Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• alpha-tubulin binding Source: MGI
• chromatin binding Source: MGI
• chromatin DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH."
    Compe E., Malerba M., Soler L., Marescaux J., Borrelli E., Egly J.M.
    Nat Neurosci 10:1414-1422(2007) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: MGIInferred from direct assayⁱ
  • "Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes."
    Guan H.P., Ishizuka T., Chui P.C., Lehrke M., Lazar M.A.
    Genes Dev 19:453-461(2005) [PubMed] [Europe PMC] [Abstract]
• estrogen receptor binding Source: MGI
• nuclear receptor binding Source: MGI
• nuclear receptor coactivator activity Source: MGI
• peroxisome proliferator activated receptor binding Source: MGI
• promoter-specific chromatin binding Source: MGI
• RNA binding Source: UniProtKB-KW
• sequence-specific DNA binding Source: UniProtKB
• transcription coactivator activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.12

    "Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism."
    Liu C., Li S., Liu T., Borjigin J., Lin J.D.
    Nature 447:477-481(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN CIRCADIAN RHYTHMS, INTERACTION WITH RORA AND RORC, TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE, MUTAGENESIS OF 142-LEU--LEU-146.
• transcription factor binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism."
    Pan D., Fujimoto M., Lopes A., Wang Y.X.
    Cell 137:73-86(2009) [PubMed] [Europe PMC] [Abstract]
• ubiquitin protein ligase binding Source: MGI

GO - Biological processⁱ

• adaptive thermogenesis Source: Ensembl
• adipose tissue development Source: CACAO <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.16

    "A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis."
    Bostrom P., Wu J., Jedrychowski M.P., Korde A., Ye L., Lo J.C., Rasbach K.A., Bostrom E.A., Choi J.H., Long J.Z., Kajimura S., Zingaretti M.C., Vind B.F., Tu H., Cinti S., Hojlund K., Gygi S.P., Spiegelman B.M.
    Nature 481:463-468(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION.
• aging Source: Ensembl
• androgen metabolic process Source: Ensembl
• autophagy of mitochondrion Source: Ensembl
• cellular response to caffeine Source: Ensembl
• cellular response to estradiol stimulus Source: Ensembl
• cellular response to follicle-stimulating hormone stimulus Source: MGI
• cellular response to fructose stimulus Source: Ensembl
• cellular response to glucose stimulus Source: Ensembl
• cellular response to hypoxia Source: Ensembl
• cellular response to interleukin-6 Source: Ensembl
• cellular response to ionomycin Source: Ensembl
• cellular response to lipopolysaccharide Source: Ensembl
• cellular response to nitrite Source: Ensembl
• cellular response to oxidative stress Source: MGIInferred from mutant phenotypeⁱ
  • "NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection."
    Volakakis N., Kadkhodaei B., Joodmardi E., Wallis K., Panman L., Silvaggi J., Spiegelman B.M., Perlmann T.
    Proc. Natl. Acad. Sci. U.S.A. 107:12317-12322(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to potassium ion Source: Ensembl
• cellular response to resveratrol Source: Ensembl
• cellular response to thyroid hormone stimulus Source: MGI
• cellular response to transforming growth factor beta stimulus Source: MGI
• cellular response to tumor necrosis factor Source: Ensembl
• cerebellum development Source: Ensembl
• circadian regulation of gene expression Source: UniProtKBInferred from direct assayⁱ
  • Ref.12

    "Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism."
    Liu C., Li S., Liu T., Borjigin J., Lin J.D.
    Nature 447:477-481(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN CIRCADIAN RHYTHMS, INTERACTION WITH RORA AND RORC, TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE, MUTAGENESIS OF 142-LEU--LEU-146.
• energy homeostasis Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN."
    Hasumi H., Baba M., Hasumi Y., Huang Y., Oh H., Hughes R.M., Klein M.E., Takikita S., Nagashima K., Schmidt L.S., Linehan W.M.
    J Natl Cancer Inst 104:1750-1764(2012) [PubMed] [Europe PMC] [Abstract]
• fatty acid oxidation Source: Ensembl
• flavone metabolic process Source: Ensembl
• forebrain development Source: Ensembl
• galactose metabolic process Source: Ensembl
• gluconeogenesis Source: Ensembl
• mitochondrion organization Source: MGI
• negative regulation of glycolytic process Source: MGI
• negative regulation of mitochondrial fission Source: MGI
• negative regulation of neuron apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection."
    Volakakis N., Kadkhodaei B., Joodmardi E., Wallis K., Panman L., Silvaggi J., Spiegelman B.M., Perlmann T.
    Proc. Natl. Acad. Sci. U.S.A. 107:12317-12322(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neuron death Source: UniProtKB
• negative regulation of protein phosphorylation Source: MGI
• negative regulation of signaling receptor activity Source: MGI
• negative regulation of smooth muscle cell migration Source: MGI
• negative regulation of smooth muscle cell proliferation Source: MGI
• positive regulation of ATP biosynthetic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN."
    Hasumi H., Baba M., Hasumi Y., Huang Y., Oh H., Hughes R.M., Klein M.E., Takikita S., Nagashima K., Schmidt L.S., Linehan W.M.
    J Natl Cancer Inst 104:1750-1764(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cellular metabolic process Source: MGI
• positive regulation of cellular respiration Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN."
    Hasumi H., Baba M., Hasumi Y., Huang Y., Oh H., Hughes R.M., Klein M.E., Takikita S., Nagashima K., Schmidt L.S., Linehan W.M.
    J Natl Cancer Inst 104:1750-1764(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cold-induced thermogenesis Source: YuBioLabInferred from mutant phenotypeⁱ
  • "Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice."
    Lin J., Wu P.H., Tarr P.T., Lindenberg K.S., St-Pierre J., Zhang C.Y., Mootha V.K., Jager S., Vianna C.R., Reznick R.M., Cui L., Manieri M., Donovan M.X., Wu Z., Cooper M.P., Fan M.C., Rohas L.M., Zavacki A.M.

    , Cinti S., Shulman G.I., Lowell B.B., Krainc D., Spiegelman B.M.
    Cell 119:121-135(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA-binding transcription factor activity Source: BHF-UCLInferred from direct assayⁱ
  • "DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression."
    Nedumaran B., Hong S., Xie Y.B., Kim Y.H., Seo W.Y., Lee M.W., Lee C.H., Koo S.H., Choi H.S.
    J Biol Chem 284:27511-27523(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fatty acid oxidation Source: MGI
• positive regulation of gene expression Source: MGI
• positive regulation of glomerular visceral epithelial cell apoptotic process Source: MGI
• positive regulation of mitochondrial DNA metabolic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN."
    Hasumi H., Baba M., Hasumi Y., Huang Y., Oh H., Hughes R.M., Klein M.E., Takikita S., Nagashima K., Schmidt L.S., Linehan W.M.
    J Natl Cancer Inst 104:1750-1764(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mitochondrion organization Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN."
    Hasumi H., Baba M., Hasumi Y., Huang Y., Oh H., Hughes R.M., Klein M.E., Takikita S., Nagashima K., Schmidt L.S., Linehan W.M.
    J Natl Cancer Inst 104:1750-1764(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of muscle tissue development Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN."
    Hasumi H., Baba M., Hasumi Y., Huang Y., Oh H., Hughes R.M., Klein M.E., Takikita S., Nagashima K., Schmidt L.S., Linehan W.M.
    J Natl Cancer Inst 104:1750-1764(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of progesterone biosynthetic process Source: MGI
• positive regulation of smooth muscle cell proliferation Source: MGI
• positive regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • Ref.7

    "Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK."
    Fan M., Rhee J., St Pierre J., Handschin C., Puigserver P., Lin J., Jaeger S., Erdjument-Bromage H., Tempst P., Spiegelman B.M.
    Genes Dev. 18:278-289(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH MYBBP1A.
  • "Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes."
    Guan H.P., Ishizuka T., Chui P.C., Lehrke M., Lazar M.A.
    Genes Dev 19:453-461(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types."
    Rasbach K.A., Gupta R.K., Ruas J.L., Wu J., Naseri E., Estall J.L., Spiegelman B.M.
    Proc Natl Acad Sci U S A 107:21866-21871(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of circadian rhythm Source: UniProtKBInferred from direct assayⁱ
  • Ref.12

    "Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism."
    Liu C., Li S., Liu T., Borjigin J., Lin J.D.
    Nature 447:477-481(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN CIRCADIAN RHYTHMS, INTERACTION WITH RORA AND RORC, TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE, MUTAGENESIS OF 142-LEU--LEU-146.
• regulation of NMDA receptor activity Source: MGI
• regulation of transcription, DNA-templated Source: UniProtKB
• respiratory electron transport chain Source: MGIInferred from direct assayⁱ
  • Ref.7

    "Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK."
    Fan M., Rhee J., St Pierre J., Handschin C., Puigserver P., Lin J., Jaeger S., Erdjument-Bromage H., Tempst P., Spiegelman B.M.
    Genes Dev. 18:278-289(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH MYBBP1A.
• response to activity Source: MGI
• response to cold Source: Ensembl
• response to dietary excess Source: MGIInferred from direct assayⁱ
  • "RB tumor suppressive function in response to xenobiotic hepatocarcinogens."
    Reed C., Hutcheson J., Mayhew C.N., Witkiewicz A.K., Knudsen E.S.
    Am J Pathol 184:1853-1859(2014) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: Ensembl
• response to electrical stimulus involved in regulation of muscle adaptation Source: Ensembl
• response to epinephrine Source: Ensembl
• response to ischemia Source: Ensembl
• response to leucine Source: Ensembl
• response to metformin Source: Ensembl
• response to methionine Source: Ensembl
• response to muscle activity Source: MGIInferred from direct assayⁱ
  • "The microRNA miR-696 regulates PGC-1{alpha} in mouse skeletal muscle in response to physical activity."
    Aoi W., Naito Y., Mizushima K., Takanami Y., Kawai Y., Ichikawa H., Yoshikawa T.
    Am J Physiol Endocrinol Metab 298:E799-806(2010) [PubMed] [Europe PMC] [Abstract]
• response to norepinephrine Source: Ensembl
• response to reactive oxygen species Source: Ensembl
• response to starvation Source: Ensembl
• skeletal muscle atrophy Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• alpha-tubulin binding Source: MGI
• estrogen receptor binding Source: MGI
• nuclear receptor binding Source: MGI
• peroxisome proliferator activated receptor binding Source: MGI
• transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism."
    Pan D., Fujimoto M., Lopes A., Wang Y.X.
    Cell 137:73-86(2009) [PubMed] [Europe PMC] [Abstract]
• ubiquitin protein ligase binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MAWDMCSQDS VWSDIECAAL VGEDQPLCPD LPELDLSELD VNDLDTDSFL 
        60         70         80         90        100
GGLKWCSDQS EIISNQYNNE PANIFEKIDE ENEANLLAVL TETLDSLPVD 
       110        120        130        140        150
EDGLPSFDAL TDGAVTTDNE ASPSSMPDGT PPPQEAEEPS LLKKLLLAPA 
       160        170        180        190        200
NTQLSYNECS GLSTQNHAAN HTHRIRTNPA IVKTENSWSN KAKSICQQQK 
       210        220        230        240        250
PQRRPCSELL KYLTTNDDPP HTKPTENRNS SRDKCASKKK SHTQPQSQHA 
       260        270        280        290        300
QAKPTTLSLP LTPESPNDPK GSPFENKTIE RTLSVELSGT AGLTPPTTPP 
       310        320        330        340        350
HKANQDNPFK ASPKLKPSCK TVVPPPTKRA RYSECSGTQG SHSTKKGPEQ 
       360        370        380        390        400
SELYAQLSKS SGLSRGHEER KTKRPSLRLF GDHDYCQSLN SKTDILINIS 
       410        420        430        440        450
QELQDSRQLD FKDASCDWQG HICSSTDSGQ CYLRETLEAS KQVSPCSTRK 
       460        470        480        490        500
QLQDQEIRAE LNKHFGHPCQ AVFDDKSDKT SELRDGDFSN EQFSKLPVFI 
       510        520        530        540        550
NSGLAMDGLF DDSEDESDKL SYPWDGTQPY SLFDVSPSCS SFNSPCRDSV 
       560        570        580        590        600
SPPKSLFSQR PQRMRSRSRS FSRHRSCSRS PYSRSRSRSP GSRSSSRSCY 
       610        620        630        640        650
YYESSHYRHR THRNSPLYVR SRSRSPYSRR PRYDSYEAYE HERLKRDEYR 
       660        670        680        690        700
KEHEKRESER AKQRERQKQK AIEERRVIYV GKIRPDTTRT ELRDRFEVFG 
       710        720        730        740        750
EIEECTVNLR DDGDSYGFIT YRYTCDAFAA LENGYTLRRS NETDFELYFC 
       760        770        780        790 
GRKQFFKSNY ADLDTNSDDF DPASTKSKYD SLDFDSLLKE AQRSLRR    

        10         20         30         40         50
MLGLSSMDSI LKCAALVGED QPLCPDLPEL DLSELDVNDL DTDSFLGGLK 
        60         70         80         90        100
WCSDQSEIIS NQYNNEPANI FEKIDEENEA NLLAVLTETL DSLPVDEDGL 
       110        120        130        140        150
PSFENKTIER TLSVELSGTA GLTPPTTPPH KANQDNPFKA SPKLKPSCKT 
       160        170        180        190        200
VVPPPTKRAR YSECSGTQGS HSTKKGPEQS ELYAQLSKSS GLSRGHEERK 
       210        220        230        240        250
TKRPSLRLFG DHDYCQSLNS KTDILINISQ ELQDSRQLDF KDASCDWQGH 
       260        270        280        290        300
ICSSTDSGQC YLRETLEASK QVSPCSTRKQ LQDQEIRAEL NKHFGHPCQA 
       310        320        330        340        350
VFDDKSDKTS ELRDGDFSNE QFSKLPVFIN SGLAMDGLFD DSEDESDKLS 
       360        370 
YPWDGTQPYS LFDVSPSCSS FNSLNVIIT                        

        10         20         30         40         50
MLLCAALVGE DQPLCPDLPE LDLSELDVND LDTDSFLGGL KWCSDQSEII 
        60         70         80         90        100
SNQYNNEPAN IFEKIDEENE ANLLAVLTET LDSLPVDEDG LPSFENKTIE 
       110        120        130        140        150
RTLSVELSGT AGLTPPTTPP HKANQDNPFK ASPKLKPSCK TVVPPPTKRA 
       160        170        180        190        200
RYSECSGTQG SHSTKKGPEQ SELYAQLSKS SGLSRGHEER KTKRPSLRLF 
       210        220        230        240        250
GDHDYCQSLN SKTDILINIS QELQDSRQLD FKDASCDWQG HICSSTDSGQ 
       260        270        280        290        300
CYLRETLEAS KQVSPCSTRK QLQDQEIRAE LNKHFGHPCQ AVFDDKSDKT 
       310        320        330        340        350
SELRDGDFSN EQFSKLPVFI NSGLAMDGLF DDSEDESDKL SYPWDGTQPY 
       360        370
SLFDVSPSCS SFNSLNVIIT                                  

        10         20         30         40         50
MLGLSSMDSI LKCAALVGED QPLCPDLPEL DLSELDVNDL DTDSFLGGLK 
        60         70         80         90        100
WCSDQSEIIS NQYNNEPANI FEKIDEENEA NLLAVLTETL DSLPVDEDGL 
       110        120        130        140        150
PSFDALTDGA VTTDNEASPS SMPDGTPPPQ EAEEPSLLKK LLLAPANTQL 
       160        170        180        190        200
SYNECSGLST QNHAANHTHR IRTNPAIVKT ENSWSNKAKS ICQQQKPQRR 
       210        220        230        240        250
PCSELLKYLT TNDDPPHTKP TENRNSSRDK CASKKKSHTQ PQSQHAQAKP 
       260 
TTLSLPLTPE SPNLFL                                      

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references