Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ataxin-2

Gene

Atxn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ataxin-2
Alternative name(s):
Spinocerebellar ataxia type 2 protein homolog
Gene namesi
Name:Atxn2
Synonyms:Atx2, Sca2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1277223 Atxn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000647571 – 1285Ataxin-2Add BLAST1285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei218PhosphoserineCombined sources1
Modified residuei219PhosphoserineCombined sources1
Modified residuei362PhosphoserineBy similarity1
Modified residuei435PhosphoserineCombined sources1
Modified residuei477PhosphoserineBy similarity1
Modified residuei523PhosphoserineBy similarity1
Modified residuei593PhosphoserineCombined sources1
Modified residuei609Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei609Omega-N-methylarginine; alternateCombined sources1
Modified residuei611PhosphoserineBy similarity1
Modified residuei653PhosphoserineCombined sources1
Modified residuei697PhosphoserineBy similarity1
Modified residuei710PhosphothreonineBy similarity1
Modified residuei741PhosphoserineBy similarity1
Modified residuei753PhosphoserineBy similarity1
Modified residuei827PhosphoserineCombined sources1
Modified residuei828PhosphoserineBy similarity1
Modified residuei832PhosphoserineCombined sources1
Modified residuei836PhosphoserineCombined sources1
Modified residuei838PhosphoserineCombined sources1
Modified residuei859PhosphoserineBy similarity1
Modified residuei860PhosphoserineBy similarity1
Cross-linki864Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO70305
PaxDbiO70305
PeptideAtlasiO70305
PRIDEiO70305

PTM databases

iPTMnetiO70305
PhosphoSitePlusiO70305

Expressioni

Tissue specificityi

Expressed in the heart, lung, liver, kidney, skeletal muscle, spleen and intestine. Predominant expression was seen in the brain where a high level expression was found in the pyramidal cortical neurons, large brain stem neurons and cerebellar Purkinje cells. All three isoforms were found in all the tissues except skeletal muscle where only isoform 1 was found.1 Publication

Developmental stagei

Detectable at embryonic days E8-E16 and lowest expression was seen at E8.1 Publication

Gene expression databases

CleanExiMM_ATXN2

Interactioni

Subunit structurei

Interacts with RBFOX1 (By similarity). Monomer. Can also form homodimers. Interacts with polyribosomes (By similarity). Interacts with EGFR (By similarity). Interacts with SH3GL3 (By similarity). Interacts with SH3GL2, SH3KBP1 and CBL (PubMed:18602463). Interacts with ATXN2L (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203084, 8 interactors
IntActiO70305, 3 interactors
MINTiO70305
STRINGi10090.ENSMUSP00000056715

Structurei

3D structure databases

ProteinModelPortaliO70305
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 197Pro-richAdd BLAST152
Compositional biasi520 – 703Pro-richAdd BLAST184
Compositional biasi808 – 841Ser-richAdd BLAST34
Compositional biasi900 – 961Pro-richAdd BLAST62

Sequence similaritiesi

Belongs to the ataxin-2 family.Curated

Phylogenomic databases

eggNOGiKOG2375 Eukaryota
COG5180 LUCA
HOGENOMiHOG000234354
HOVERGENiHBG050623
InParanoidiO70305
PhylomeDBiO70305

Family and domain databases

InterProiView protein in InterPro
IPR009818 Ataxin-2_C
IPR033093 ATXN2
IPR010920 LSM_dom_sf
IPR009604 LsmAD_domain
IPR025852 SM_dom_ATX
PANTHERiPTHR12854:SF11 PTHR12854:SF11, 1 hit
PfamiView protein in Pfam
PF06741 LsmAD, 1 hit
PF07145 PAM2, 1 hit
PF14438 SM-ATX, 1 hit
SMARTiView protein in SMART
SM01272 LsmAD, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O70305-1) [UniParc]FASTAAdd to basket
Also known as: Type I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSSTAAVQR PAAGDPEPRR PAGWAARRSL PRTARRGGRG GAVAYPSAGP
60 70 80 90 100
PPRGPGAPPR GPRSPPCASD CFGSNGHGAS RPGSRRLLGV CGPPRPFVVV
110 120 130 140 150
LLALAPAATP ARACPPGVRA SPPRSGVSSS ARPAPGCPRP ACEPVYGPLT
160 170 180 190 200
MSLKPQPQPP APATGRKPGG GLLSSPGAAP ASAAVTSASV VPAPAAPVAS
210 220 230 240 250
SSAAAGGGRP GLGRGRNSSK GLPQPTISFD GIYANVRMVH ILTSVVGSKC
260 270 280 290 300
EVQVKNGGIY EGVFKTYSPK CDLVLDAAHE KSTESSSGPK REEIMESVLF
310 320 330 340 350
KCSDFVVVQF KDTDSSYARR DAFTDSALSA KVNGEHKEKD LEPWDAGELT
360 370 380 390 400
ASEELELEND VSNGWDPNDM FRYNEENYGV VSTYDSSLSS YTVPLERDNS
410 420 430 440 450
EEFLKREARA NQLAEEIESS AQYKARVALE NDDRSEEEKY TAVQRNCSDR
460 470 480 490 500
EGHGPNTRDN KYIPPGQRNR EVLSWGSGRQ SSPRMGQPGP GSMPSRAASH
510 520 530 540 550
TSDFNPNAGS DQRVVNGGVP WPSPCPSHSS RPPSRYQSGP NSLPPRAATH
560 570 580 590 600
TRPPSRPPSR PSRPPSHPSA HGSPAPVSTM PKRMSSEGPP RMSPKAQRHP
610 620 630 640 650
RNHRVSAGRG SMSSGLEFVS HNPPSEAAAP PVARTSPAGG TWSSVVSGVP
660 670 680 690 700
RLSPKTHRPR SPRQSSIGNS PSGPVLASPQ AGIIPAEAVS MPVPAASPTP
710 720 730 740 750
ASPASNRALT PSIEAKDSRL QDQRQNSPAG SKENVKASET SPSFSKADNK
760 770 780 790 800
GMSPVVSEHR KQIDDLKKFK NDFRLQPSST SESMDQLLSK NREGEKSRDL
810 820 830 840 850
IKDKTEASAK DSFIDSSSSS SNCTSGSSKT NSPSISPSML SNAEHKRGPE
860 870 880 890 900
VTSQGVQTSS PACKQEKDDR EEKKDTTEQV RKSTLNPNAK EFNPRSFSQP
910 920 930 940 950
KPSTTPTSPR PQAQPSPSMV GHQQPAPVYT QPVCFAPNMM YPVPVSPGVQ
960 970 980 990 1000
PLYPIPMTPM PVNQAKTYRA GKVPNMPQQR QDQHHQSTMM HPASAAGPPI
1010 1020 1030 1040 1050
VATPPAYSTQ YVAYSPQQFP NQPLVQHVPH YQSQHPHVYS PVIQGNARMM
1060 1070 1080 1090 1100
APPAHAQPGL VSSSAAQFGA HEQTHAMYAC PKLPYNKETS PSFYFAISTG
1110 1120 1130 1140 1150
SLAQQYAHPN AALHPHTPHP QPSATPTGQQ QSQHGGSHPA PSPVQHHQHQ
1160 1170 1180 1190 1200
AAQALHLASP QQQSAIYHAG LAPTPPSMTP ASNTQSPQSS FPAAQQTVFT
1210 1220 1230 1240 1250
IHPSHVQPAY TTPPHMAHVP QAHVQSGMVP SHPTAHAPMM LMTTQPPGPK
1260 1270 1280
AALAQSALQP IPVSTTAHFP YMTHPSVQAH HQQQL
Length:1,285
Mass (Da):136,485
Last modified:August 1, 1998 - v1
Checksum:i2C72EF68A79F3793
GO
Isoform 2 (identifier: O70305-2) [UniParc]FASTAAdd to basket
Also known as: Type II

The sequence of this isoform differs from the canonical sequence as follows:
     519-588: Missing.

Show »
Length:1,215
Mass (Da):129,067
Checksum:iCAEC4D66129F7C88
GO
Isoform 3 (identifier: O70305-3) [UniParc]FASTAAdd to basket
Also known as: Type III

The sequence of this isoform differs from the canonical sequence as follows:
     519-588: Missing.
     589-649: Missing.

Show »
Length:1,154
Mass (Da):122,798
Checksum:iEC3D2183836928E7
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QM77E9QM77_MOUSE
Ataxin-2
Atxn2
1,286Annotation score:
F6U2C2F6U2C2_MOUSE
Ataxin-2
Atxn2
929Annotation score:
F7B6X4F7B6X4_MOUSE
Ataxin-2
Atxn2
330Annotation score:
F6V8M6F6V8M6_MOUSE
Ataxin-2
Atxn2
662Annotation score:
A0A286YDU2A0A286YDU2_MOUSE
Ataxin-2
Atxn2
402Annotation score:
F6UTV7F6UTV7_MOUSE
Ataxin-2
Atxn2
234Annotation score:
F6U209F6U209_MOUSE
Ataxin-2
Atxn2
65Annotation score:
F6U2Q5F6U2Q5_MOUSE
Ataxin-2
Atxn2
96Annotation score:
A0A0G2JF15A0A0G2JF15_MOUSE
Ataxin-2
Atxn2
64Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145 – 146VY → HE in AAB19202 (PubMed:8896555).Curated2
Sequence conflicti528H → P in AAB19202 (PubMed:8896555).Curated1
Sequence conflicti550H → P in AAB19202 (PubMed:8896555).Curated1
Sequence conflicti554 – 563PSRPPSRPSR → RAEFLQPGDP in AAB19202 (PubMed:8896555).Curated10

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011583519 – 588Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_011584589 – 649Missing in isoform 3. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041472 mRNA Translation: AAC09275.1
U70670 mRNA Translation: AAB19202.1
PIRiT14171
RefSeqiNP_033151.2, NM_009125.2
UniGeneiMm.260900

Genome annotation databases

GeneIDi20239
KEGGimmu:20239

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041472 mRNA Translation: AAC09275.1
U70670 mRNA Translation: AAB19202.1
PIRiT14171
RefSeqiNP_033151.2, NM_009125.2
UniGeneiMm.260900

3D structure databases

ProteinModelPortaliO70305
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203084, 8 interactors
IntActiO70305, 3 interactors
MINTiO70305
STRINGi10090.ENSMUSP00000056715

PTM databases

iPTMnetiO70305
PhosphoSitePlusiO70305

Proteomic databases

MaxQBiO70305
PaxDbiO70305
PeptideAtlasiO70305
PRIDEiO70305

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20239
KEGGimmu:20239

Organism-specific databases

CTDi6311
MGIiMGI:1277223 Atxn2

Phylogenomic databases

eggNOGiKOG2375 Eukaryota
COG5180 LUCA
HOGENOMiHOG000234354
HOVERGENiHBG050623
InParanoidiO70305
PhylomeDBiO70305

Miscellaneous databases

ChiTaRSiAtxn2 mouse
PROiPR:O70305
SOURCEiSearch...

Gene expression databases

CleanExiMM_ATXN2

Family and domain databases

InterProiView protein in InterPro
IPR009818 Ataxin-2_C
IPR033093 ATXN2
IPR010920 LSM_dom_sf
IPR009604 LsmAD_domain
IPR025852 SM_dom_ATX
PANTHERiPTHR12854:SF11 PTHR12854:SF11, 1 hit
PfamiView protein in Pfam
PF06741 LsmAD, 1 hit
PF07145 PAM2, 1 hit
PF14438 SM-ATX, 1 hit
SMARTiView protein in SMART
SM01272 LsmAD, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATX2_MOUSE
AccessioniPrimary (citable) accession number: O70305
Secondary accession number(s): P97421
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again