Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

T-box transcription factor TBX15

Gene

Tbx15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi122 – 304T-boxPROSITE-ProRule annotationAdd BLAST183

GO - Molecular functioni

GO - Biological processi

  • embryonic cranial skeleton morphogenesis Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX15
Short name:
T-box protein 15
Alternative name(s):
MmTBx8
T-box transcription factor TBX14
Short name:
T-box protein 14
Gene namesi
Name:Tbx15
Synonyms:Tbx14, Tbx8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1277234 Tbx15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice show a general reduction of bone size and changes of bone shape. In the forelimb skeleton, the scapula lacks the central region of the blade. Cartilaginous templates are already reduced in size and show a transient delay in ossification in mutant embryos. Mice show a significantly reduced proliferation of prehypertrophic chondrocytes as well as of mesenchymal precursor cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844451 – 602T-box transcription factor TBX15Add BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei330PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO70306
PaxDbiO70306
PRIDEiO70306

PTM databases

iPTMnetiO70306
PhosphoSitePlusiO70306

Expressioni

Developmental stagei

Expressed during limb development, first in the mesenchyme of the early limb bud, then during early endochondral bone development in prehypertrophic chondrocytes of cartilaginous templates. Expression is also found in mesenchymal precursor cells and prehypertrophic chondrocytes, respectively, during development of skeletal elements of the vertebral column and the head.1 Publication

Gene expression databases

BgeeiENSMUSG00000027868 Expressed in 166 organ(s), highest expression level in extra-ocular muscle
CleanExiMM_TBX15
ExpressionAtlasiO70306 baseline and differential
GenevisibleiO70306 MM

Interactioni

Subunit structurei

Can form a heterodimer with TBX18.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203986, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliO70306
SMRiO70306
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3586 Eukaryota
ENOG410Y98J LUCA
GeneTreeiENSGT00760000118897
HOGENOMiHOG000039966
HOVERGENiHBG055831
InParanoidiO70306
KOiK10182
OMAiLPTGMEH
OrthoDBiEOG091G0I8R
TreeFamiTF106341

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O70306-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSERRRSAVA LSSRAHAFSV EALIGSNKKR KLRDWEEKGL DLSMEALSPA
60 70 80 90 100
GPLGDTDDPA THGLEPHPDS EQSTGSDSEV LTERTSCSFS THTDLASGAA
110 120 130 140 150
GPVPAAMSSM EEIQVELQCA DLWKRFHDIG TEMIITKAGR RMFPAMRVKI
160 170 180 190 200
TGLDPHQQYY IAMDIVPVDN KRYRYVYHSS KWMVAGNADS PVPPRVYIHP
210 220 230 240 250
DSLASGDTWM RQVVSFDKLK LTNNELDDQG HIILHSMHKY QPRVHVIRKD
260 270 280 290 300
FSSDLSPTKP VPVGDGVKTF NFPETVFTTV TAYQNQQITR LKIDRNPFAK
310 320 330 340 350
GFRDSGRNRT GLEAIMETYA FWRPPVRTLT FEDFTTMQKQ QGGSTGTSPT
360 370 380 390 400
TSSTGTPSPS ASSHLLSPSC SPPTFHLAPN TFNVGCRESQ LCNLNLSDYP
410 420 430 440 450
PCARSNMAAL QSYPGLSDSG YNRLQSGTAS ATQPSETFMP QRTPSLISGI
460 470 480 490 500
PTPPSLPSNS KMEAYGGQLG SFPTSQFQYV MQAGNAASSS SSPHMFGGSH
510 520 530 540 550
MQQSSYNAFS LHNPYNLYGY NFPTSPRLAA SPEKLSASQS TLLCSSPSNG
560 570 580 590 600
AFGERQYLPT GMEHSMHMIS PSTNNQQATN TCDGRQYGAV PGSASQMSVH

MV
Length:602
Mass (Da):65,802
Last modified:July 27, 2011 - v2
Checksum:i8B476A8E61DA9223
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JDG4A0A0G2JDG4_MOUSE
T-box transcription factor TBX15
Tbx15
141Annotation score:
A0A0G2JG43A0A0G2JG43_MOUSE
T-box transcription factor TBX15
Tbx15
51Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100 – 102AGP → RAT in AAC32316 (PubMed:9693034).Curated3
Sequence conflicti309R → G in AAC32316 (PubMed:9693034).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041822 mRNA Translation: AAC32316.1
AY662679 mRNA Translation: AAV80417.1
AK132578 mRNA Translation: BAE21240.1
AL606747, AC080018 Genomic DNA Translation: CAM25767.1
AF013282 mRNA Translation: AAC40115.1
CCDSiCCDS17673.1
RefSeqiNP_033349.2, NM_009323.2
UniGeneiMm.88761

Genome annotation databases

EnsembliENSMUST00000029462; ENSMUSP00000029462; ENSMUSG00000027868
GeneIDi21384
KEGGimmu:21384
UCSCiuc008qql.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041822 mRNA Translation: AAC32316.1
AY662679 mRNA Translation: AAV80417.1
AK132578 mRNA Translation: BAE21240.1
AL606747, AC080018 Genomic DNA Translation: CAM25767.1
AF013282 mRNA Translation: AAC40115.1
CCDSiCCDS17673.1
RefSeqiNP_033349.2, NM_009323.2
UniGeneiMm.88761

3D structure databases

ProteinModelPortaliO70306
SMRiO70306
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203986, 1 interactor

PTM databases

iPTMnetiO70306
PhosphoSitePlusiO70306

Proteomic databases

MaxQBiO70306
PaxDbiO70306
PRIDEiO70306

Protocols and materials databases

DNASUi21384
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029462; ENSMUSP00000029462; ENSMUSG00000027868
GeneIDi21384
KEGGimmu:21384
UCSCiuc008qql.1 mouse

Organism-specific databases

CTDi6913
MGIiMGI:1277234 Tbx15

Phylogenomic databases

eggNOGiKOG3586 Eukaryota
ENOG410Y98J LUCA
GeneTreeiENSGT00760000118897
HOGENOMiHOG000039966
HOVERGENiHBG055831
InParanoidiO70306
KOiK10182
OMAiLPTGMEH
OrthoDBiEOG091G0I8R
TreeFamiTF106341

Miscellaneous databases

ChiTaRSiTbx15 mouse
PROiPR:O70306
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027868 Expressed in 166 organ(s), highest expression level in extra-ocular muscle
CleanExiMM_TBX15
ExpressionAtlasiO70306 baseline and differential
GenevisibleiO70306 MM

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBX15_MOUSE
AccessioniPrimary (citable) accession number: O70306
Secondary accession number(s): O54840, Q5GBG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again