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Protein

Ataxin-2

Gene

Atxn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ataxin-2
Alternative name(s):
Spinocerebellar ataxia type 2 protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Atxn2
Synonyms:Atx2, Sca2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1277223 Atxn2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000647571 – 1285Ataxin-2Add BLAST1285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei218PhosphoserineCombined sources1
Modified residuei219PhosphoserineCombined sources1
Modified residuei362PhosphoserineBy similarity1
Modified residuei435PhosphoserineCombined sources1
Modified residuei477PhosphoserineBy similarity1
Modified residuei523PhosphoserineBy similarity1
Modified residuei593PhosphoserineCombined sources1
Modified residuei609Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei609Omega-N-methylarginine; alternateCombined sources1
Modified residuei611PhosphoserineBy similarity1
Modified residuei653PhosphoserineCombined sources1
Modified residuei697PhosphoserineBy similarity1
Modified residuei710PhosphothreonineBy similarity1
Modified residuei741PhosphoserineBy similarity1
Modified residuei753PhosphoserineBy similarity1
Modified residuei827PhosphoserineCombined sources1
Modified residuei828PhosphoserineBy similarity1
Modified residuei832PhosphoserineCombined sources1
Modified residuei836PhosphoserineCombined sources1
Modified residuei838PhosphoserineCombined sources1
Modified residuei859PhosphoserineBy similarity1
Modified residuei860PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki864Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O70305

MaxQB - The MaxQuant DataBase

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MaxQBi
O70305

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O70305

PeptideAtlas

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PeptideAtlasi
O70305

PRoteomics IDEntifications database

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PRIDEi
O70305

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O70305

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O70305

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the heart, lung, liver, kidney, skeletal muscle, spleen and intestine. Predominant expression was seen in the brain where a high level expression was found in the pyramidal cortical neurons, large brain stem neurons and cerebellar Purkinje cells. All three isoforms were found in all the tissues except skeletal muscle where only isoform 1 was found.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detectable at embryonic days E8-E16 and lowest expression was seen at E8.1 Publication

Gene expression databases

CleanEx database of gene expression profiles

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CleanExi
MM_ATXN2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RBFOX1 (By similarity). Monomer. Can also form homodimers. Interacts with polyribosomes (By similarity). Interacts with EGFR (By similarity). Interacts with SH3GL3 (By similarity). Interacts with SH3GL2, SH3KBP1 and CBL (PubMed:18602463). Interacts with ATXN2L (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
203084, 8 interactors

Protein interaction database and analysis system

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IntActi
O70305, 3 interactors

Molecular INTeraction database

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MINTi
O70305

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000056715

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O70305

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi46 – 197Pro-richAdd BLAST152
Compositional biasi520 – 703Pro-richAdd BLAST184
Compositional biasi808 – 841Ser-richAdd BLAST34
Compositional biasi900 – 961Pro-richAdd BLAST62

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ataxin-2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2375 Eukaryota
COG5180 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234354

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050623

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O70305

Database of Orthologous Groups

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OrthoDBi
282700at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O70305

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009818 Ataxin-2_C
IPR033093 ATXN2
IPR010920 LSM_dom_sf
IPR009604 LsmAD_domain
IPR025852 SM_dom_ATX

The PANTHER Classification System

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PANTHERi
PTHR12854:SF11 PTHR12854:SF11, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF06741 LsmAD, 1 hit
PF07145 PAM2, 1 hit
PF14438 SM-ATX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01272 LsmAD, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50182 SSF50182, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O70305-1) [UniParc]FASTAAdd to basket
Also known as: Type I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSSTAAVQR PAAGDPEPRR PAGWAARRSL PRTARRGGRG GAVAYPSAGP
60 70 80 90 100
PPRGPGAPPR GPRSPPCASD CFGSNGHGAS RPGSRRLLGV CGPPRPFVVV
110 120 130 140 150
LLALAPAATP ARACPPGVRA SPPRSGVSSS ARPAPGCPRP ACEPVYGPLT
160 170 180 190 200
MSLKPQPQPP APATGRKPGG GLLSSPGAAP ASAAVTSASV VPAPAAPVAS
210 220 230 240 250
SSAAAGGGRP GLGRGRNSSK GLPQPTISFD GIYANVRMVH ILTSVVGSKC
260 270 280 290 300
EVQVKNGGIY EGVFKTYSPK CDLVLDAAHE KSTESSSGPK REEIMESVLF
310 320 330 340 350
KCSDFVVVQF KDTDSSYARR DAFTDSALSA KVNGEHKEKD LEPWDAGELT
360 370 380 390 400
ASEELELEND VSNGWDPNDM FRYNEENYGV VSTYDSSLSS YTVPLERDNS
410 420 430 440 450
EEFLKREARA NQLAEEIESS AQYKARVALE NDDRSEEEKY TAVQRNCSDR
460 470 480 490 500
EGHGPNTRDN KYIPPGQRNR EVLSWGSGRQ SSPRMGQPGP GSMPSRAASH
510 520 530 540 550
TSDFNPNAGS DQRVVNGGVP WPSPCPSHSS RPPSRYQSGP NSLPPRAATH
560 570 580 590 600
TRPPSRPPSR PSRPPSHPSA HGSPAPVSTM PKRMSSEGPP RMSPKAQRHP
610 620 630 640 650
RNHRVSAGRG SMSSGLEFVS HNPPSEAAAP PVARTSPAGG TWSSVVSGVP
660 670 680 690 700
RLSPKTHRPR SPRQSSIGNS PSGPVLASPQ AGIIPAEAVS MPVPAASPTP
710 720 730 740 750
ASPASNRALT PSIEAKDSRL QDQRQNSPAG SKENVKASET SPSFSKADNK
760 770 780 790 800
GMSPVVSEHR KQIDDLKKFK NDFRLQPSST SESMDQLLSK NREGEKSRDL
810 820 830 840 850
IKDKTEASAK DSFIDSSSSS SNCTSGSSKT NSPSISPSML SNAEHKRGPE
860 870 880 890 900
VTSQGVQTSS PACKQEKDDR EEKKDTTEQV RKSTLNPNAK EFNPRSFSQP
910 920 930 940 950
KPSTTPTSPR PQAQPSPSMV GHQQPAPVYT QPVCFAPNMM YPVPVSPGVQ
960 970 980 990 1000
PLYPIPMTPM PVNQAKTYRA GKVPNMPQQR QDQHHQSTMM HPASAAGPPI
1010 1020 1030 1040 1050
VATPPAYSTQ YVAYSPQQFP NQPLVQHVPH YQSQHPHVYS PVIQGNARMM
1060 1070 1080 1090 1100
APPAHAQPGL VSSSAAQFGA HEQTHAMYAC PKLPYNKETS PSFYFAISTG
1110 1120 1130 1140 1150
SLAQQYAHPN AALHPHTPHP QPSATPTGQQ QSQHGGSHPA PSPVQHHQHQ
1160 1170 1180 1190 1200
AAQALHLASP QQQSAIYHAG LAPTPPSMTP ASNTQSPQSS FPAAQQTVFT
1210 1220 1230 1240 1250
IHPSHVQPAY TTPPHMAHVP QAHVQSGMVP SHPTAHAPMM LMTTQPPGPK
1260 1270 1280
AALAQSALQP IPVSTTAHFP YMTHPSVQAH HQQQL
Length:1,285
Mass (Da):136,485
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C72EF68A79F3793
GO
Isoform 2 (identifier: O70305-2) [UniParc]FASTAAdd to basket
Also known as: Type II

The sequence of this isoform differs from the canonical sequence as follows:
     519-588: Missing.

Show »
Length:1,215
Mass (Da):129,067
Checksum:iCAEC4D66129F7C88
GO
Isoform 3 (identifier: O70305-3) [UniParc]FASTAAdd to basket
Also known as: Type III

The sequence of this isoform differs from the canonical sequence as follows:
     519-588: Missing.
     589-649: Missing.

Show »
Length:1,154
Mass (Da):122,798
Checksum:iEC3D2183836928E7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QM77E9QM77_MOUSE
Ataxin-2
Atxn2
1,286Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6U2C2F6U2C2_MOUSE
Ataxin-2
Atxn2
929Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7B6X4F7B6X4_MOUSE
Ataxin-2
Atxn2
330Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6V8M6F6V8M6_MOUSE
Ataxin-2
Atxn2
662Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YDU2A0A286YDU2_MOUSE
Ataxin-2
Atxn2
402Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UTV7F6UTV7_MOUSE
Ataxin-2
Atxn2
234Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6U209F6U209_MOUSE
Ataxin-2
Atxn2
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6U2Q5F6U2Q5_MOUSE
Ataxin-2
Atxn2
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JF15A0A0G2JF15_MOUSE
Ataxin-2
Atxn2
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti145 – 146VY → HE in AAB19202 (PubMed:8896555).Curated2
Sequence conflicti528H → P in AAB19202 (PubMed:8896555).Curated1
Sequence conflicti550H → P in AAB19202 (PubMed:8896555).Curated1
Sequence conflicti554 – 563PSRPPSRPSR → RAEFLQPGDP in AAB19202 (PubMed:8896555).Curated10

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011583519 – 588Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_011584589 – 649Missing in isoform 3. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF041472 mRNA Translation: AAC09275.1
U70670 mRNA Translation: AAB19202.1

Protein sequence database of the Protein Information Resource

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PIRi
T14171

NCBI Reference Sequences

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RefSeqi
NP_033151.2, NM_009125.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.260900

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
20239

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:20239

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041472 mRNA Translation: AAC09275.1
U70670 mRNA Translation: AAB19202.1
PIRiT14171
RefSeqiNP_033151.2, NM_009125.2
UniGeneiMm.260900

3D structure databases

ProteinModelPortaliO70305
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203084, 8 interactors
IntActiO70305, 3 interactors
MINTiO70305
STRINGi10090.ENSMUSP00000056715

PTM databases

iPTMnetiO70305
PhosphoSitePlusiO70305

Proteomic databases

jPOSTiO70305
MaxQBiO70305
PaxDbiO70305
PeptideAtlasiO70305
PRIDEiO70305

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20239
KEGGimmu:20239

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6311
MGIiMGI:1277223 Atxn2

Phylogenomic databases

eggNOGiKOG2375 Eukaryota
COG5180 LUCA
HOGENOMiHOG000234354
HOVERGENiHBG050623
InParanoidiO70305
OrthoDBi282700at2759
PhylomeDBiO70305

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Atxn2 mouse

Protein Ontology

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PROi
PR:O70305

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

CleanExiMM_ATXN2

Family and domain databases

InterProiView protein in InterPro
IPR009818 Ataxin-2_C
IPR033093 ATXN2
IPR010920 LSM_dom_sf
IPR009604 LsmAD_domain
IPR025852 SM_dom_ATX
PANTHERiPTHR12854:SF11 PTHR12854:SF11, 1 hit
PfamiView protein in Pfam
PF06741 LsmAD, 1 hit
PF07145 PAM2, 1 hit
PF14438 SM-ATX, 1 hit
SMARTiView protein in SMART
SM01272 LsmAD, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATX2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O70305
Secondary accession number(s): P97421
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: August 1, 1998
Last modified: January 16, 2019
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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