Ppargc1a

Functionⁱ

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. Isoform 4 specifically activates the expression of IGF1 and suppresses myostatin expression in skeletal muscle leading to muscle fiber hypertrophy.4 Publications

GO - Molecular functionⁱ

alpha-tubulin binding Source: MGI
chromatin binding Source: MGI
chromatin DNA binding
Source: MGI
Inferred from direct assayⁱ
- 17952069
DNA binding
Source: MGI
Inferred from direct assayⁱ
- 15681609
estrogen receptor binding Source: MGI
nuclear receptor binding Source: MGI
nuclear receptor transcription coactivator activity Source: MGI
peroxisome proliferator activated receptor binding Source: MGI
promoter-specific chromatin binding Source: MGI
RNA binding Source: UniProtKB-KW
sequence-specific DNA binding Source: UniProtKB
transcription coactivator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17476214
transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19345188
ubiquitin protein ligase binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive thermogenesis Source: Ensembl
adipose tissue development
Source: CACAO
Inferred from mutant phenotypeⁱ
- 22237023
aging Source: Ensembl
androgen metabolic process Source: Ensembl
autophagy of mitochondrion Source: Ensembl
brown fat cell differentiation Source: InterPro
cellular response to caffeine Source: Ensembl
cellular response to estradiol stimulus Source: Ensembl
cellular response to follicle-stimulating hormone stimulus Source: MGI
cellular response to fructose stimulus Source: Ensembl
cellular response to glucose stimulus Source: Ensembl
cellular response to hypoxia Source: Ensembl
cellular response to interleukin-6 Source: Ensembl
cellular response to ionomycin Source: Ensembl
cellular response to lipopolysaccharide Source: Ensembl
cellular response to nitrite Source: Ensembl
cellular response to oxidative stress
Source: MGI
Inferred from mutant phenotypeⁱ
- 20566846
cellular response to potassium ion Source: Ensembl
cellular response to resveratrol Source: Ensembl
cellular response to thyroid hormone stimulus Source: MGI
cellular response to transforming growth factor beta stimulus Source: MGI
cellular response to tumor necrosis factor Source: Ensembl
cerebellum development Source: Ensembl
circadian regulation of gene expression
Source: UniProtKB
Inferred from direct assayⁱ
- 17476214
energy homeostasis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23150719
fatty acid oxidation Source: Ensembl
flavone metabolic process Source: Ensembl
forebrain development Source: Ensembl
galactose metabolic process Source: Ensembl
gluconeogenesis Source: Ensembl
mitochondrion organization Source: MGI
negative regulation of glycolytic process Source: MGI
negative regulation of mitochondrial fission Source: MGI
negative regulation of neuron apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 20566846
negative regulation of neuron death Source: UniProtKB
negative regulation of protein phosphorylation Source: MGI
negative regulation of signaling receptor activity Source: MGI
negative regulation of smooth muscle cell migration Source: MGI
negative regulation of smooth muscle cell proliferation Source: MGI
positive regulation of ATP biosynthetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23150719
positive regulation of cellular metabolic process Source: MGI
positive regulation of cellular respiration
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23150719
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from mutant phenotypeⁱ
- 15454086
positive regulation of DNA-binding transcription factor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19651776
positive regulation of fatty acid oxidation Source: MGI
positive regulation of glomerular visceral epithelial cell apoptotic process Source: MGI
positive regulation of mitochondrial DNA metabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23150719
positive regulation of mitochondrion organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23150719
positive regulation of muscle tissue development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23150719
positive regulation of progesterone biosynthetic process Source: MGI
positive regulation of smooth muscle cell proliferation Source: MGI
positive regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 14744933
- 15681609
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21106753
regulation of circadian rhythm
Source: UniProtKB
Inferred from direct assayⁱ
- 17476214
regulation of NMDA receptor activity Source: MGI
regulation of transcription, DNA-templated Source: UniProtKB
respiratory electron transport chain
Source: MGI
Inferred from direct assayⁱ
- 14744933
response to activity Source: MGI
response to cold Source: Ensembl
response to dietary excess
Source: MGI
Inferred from direct assayⁱ
- 24726645
response to electrical stimulus involved in regulation of muscle adaptation Source: Ensembl
response to epinephrine Source: Ensembl
response to ischemia Source: Ensembl
response to leucine Source: Ensembl
response to metformin Source: Ensembl
response to methionine Source: Ensembl
response to muscle activity
Source: MGI
Inferred from direct assayⁱ
- 20086200
response to norepinephrine Source: Ensembl
response to reactive oxygen species Source: Ensembl
response to starvation Source: Ensembl
skeletal muscle atrophy Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, RNA-binding
Biological process	Biological rhythms, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Short name: PGC-1-alpha Short name: PPAR-gamma coactivator 1-alpha Short name: PPARGC-1-alpha
Gene namesⁱ	Name:Ppargc1a Synonyms:Pgc1, Pgc1a, Ppargc1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:1342774 Ppargc1a

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice show abnormal diurnal rhythms of activity, body temperature and metabolic rate.1 Publication

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	142 – 146	LKKLL → AKKAA: Strongly reduces coactivation of RORA activity. 1 Publication	5
Mutagenesisⁱ	177	T → A: Abolishes AMPK-mediated phosphorylation; when associated with A-538. 1 Publication	1
Mutagenesisⁱ	538	S → A: Abolishes AMPK-mediated phosphorylation; when associated with A-177. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000081733	1 – 797	Peroxisome proliferator-activated receptor gamma coactivator 1-alphaAdd BLAST		797

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	77	N6-acetyllysine1 Publication	1
Modified residueⁱ	144	N6-acetyllysine1 Publication	1
Modified residueⁱ	177	Phosphothreonine; by AMPK1 Publication	1
Modified residueⁱ	183	N6-acetyllysine1 Publication	1
Modified residueⁱ	253	N6-acetyllysine1 Publication	1
Modified residueⁱ	270	N6-acetyllysine1 Publication	1
Modified residueⁱ	277	N6-acetyllysine1 Publication	1
Modified residueⁱ	320	N6-acetyllysine1 Publication	1
Modified residueⁱ	346	N6-acetyllysine1 Publication	1
Modified residueⁱ	412	N6-acetyllysine1 Publication	1
Modified residueⁱ	441	N6-acetyllysine1 Publication	1
Modified residueⁱ	450	N6-acetyllysine1 Publication	1
Modified residueⁱ	538	Phosphoserine; by AMPK1 Publication	1
Modified residueⁱ	757	N6-acetyllysine1 Publication	1
Modified residueⁱ	778	N6-acetyllysine1 Publication	1

Post-translational modificationⁱ

Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2.2 Publications

Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions.1 Publication

Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation.By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	O70343
PRIDEⁱ	O70343

PTM databases

iPTMnetⁱ	O70343
PhosphoSitePlusⁱ	O70343

Expressionⁱ

Tissue specificityⁱ

White quadriceps and red tibialis anterior (TA) muscles, liver, kidney and brown adipose tissue (at protein level). Skeletal muscle, brown adipose tissue, heart, kidney and brain.3 Publications

Inductionⁱ

Dramatically induced in brown adipose tissue and skeletal muscle by exposure of animals to cold. Up-regulated in brown adipose tissue of obese leptin-deficient (ob/ob) and leptin-unresponsive (db/db) mice. Leptin is required for normal basal and cold-stimulated expression in brown adipose tissue and hyperleptinemia rapidly up-regulates its expression. Induced in muscle by exercise. Oscillates diurnally in liver and skeletal muscle.5 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000029167 Expressed in 280 organ(s), highest expression level in diaphragm
ExpressionAtlasⁱ	O70343 baseline and differential
Genevisibleⁱ	O70343 MM

Interactionⁱ

Subunit structureⁱ

Homooligomer (By similarity). Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation. Interacts with PRDM16, LPIN1 and PML. Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation. Interacts with LRPPRC (By similarity). Interacts with RNF34 (via RING-type zinc finger) (By similarity).By similarity6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
Irf4	Q64287	6	EBI-1371053,EBI-6398485
Lrpprc	Q6PB66	2	EBI-1371053,EBI-1371262
Nr1h4	Q60641-1	3	EBI-11359934,EBI-11659377
Nr1h4	Q60641-2	2	EBI-11359934,EBI-11659386
Sirt1	Q923E4	6	EBI-1371053,EBI-1802585
Yy1	Q00899	5	EBI-1371053,EBI-6921536

GO - Molecular functionⁱ

alpha-tubulin binding Source: MGI
estrogen receptor binding Source: MGI
nuclear receptor binding Source: MGI
peroxisome proliferator activated receptor binding Source: MGI
transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19345188
ubiquitin protein ligase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	202321, 14 interactors
CORUMⁱ	O70343
Database of interacting proteins More...DIPⁱ	DIP-38447N
IntActⁱ	O70343, 14 interactors
STRINGⁱ	10090.ENSMUSP00000117040

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	141 – 147	Combined sources		7

Show more details

3D structure databases

ProteinModelPortalⁱ	O70343
SMRⁱ	O70343
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O70343

EvolutionaryTraceⁱ

O70343

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	676 – 752	RRMPROSITE-ProRule annotationAdd BLAST		77

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	292 – 338	Interaction with PPARGBy similarityAdd BLAST		47
Regionⁱ	349 – 797	Mediates interaction with RNF34By similarityAdd BLAST		449

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	142 – 146	LXXLL motif		5

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	565 – 598	Arg/Ser-richAdd BLAST		34
Compositional biasⁱ	620 – 632	Arg/Ser-richAdd BLAST		13

Phylogenomic databases

eggNOGⁱ	ENOG410IIVU Eukaryota ENOG410YQI0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063196
HOGENOMⁱ	HOG000037431
HOVERGENⁱ	HBG053678
InParanoidⁱ	O70343
KEGG Orthology (KO) More...KOⁱ	K07202
OMAⁱ	YESSHCR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G029M
PhylomeDBⁱ	O70343
TreeFamⁱ	TF343068

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12623 RRM_PPARGC1A, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR034605 PGC-1 IPR034625 PGC-1alpha IPR034833 PPARGC1A_RRM IPR035979 RBD_domain_sf IPR000504 RRM_dom
PANTHERⁱ	PTHR15528 PTHR15528, 1 hit PTHR15528:SF10 PTHR15528:SF10, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative promoter usage and alternative splicing. Align Add to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O70343-1) [UniParc]FASTA Add to basket

Also known as: PGC-1a1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWDMCSQDS VWSDIECAAL VGEDQPLCPD LPELDLSELD VNDLDTDSFL 
        60         70         80         90        100
GGLKWCSDQS EIISNQYNNE PANIFEKIDE ENEANLLAVL TETLDSLPVD 
       110        120        130        140        150
EDGLPSFDAL TDGAVTTDNE ASPSSMPDGT PPPQEAEEPS LLKKLLLAPA 
       160        170        180        190        200
NTQLSYNECS GLSTQNHAAN HTHRIRTNPA IVKTENSWSN KAKSICQQQK 
       210        220        230        240        250
PQRRPCSELL KYLTTNDDPP HTKPTENRNS SRDKCASKKK SHTQPQSQHA 
       260        270        280        290        300
QAKPTTLSLP LTPESPNDPK GSPFENKTIE RTLSVELSGT AGLTPPTTPP 
       310        320        330        340        350
HKANQDNPFK ASPKLKPSCK TVVPPPTKRA RYSECSGTQG SHSTKKGPEQ 
       360        370        380        390        400
SELYAQLSKS SGLSRGHEER KTKRPSLRLF GDHDYCQSLN SKTDILINIS 
       410        420        430        440        450
QELQDSRQLD FKDASCDWQG HICSSTDSGQ CYLRETLEAS KQVSPCSTRK 
       460        470        480        490        500
QLQDQEIRAE LNKHFGHPCQ AVFDDKSDKT SELRDGDFSN EQFSKLPVFI 
       510        520        530        540        550
NSGLAMDGLF DDSEDESDKL SYPWDGTQPY SLFDVSPSCS SFNSPCRDSV 
       560        570        580        590        600
SPPKSLFSQR PQRMRSRSRS FSRHRSCSRS PYSRSRSRSP GSRSSSRSCY 
       610        620        630        640        650
YYESSHYRHR THRNSPLYVR SRSRSPYSRR PRYDSYEAYE HERLKRDEYR 
       660        670        680        690        700
KEHEKRESER AKQRERQKQK AIEERRVIYV GKIRPDTTRT ELRDRFEVFG 
       710        720        730        740        750
EIEECTVNLR DDGDSYGFIT YRYTCDAFAA LENGYTLRRS NETDFELYFC 
       760        770        780        790 
GRKQFFKSNY ADLDTNSDDF DPASTKSKYD SLDFDSLLKE AQRSLRR

Length:797

Mass (Da):90,588

Last modified:August 1, 1998 - v1

Checksum:ⁱAE73EE2B3A622B05

GO

Isoform 2 (identifier: O70343-2) [UniParc]FASTA Add to basket

Also known as: PGC-1a2

The sequence of this isoform differs from the canonical sequence as follows:
     2-16: AWDMCSQDSVWSDIE → LGLSSMDSILK
     108-274: Missing.
     545-680: PCRDSVSPPK...AIEERRVIYV → LNVIIT
     681-797: Missing.

« Hide

        10         20         30         40         50
MLGLSSMDSI LKCAALVGED QPLCPDLPEL DLSELDVNDL DTDSFLGGLK 
        60         70         80         90        100
WCSDQSEIIS NQYNNEPANI FEKIDEENEA NLLAVLTETL DSLPVDEDGL 
       110        120        130        140        150
PSFENKTIER TLSVELSGTA GLTPPTTPPH KANQDNPFKA SPKLKPSCKT 
       160        170        180        190        200
VVPPPTKRAR YSECSGTQGS HSTKKGPEQS ELYAQLSKSS GLSRGHEERK 
       210        220        230        240        250
TKRPSLRLFG DHDYCQSLNS KTDILINISQ ELQDSRQLDF KDASCDWQGH 
       260        270        280        290        300
ICSSTDSGQC YLRETLEASK QVSPCSTRKQ LQDQEIRAEL NKHFGHPCQA 
       310        320        330        340        350
VFDDKSDKTS ELRDGDFSNE QFSKLPVFIN SGLAMDGLFD DSEDESDKLS 
       360        370 
YPWDGTQPYS LFDVSPSCSS FNSLNVIIT

Note: Produced by alternative promoter usage and alternative splicing.

Show »

Length:379

Mass (Da):41,921

Checksum:ⁱF9FC43F94A209D82

GO

Isoform 3 (identifier: O70343-3) [UniParc]FASTA Add to basket

Also known as: PGC-1a3

The sequence of this isoform differs from the canonical sequence as follows:
     2-16: AWDMCSQDSVWSDIE → LL
     108-274: Missing.
     545-680: PCRDSVSPPK...AIEERRVIYV → LNVIIT
     681-797: Missing.

« Hide

        10         20         30         40         50
MLLCAALVGE DQPLCPDLPE LDLSELDVND LDTDSFLGGL KWCSDQSEII 
        60         70         80         90        100
SNQYNNEPAN IFEKIDEENE ANLLAVLTET LDSLPVDEDG LPSFENKTIE 
       110        120        130        140        150
RTLSVELSGT AGLTPPTTPP HKANQDNPFK ASPKLKPSCK TVVPPPTKRA 
       160        170        180        190        200
RYSECSGTQG SHSTKKGPEQ SELYAQLSKS SGLSRGHEER KTKRPSLRLF 
       210        220        230        240        250
GDHDYCQSLN SKTDILINIS QELQDSRQLD FKDASCDWQG HICSSTDSGQ 
       260        270        280        290        300
CYLRETLEAS KQVSPCSTRK QLQDQEIRAE LNKHFGHPCQ AVFDDKSDKT 
       310        320        330        340        350
SELRDGDFSN EQFSKLPVFI NSGLAMDGLF DDSEDESDKL SYPWDGTQPY 
       360        370
SLFDVSPSCS SFNSLNVIIT

Note: Produced by alternative promoter usage and alternative splicing.

Show »

Length:370

Mass (Da):41,002

Checksum:ⁱAA98B0425EE8F122

GO

Isoform 4 (identifier: O70343-4) [UniParc]FASTA Add to basket

Also known as: PGC-1a4

The sequence of this isoform differs from the canonical sequence as follows:
     2-16: AWDMCSQDSVWSDIE → LGLSSMDSILK
     268-500: DPKGSPFENK...EQFSKLPVFI → LFL
     501-797: Missing.

« Hide

        10         20         30         40         50
MLGLSSMDSI LKCAALVGED QPLCPDLPEL DLSELDVNDL DTDSFLGGLK 
        60         70         80         90        100
WCSDQSEIIS NQYNNEPANI FEKIDEENEA NLLAVLTETL DSLPVDEDGL 
       110        120        130        140        150
PSFDALTDGA VTTDNEASPS SMPDGTPPPQ EAEEPSLLKK LLLAPANTQL 
       160        170        180        190        200
SYNECSGLST QNHAANHTHR IRTNPAIVKT ENSWSNKAKS ICQQQKPQRR 
       210        220        230        240        250
PCSELLKYLT TNDDPPHTKP TENRNSSRDK CASKKKSHTQ PQSQHAQAKP 
       260 
TTLSLPLTPE SPNLFL

Note: Produced by alternative promoter usage and alternative splicing.

Show »

Length:266

Mass (Da):29,115

Checksum:ⁱ317BEC86DF2E9DFB

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0G2JGG3	A0A0G2JGG3_MOUSE	Peroxisome proliferator-activated r... Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	Ppargc1a	696	Annotation score:
Q3LIG2	Q3LIG2_MOUSE	PPAR gamma coactivator variant form PPAR gamma coactivator variant form (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha)	Ppargc1a PGC-1v	270	Annotation score:
D3YZS8	D3YZS8_MOUSE	Peroxisome proliferator-activated r... Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	Ppargc1a	142	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	587	S → L in AAH66868 (PubMed:15489334).Curated		1
Sequence conflictⁱ	629	R → C in AAH66868 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_053275	2 – 16	AWDMC…WSDIE → LGLSSMDSILK in isoform 2 and isoform 4. 1 PublicationAdd BLAST	15
Alternative sequenceⁱVSP_053276	2 – 16	AWDMC…WSDIE → LL in isoform 3. 1 PublicationAdd BLAST	15
Alternative sequenceⁱVSP_053277	108 – 274	Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST	167
Alternative sequenceⁱVSP_053279	268 – 500	DPKGS…LPVFI → LFL in isoform 4. 1 PublicationAdd BLAST	233
Alternative sequenceⁱVSP_053281	501 – 797	Missing in isoform 4. 1 PublicationAdd BLAST	297
Alternative sequenceⁱVSP_053278	545 – 680	PCRDS…RVIYV → LNVIIT in isoform 2 and isoform 3. 1 PublicationAdd BLAST	136
Alternative sequenceⁱVSP_053280	681 – 797	Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST	117

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF049330 mRNA Translation: AAC13554.1 JX866946 mRNA Translation: AFZ74947.1 JX866947 mRNA Translation: AFZ74948.1 JX866948 mRNA Translation: AFZ74949.1 AK138668 mRNA Translation: BAE23740.1 AK143753 mRNA Translation: BAE25525.1 CH466524 Genomic DNA Translation: EDL37647.1 BC066868 mRNA Translation: AAH66868.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19282.1 [O70343-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_032930.1, NM_008904.2 [O70343-1]
UniGeneⁱ	Mm.259072

Genome annotation databases

Ensemblⁱ	ENSMUST00000132734; ENSMUSP00000117040; ENSMUSG00000029167 [O70343-1] ENSMUST00000151104; ENSMUSP00000116566; ENSMUSG00000029167 [O70343-4]
GeneIDⁱ	19017
KEGGⁱ	mmu:19017
UCSC genome browser More...UCSCⁱ	uc008xkc.2 mouse [O70343-1]

Keywords - Coding sequence diversityⁱ

Alternative promoter usage, Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O70343	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	)	HUMAN		798	UniRef90_Q9UBK2
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha		BOVIN		796
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha		PIG		796
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha		RAT		796
Uncharacterized protein		SHEEP		819
+396
O70343-4	Isoform 8a of Peroxisome proliferator-activated receptor gamma coactivator 1-alpha		HUMAN		301	UniRef90_Q9UBK2-8
Uncharacterized protein		COLAP		297
Uncharacterized protein		RHIRO		297
Uncharacterized protein		AOTNA		297
Uncharacterized protein		NOMLE		297
+42

Protein	Similar proteins		Species	Score	Length	Source
O70343	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	)	HUMAN		798	UniRef50_Q9UBK2
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha		PIG		796
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha		BOVIN		796
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha		RAT		796
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha		BUBBU		819
+647
O70343-2	Isoform 3 of Peroxisome proliferator-activated receptor gamma coactivator 1-alpha		MOUSE		370	UniRef50_O70343-2
Uncharacterized protein (Fragment)		NEOLE		323
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (Fragment)		PIG		380
UPI000520D69D		GAVST		390
O70343-3	Isoform 2 of Peroxisome proliferator-activated receptor gamma coactivator 1-alpha		MOUSE		379	UniRef50_O70343-2
Uncharacterized protein (Fragment)		NEOLE		323
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (Fragment)		PIG		380
UPI000520D69D		GAVST		390
O70343-4	Isoform 8a of Peroxisome proliferator-activated receptor gamma coactivator 1-alpha		HUMAN		301	UniRef50_Q9UBK2-8
Uncharacterized protein		COLAP		297
Uncharacterized protein		RHIRO		297
Uncharacterized protein		AOTNA		297
Uncharacterized protein		NOMLE		297
+50

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF049330 mRNA Translation: AAC13554.1 JX866946 mRNA Translation: AFZ74947.1 JX866947 mRNA Translation: AFZ74948.1 JX866948 mRNA Translation: AFZ74949.1 AK138668 mRNA Translation: BAE23740.1 AK143753 mRNA Translation: BAE25525.1 CH466524 Genomic DNA Translation: EDL37647.1 BC066868 mRNA Translation: AAH66868.1
CCDSⁱ	CCDS19282.1 [O70343-1]
RefSeqⁱ	NP_032930.1, NM_008904.2 [O70343-1]
UniGeneⁱ	Mm.259072

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3F7D	X-ray	2.20	B	137-150	[»]
ProteinModelPortalⁱ	O70343
SMRⁱ	O70343
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	202321, 14 interactors
CORUMⁱ	O70343
DIPⁱ	DIP-38447N
IntActⁱ	O70343, 14 interactors
STRINGⁱ	10090.ENSMUSP00000117040

PTM databases

iPTMnetⁱ	O70343
PhosphoSitePlusⁱ	O70343

Proteomic databases

PaxDbⁱ	O70343
PRIDEⁱ	O70343

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000132734; ENSMUSP00000117040; ENSMUSG00000029167 [O70343-1] ENSMUST00000151104; ENSMUSP00000116566; ENSMUSG00000029167 [O70343-4]
GeneIDⁱ	19017
KEGGⁱ	mmu:19017
UCSCⁱ	uc008xkc.2 mouse [O70343-1]

Organism-specific databases

CTDⁱ	10891
MGIⁱ	MGI:1342774 Ppargc1a

Phylogenomic databases

eggNOGⁱ	ENOG410IIVU Eukaryota ENOG410YQI0 LUCA
GeneTreeⁱ	ENSGT00530000063196
HOGENOMⁱ	HOG000037431
HOVERGENⁱ	HBG053678
InParanoidⁱ	O70343
KOⁱ	K07202
OMAⁱ	YESSHCR
OrthoDBⁱ	EOG091G029M
PhylomeDBⁱ	O70343
TreeFamⁱ	TF343068

Miscellaneous databases

ChiTaRSⁱ	Ppargc1a mouse
EvolutionaryTraceⁱ	O70343
Protein Ontology More...PROⁱ	PR:O70343
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000029167 Expressed in 280 organ(s), highest expression level in diaphragm
ExpressionAtlasⁱ	O70343 baseline and differential
Genevisibleⁱ	O70343 MM

Family and domain databases

CDDⁱ	cd12623 RRM_PPARGC1A, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR034605 PGC-1 IPR034625 PGC-1alpha IPR034833 PPARGC1A_RRM IPR035979 RBD_domain_sf IPR000504 RRM_dom
PANTHERⁱ	PTHR15528 PTHR15528, 1 hit PTHR15528:SF10 PTHR15528:SF10, 1 hit
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PRGC1_MOUSE
Accessionⁱ	O70343Primary (citable) accession number: O70343 Secondary accession number(s): L0AM20 , L0AN96, L0APB0, Q3UP72
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
	Last sequence update:	August 1, 1998
	Last modified:	November 7, 2018
	This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - O70343 (PRGC1_MOUSE)

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Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

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Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Keywords - Cellular componenti

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Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Phylogenomic databases

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Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ