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Protein

Glycylpeptide N-tetradecanoyltransferase 2

Gene

Nmt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.By similarity

Catalytic activityi

Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein].By similarity

GO - Molecular functioni

GO - Biological processi

  • N-terminal peptidyl-glycine N-myristoylation Source: UniProtKB
  • N-terminal protein myristoylation Source: MGI

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.97 3474
ReactomeiR-MMU-2514859 Inactivation, recovery and regulation of the phototransduction cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferase 2 (EC:2.3.1.97By similarity)
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase 2
Short name:
NMT 2
Peptide N-myristoyltransferase 2
Type II N-myristoyltransferase
Gene namesi
Name:Nmt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1202298 Nmt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642271 – 529Glycylpeptide N-tetradecanoyltransferase 2Add BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO70311
PaxDbiO70311
PRIDEiO70311

PTM databases

iPTMnetiO70311
PhosphoSitePlusiO70311

Expressioni

Gene expression databases

BgeeiENSMUSG00000026643 Expressed in 249 organ(s), highest expression level in cumulus cell
CleanExiMM_NMT2
ExpressionAtlasiO70311 baseline and differential
GenevisibleiO70311 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080600

Structurei

3D structure databases

ProteinModelPortaliO70311
SMRiO70311
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni151 – 153Myristoyl-CoA bindingBy similarity3
Regioni281 – 283Myristoyl-CoA bindingBy similarity3
Regioni289 – 293Myristoyl-CoA bindingBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 56Poly-LysAdd BLAST11

Sequence similaritiesi

Belongs to the NMT family.Curated

Phylogenomic databases

eggNOGiKOG2779 Eukaryota
COG5092 LUCA
GeneTreeiENSGT00390000017837
HOGENOMiHOG000189123
HOVERGENiHBG003404
InParanoidiO70311
KOiK00671
OrthoDBiEOG091G06JB
PhylomeDBiO70311
TreeFamiTF300701

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000903 MyristoylCoA_TrFase
IPR022677 MyristoylCoA_TrFase_C
IPR022678 MyristoylCoA_TrFase_CS
IPR022676 MyristoylCoA_TrFase_N
PANTHERiPTHR11377 PTHR11377, 1 hit
PfamiView protein in Pfam
PF01233 NMT, 1 hit
PF02799 NMT_C, 1 hit
PIRSFiPIRSF015892 N-myristl_transf, 1 hit
SUPFAMiSSF55729 SSF55729, 2 hits
PROSITEiView protein in PROSITE
PS00975 NMT_1, 1 hit
PS00976 NMT_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O70311-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEDSESAAS QQSLELDDQD TCGIDGDNEE ETEHAKGSPG GDLGAKKKKK
60 70 80 90 100
KQKRKKEKPN SGGTKSDSAS DSQEIKIQQS SKHNAIWQQI SAGAAMGGDT
110 120 130 140 150
MEGEWIDLRM YHKNPTIPIQ KLQDIQRAME LLSACQGPAR NIDEATKRRY
160 170 180 190 200
QFWDTQPVPK LNEVITSHGA IEPDKDNIRQ EPYSLPQGFM WDTLDLSNAE
210 220 230 240 250
VLKELYTLLN ENYVEDDDNM FRFDYSPEFL LWALRPPGWL LQWHCGVRVS
260 270 280 290 300
SNKKLVGFIS AIPANIRIYD SVKRMVEINF LCVHKKLRSK RVAPVLIREI
310 320 330 340 350
TRRVNLEGIF QAVYTAGVVL PKPVATCRYW HRSLNPRKLV EVKFSHLSRN
360 370 380 390 400
MTLQRTMKLY RLPDVTKTSG LRPMEPKDIK AVRELINIYL KQFHLAPVMD
410 420 430 440 450
DAEVAHWFLP REHIIDTFVV ENPSGKLTDF LSFYTLPSTV MHHPAHKSLK
460 470 480 490 500
AAYSFYNIHT ETPLLDLMND ALIIAKLKGF DVFNALDLME NKTFLEKLKF
510 520
GIGDGNLQYY LYNWRCPGTD SEKVGLVLQ
Length:529
Mass (Da):60,484
Last modified:August 1, 1998 - v1
Checksum:i7D5C93D9159F315C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AJH3A2AJH3_MOUSE
Glycylpeptide N-tetradecanoyltransf...
Nmt2
498Annotation score:
F7APP3F7APP3_MOUSE
Glycylpeptide N-tetradecanoyltransf...
Nmt2
485Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043327 mRNA Translation: AAC09297.1
CCDSiCCDS15644.1
RefSeqiNP_032734.1, NM_008708.2
UniGeneiMm.392918
Mm.65021

Genome annotation databases

EnsembliENSMUST00000081932; ENSMUSP00000080600; ENSMUSG00000026643
GeneIDi18108
KEGGimmu:18108
UCSCiuc008idq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043327 mRNA Translation: AAC09297.1
CCDSiCCDS15644.1
RefSeqiNP_032734.1, NM_008708.2
UniGeneiMm.392918
Mm.65021

3D structure databases

ProteinModelPortaliO70311
SMRiO70311
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080600

PTM databases

iPTMnetiO70311
PhosphoSitePlusiO70311

Proteomic databases

EPDiO70311
PaxDbiO70311
PRIDEiO70311

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081932; ENSMUSP00000080600; ENSMUSG00000026643
GeneIDi18108
KEGGimmu:18108
UCSCiuc008idq.2 mouse

Organism-specific databases

CTDi9397
MGIiMGI:1202298 Nmt2

Phylogenomic databases

eggNOGiKOG2779 Eukaryota
COG5092 LUCA
GeneTreeiENSGT00390000017837
HOGENOMiHOG000189123
HOVERGENiHBG003404
InParanoidiO70311
KOiK00671
OrthoDBiEOG091G06JB
PhylomeDBiO70311
TreeFamiTF300701

Enzyme and pathway databases

BRENDAi2.3.1.97 3474
ReactomeiR-MMU-2514859 Inactivation, recovery and regulation of the phototransduction cascade

Miscellaneous databases

PROiPR:O70311
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026643 Expressed in 249 organ(s), highest expression level in cumulus cell
CleanExiMM_NMT2
ExpressionAtlasiO70311 baseline and differential
GenevisibleiO70311 MM

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000903 MyristoylCoA_TrFase
IPR022677 MyristoylCoA_TrFase_C
IPR022678 MyristoylCoA_TrFase_CS
IPR022676 MyristoylCoA_TrFase_N
PANTHERiPTHR11377 PTHR11377, 1 hit
PfamiView protein in Pfam
PF01233 NMT, 1 hit
PF02799 NMT_C, 1 hit
PIRSFiPIRSF015892 N-myristl_transf, 1 hit
SUPFAMiSSF55729 SSF55729, 2 hits
PROSITEiView protein in PROSITE
PS00975 NMT_1, 1 hit
PS00976 NMT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNMT2_MOUSE
AccessioniPrimary (citable) accession number: O70311
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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