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Protein

Neuropeptide Y receptor type 5

Gene

Npy5r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 5
Short name:
NPY5-R
Alternative name(s):
NPY-Y5 receptor
Short name:
NPYY5-R
Short name:
Y5 receptor
Gene namesi
Name:Npy5r
Synonyms:Npy5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:108082 Npy5r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 63ExtracellularSequence analysisAdd BLAST63
Transmembranei64 – 84Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini85 – 98CytoplasmicSequence analysisAdd BLAST14
Transmembranei99 – 119Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini120 – 138ExtracellularSequence analysisAdd BLAST19
Transmembranei139 – 159Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini160 – 177CytoplasmicSequence analysisAdd BLAST18
Transmembranei178 – 198Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini199 – 229ExtracellularSequence analysisAdd BLAST31
Transmembranei230 – 250Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini251 – 389CytoplasmicSequence analysisAdd BLAST139
Transmembranei390 – 410Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini411 – 427ExtracellularSequence analysisAdd BLAST17
Transmembranei428 – 448Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini449 – 466CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3802

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699401 – 466Neuropeptide Y receptor type 5Add BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi135 ↔ 219PROSITE-ProRule annotation
Lipidationi462S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO70342
PRIDEiO70342

PTM databases

PhosphoSitePlusiO70342
SwissPalmiO70342

Expressioni

Gene expression databases

BgeeiENSMUSG00000044014 Expressed in 65 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_NPY5R
ExpressionAtlasiO70342 baseline and differential
GenevisibleiO70342 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065157

Chemistry databases

BindingDBiO70342

Structurei

3D structure databases

ProteinModelPortaliO70342
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00920000148949
HOGENOMiHOG000294210
HOVERGENiHBG052662
InParanoidiO70342
KOiK04207
OrthoDBiEOG091G0ZDG
PhylomeDBiO70342
TreeFamiTF315303

Family and domain databases

CDDicd15398 7tmA_NPY5R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000393 NPY5_rcpt
IPR000611 NPY_rcpt
PANTHERiPTHR45422 PTHR45422, 2 hits
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01016 NRPEPTIDEY5R
PR01012 NRPEPTIDEYR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O70342-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVKLEEHFN KTFVTENNTA ASQNTASPAW EDYRGTENNT SAARNTAFPV
60 70 80 90 100
WEDYRGSVDD LQYFLIGLYT FVSLLGFMGN LLILMAVMKK RNQKTTVNFL
110 120 130 140 150
IGNLAFSDIL VVLFCSPFTL TSVLLDQWMF GKAMCHIMPF LQCVSVLVST
160 170 180 190 200
LILISIAIVR YHMIKHPISN NLTANHGYFL IATVWTLGFA ICSPLPVFHS
210 220 230 240 250
LVELKETFGS ALLSSKYLCV ESWPSDSYRI AFTISLLLVQ YILPLVCLTV
260 270 280 290 300
SHTSVCRSIS CGLSHKENRL EENEMINLTL HPSKKSRDQA KPPSTQKWSY
310 320 330 340 350
SFIRKHRRRY SKKTACVLPA PAGPSQEKHL TVPENPGSVR SQLSPSSKVI
360 370 380 390 400
PGVPICFEVK PEESSDAQEM RVKRSLTRIK KRSRSVFYRL TILILVFAVS
410 420 430 440 450
WMPLHVFHVV TDFNDNLISN RHFKLVYCIC HLLGMMSCCL NPILYGFLNN
460
GIKADLRALI HCLHMS
Length:466
Mass (Da):52,785
Last modified:February 21, 2001 - v2
Checksum:iB157F236EF2D4385
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195L → F in AAC17839 (PubMed:9802393).Curated1
Sequence conflicti284K → Q in BAA89538 (PubMed:9315606).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049329 mRNA Translation: AAC17839.1
AF022948 Genomic DNA Translation: AAB81829.1
AB001346 mRNA Translation: BAA89538.1
CCDSiCCDS22335.1
RefSeqiNP_057917.2, NM_016708.3
XP_006509661.1, XM_006509598.3
XP_006509662.1, XM_006509599.3
UniGeneiMm.10685

Genome annotation databases

EnsembliENSMUST00000070810; ENSMUSP00000065157; ENSMUSG00000044014
ENSMUST00000211920; ENSMUSP00000148410; ENSMUSG00000044014
ENSMUST00000212563; ENSMUSP00000148589; ENSMUSG00000044014
GeneIDi18168
KEGGimmu:18168
UCSCiuc009lvr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNPY5R_MOUSE
AccessioniPrimary (citable) accession number: O70342
Secondary accession number(s): O35380, Q9JMK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 21, 2001
Last modified: September 12, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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