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Protein

Cysteine-rich PDZ-binding protein

Gene

Cript

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich PDZ-binding protein
Alternative name(s):
Cysteine-rich interactor of PDZ three
Short name:
Cysteine-rich interactor of PDZ3
Gene namesi
Name:Cript
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1929655 Cript

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003145641 – 101Cysteine-rich PDZ-binding proteinAdd BLAST101

Proteomic databases

EPDiO70333
MaxQBiO70333
PaxDbiO70333
PRIDEiO70333

PTM databases

iPTMnetiO70333
PhosphoSitePlusiO70333

Expressioni

Gene expression databases

BgeeiENSMUSG00000024146 Expressed in 276 organ(s), highest expression level in blood
CleanExiMM_CRIPT
ExpressionAtlasiO70333 baseline and differential
GenevisibleiO70333 MM

Interactioni

Subunit structurei

Interacts with TUBB1. Interacts strongly with the PDZ3 domain of members of the DLG4 family. Associates with microtubules (By similarity). Interacts with DLG4.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiO70333, 1 interactor
STRINGi10090.ENSMUSP00000024959

Structurei

3D structure databases

SMRiO70333
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni95 – 101Sufficient for interaction with DLG41 Publication7
Regioni98 – 101PDZ3-binding4

Sequence similaritiesi

Belongs to the CRIPT family.Curated

Phylogenomic databases

eggNOGiKOG3476 Eukaryota
ENOG4111RAI LUCA
GeneTreeiENSGT00390000002260
HOGENOMiHOG000242625
HOVERGENiHBG097641
InParanoidiO70333
PhylomeDBiO70333
TreeFamiTF300144

Family and domain databases

InterProiView protein in InterPro
IPR019367 PDZ-binding_CRIPT
PANTHERiPTHR11805 PTHR11805, 1 hit
PfamiView protein in Pfam
PF10235 Cript, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O70333-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVCEKCEKKL GRVITPDTWK DGARNTTESG GRKLNENKAL TSKKARFDPY
60 70 80 90 100
GKNKFSTCRI CKSSVHQPGS HYCQGCAYKK GICAMCGKKV LDTKNYKQTS

V
Length:101
Mass (Da):11,271
Last modified:August 1, 1998 - v1
Checksum:i161D694AC81BFDCB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6TQQ9F6TQQ9_MOUSE
Cysteine-rich PDZ-binding protein
Cript
110Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86C → Y in BAB23596 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151637 mRNA Translation: AAD38045.1
AK004828 mRNA Translation: BAB23596.1
AK008523 mRNA Translation: BAB25719.1
AK029409 mRNA Translation: BAC26438.1
BC002258 mRNA Translation: AAH02258.1
BC023013 mRNA Translation: AAH23013.1
CCDSiCCDS29012.1
RefSeqiNP_064320.1, NM_019936.3
UniGeneiMm.109329

Genome annotation databases

EnsembliENSMUST00000024959; ENSMUSP00000024959; ENSMUSG00000024146
GeneIDi56724
KEGGimmu:56724
UCSCiuc008duo.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151637 mRNA Translation: AAD38045.1
AK004828 mRNA Translation: BAB23596.1
AK008523 mRNA Translation: BAB25719.1
AK029409 mRNA Translation: BAC26438.1
BC002258 mRNA Translation: AAH02258.1
BC023013 mRNA Translation: AAH23013.1
CCDSiCCDS29012.1
RefSeqiNP_064320.1, NM_019936.3
UniGeneiMm.109329

3D structure databases

SMRiO70333
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO70333, 1 interactor
STRINGi10090.ENSMUSP00000024959

PTM databases

iPTMnetiO70333
PhosphoSitePlusiO70333

Proteomic databases

EPDiO70333
MaxQBiO70333
PaxDbiO70333
PRIDEiO70333

Protocols and materials databases

DNASUi56724
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024959; ENSMUSP00000024959; ENSMUSG00000024146
GeneIDi56724
KEGGimmu:56724
UCSCiuc008duo.2 mouse

Organism-specific databases

CTDi9419
MGIiMGI:1929655 Cript

Phylogenomic databases

eggNOGiKOG3476 Eukaryota
ENOG4111RAI LUCA
GeneTreeiENSGT00390000002260
HOGENOMiHOG000242625
HOVERGENiHBG097641
InParanoidiO70333
PhylomeDBiO70333
TreeFamiTF300144

Miscellaneous databases

PROiPR:O70333
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024146 Expressed in 276 organ(s), highest expression level in blood
CleanExiMM_CRIPT
ExpressionAtlasiO70333 baseline and differential
GenevisibleiO70333 MM

Family and domain databases

InterProiView protein in InterPro
IPR019367 PDZ-binding_CRIPT
PANTHERiPTHR11805 PTHR11805, 1 hit
PfamiView protein in Pfam
PF10235 Cript, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRIPT_MOUSE
AccessioniPrimary (citable) accession number: O70333
Secondary accession number(s): Q99LR6, Q9DBP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 1, 1998
Last modified: September 12, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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