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Protein

Cell death activator CIDE-A

Gene

Cidea

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.4 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-8964572 Lipid particle organization

Names & Taxonomyi

Protein namesi
Recommended name:
Cell death activator CIDE-A
Alternative name(s):
Cell death-inducing DFFA-like effector A
Gene namesi
Name:Cidea
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1270845 Cidea

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lipid droplet, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mutant animals appear normal and fertile and produce the expected Mendelian ratio of heterozygous and homozygous descendents. They are lean and resistant to diet-induced obesity and diabetes. They exhibit higher metabolic rate, lipolysis in brown adipose tissue and core body temperature when subjected to cold treatment. Mutant females are unable to properly feed their pups who die within 3 days postpartum due to severely reduced milk lipids.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi23K → A: Sustantial reduction in nuclear localization and loss of XDH induction; when associated with A-24. 1 Publication1
Mutagenesisi23K → R: Increased nuclear localization. 1 Publication1
Mutagenesisi24K → A: Sustantial reduction in nuclear localization and loss of XDH induction; when associated with A-23. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447191 – 217Cell death activator CIDE-AAdd BLAST217

Proteomic databases

PaxDbiO70302
PRIDEiO70302

Expressioni

Tissue specificityi

Highly expressed in brown adipose tissue and, at lower levels, in white adipose tissue (at protein level). Expressed in mammary gland during pregnancy and lactation, in epithelial cells, but not in the surrounding adipose tissue. Secreted into milk via milk fat globules. Undetectable in undifferentiated preadipocytes.3 Publications

Developmental stagei

Expressed at 15 dpc in the interscapular region of the embryo, that could correspond to the developing brown adipose tissue. Expression continues in the interscapular region at 18 dpc and postnatally. In mammary glands, begins to be highly expressed at day 14.5 of pregnancy. Expression is maintained at high levels throughout lactation and declines during post-lactational involution.1 Publication

Inductioni

Up-regulated under conditions that enhance triacylglycerol deposition, including rosiglitazone treatment and high-fat diet. This up-regulation is mediated by PPARG.1 Publication

Gene expression databases

BgeeiENSMUSG00000024526 Expressed in 132 organ(s), highest expression level in brown adipose tissue
GenevisibleiO70302 MM

Interactioni

Subunit structurei

Interacts with CIDEC (By similarity). Directly interacts with CEBPB.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PRKAB1Q9Y4784EBI-7927848,EBI-719769From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198712, 3 interactors
IntActiO70302, 7 interactors
MINTiO70302
STRINGi10090.ENSMUSP00000025404

Structurei

3D structure databases

ProteinModelPortaliO70302
SMRiO70302
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 110CIDE-NPROSITE-ProRule annotationAdd BLAST78

Phylogenomic databases

eggNOGiENOG410IVIC Eukaryota
ENOG4111SUV LUCA
GeneTreeiENSGT00390000018596
HOGENOMiHOG000029211
HOVERGENiHBG050961
InParanoidiO70302
OMAiIRPLTFM
OrthoDBiEOG091G0H6W
TreeFamiTF334321

Family and domain databases

InterProiView protein in InterPro
IPR032936 CIDE-A
IPR003508 CIDE-N_dom
PANTHERiPTHR12306:SF8 PTHR12306:SF8, 1 hit
PfamiView protein in Pfam
PF02017 CIDE-N, 1 hit
SMARTiView protein in SMART
SM00266 CAD, 1 hit
PROSITEiView protein in PROSITE
PS51135 CIDE_N, 1 hit

Sequencei

Sequence statusi: Complete.

O70302-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METARDYAGA LIRPLTFMGL QTKKVLLTPL IHPARPFRVS NHDRSSRRGV
60 70 80 90 100
MASSLQELIS KTLDVLVITT GLVTLVLEED GTVVDTEEFF QTLRDNTHFM
110 120 130 140 150
ILEKGQKWTP GSKYVPVCKQ PKKSGIARVT FDLYRLNPKD FLGCLNVKAT
160 170 180 190 200
MYEMYSVSYD IRCTSFKAVL RNLLRFMSYA AQMTGQFLVY AGTYMLRVLG
210
DTEEQPSPKP STKGWFM
Length:217
Mass (Da):24,669
Last modified:October 3, 2012 - v2
Checksum:iC9E406895CFD4CBA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165S → R in AAC34985 (PubMed:9564035).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041376 mRNA Translation: AAC34985.1
AC154125 Genomic DNA No translation available.
CH466528 Genomic DNA Translation: EDL09649.1
CH466528 Genomic DNA Translation: EDL09650.1
BC096649 mRNA Translation: AAH96649.1
CCDSiCCDS37846.1
RefSeqiNP_031728.2, NM_007702.2
UniGeneiMm.449

Genome annotation databases

EnsembliENSMUST00000025404; ENSMUSP00000025404; ENSMUSG00000024526
GeneIDi12683
KEGGimmu:12683
UCSCiuc012beh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041376 mRNA Translation: AAC34985.1
AC154125 Genomic DNA No translation available.
CH466528 Genomic DNA Translation: EDL09649.1
CH466528 Genomic DNA Translation: EDL09650.1
BC096649 mRNA Translation: AAH96649.1
CCDSiCCDS37846.1
RefSeqiNP_031728.2, NM_007702.2
UniGeneiMm.449

3D structure databases

ProteinModelPortaliO70302
SMRiO70302
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198712, 3 interactors
IntActiO70302, 7 interactors
MINTiO70302
STRINGi10090.ENSMUSP00000025404

Proteomic databases

PaxDbiO70302
PRIDEiO70302

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025404; ENSMUSP00000025404; ENSMUSG00000024526
GeneIDi12683
KEGGimmu:12683
UCSCiuc012beh.1 mouse

Organism-specific databases

CTDi1149
MGIiMGI:1270845 Cidea

Phylogenomic databases

eggNOGiENOG410IVIC Eukaryota
ENOG4111SUV LUCA
GeneTreeiENSGT00390000018596
HOGENOMiHOG000029211
HOVERGENiHBG050961
InParanoidiO70302
OMAiIRPLTFM
OrthoDBiEOG091G0H6W
TreeFamiTF334321

Enzyme and pathway databases

ReactomeiR-MMU-8964572 Lipid particle organization

Miscellaneous databases

PROiPR:O70302
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024526 Expressed in 132 organ(s), highest expression level in brown adipose tissue
GenevisibleiO70302 MM

Family and domain databases

InterProiView protein in InterPro
IPR032936 CIDE-A
IPR003508 CIDE-N_dom
PANTHERiPTHR12306:SF8 PTHR12306:SF8, 1 hit
PfamiView protein in Pfam
PF02017 CIDE-N, 1 hit
SMARTiView protein in SMART
SM00266 CAD, 1 hit
PROSITEiView protein in PROSITE
PS51135 CIDE_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCIDEA_MOUSE
AccessioniPrimary (citable) accession number: O70302
Secondary accession number(s): Q4V9X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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