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Protein

Bcl-2-interacting killer

Gene

Bik

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accelerates programmed cell death. Binding to the apoptosis repressors Bcl-X(L), BHRF1 or Bcl-2 suppresses this death-promoting activity.1 Publication

GO - Molecular functioni

GO - Biological processi

  • apoptotic mitochondrial changes Source: MGI
  • male gonad development Source: MGI
  • positive regulation of protein homooligomerization Source: MGI
  • positive regulation of release of cytochrome c from mitochondria Source: MGI
  • spermatogenesis Source: MGI

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-interacting killer
Alternative name(s):
Apoptosis inducer NBK
Bik-like killer protein
Gene namesi
Name:Bik
Synonyms:Biklk, Blk, Nbk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1206591 Bik

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004192021 – 150Bcl-2-interacting killerAdd BLAST150

Post-translational modificationi

Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei143 – 144Cleavage; by RHBDL4/RHBDD1By similarity2

Proteomic databases

PaxDbiO70337
PRIDEiO70337

PTM databases

iPTMnetiO70337
PhosphoSitePlusiO70337

Expressioni

Tissue specificityi

Expressed in testis, kidney, liver, lung and heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000016758 Expressed in 156 organ(s), highest expression level in heart left ventricle
GenevisibleiO70337 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-310 BIK:BCL-w complex
ELMiO70337
STRINGi10090.ENSMUSP00000016902

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 148Leucine-zipperSequence analysisAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 65BH3By similarityAdd BLAST15

Domaini

Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.By similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JHX0 Eukaryota
ENOG41116I0 LUCA
GeneTreeiENSGT00530000064453
HOVERGENiHBG001515
InParanoidiO70337
KOiK18452
OrthoDBiEOG091G0VGV
TreeFamiTF338339

Family and domain databases

InterProiView protein in InterPro
IPR024579 Bcl2-int_killer
PANTHERiPTHR15018 PTHR15018, 1 hit
PfamiView protein in Pfam
PF12201 bcl-2I13, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD032623 PD032623, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

O70337-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEARLMARD VIKTVPHDQV PQPPVASETP SMKEPVRDVD LMECVEGRNQ
60 70 80 90 100
VALRLACIGD EMDLCLRSPR LVQLPGIAIH RLAVTYSRTG VRGIFRSLIR
110 120 130 140 150
SLTNLRENIW SWRVLTPGAW VSPDQDPGQL FPMVLLVFLL LGGAWYLQLQ
Length:150
Mass (Da):16,901
Last modified:August 1, 1998 - v1
Checksum:i120CB6BAA4612788
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VI69A0A2R8VI69_MOUSE
Bcl-2-interacting killer
Bik
106Annotation score:
A0A2R8W6U8A0A2R8W6U8_MOUSE
Bcl-2-interacting killer
Bik
143Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF048838 mRNA Translation: AAC40079.1
AL583889 Genomic DNA No translation available.
CH467427 Genomic DNA Translation: EDL01409.1
CCDSiCCDS27703.1
RefSeqiNP_031572.1, NM_007546.2
XP_006520418.1, XM_006520355.3
XP_006520419.1, XM_006520356.2
XP_006520420.1, XM_006520357.3
UniGeneiMm.267006

Genome annotation databases

EnsembliENSMUST00000016902; ENSMUSP00000016902; ENSMUSG00000016758
ENSMUST00000230912; ENSMUSP00000155083; ENSMUSG00000016758
GeneIDi12124
KEGGimmu:12124
UCSCiuc007xbd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBIK_MOUSE
AccessioniPrimary (citable) accession number: O70337
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: August 1, 1998
Last modified: September 12, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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