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 346 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 412 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 441 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 450 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 538 | Phosphoserine; by AMPK1 Publication | 1 | |
Modified residuei | 757 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 778 | N6-acetyllysine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | O70343 |
PRIDEi | O70343 |
ProteomicsDBi | 291873 [O70343-1] 291876 [O70343-4] |
PTM databases
iPTMneti | O70343 |
PhosphoSitePlusi | O70343 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000029167, Expressed in diaphragm and 302 other tissues |
Genevisiblei | O70343, MM |
Interactioni
Subunit structurei
Homooligomer (By similarity).
Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation (PubMed:14744933).
Interacts with PRDM16, LPIN1 and PML (PubMed:16950137, PubMed:17618855, PubMed:18483224, PubMed:22886304).
Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation (PubMed:17476214).
Interacts with LRPPRC (By similarity).
Interacts with FOXO1 (PubMed:12754525).
By similarity7 PublicationsBinary interactionsi
O70343
With | #Exp. | IntAct |
---|---|---|
Irf4 [Q64287] | 6 | EBI-1371053,EBI-6398485 |
Lrpprc [Q6PB66] | 2 | EBI-1371053,EBI-1371262 |
Sirt1 [Q923E4] | 6 | EBI-1371053,EBI-1802585 |
Yy1 [Q00899] | 5 | EBI-1371053,EBI-6921536 |
Isoform 1 [O70343-1]
With | #Exp. | IntAct |
---|---|---|
Nr1h4 - isoform 1 [Q60641-1] | 3 | EBI-11359934,EBI-11659377 |
Nr1h4 - isoform 2 [Q60641-2] | 2 | EBI-11359934,EBI-11659386 |
GO - Molecular functioni
- alpha-tubulin binding Source: MGI
- estrogen receptor binding Source: MGI
- nuclear receptor binding Source: MGI
- peroxisome proliferator activated receptor binding Source: MGI
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
- ubiquitin protein ligase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 202321, 16 interactors |
CORUMi | O70343 |
DIPi | DIP-38447N |
IntActi | O70343, 15 interactors |
STRINGi | 10090.ENSMUSP00000117040 |
Miscellaneous databases
RNActi | O70343, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | O70343 |
SMRi | O70343 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O70343 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 676 – 752 | RRMPROSITE-ProRule annotationAdd BLAST | 77 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 101 – 138 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 212 – 276 | DisorderedSequence analysisAdd BLAST | 65 | |
Regioni | 289 – 376 | DisorderedSequence analysisAdd BLAST | 88 | |
Regioni | 292 – 338 | Interaction with PPARGBy similarityAdd BLAST | 47 | |
Regioni | 349 – 797 | Mediates interaction with RNF34By similarityAdd BLAST | 449 | |
Regioni | 543 – 598 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 612 – 634 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 648 – 668 | DisorderedSequence analysisAdd BLAST | 21 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 142 – 146 | LXXLL motif1 Publication | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 221 – 240 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 241 – 276 | Polar residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 289 – 305 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 332 – 362 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 543 – 565 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 575 – 598 | Polar residuesSequence analysisAdd BLAST | 24 |
Phylogenomic databases
eggNOGi | ENOG502QSXU, Eukaryota |
GeneTreei | ENSGT00950000183137 |
HOGENOMi | CLU_020104_0_0_1 |
InParanoidi | O70343 |
OMAi | KCPSKKK |
OrthoDBi | 94418at2759 |
PhylomeDBi | O70343 |
TreeFami | TF343068 |
Family and domain databases
CDDi | cd12623, RRM_PPARGC1A, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
IDEALi | IID50038 |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR034605, PGC-1 IPR034625, PGC-1alpha IPR034833, PPARGC1A_RRM IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR15528, PTHR15528, 1 hit PTHR15528:SF10, PTHR15528:SF10, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAWDMCSQDS VWSDIECAAL VGEDQPLCPD LPELDLSELD VNDLDTDSFL
60 70 80 90 100
GGLKWCSDQS EIISNQYNNE PANIFEKIDE ENEANLLAVL TETLDSLPVD
110 120 130 140 150
EDGLPSFDAL TDGAVTTDNE ASPSSMPDGT PPPQEAEEPS LLKKLLLAPA
160 170 180 190 200
NTQLSYNECS GLSTQNHAAN HTHRIRTNPA IVKTENSWSN KAKSICQQQK
210 220 230 240 250
PQRRPCSELL KYLTTNDDPP HTKPTENRNS SRDKCASKKK SHTQPQSQHA
260 270 280 290 300
QAKPTTLSLP LTPESPNDPK GSPFENKTIE RTLSVELSGT AGLTPPTTPP
310 320 330 340 350
HKANQDNPFK ASPKLKPSCK TVVPPPTKRA RYSECSGTQG SHSTKKGPEQ
360 370 380 390 400
SELYAQLSKS SGLSRGHEER KTKRPSLRLF GDHDYCQSLN SKTDILINIS
410 420 430 440 450
QELQDSRQLD FKDASCDWQG HICSSTDSGQ CYLRETLEAS KQVSPCSTRK
460 470 480 490 500
QLQDQEIRAE LNKHFGHPCQ AVFDDKSDKT SELRDGDFSN EQFSKLPVFI
510 520 530 540 550
NSGLAMDGLF DDSEDESDKL SYPWDGTQPY SLFDVSPSCS SFNSPCRDSV
560 570 580 590 600
SPPKSLFSQR PQRMRSRSRS FSRHRSCSRS PYSRSRSRSP GSRSSSRSCY
610 620 630 640 650
YYESSHYRHR THRNSPLYVR SRSRSPYSRR PRYDSYEAYE HERLKRDEYR
660 670 680 690 700
KEHEKRESER AKQRERQKQK AIEERRVIYV GKIRPDTTRT ELRDRFEVFG
710 720 730 740 750
EIEECTVNLR DDGDSYGFIT YRYTCDAFAA LENGYTLRRS NETDFELYFC
760 770 780 790
GRKQFFKSNY ADLDTNSDDF DPASTKSKYD SLDFDSLLKE AQRSLRR
The sequence of this isoform differs from the canonical sequence as follows:
2-16: AWDMCSQDSVWSDIE → LGLSSMDSILK
108-274: Missing.
545-680: PCRDSVSPPK...AIEERRVIYV → LNVIIT
681-797: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
2-16: AWDMCSQDSVWSDIE → LL
108-274: Missing.
545-680: PCRDSVSPPK...AIEERRVIYV → LNVIIT
681-797: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
2-16: AWDMCSQDSVWSDIE → LGLSSMDSILK
268-500: DPKGSPFENK...EQFSKLPVFI → LFL
501-797: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ3LIG2 | Q3LIG2_MOUSE | PPAR gamma coactivator variant form | Ppargc1a PGC-1v | 270 | Annotation score: | ||
A0A0G2JGG3 | A0A0G2JGG3_MOUSE | Peroxisome proliferator-activated r... | Ppargc1a | 696 | Annotation score: | ||
D3YZS8 | D3YZS8_MOUSE | Peroxisome proliferator-activated r... | Ppargc1a | 142 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 587 | S → L in AAH66868 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 629 | R → C in AAH66868 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053275 | 2 – 16 | AWDMC…WSDIE → LGLSSMDSILK in isoform 2 and isoform 4. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_053276 | 2 – 16 | AWDMC…WSDIE → LL in isoform 3. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_053277 | 108 – 274 | Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 167 | |
Alternative sequenceiVSP_053279 | 268 – 500 | DPKGS…LPVFI → LFL in isoform 4. 1 PublicationAdd BLAST | 233 | |
Alternative sequenceiVSP_053281 | 501 – 797 | Missing in isoform 4. 1 PublicationAdd BLAST | 297 | |
Alternative sequenceiVSP_053278 | 545 – 680 | PCRDS…RVIYV → LNVIIT in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 136 | |
Alternative sequenceiVSP_053280 | 681 – 797 | Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 117 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF049330 mRNA Translation: AAC13554.1 JX866946 mRNA Translation: AFZ74947.1 JX866947 mRNA Translation: AFZ74948.1 JX866948 mRNA Translation: AFZ74949.1 AK138668 mRNA Translation: BAE23740.1 AK143753 mRNA Translation: BAE25525.1 CH466524 Genomic DNA Translation: EDL37647.1 BC066868 mRNA Translation: AAH66868.1 |
CCDSi | CCDS19282.1 [O70343-1] |
RefSeqi | NP_032930.1, NM_008904.2 [O70343-1] |
Genome annotation databases
Ensembli | ENSMUST00000132734; ENSMUSP00000117040; ENSMUSG00000029167 [O70343-1] ENSMUST00000151104; ENSMUSP00000116566; ENSMUSG00000029167 [O70343-4] |
GeneIDi | 19017 |
KEGGi | mmu:19017 |
UCSCi | uc008xkc.2, mouse [O70343-1] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF049330 mRNA Translation: AAC13554.1 JX866946 mRNA Translation: AFZ74947.1 JX866947 mRNA Translation: AFZ74948.1 JX866948 mRNA Translation: AFZ74949.1 AK138668 mRNA Translation: BAE23740.1 AK143753 mRNA Translation: BAE25525.1 CH466524 Genomic DNA Translation: EDL37647.1 BC066868 mRNA Translation: AAH66868.1 |
CCDSi | CCDS19282.1 [O70343-1] |
RefSeqi | NP_032930.1, NM_008904.2 [O70343-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3F7D | X-ray | 2.20 | B | 137-150 | [»] | |
AlphaFoldDBi | O70343 | |||||
SMRi | O70343 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 202321, 16 interactors |
CORUMi | O70343 |
DIPi | DIP-38447N |
IntActi | O70343, 15 interactors |
STRINGi | 10090.ENSMUSP00000117040 |
PTM databases
iPTMneti | O70343 |
PhosphoSitePlusi | O70343 |
Proteomic databases
PaxDbi | O70343 |
PRIDEi | O70343 |
ProteomicsDBi | 291873 [O70343-1] 291876 [O70343-4] |
Protocols and materials databases
Antibodypediai | 10142, 358 antibodies from 40 providers |
DNASUi | 19017 |
Genome annotation databases
Ensembli | ENSMUST00000132734; ENSMUSP00000117040; ENSMUSG00000029167 [O70343-1] ENSMUST00000151104; ENSMUSP00000116566; ENSMUSG00000029167 [O70343-4] |
GeneIDi | 19017 |
KEGGi | mmu:19017 |
UCSCi | uc008xkc.2, mouse [O70343-1] |
Organism-specific databases
CTDi | 10891 |
MGIi | MGI:1342774, Ppargc1a |
VEuPathDBi | HostDB:ENSMUSG00000029167 |
Phylogenomic databases
eggNOGi | ENOG502QSXU, Eukaryota |
GeneTreei | ENSGT00950000183137 |
HOGENOMi | CLU_020104_0_0_1 |
InParanoidi | O70343 |
OMAi | KCPSKKK |
OrthoDBi | 94418at2759 |
PhylomeDBi | O70343 |
TreeFami | TF343068 |
Miscellaneous databases
BioGRID-ORCSi | 19017, 2 hits in 78 CRISPR screens |
ChiTaRSi | Ppargc1a, mouse |
EvolutionaryTracei | O70343 |
PROi | PR:O70343 |
RNActi | O70343, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029167, Expressed in diaphragm and 302 other tissues |
Genevisiblei | O70343, MM |
Family and domain databases
CDDi | cd12623, RRM_PPARGC1A, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
IDEALi | IID50038 |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR034605, PGC-1 IPR034625, PGC-1alpha IPR034833, PPARGC1A_RRM IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR15528, PTHR15528, 1 hit PTHR15528:SF10, PTHR15528:SF10, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PRGC1_MOUSE | |
Accessioni | O70343Primary (citable) accession number: O70343 Secondary accession number(s): L0AM20 Q3UP72 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | August 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 192 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references